Jeffrey N Weiser

Jeffrey N Weiser

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Jeffrey N Weiser

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Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Infection.

J Immunol 2020 Jan 27;204(1):101-111. Epub 2019 Nov 27.

Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111;

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http://dx.doi.org/10.4049/jimmunol.1800748DOI Listing
January 2020

Regenerative therapy based on miRNA-302 mimics for enhancing host recovery from pneumonia caused by .

Proc Natl Acad Sci U S A 2019 Apr 10;116(17):8493-8498. Epub 2019 Apr 10.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1818522116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486708PMC
April 2019

Fast and flexible bacterial genomic epidemiology with PopPUNK.

Genome Res 2019 02 24;29(2):304-316. Epub 2019 Jan 24.

MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, United Kingdom.

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http://dx.doi.org/10.1101/gr.241455.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360808PMC
February 2019

Pneumococcal quorum sensing drives an asymmetric owner-intruder competitive strategy during carriage via the competence regulon.

Nat Microbiol 2019 01 10;4(1):198-208. Epub 2018 Dec 10.

Department of Microbiology, New York University School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1038/s41564-018-0314-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342471PMC
January 2019

pyseer: a comprehensive tool for microbial pangenome-wide association studies.

Bioinformatics 2018 12;34(24):4310-4312

Department of Parasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1093/bioinformatics/bty539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289128PMC
December 2018

Age-related differences in IL-1 signaling and capsule serotype affect persistence of Streptococcus pneumoniae colonization.

PLoS Pathog 2018 10 31;14(10):e1007396. Epub 2018 Oct 31.

Department of Microbiology, New York University School of Medicine, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231672PMC
October 2018

Streptococcus pneumoniae: transmission, colonization and invasion.

Nat Rev Microbiol 2018 06;16(6):355-367

University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1038/s41579-018-0001-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949087PMC
June 2018

Capsule Prolongs Survival of Streptococcus pneumoniae during Starvation.

Infect Immun 2018 03 20;86(3). Epub 2018 Feb 20.

Department of Microbiology, New York University School of Medicine, New York, New York, USA

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http://dx.doi.org/10.1128/IAI.00802-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820961PMC
March 2018

The immunological mechanisms that control pneumococcal carriage.

PLoS Pathog 2017 12 21;13(12):e1006665. Epub 2017 Dec 21.

Department of Clinicial Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1006665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739485PMC
December 2017

Capsule Type and Amount Affect Shedding and Transmission of .

mBio 2017 08 22;8(4). Epub 2017 Aug 22.

Department of Microbiology, New York University School of Medicine, New York, New York, USA

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http://dx.doi.org/10.1128/mBio.00989-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565965PMC
August 2017

Transmission Is Blocked by Type-Specific Immunity in an Infant Mouse Model.

mBio 2017 03 14;8(2). Epub 2017 Mar 14.

Department of Microbiology, New York University School of Medicine, New York, New York, USA

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http://dx.doi.org/10.1128/mBio.00188-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350464PMC
March 2017

Host-to-Host Transmission of Streptococcus pneumoniae Is Driven by Its Inflammatory Toxin, Pneumolysin.

Cell Host Microbe 2017 Jan;21(1):73-83

Department of Microbiology, New York University, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267320PMC
January 2017

Single Cell Bottlenecks in the Pathogenesis of Streptococcus pneumoniae.

PLoS Pathog 2016 Oct 12;12(10):e1005887. Epub 2016 Oct 12.

Department of Microbiology, New York University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061371PMC
October 2016

Infant Mouse Model for the Study of Shedding and Transmission during Streptococcus pneumoniae Monoinfection.

Infect Immun 2016 09 19;84(9):2714-22. Epub 2016 Aug 19.

Department of Microbiology, New York University, New York, New York, USA

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http://dx.doi.org/10.1128/IAI.00416-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995895PMC
September 2016

Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis.

Blood 2016 05 17;127(20):2460-71. Epub 2016 Mar 17.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; and Department of Microbiology, New York University School of Medicine, New York, NY.

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http://dx.doi.org/10.1182/blood-2015-10-675173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874226PMC
May 2016

Sensing of interleukin-1 cytokines during Streptococcus pneumoniae colonization contributes to macrophage recruitment and bacterial clearance.

Infect Immun 2015 Aug 1;83(8):3204-12. Epub 2015 Jun 1.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://iai.asm.org/lookup/doi/10.1128/IAI.00224-15
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http://dx.doi.org/10.1128/IAI.00224-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496617PMC
August 2015

Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking.

PLoS Pathog 2015 Jun 24;11(6):e1005004. Epub 2015 Jun 24.

Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America; Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479461PMC
June 2015

Degradation products of the extracellular pathogen Streptococcus pneumoniae access the cytosol via its pore-forming toxin.

mBio 2015 Jan 20;6(1). Epub 2015 Jan 20.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/mBio.02110-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313911PMC
January 2015

Binding of human factor H to outer membrane protein P5 of non-typeable Haemophilus influenzae contributes to complement resistance.

Mol Microbiol 2014 Oct 18;94(1):89-106. Epub 2014 Aug 18.

Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA; Department of Pediatrics, Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/mmi.12741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497536PMC
October 2014

Unravelling the multiple functions of the architecturally intricate Streptococcus pneumoniae β-galactosidase, BgaA.

PLoS Pathog 2014 Sep 11;10(9):e1004364. Epub 2014 Sep 11.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America; Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161441PMC
September 2014

TLR2 signaling decreases transmission of Streptococcus pneumoniae by limiting bacterial shedding in an infant mouse Influenza A co-infection model.

PLoS Pathog 2014 Aug 28;10(8):e1004339. Epub 2014 Aug 28.

Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148449PMC
August 2014

Tolerance of a phage element by Streptococcus pneumoniae leads to a fitness defect during colonization.

J Bacteriol 2014 Jul 9;196(14):2670-80. Epub 2014 May 9.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

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http://jb.asm.org/cgi/doi/10.1128/JB.01556-14
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http://dx.doi.org/10.1128/JB.01556-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097588PMC
July 2014

Macrophage migration inhibitory factor promotes clearance of pneumococcal colonization.

J Immunol 2014 Jul 13;193(2):764-72. Epub 2014 Jun 13.

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104; and.

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http://dx.doi.org/10.4049/jimmunol.1400133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085577PMC
July 2014

Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source.

Cell Host Microbe 2014 Jul;16(1):55-67

Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2014.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096718PMC
July 2014

Shielding of a lipooligosaccharide IgM epitope allows evasion of neutrophil-mediated killing of an invasive strain of nontypeable Haemophilus influenzae.

mBio 2014 Jul 22;5(4):e01478-14. Epub 2014 Jul 22.

Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/mBio.01478-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120200PMC
July 2014

The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice.

Nat Med 2014 May 20;20(5):524-30. Epub 2014 Apr 20.

1] Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. [2] Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nm.3542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016187PMC
May 2014

Evasion of killing by human antibody and complement through multiple variations in the surface oligosaccharide of Haemophilus influenzae.

Mol Microbiol 2013 May 12;88(3):603-18. Epub 2013 Apr 12.

Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/mmi.12214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550093PMC
May 2013

Microbial modulation of host immunity with the small molecule phosphorylcholine.

Infect Immun 2013 Feb 10;81(2):392-401. Epub 2012 Dec 10.

Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1128/IAI.01168-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553803PMC
February 2013

The battle with the host over microbial size.

Authors:
Jeffrey N Weiser

Curr Opin Microbiol 2013 Feb 8;16(1):59-62. Epub 2013 Feb 8.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States.

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http://dx.doi.org/10.1016/j.mib.2013.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622179PMC
February 2013

Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia.

mBio 2012 Nov 20;3(6). Epub 2012 Nov 20.

Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/mBio.00224-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509427PMC
November 2012

Increased chain length promotes pneumococcal adherence and colonization.

Infect Immun 2012 Oct 23;80(10):3454-9. Epub 2012 Jul 23.

Departments of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://iai.asm.org/lookup/doi/10.1128/IAI.00587-12
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http://dx.doi.org/10.1128/IAI.00587-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457561PMC
October 2012

Co-infection subverts mucosal immunity in the upper respiratory tract.

Curr Opin Immunol 2012 Aug 2;24(4):417-23. Epub 2012 Jun 2.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.1016/j.coi.2012.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423578PMC
August 2012

Protection from the acquisition of Staphylococcus aureus nasal carriage by cross-reactive antibody to a pneumococcal dehydrogenase.

Proc Natl Acad Sci U S A 2012 Aug 6;109(34):13823-8. Epub 2012 Aug 6.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.1208075109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427079PMC
August 2012

Phosphorylcholine allows for evasion of bactericidal antibody by Haemophilus influenzae.

PLoS Pathog 2012 1;8(3):e1002521. Epub 2012 Mar 1.

Department of Microbiology, University of Pennsylvania, Philadelphia, PA, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291618PMC
July 2012

Minimization of bacterial size allows for complement evasion and is overcome by the agglutinating effect of antibody.

Cell Host Microbe 2011 Nov;10(5):486-96

Department of Microbiology, University of Pennsylvania, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1016/j.chom.2011.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222866PMC
November 2011

Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice.

J Clin Invest 2011 Sep 15;121(9):3657-65. Epub 2011 Aug 15.

Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6076, USA.

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http://dx.doi.org/10.1172/JCI57762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163966PMC
September 2011

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice.

J Clin Invest 2011 Sep 15;121(9):3666-76. Epub 2011 Aug 15.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.

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http://dx.doi.org/10.1172/JCI57761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163965PMC
September 2011

Intracellular sensors of extracellular bacteria.

Immunol Rev 2011 Sep;243(1):9-25

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01039.xDOI Listing
September 2011

Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2.

Infect Immun 2011 Aug 16;79(8):3309-16. Epub 2011 May 16.

Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1128/IAI.05114-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147564PMC
August 2011

Invasive bacterial pathogens exploit TLR-mediated downregulation of tight junction components to facilitate translocation across the epithelium.

Cell Host Microbe 2011 May;9(5):404-14

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.chom.2011.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536975PMC
May 2011

Modifications to the peptidoglycan backbone help bacteria to establish infection.

Infect Immun 2011 Feb 1;79(2):562-70. Epub 2010 Nov 1.

Department of Microbiology, University of Pennsylvania School of Medicine, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1128/IAI.00651-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028845PMC
February 2011

Within-host competition drives selection for the capsule virulence determinant of Streptococcus pneumoniae.

Curr Biol 2010 Jul 17;20(13):1222-6. Epub 2010 Jun 17.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09609822100065
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http://dx.doi.org/10.1016/j.cub.2010.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913241PMC
July 2010

Three surface exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, promote resistance to opsonophagocytic killing by human neutrophils.

Infect Immun 2010 May 16;78(5):2108-16. Epub 2010 Feb 16.

Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/IAI.01125-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863504PMC
May 2010

Identification of the targets of cross-reactive antibodies induced by Streptococcus pneumoniae colonization.

Infect Immun 2010 May 15;78(5):2231-9. Epub 2010 Mar 15.

Department of Microbiology, University of Pennsylvania School of Medicine, 402A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1128/IAI.01058-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863509PMC
May 2010

The pneumococcus: why a commensal misbehaves.

Authors:
Jeffrey N Weiser

J Mol Med (Berl) 2010 Feb 7;88(2):97-102. Epub 2009 Nov 7.

Department of Microbiology and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00109-009-0557-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487619PMC
February 2010

Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype.

Infect Immun 2010 Feb 30;78(2):716-25. Epub 2009 Nov 30.

Centre for Respiratory Research, Department of Medicine, University College Medical School, Rayne Institute, 5 University Street, London WC1E 6JJ, United Kingdom.

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http://dx.doi.org/10.1128/IAI.01056-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812205PMC
February 2010

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity.

Nat Med 2010 Feb 17;16(2):228-31. Epub 2010 Jan 17.

Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nm.2087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497535PMC
February 2010

Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin.

PLoS Pathog 2009 Oct 16;5(10):e1000622. Epub 2009 Oct 16.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1371/journal.ppat.1000622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757716PMC
October 2009

Natural antibody to conserved targets of Haemophilus influenzae limits colonization of the murine nasopharynx.

Infect Immun 2009 Aug 18;77(8):3458-65. Epub 2009 May 18.

Departments of Microbiology, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1128/IAI.01564-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715656PMC
August 2009

Human neutrophils kill Streptococcus pneumoniae via serine proteases.

J Immunol 2009 Aug 20;183(4):2602-9. Epub 2009 Jul 20.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0900688
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http://dx.doi.org/10.4049/jimmunol.0900688DOI Listing
August 2009

Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice.

J Clin Invest 2009 Jul 8;119(7):1899-909. Epub 2009 Jun 8.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1172/JCI36731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701860PMC
July 2009

Early bacterial colonization induces toll-like receptor-dependent transforming growth factor beta signaling in the epithelium.

Infect Immun 2009 May 2;77(5):2212-20. Epub 2009 Mar 2.

402A Johnson Pavilion, Department of Microbiology and Pediatrics, University of Pennsylvania, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1128/IAI.01224-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681725PMC
May 2009

Mucosal clearance of capsule-expressing bacteria requires both TLR and nucleotide-binding oligomerization domain 1 signaling.

J Immunol 2008 Dec;181(11):7909-16

Department of Microbiology, University of Pennsylvania,Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.181.11.7909DOI Listing
December 2008

Resistance to mucosal lysozyme compensates for the fitness deficit of peptidoglycan modifications by Streptococcus pneumoniae.

PLoS Pathog 2008 Dec 12;4(12):e1000241. Epub 2008 Dec 12.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1371/journal.ppat.1000241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587705PMC
December 2008

Neutrophil-toxin interactions promote antigen delivery and mucosal clearance of Streptococcus pneumoniae.

J Immunol 2008 May;180(9):6246-54

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.180.9.6246DOI Listing
May 2008

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease.

Nat Rev Microbiol 2008 Apr;6(4):288-301

Department of Infection, Immunity & Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom.

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http://www.acsu.buffalo.edu/~andersh/downloads/Kadioglu-2008
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http://www.nature.com/doifinder/10.1038/nrmicro1871
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http://dx.doi.org/10.1038/nrmicro1871DOI Listing
April 2008

Role of p38 MAP kinase and transforming growth factor-beta signaling in transepithelial migration of invasive bacterial pathogens.

J Biol Chem 2007 Sep 24;282(39):28700-8. Epub 2007 Jul 24.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M703576200DOI Listing
September 2007

Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis.

Antimicrob Agents Chemother 2007 Sep 30;51(9):3225-9. Epub 2007 Jul 30.

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1128/AAC.00336-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043225PMC
September 2007

Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing.

PLoS Pathog 2007 Aug;3(8):e118

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.0030118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950946PMC
August 2007

Interleukin-8 secretion in response to aferric enterobactin is potentiated by siderocalin.

Infect Immun 2007 Jun 9;75(6):3160-8. Epub 2007 Apr 9.

Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1128/IAI.01719-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1932857PMC
June 2007

Live attenuated Streptococcus pneumoniae strains induce serotype-independent mucosal and systemic protection in mice.

Infect Immun 2007 May 5;75(5):2469-75. Epub 2007 Mar 5.

Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104-6076, USA.

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http://iai.asm.org/cgi/doi/10.1128/IAI.01972-06
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http://dx.doi.org/10.1128/IAI.01972-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865756PMC
May 2007

Nod1 mediates cytoplasmic sensing of combinations of extracellular bacteria.

Cell Microbiol 2007 May;9(5):1343-51

Departments of Microbiology and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1462-5822.2006.00878.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867455PMC
May 2007

Impact of the molecular form of immunoglobulin A on functional activity in defense against Streptococcus pneumoniae.

Infect Immun 2007 Apr 29;75(4):1801-10. Epub 2007 Jan 29.

Division of Infectious Diseases and International Medicine, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1128/IAI.01758-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865688PMC
April 2007

Effect of pneumococcal polysaccharide vaccine on nonbacteremic pneumococcal pneumonia.

Clin Infect Dis 2007 Apr;44(8):1139-40; author reply 1140-1

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http://dx.doi.org/10.1086/513032DOI Listing
April 2007

The blp bacteriocins of Streptococcus pneumoniae mediate intraspecies competition both in vitro and in vivo.

Infect Immun 2007 Jan 30;75(1):443-51. Epub 2006 Oct 30.

Department of Microbiology, University of Pennsylvania, 402A Johnson Pavilion, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1128/IAI.01775-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828380PMC
January 2007

Capsule enhances pneumococcal colonization by limiting mucus-mediated clearance.

Infect Immun 2007 Jan 6;75(1):83-90. Epub 2006 Nov 6.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1128/IAI.01475-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828419PMC
January 2007

The atypical amino-terminal LPNTG-containing domain of the pneumococcal human IgA1-specific protease is required for proper enzyme localization and function.

Mol Microbiol 2006 Jul 15;61(2):526-43. Epub 2006 Jun 15.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://doi.wiley.com/10.1111/j.1365-2958.2006.05256.x
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http://dx.doi.org/10.1111/j.1365-2958.2006.05256.xDOI Listing
July 2006

Epithelial cells are sensitive detectors of bacterial pore-forming toxins.

J Biol Chem 2006 May 6;281(18):12994-8. Epub 2006 Mar 6.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M511431200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1586115PMC
May 2006

Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae.

Mol Microbiol 2006 Feb;59(3):961-74

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2005.04984.xDOI Listing
February 2006

Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model.

Infect Immun 2005 Nov;73(11):7718-26

University of Pennsylvania, 402A Johnson Pavilion, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1128/IAI.73.11.7718-7726.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1273875PMC
November 2005

Bacterial colonization of nasal mucosa induces expression of siderocalin, an iron-sequestering component of innate immunity.

Cell Microbiol 2005 Oct;7(10):1404-17

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1111/j.1462-5822.2005.00566.xDOI Listing
October 2005

The role of innate immune responses in the outcome of interspecies competition for colonization of mucosal surfaces.

PLoS Pathog 2005 Sep 22;1(1):e1. Epub 2005 Jul 22.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.0010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1238736PMC
September 2005

Synergistic proinflammatory responses induced by polymicrobial colonization of epithelial surfaces.

Proc Natl Acad Sci U S A 2005 Mar 22;102(9):3429-34. Epub 2005 Feb 22.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0500599102
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http://dx.doi.org/10.1073/pnas.0500599102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC552945PMC
March 2005

Cross-reactivity of human immunoglobulin G2 recognizing phosphorylcholine and evidence for protection against major bacterial pathogens of the human respiratory tract.

J Infect Dis 2004 Oct 31;190(7):1254-63. Epub 2004 Aug 31.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6076, USA.

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http://dx.doi.org/10.1086/424517DOI Listing
October 2004

Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization.

Infect Immun 2004 Oct;72(10):5807-13

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.

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http://dx.doi.org/10.1128/IAI.72.10.5807-5813.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517579PMC
October 2004

Phase variable desialylation of host proteins that bind to Streptococcus pneumoniae in vivo and protect the airway.

Mol Microbiol 2004 Oct;54(1):159-71

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2004.04252.xDOI Listing
October 2004

Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization.

Infect Immun 2003 Oct;71(10):5724-32

Department of Microbiology and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC201056PMC
http://dx.doi.org/10.1128/iai.71.10.5724-5732.2003DOI Listing
October 2003

Multiple mechanisms for choline transport and utilization in Haemophilus influenzae.

Mol Microbiol 2003 Oct;50(2):537-48

University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1046/j.1365-2958.2003.03703.xDOI Listing
October 2003

Antibody-enhanced pneumococcal adherence requires IgA1 protease.

Proc Natl Acad Sci U S A 2003 Apr 17;100(7):4215-20. Epub 2003 Mar 17.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0637469100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153073PMC
April 2003

Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A.

Antimicrob Agents Chemother 2003 Jan;47(1):1-6

Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149021PMC
http://dx.doi.org/10.1128/aac.47.1.1-6.2003DOI Listing
January 2003

The inhibitory effect of C-reactive protein on bacterial phosphorylcholine platelet-activating factor receptor-mediated adherence is blocked by surfactant.

J Infect Dis 2002 Aug 10;186(3):361-71. Epub 2002 Jul 10.

Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19104-6076, USA.

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http://dx.doi.org/10.1086/341658DOI Listing
August 2002