Jeffrey R Koup

Jeffrey R Koup

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Jeffrey R Koup

Jeffrey R Koup

Publications by authors named "Jeffrey R Koup"

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Pharmacokinetic-pharmacodynamic modeling of biomarker response and tumor growth inhibition to an orally available cMet kinase inhibitor in human tumor xenograft mouse models.

Drug Metab Dispos 2008 Jul 1;36(7):1267-74. Epub 2008 Apr 1.

Pharmacokinetics, Dynamics and Metabolism, La Jolla Laboratories, Pfizer Global Research and Development, 10777 Science Center Dr., San Diego, CA 92121, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.107.019711
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http://dx.doi.org/10.1124/dmd.107.019711DOI Listing
July 2008

A novel simultaneous modeling approach to estimate linearity of pharmacokinetic parameters, including saturation of intestinal efflux, in the rat.

J Pharmacol Toxicol Methods 2005 Nov-Dec;52(3):307-13. Epub 2005 Jun 23.

Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, MI 48105, USA.

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http://dx.doi.org/10.1016/j.vascn.2005.04.014DOI Listing
March 2006

How modeling and simulation have enhanced decision making in new drug development.

J Pharmacokinet Pharmacodyn 2005 Apr 7;32(2):185-97. Epub 2005 Nov 7.

Pfizer Global Research and Development, Pfizer Inc, Ann Arbor, MI 48105, USA.

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http://dx.doi.org/10.1007/s10928-005-0074-7DOI Listing
April 2005

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios.

Drug Metab Dispos 2004 Nov 10;32(11):1201-8. Epub 2004 Aug 10.

Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.

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http://dx.doi.org/10.1124/dmd.104.000794DOI Listing
November 2004