Jeffrey Rubnitz

Jeffrey Rubnitz

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Jeffrey Rubnitz

Jeffrey Rubnitz

Publications by authors named "Jeffrey Rubnitz"

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A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia.

Leukemia 2019 Oct 23. Epub 2019 Oct 23.

Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1038/s41375-019-0604-8DOI Listing
October 2019

Genome-wide association analysis identifies SNPs predictive of leukemic cell sensitivity to cytarabine in pediatric AML.

Oncotarget 2018 Oct 9;9(79):34859-34875. Epub 2018 Oct 9.

Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.18632/oncotarget.26163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201857PMC
October 2018

POST: A framework for set-based association analysis in high-dimensional data.

Methods 2018 08 17;145:76-81. Epub 2018 May 17.

Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2018.05.011DOI Listing
August 2018

Adverse Effects of Intravenous Vancomycin-Based Prophylaxis during Therapy for Pediatric Acute Myeloid Leukemia.

Antimicrob Agents Chemother 2018 03 23;62(3). Epub 2018 Feb 23.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.01838-17
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http://dx.doi.org/10.1128/AAC.01838-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826122PMC
March 2018

Opportunities for expanding clinical trial enrollment for relapsed and refractory pediatric acute myeloid leukemia in the United States and Canada.

Pediatr Blood Cancer 2017 11 16;64(11). Epub 2017 May 16.

Departments of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.26632DOI Listing
November 2017

Genetics of pleiotropic effects of dexamethasone.

Pharmacogenet Genomics 2017 08;27(8):294-302

Departments of aPharmaceutical Sciences bBiostatistics cOncology dComprehensive Cancer Center, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523978PMC
August 2017

Current Management of Childhood Acute Myeloid Leukemia.

Paediatr Drugs 2017 Feb;19(1):1-10

Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA.

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http://dx.doi.org/10.1007/s40272-016-0200-6DOI Listing
February 2017

Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination With Fludarabine and Cytarabine, in Pediatric Relapsed or Refractory Acute Leukemia.

J Clin Oncol 2016 12 31;34(34):4094-4101. Epub 2016 Oct 31.

Thomas B. Alexander, John K. Choi, Raul C. Ribeiro, Ching-Hon Pui, and Jeffrey E. Rubnitz, St Jude Children's Research Hospital; Raul C. Ribeiro, Ching-Hon Pui, and Jeffrey E. Rubnitz, University of Tennessee College of Medicine, Memphis, TN; and Norman J. Lacayo, Lucile Packard Children's Hospital Stanford, Stanford, CA.

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http://dx.doi.org/10.1200/JCO.2016.67.5066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477824PMC
December 2016

Evaluation of artemisinins for the treatment of acute myeloid leukemia.

Cancer Chemother Pharmacol 2016 06 28;77(6):1231-43. Epub 2016 Apr 28.

Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 W. 12th St., Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1007/s00280-016-3038-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918815PMC
June 2016

Monitoring Central Venous Catheter Resistance to Predict Imminent Occlusion: A Prospective Pilot Study.

PLoS One 2015 31;10(8):e0135904. Epub 2015 Aug 31.

Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135904PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555832PMC
May 2016

Clinical Impact of Additional Cytogenetic Aberrations, cKIT and RAS Mutations, and Treatment Elements in Pediatric t(8;21)-AML: Results From an International Retrospective Study by the International Berlin-Frankfurt-Münster Study Group.

J Clin Oncol 2015 Dec 16;33(36):4247-58. Epub 2015 Nov 16.

Kim Klein, Gertjan Kaspers, Jacqueline Cloos, and Mathilda Bongers, Vrije Universiteit University Medical Center Amsterdam; Gertjan Kaspers and Ardine Reedijk, Dutch Childhood Oncology Group, The Hague; H. Berna Beverloo, Erasmus Medical Center, Rotterdam, the Netherlands; Christine J. Harrison, Newcastle University, Newcastle upon Tyne; Brenda Gibson, Royal Hospital for Sick Children, Glasgow, United Kingdom; Andrea Pession, Italian Association of Pediatric Hematology Oncology, Bologna, Italy; Dirk Reinhardt, Berlin-Frankfurt-Münster (BFM) -Germany, Essen; Martin Zimmerman and Ursula Creutzig, BFM-Germany, Hannover, Germany; Michael Dworzak, BFM-Austria, Vienna, Austria; Todd Alonzo, Donna Johnston, and Betsy Hirsch, Children's Oncology Group (COG) including Children's Cancer Group and Pediatric Oncology Group, Philadelphia (COG chair's office), PA; Michal Zapotocky, Czech Paediatric Hematology Working Group, Prague, Czech Republic; Barbara De Moerloose, European Organisation for Research and Treatment of Cancer-Children's Leukemia Group, Brussels, Belgium; Alcira Flynn, Grupo Argentino de Tratamiento de la Leucemia Aguda, Buenos Aires, Argentina; Vincent Lee, Hong Kong Paediatric Haematology and Oncology Study Group, Hong Kong, Special Administrative Region, People's Republic of China; Takashi Taga, Japanese Pediatric Leukemia/Lymphoma Study Group, Otsu; Akio Tawa, Japanese Pediatric Leukemia/Lymphoma Study Group, Osaka, Japan; Anne Auvrignon, French Leucémie Aiguë Myéloblastique Enfant Cooperative Group, Paris, France; Bernward Zeller, Nordic Society of Paediatric Haematology and Oncology, Oslo, Norway; Erik Forestier, Nordic Society of Paediatric Haematology and Oncology, Umeå, Sweden; Carmen Salgado, The National Program for Antineoplastic Drugs for Children, Santiago, Chile; Walentyna Balwierz, Polish Pediatric Leukemia Lymphoma Study Group, Krakow, Poland; Alexander Popa, Russian Acute Myeloid Leukemia Study Group, Moscow, Russia; and Jeffrey Rubnitz and

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http://dx.doi.org/10.1200/JCO.2015.61.1947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321085PMC
December 2015

Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia.

J Clin Oncol 2015 Sep 24;33(27):2949-62. Epub 2015 Aug 24.

C. Michel Zwaan, Marry M. van den Heuvel-Eibrink, Sophia Children's Hospital/Erasmus MC, Rotterdam; C. Michel Zwaan, International Berlin-Frankfurt-Münster Study Group (I-BFM-SG) New Agents Committee; C. Michel Zwaan, Innovative Therapies for Children With Cancer Consortium; C. Michel Zwaan, Eveline S.J.M. De Bont, Marry M. van den Heuvel-Eibrink, Gertjan J.L. Kaspers, Dutch Childhood Oncology Group, Den Haag; Eveline S.J.M. De Bont, University of Groningen, University Medical Center Groningen, Groningen; Marry M. van den Heuvel-Eibrink, Gertjan J.L. Kaspers, Princess Máxima Center for Pediatric Oncology, Utrecht; Gertjan J.L. Kaspers, Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Edward A. Kolb, Nemours/Alfred I. du Pont Hospital for Children, Wilmington, DE; Edward A. Kolb, Richard Aplenc, Lilian Sung, Children's Oncology Group, Monrovia, CA; Dirk Reinhardt, Universitäts-Klinikum, Essen; Ursula Creutzig, Hannover Medical School, Hannover; Dirk Reinhardt, Michael Dworzak, Henrik Hasle, Ursula Creutzig, Gertjan J.L. Kaspers, I-BFM Acute Myeloid Leukemia (AML) Study Group, Kiel, Germany; Jonas Abrahamsson, Sahlgrenska University Hospital, Goteborg; Jonas Abrahamsson and Henrik Hasle, Nordic Society for Pediatric Hematology and Oncology, Stockholm, Sweden; Souichi Adachi, Kyoto University, Kyoto; Souichi Adachi, Daisuke Tomizawa, The Japanese Pediatric Leukemia/Lymphoma Study Group, Nagoya; Daisuke Tomizawa, National Center for Child Health and Development, Tokyo, Japan; Richard Aplenc, Children's Hospital of Philadelphia, Philadelphia, PA; Barbara De Moerloose, Ghent University Hospital and Belgian Society of Paediatric Haematology Oncology, Ghent, Belgium; Michael Dworzak, St Anna Children's Hospital and Children's Cancer Research Institute, Medical University of Vienna, Vienna, Austria; Brenda E.S. Gibson, Royal Hospital for Sick Children, Glasgow; Brenda E.S. Gibson and Owen Smith, Children's Cancer and Leukemia Study Group, London, United King

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http://dx.doi.org/10.1200/JCO.2015.62.8289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567700PMC
September 2015

Natural killer cell therapy in children with relapsed leukemia.

Pediatr Blood Cancer 2015 Aug 30;62(8):1468-72. Epub 2015 Apr 30.

Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.25555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634362PMC
August 2015

New approaches for the immunotherapy of acute myeloid leukemia.

Discov Med 2015 Apr;19(105):275-84

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628787PMC
April 2015

Utility of early screening magnetic resonance imaging for extensive hip osteonecrosis in pediatric patients treated with glucocorticoids.

J Clin Oncol 2015 Feb 20;33(6):610-5. Epub 2015 Jan 20.

Sue C. Kaste, Deqing Pei, Cheng Cheng, Michael D. Neel, Raul C. Ribeiro, Monika L. Metzger, Deepa Bhojwani, Hiroto Inaba, Patrick Campbell, Jeffrey E. Rubnitz, Sima Jeha, John T. Sandlund, James R. Downing, Mary V. Relling, Ching-Hon Pui, and Scott C. Howard, St Jude Children's Research Hospital; Sue C. Kaste, University of Tennessee Health Sciences Center, Memphis, TN; and W. Paul Bowman, Cook Children's Medical Center, Fort Worth, TX.

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http://dx.doi.org/10.1200/JCO.2014.57.5480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322260PMC
February 2015

Definition of cure in childhood acute myeloid leukemia.

Cancer 2014 Aug 2;120(16):2490-6. Epub 2014 May 2.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.

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http://doi.wiley.com/10.1002/cncr.28742
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http://dx.doi.org/10.1002/cncr.28742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282842PMC
August 2014

Recent research and future prospects for gemtuzumab ozogamicin: could it make a comeback?

Expert Rev Hematol 2014 Aug 29;7(4):427-9. Epub 2014 May 29.

Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 260, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1586/17474086.2014.924849DOI Listing
August 2014

Feasibility, efficacy, and adverse effects of outpatient antibacterial prophylaxis in children with acute myeloid leukemia.

Cancer 2014 Jul 26;120(13):1985-92. Epub 2014 Mar 26.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.

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http://dx.doi.org/10.1002/cncr.28688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063871PMC
July 2014

Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.

J Clin Oncol 2014 Mar 18;32(9):949-59. Epub 2014 Feb 18.

All authors: St Jude Children's Research Hospital; and Deepa Bhojwani, Jun J. Yang, Hiroto Inaba, Jeffrey E. Rubnitz, Monika L. Metzger, Scott C. Howard, Raul C. Ribeiro, Sima Jeha, John T. Sandlund, and Ching-Hon Pui, University of Tennessee Health Sciences Center, College of Medicine, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2013.53.0808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948096PMC
March 2014

Voriconazole prophylaxis in children with cancer: changing outcomes and epidemiology of fungal infections.

Pediatr Infect Dis J 2013 Dec;32(12):e451-5

From the Departments of *Infectious Diseases, †Pathology, and ‡Oncology, St. Jude Children's Research Hospital; and Departments of §Pediatrics and ¶Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN.

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http://dx.doi.org/10.1097/INF.0b013e3182a74233DOI Listing
December 2013

Gemtuzumab ozogamicin can reduce minimal residual disease in patients with childhood acute myeloid leukemia.

Cancer 2013 Nov 4;119(22):4036-43. Epub 2013 Sep 4.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.

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http://dx.doi.org/10.1002/cncr.28334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271731PMC
November 2013

Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia.

Clin Cancer Res 2013 Oct 22;19(20):5758-68. Epub 2013 Aug 22.

Authors' Affiliations: Departments of Pharmaceutical Sciences, Structural Biology, Pathology, and Oncology, Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital; and Department of Pediatrics, University of Tennessee, Memphis, Tennessee.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878304PMC
October 2013

Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments.

Cancer Chemother Pharmacol 2013 Aug 13;72(2):369-78. Epub 2013 Jun 13.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.

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http://dx.doi.org/10.1007/s00280-013-2206-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719000PMC
August 2013

Sequential administration of methotrexate and asparaginase in relapsed or refractory pediatric acute myeloid leukemia.

Pediatr Blood Cancer 2013 Jul 17;60(7):1161-4. Epub 2013 Jan 17.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA.

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http://dx.doi.org/10.1002/pbc.24470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005561PMC
July 2013

Treatment outcome in older patients with childhood acute myeloid leukemia.

Cancer 2012 Dec 6;118(24):6253-9. Epub 2012 Jun 6.

Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

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http://dx.doi.org/10.1002/cncr.27659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557958PMC
December 2012

Childhood acute myeloid leukaemia.

Br J Haematol 2012 Nov 12;159(3):259-76. Epub 2012 Sep 12.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://doi.wiley.com/10.1111/bjh.12040
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http://dx.doi.org/10.1111/bjh.12040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468705PMC
November 2012

Ontogeny and sorafenib metabolism.

Clin Cancer Res 2012 Oct 27;18(20):5788-95. Epub 2012 Aug 27.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-1967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490489PMC
October 2012

How I treat pediatric acute myeloid leukemia.

Blood 2012 Jun 7;119(25):5980-8. Epub 2012 May 7.

Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-2794, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-02-39
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http://dx.doi.org/10.1182/blood-2012-02-392506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383013PMC
June 2012

Inhibition of OCTN2-mediated transport of carnitine by etoposide.

Mol Cancer Ther 2012 Apr 2;11(4):921-9. Epub 2012 Mar 2.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466062PMC
April 2012

Isolated nasal septum necrosis caused by Aspergillus flavus in an immunocompromised child.

Pediatr Infect Dis J 2011 Jul;30(7):627-9

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1097/INF.0b013e31820b7c3aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873770PMC
July 2011

Mechanisms of synergistic antileukemic interactions between valproic acid and cytarabine in pediatric acute myeloid leukemia.

Clin Cancer Res 2010 Nov 1;16(22):5499-510. Epub 2010 Oct 1.

Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 110 E. Warren Avenue, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018695PMC
November 2010

NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia.

J Clin Oncol 2010 Feb 19;28(6):955-9. Epub 2010 Jan 19.

Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1200/JCO.2009.24.4590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834435PMC
February 2010

Acute myeloid leukemia.

Hematol Oncol Clin North Am 2010 Feb;24(1):35-63

Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S088985880900203
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http://dx.doi.org/10.1016/j.hoc.2009.11.008DOI Listing
February 2010

Levetiracetam as monotherapy for seizures in a neonate with acute lymphoblastic leukemia.

Eur J Paediatr Neurol 2010 Jan 30;14(1):78-9. Epub 2009 Jan 30.

Division of Neurology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.ejpn.2008.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902105PMC
January 2010

Minimal residual disease quantitation in acute myeloid leukemia.

Clin Lymphoma Myeloma 2009 ;9 Suppl 3:S281-5

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.

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http://dx.doi.org/10.3816/CLM.2009.s.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785493PMC
January 2010

Health-related quality of life in adolescents at the time of diagnosis with osteosarcoma or acute myeloid leukemia.

Eur J Oncol Nurs 2009 Jul 15;13(3):156-63. Epub 2008 Oct 15.

Division of Nursing Research, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.ejon.2008.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017853PMC
July 2009

Cutaneous infection caused by Macrophomina phaseolina in a child with acute myeloid leukemia.

J Clin Microbiol 2009 Jun 22;47(6):1969-72. Epub 2009 Apr 22.

Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 260, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1128/JCM.02397-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691108PMC
June 2009