Publications by authors named "Jeffrey Milbrandt"

100Publications

High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation.

Genome Res 2020 Sep 4;30(9):1317-1331. Epub 2020 Sep 4.

Department of Genetics, Washington University in St. Louis School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1101/gr.262295.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545139PMC
September 2020

SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration.

J Cell Biol 2020 Aug;219(8)

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1083/jcb.201912047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401797PMC
August 2020

Domain-centric database to uncover structure of minimally characterized viral genomes.

Sci Data 2020 06 25;7(1):202. Epub 2020 Jun 25.

Department of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA.

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http://dx.doi.org/10.1038/s41597-020-0536-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316859PMC
June 2020

Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia.

Nat Commun 2020 05 21;11(1):2552. Epub 2020 May 21.

Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1038/s41467-020-16355-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242366PMC
May 2020

Cell-autonomous expression of the acid hydrolase galactocerebrosidase.

Proc Natl Acad Sci U S A 2020 04 6;117(16):9032-9041. Epub 2020 Apr 6.

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1917675117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183170PMC
April 2020

cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons.

Exp Neurol 2020 Jul 19;329:113252. Epub 2020 Feb 19.

Washington University in Saint Louis, Developmental Biology, St. Louis, MO, USA; Needleman Center for Neurometabolism and Axonal Therapeutics, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2020.113252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302925PMC
July 2020

Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy.

Glia 2020 05 23;68(5):963-978. Epub 2019 Nov 23.

Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri.

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http://dx.doi.org/10.1002/glia.23755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067678PMC
May 2020

DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration.

Mol Neurobiol 2020 Feb 7;57(2):1146-1158. Epub 2019 Nov 7.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s12035-019-01796-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035184PMC
February 2020

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.

J Exp Med 2019 02 14;216(2):294-303. Epub 2019 Jan 14.

Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO

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http://dx.doi.org/10.1084/jem.20181040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363435PMC
February 2019

HSP90 is a chaperone for DLK and is required for axon injury signaling.

Proc Natl Acad Sci U S A 2018 10 1;115(42):E9899-E9908. Epub 2018 Oct 1.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1805351115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196532PMC
October 2018

Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia.

Cell Rep 2018 09;24(13):3619-3629.e4

Department of Genetics, Washington University, School of Medicine, St. Louis, MO 63110, USA; Center for Genome Sciences and Systems Biology, Washington University, School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.08.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357782PMC
September 2018

Palmitoylation enables MAPK-dependent proteostasis of axon survival factors.

Proc Natl Acad Sci U S A 2018 09 27;115(37):E8746-E8754. Epub 2018 Aug 27.

Department of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1806933115
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http://dx.doi.org/10.1073/pnas.1806933115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140512PMC
September 2018

Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN.

Proc Natl Acad Sci U S A 2018 07 16;115(31):8019-8024. Epub 2018 Jul 16.

Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1805538115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077742PMC
July 2018

Dysregulation of NAD Metabolism Induces a Schwann Cell Dedifferentiation Program.

J Neurosci 2018 07 19;38(29):6546-6562. Epub 2018 Jun 19.

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110.

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http://dx.doi.org/10.1523/JNEUROSCI.3304-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052240PMC
July 2018

TIR Domain Proteins Are an Ancient Family of NAD-Consuming Enzymes.

Curr Biol 2018 02 25;28(3):421-430.e4. Epub 2018 Jan 25.

Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2017.12.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802418PMC
February 2018

NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia.

Ann Clin Transl Neurol 2017 10 30;4(10):722-738. Epub 2017 Aug 30.

Department of Neurology Hope Center for Neurological Disorders Washington University St. Louis Missouri 63110.

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http://dx.doi.org/10.1002/acn3.450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634348PMC
October 2017

mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.

Proc Natl Acad Sci U S A 2017 05 8;114(21):E4261-E4270. Epub 2017 May 8.

Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.

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http://dx.doi.org/10.1073/pnas.1620761114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448230PMC
May 2017

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD Cleavage Activity that Promotes Pathological Axonal Degeneration.

Neuron 2017 Mar;93(6):1334-1343.e5

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284238PMC
March 2017

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.

Elife 2017 01 17;6. Epub 2017 Jan 17.

Department of Developmental Biology, Washington University Medical School, Saint Louis, United States.

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http://dx.doi.org/10.7554/eLife.22540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241118PMC
January 2017

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.

Brain 2016 12 25;139(Pt 12):3092-3108. Epub 2016 Oct 25.

3 Hope Center for Neurological Diseases, Washington University School of Medicine, Saint Louis, MO, USA

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http://dx.doi.org/10.1093/brain/aww251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840884PMC
December 2016

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD depletion.

Elife 2016 10 13;5. Epub 2016 Oct 13.

Department of Genetics, Washington University School of Medicine, Saint Louis, United States.

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http://dx.doi.org/10.7554/eLife.19749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063586PMC
October 2016

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.

Proc Natl Acad Sci U S A 2016 10 26;113(41):E6271-E6280. Epub 2016 Sep 26.

Department of Genetics, Washington University in St. Louis, St. Louis, MO 63110; Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, MO 63110

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http://dx.doi.org/10.1073/pnas.1601506113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068253PMC
October 2016

Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity.

J Neurosci 2016 09;36(37):9633-46

Department of Genetics and Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, Missouri 63110,

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http://dx.doi.org/10.1523/JNEUROSCI.1235-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039245PMC
September 2016

Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy.

Ann Clin Transl Neurol 2016 06 6;3(6):434-42. Epub 2016 May 6.

Departments of Neurology Washington University School of Medicine St. Louis Missouri; Hope Center for Neurological Disorders Washington University School of Medicine St. Louis Missouri; Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri.

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http://dx.doi.org/10.1002/acn3.308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891997PMC
June 2016

TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance.

J Neurosci 2016 04;36(17):4681-9

Department of Developmental Biology, Washington University in St. Louis, St. Louis, Missouri 63110.

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http://dx.doi.org/10.1523/JNEUROSCI.2893-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846669PMC
April 2016

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.

Neuron 2016 Feb;89(3):449-60

Department of Developmental Biology, Washington University School of Medicine in St. Louis, 660 Euclid Avenue, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine in St. Louis, 660 Euclid Avenue, St. Louis, MO 63110, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273150112
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http://dx.doi.org/10.1016/j.neuron.2015.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742785PMC
February 2016

Feeding the brain and nurturing the mind: Linking nutrition and the gut microbiota to brain development.

Proc Natl Acad Sci U S A 2015 Nov;112(46):14105-12

Neuroimaging Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110;

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http://dx.doi.org/10.1073/pnas.1511465112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655552PMC
November 2015

Characterization of Leber Congenital Amaurosis-associated NMNAT1 Mutants.

J Biol Chem 2015 Jul 27;290(28):17228-38. Epub 2015 May 27.

From the Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110.

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http://dx.doi.org/10.1074/jbc.M115.637850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498062PMC
July 2015

SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.

Science 2015 Apr 23;348(6233):453-7. Epub 2015 Apr 23.

Department of Genetics, Washington University Medical School, Saint Louis, MO, USA. Hope Center for Neurological Disorders, Saint Louis, MO, USA.

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http://dx.doi.org/10.1126/science.1258366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513950PMC
April 2015

Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.

Nat Neurosci 2014 Oct 7;17(10):1351-61. Epub 2014 Sep 7.

1] Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://www.nature.com/articles/nn.3809
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http://dx.doi.org/10.1038/nn.3809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494117PMC
October 2014

Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons.

J Neurosci 2014 Jul;34(28):9338-50

Department of Genetics, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110

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http://dx.doi.org/10.1523/JNEUROSCI.0877-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087211PMC
July 2014

Sarm1-mediated axon degeneration requires both SAM and TIR interactions.

J Neurosci 2013 Aug;33(33):13569-80

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1197-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742939PMC
August 2013

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.

Cell Rep 2013 May 9;3(5):1422-9. Epub 2013 May 9.

Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671584PMC
May 2013

Role of oxygen consumption in hypoxia protection by translation factor depletion.

J Exp Biol 2013 Jun 26;216(Pt 12):2283-92. Epub 2013 Mar 26.

Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/jeb.082263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667128PMC
June 2013

An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury.

BMC Genomics 2013 Feb 6;14:84. Epub 2013 Feb 6.

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St, Louis, MO 63110, USA.

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http://dx.doi.org/10.1186/1471-2164-14-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599357PMC
February 2013

Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.

Invest Ophthalmol Vis Sci 2013 Jan 2;54(1):25-36. Epub 2013 Jan 2.

Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1167/iovs.12-10861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541947PMC
January 2013

SCG10 is a JNK target in the axonal degeneration pathway.

Proc Natl Acad Sci U S A 2012 Dec 27;109(52):E3696-705. Epub 2012 Nov 27.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.1216204109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535671PMC
December 2012

Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration.

Neuron 2012 Jun;74(6):1015-22

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383631PMC
June 2012

The AMPK β2 subunit is required for energy homeostasis during metabolic stress.

Mol Cell Biol 2012 Jul 14;32(14):2837-48. Epub 2012 May 14.

Department of Pediatrics, Division of Hematology and Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.05853-11
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http://dx.doi.org/10.1128/MCB.05853-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416196PMC
July 2012

A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration.

J Neurosci 2012 Apr;32(15):5054-61

Department of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4951-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336743PMC
April 2012

Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration.

J Neurosci 2012 Mar;32(12):4145-55

Department of Neurology and Genetics, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.6338-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319368PMC
March 2012

Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction.

PLoS One 2011 16;6(11):e27727. Epub 2011 Nov 16.

Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027727PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218017PMC
March 2012

Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration.

J Biol Chem 2011 Aug 17;286(32):28011-8. Epub 2011 Jun 17.

Department of Genetics, Washington University Medical School, St Louis, Missouri 63110, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.250472
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http://dx.doi.org/10.1074/jbc.M111.250472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151046PMC
August 2011

Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus.

Proc Natl Acad Sci U S A 2010 Dec 24;107(50):21836-41. Epub 2010 Nov 24.

Department of Genetics, and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.1002130107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003122PMC
December 2010

Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.

J Biol Chem 2010 Dec 11;285(53):41211-5. Epub 2010 Nov 11.

Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C110.193904
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http://dx.doi.org/10.1074/jbc.C110.193904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009846PMC
December 2010

Persephin signaling through GFRalpha1: the potential for the treatment of Parkinson's disease.

Mol Cell Neurosci 2010 Jul 27;44(3):223-32. Epub 2010 Mar 27.

Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki, FIN-00014, Finland.

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http://dx.doi.org/10.1016/j.mcn.2010.03.009DOI Listing
July 2010

Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex.

J Neurosci 2010 Mar;30(12):4232-40

Department of Neurology and Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.6248-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852190PMC
March 2010

RET signaling is required for survival and normal function of nonpeptidergic nociceptors.

J Neurosci 2010 Mar;30(11):3983-94

Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5930-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850282PMC
March 2010

Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice.

J Clin Invest 2010 Mar 15;120(3):778-90. Epub 2010 Feb 15.

Department of Internal Medicine (Renal Division), Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1172/JCI41619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827965PMC
March 2010

Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions.

Biomaterials 2010 Apr 25;31(11):3079-86. Epub 2010 Jan 25.

Biomedical Engineering, Washington University School of Medicine, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2010.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827659PMC
April 2010

Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling.

Neuron 2009 Dec;64(6):841-56

Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185, USA.

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http://dx.doi.org/10.1016/j.neuron.2009.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813518PMC
December 2009

Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.

J Neurosci 2009 Aug;29(34):10695-705

Department of Neuroscience, Division of Molecular Neurobiology, Karolinska Institute, S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1523/JNEUROSCI.2658-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665705PMC
August 2009

The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons.

J Cell Sci 2009 Jul 9;122(Pt 13):2274-82. Epub 2009 Jun 9.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://jcs.biologists.org/content/joces/122/13/2274.full.pdf
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http://jcs.biologists.org/cgi/doi/10.1242/jcs.048975
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http://dx.doi.org/10.1242/jcs.048975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723145PMC
July 2009

Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo.

J Neurosci 2009 May;29(20):6526-34

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1429-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697066PMC
May 2009

A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration.

Nat Neurosci 2009 Apr 15;12(4):387-9. Epub 2009 Mar 15.

Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1038/nn.2290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696160PMC
April 2009

The purine nucleosides adenosine and guanosine delay axonal degeneration in vitro.

J Neurochem 2009 Apr 20;109(2):595-602. Epub 2009 Feb 20.

Department of Pathology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06002.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682787PMC
April 2009

AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.

Dev Cell 2009 Feb;16(2):256-70

Department of Pathology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.devcel.2009.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662481PMC
February 2009

Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11.

J Neurosci 2008 Jul;28(30):7563-73

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1659-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643251PMC
July 2008

NS21: re-defined and modified supplement B27 for neuronal cultures.

J Neurosci Methods 2008 Jun 1;171(2):239-47. Epub 2008 Apr 1.

Department of Pharmacology, University of Iowa, Iowa City, IA 52242-1109, United States.

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http://dx.doi.org/10.1016/j.jneumeth.2008.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678682PMC
June 2008

Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress.

J Neurosci 2008 May;28(19):4861-71

Department of Pathology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0525-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678678PMC
May 2008

Neurturin-mediated ret activation is required for retinal function.

J Neurosci 2008 Apr;28(16):4123-35

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0249-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704905PMC
April 2008

Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.

J Neurosci 2007 Oct;27(43):11552-9

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5497-06.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673231PMC
October 2007

Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth.

J Neurochem 2007 Aug;102(4):1184-94

Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04624.xDOI Listing
August 2007

Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.

Development 2007 Sep 25;134(17):3191-201. Epub 2007 Jul 25.

Departments of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/dev.005884DOI Listing
September 2007

Mice lacking the immediate early gene Egr3 respond to the anti-aggressive effects of clozapine yet are relatively resistant to its sedating effects.

Neuropsychopharmacology 2008 May 18;33(6):1266-75. Epub 2007 Jul 18.

Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/sj.npp.1301505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621766PMC
May 2008

Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.

Arch Neurol 2007 Jul;64(7):998-1000

Department of Neurology, Washington University School of Medicine, PO Box 8111, 660 S Euclid Ave, St Louis, MO 63110, USA.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/arc
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http://dx.doi.org/10.1001/archneur.64.7.998DOI Listing
July 2007

Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia.

Nat Med 2007 Jun 21;13(6):730-5. Epub 2007 May 21.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nm1579DOI Listing
June 2007

Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype.

Development 2007 Jun;134(11):2171-81

Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan.

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http://dx.doi.org/10.1242/dev.001388DOI Listing
June 2007

Resveratrol stimulates AMP kinase activity in neurons.

Proc Natl Acad Sci U S A 2007 Apr 16;104(17):7217-22. Epub 2007 Apr 16.

Departments of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.0610068104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855377PMC
April 2007

Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3.

Carcinogenesis 2007 Aug 13;28(8):1653-8. Epub 2007 Apr 13.

Division of Pediatric Endocrinology, Mattel Children's Hospital at University of California at Los Angeles, David Geffen School of Medicine, 10833 Le Conte Avenue, MDCC 22-315, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1093/carcin/bgm088DOI Listing
August 2007

NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation.

J Neurochem 2007 Mar 4;100(5):1169-76. Epub 2007 Jan 4.

Department of Biological Sciences, University at Buffalo, SUNY Buffalo, New York 14260, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04292.xDOI Listing
March 2007

Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations.

J Neurosci 2007 Jan;27(2):422-30

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4798-06.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672077PMC
January 2007

RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice.

J Neurosci 2006 Oct;26(43):11230-8

Department of Medicine, Renal Division, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.1876-06.2
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674643PMC
October 2006

Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy.

J Neurosci 2006 Aug;26(33):8484-91

Department of Pathology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2320-06.2
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http://dx.doi.org/10.1523/JNEUROSCI.2320-06.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674352PMC
August 2006

Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors.

Structure 2006 Jun;14(6):1083-92

Howard Hughes Medical Institute, Stanford University School of Medicine, Department of Microbiology and Immunology, Stanford, California 94305-5124, USA.

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http://dx.doi.org/10.1016/j.str.2006.05.010DOI Listing
June 2006