Jeffrey L Wrana

Jeffrey L Wrana

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Jeffrey L Wrana

Jeffrey L Wrana

Publications by authors named "Jeffrey L Wrana"

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Gaining Insights into the Function of Post-Translational Protein Modification Using Genome Engineering and Molecular Cell Biology.

J Mol Biol 2019 Sep 12;431(19):3920-3932. Epub 2019 Jul 12.

Institute for Molecular Health Sciences, ETH Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2019.07.015DOI Listing
September 2019

Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell.

Nature 2019 05 24;569(7754):121-125. Epub 2019 Apr 24.

Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://www.nature.com/articles/s41586-019-1154-y
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http://dx.doi.org/10.1038/s41586-019-1154-yDOI Listing
May 2019

Cell competition during reprogramming gives rise to dominant clones.

Science 2019 04 21;364(6438). Epub 2019 Mar 21.

Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1126/science.aan0925DOI Listing
April 2019

Regulation of Rho GTPases from the lateral sides of migrating cells.

Small GTPases 2018 07 1;9(4):345-348. Epub 2016 Nov 1.

a Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/21541248.2016.1234430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997147PMC
July 2018

Crucial Role of Postsynaptic Syntaxin 4 in Mediating Basal Neurotransmission and Synaptic Plasticity in Hippocampal CA1 Neurons.

Cell Rep 2018 06;23(10):2955-2966

Division of Fundamental Neurobiology, Krembil Research Institute, University Health Network, Toronto, ON M5T 2S8, Canada; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.026DOI Listing
June 2018

Pulmonary pericytes regulate lung morphogenesis.

Nat Commun 2018 06 22;9(1):2448. Epub 2018 Jun 22.

Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine, D-48149, Münster, Germany.

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http://dx.doi.org/10.1038/s41467-018-04913-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015030PMC
June 2018

LUMIER: A Discovery Tool for Mammalian Protein Interaction Networks.

Methods Mol Biol 2017 ;1550:137-148

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada, M5G 1X5.

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http://dx.doi.org/10.1007/978-1-4939-6747-6_11DOI Listing
February 2018

Hippo signalling in intestinal regeneration and cancer.

Curr Opin Cell Biol 2017 10 18;48:17-25. Epub 2017 May 18.

Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2017.04.005DOI Listing
October 2017

Analysis of Hippo and TGFβ signaling in polarizing epithelial cells and mouse embryos.

Differentiation 2016 Apr-Jun;91(4-5):109-18. Epub 2016 Jan 21.

Department of Biochemistry and Donnelly Centre, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2016.01.003DOI Listing
September 2017

TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation.

Cold Spring Harb Perspect Biol 2017 Jul 5;9(7). Epub 2017 Jul 5.

Lunenfeld-Tanenbam Research Institute, Mount Sinai Hospital and Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X5, Canada.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a022186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495062PMC
July 2017

Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS.

Cell Rep 2017 07;20(1):99-111

Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Krembil Discovery Tower, KDT-8-418, 60 Leonard Street, Toronto, ON M5T 2S8, Canada; Department of Ophthalmology and Vision Science, Faculty of Medicine, University of Toronto, 340 College Street, Toronto, ON M5T 3A9, Canada; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.009DOI Listing
July 2017

KATapulting toward Pluripotency and Cancer.

J Mol Biol 2017 06 6;429(13):1958-1977. Epub 2016 Oct 6.

Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382138PMC
June 2017

Recent advances in understanding contextual TGFβ signaling.

F1000Res 2017 26;6:749. Epub 2017 May 26.

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.12688/f1000research.11295.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464225PMC
May 2017

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.

J Cell Sci 2016 09 12;129(18):3396-411. Epub 2016 Aug 12.

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8

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http://jcs.biologists.org/lookup/doi/10.1242/jcs.188417
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http://dx.doi.org/10.1242/jcs.188417DOI Listing
September 2016

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma.

Clin Cancer Res 2016 08 22;22(15):3860-75. Epub 2016 Mar 22.

Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada. Clark H. Smith Brain Tumour Centre, University of Calgary, Calgary, Alberta, Canada. Department of Oncology, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1798DOI Listing
August 2016

A critical role for NF2 and the Hippo pathway in branching morphogenesis.

Nat Commun 2016 08 2;7:12309. Epub 2016 Aug 2.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1038/ncomms12309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974664PMC
August 2016

Seeing is believing: Wnt3 localization in the gut epithelium.

Cell Res 2016 05 25;26(5):515-6. Epub 2016 Mar 25.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1038/cr.2016.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856765PMC
May 2016

A lateral signalling pathway coordinates shape volatility during cell migration.

Nat Commun 2016 05 26;7:11714. Epub 2016 May 26.

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1038/ncomms11714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894969PMC
May 2016

Multiple roles for the hippo effector yap in gut regeneration and cancer initiation.

Mol Cell Oncol 2016 May 16;3(3):e1143992. Epub 2016 Mar 16.

Centre for Systems Biology, and Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1080/23723556.2016.1143992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909447PMC
May 2016

Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways.

PLoS One 2015 1;10(6):e0126466. Epub 2015 Jun 1.

Lunenfeld Tanenbaum Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada; Department of Lab Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126466PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450877PMC
February 2016

Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.

EMBO Rep 2015 Oct 11;16(10):1334-57. Epub 2015 Aug 11.

Institute of Medical Science University of Toronto, Toronto, ON, Canada Collaborative Program in Genome Biology and Bioinformatics, University of Toronto, Toronto, ON, Canada Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada Department of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON, Canada Ottawa Institute of Systems Biology, Ottawa, ON, Canada

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http://dx.doi.org/10.15252/embr.201540974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670460PMC
October 2015

Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.

Nature 2015 Oct 21;526(7575):715-8. Epub 2015 Oct 21.

Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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http://www.nature.com/articles/nature15382
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http://dx.doi.org/10.1038/nature15382DOI Listing
October 2015

PTEN regulates cilia through Dishevelled.

Nat Commun 2015 Sep 24;6:8388. Epub 2015 Sep 24.

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1038/ncomms9388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598566PMC
September 2015

Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling.

Proc Natl Acad Sci U S A 2015 Jun 26;112(23):E3000-9. Epub 2015 May 26.

Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Toronto, ON, Canada M5T 3H7; Departments of Physiology, Obstetrics and Gynaecology,

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http://www.pnas.org/lookup/doi/10.1073/pnas.1504671112
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http://dx.doi.org/10.1073/pnas.1504671112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466715PMC
June 2015

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.

Genes Dev 2015 Apr 15;29(8):803-16. Epub 2015 Apr 15.

Center for Cancer Epigenetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Smithville, Texas 78957, USA;

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http://dx.doi.org/10.1101/gad.255109.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403257PMC
April 2015

Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling.

Dev Cell 2015 Mar;32(5):652-6

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, M5G 1X5 ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8 ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807150013
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http://dx.doi.org/10.1016/j.devcel.2015.02.019DOI Listing
March 2015

Next-generation RNA sequencing of archival formalin-fixed paraffin-embedded urothelial bladder cancer.

Eur Urol 2014 Dec 6;66(6):982-6. Epub 2014 Sep 6.

The Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.07.045DOI Listing
December 2014

The emerging role of exosomes in Wnt secretion and transport.

Curr Opin Genet Dev 2014 Aug 8;27:14-9. Epub 2014 May 8.

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2014.03.006DOI Listing
August 2014

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.

Genome Med 2014 30;6(7):57. Epub 2014 Jul 30.

Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1 Canada ; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1 Canada ; Department of Computer Science, University of Toronto, Toronto, ON M5S 3E1 Canada.

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http://link.springer.com/content/pdf/10.1186%2Fs13073-014-00
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http://genomemedicine.com/content/6/7/57
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http://dx.doi.org/10.1186/s13073-014-0057-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143549PMC
August 2014

CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor.

Biochem Biophys Res Commun 2014 Mar 19;445(4):746-56. Epub 2014 Feb 19.

Donnelly Centre, University of Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Ontario, Canada; Department of Biochemistry, University of Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X140028
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http://dx.doi.org/10.1016/j.bbrc.2014.02.033DOI Listing
March 2014

Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasis.

Cancer Res 2013 Dec 21;73(23):6843-7. Epub 2013 Nov 21.

Authors' Affiliations: Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital; and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-1791DOI Listing
December 2013

Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells.

Cell Rep 2013 Dec 12;5(6):1611-24. Epub 2013 Dec 12.

Center for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247130068
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http://dx.doi.org/10.1016/j.celrep.2013.11.021DOI Listing
December 2013

Signaling by the TGFβ superfamily.

Authors:
Jeffrey L Wrana

Cold Spring Harb Perspect Biol 2013 Oct 1;5(10):a011197. Epub 2013 Oct 1.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a011197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783053PMC
October 2013

Signal integration in TGF-β, WNT, and Hippo pathways.

F1000Prime Rep 2013 3;5:17. Epub 2013 Jun 3.

Department of Biochemistry and Donnelly CCBR, University of Toronto 160 College Street, Toronto, ON Canada, M5S 3E1.

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http://www.f1000.com/prime/reports/b/5/17
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http://dx.doi.org/10.12703/P5-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672943PMC
June 2013

The TGFβ superfamily in stem cell biology and early mammalian embryonic development.

Biochim Biophys Acta 2013 Feb 5;1830(2):2268-79. Epub 2012 Sep 5.

Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S030441651200251
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http://dx.doi.org/10.1016/j.bbagen.2012.08.025DOI Listing
February 2013

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.

Proc Natl Acad Sci U S A 2013 Jan 14;110(5):1714-9. Epub 2013 Jan 14.

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada M5G 2M9.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1214014110
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http://dx.doi.org/10.1073/pnas.1214014110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562766PMC
January 2013

The return of Dr Jekyll in cancer metastasis.

EMBO J 2012 Dec 27;31(24):4486-7. Epub 2012 Nov 27.

Department of Biochemistry and Donnelly CCBR, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/emboj.2012.316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545292PMC
December 2012

A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network.

Cell Stem Cell 2012 Dec;11(6):769-82

Department of Molecular Genetics, University of Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1016/j.stem.2012.11.008DOI Listing
December 2012

Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration.

Cell 2012 Dec;151(7):1542-56

Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1016/j.cell.2012.11.024DOI Listing
December 2012

Evidence for positive selection on a number of MicroRNA regulatory interactions during recent human evolution.

PLoS Genet 2012 22;8(3):e1002578. Epub 2012 Mar 22.

Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1002578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310733PMC
September 2012

C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome.

Eur J Hum Genet 2012 Aug 8;20(8):870-7. Epub 2012 Feb 8.

Department of Pediatrics, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA.

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http://www.nature.com/articles/ejhg201212
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http://dx.doi.org/10.1038/ejhg.2012.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400726PMC
August 2012

Tissue-specific alternative splicing remodels protein-protein interaction networks.

Mol Cell 2012 Jun;46(6):884-92

Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.

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http://dx.doi.org/10.1016/j.molcel.2012.05.037DOI Listing
June 2012

Protein interaction networks in medicine and disease.

Proteomics 2012 May;12(10):1706-16

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pmic.201100594DOI Listing
May 2012

Structural basis for specificity of TGFβ family receptor small molecule inhibitors.

Cell Signal 2012 Feb 1;24(2):476-83. Epub 2011 Oct 1.

Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S08986568110030
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http://dx.doi.org/10.1016/j.cellsig.2011.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490768PMC
February 2012

Coordinating developmental signaling: novel roles for the Hippo pathway.

Trends Cell Biol 2012 Feb 5;22(2):88-96. Epub 2011 Dec 5.

Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.tcb.2011.10.002DOI Listing
February 2012

Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.

Mol Cell Biol 2012 Jan 28;32(1):173-85. Epub 2011 Oct 28.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1128/MCB.06320-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255712PMC
January 2012

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.

Bioorg Med Chem Lett 2011 Sep 30;21(18):5605-9. Epub 2011 Jun 30.

Department of Chemistry, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON, Canada L5L 1C6.

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http://dx.doi.org/10.1016/j.bmcl.2011.06.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530782PMC
September 2011

TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs.

EMBO J 2011 Apr 18;30(7):1263-76. Epub 2011 Mar 18.

Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA.

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http://dx.doi.org/10.1038/emboj.2011.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094126PMC
April 2011

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells.

Cancer Res 2011 Feb 8;71(4):1385-95. Epub 2011 Feb 8.

Cell Biology Program and James Birrell Laboratories, The Hospital for Sick Children, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2484DOI Listing
February 2011

Looking into the black box: insights into the mechanisms of somatic cell reprogramming.

Genes (Basel) 2011 Jan 13;2(1):81-106. Epub 2011 Jan 13.

Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave. B 119, Toronto, ON M5G 1X5, Canada.

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http://www.mdpi.com/2073-4425/2/1/81
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http://dx.doi.org/10.3390/genes2010081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924844PMC
January 2011

Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.

Proc Natl Acad Sci U S A 2010 Oct 11;107(43):18404-9. Epub 2010 Oct 11.

Program in Molecular Structure and Function, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.

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http://dx.doi.org/10.1073/pnas.1003023107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972958PMC
October 2010

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming.

Cell Stem Cell 2010 Jul 17;7(1):64-77. Epub 2010 Jun 17.

Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1016/j.stem.2010.04.015DOI Listing
July 2010

Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling.

PLoS Genet 2010 May 20;6(5):e1000963. Epub 2010 May 20.

Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1000963
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http://dx.doi.org/10.1371/journal.pgen.1000963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873917PMC
May 2010

The Hippo pathway regulates Wnt/beta-catenin signaling.

Dev Cell 2010 Apr;18(4):579-91

Center for Systems Biology, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.

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http://dx.doi.org/10.1016/j.devcel.2010.03.007DOI Listing
April 2010

The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates.

J Biol Chem 2010 Feb 21;285(9):6308-15. Epub 2009 Dec 21.

Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.044537
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http://dx.doi.org/10.1074/jbc.M109.044537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825426PMC
February 2010

A role for the TGFbeta-Par6 polarity pathway in breast cancer progression.

Proc Natl Acad Sci U S A 2009 Aug 10;106(33):14028-33. Epub 2009 Aug 10.

Center for Systems Biology, Samuel Lunenfeld Research Institute, Room 1078 Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada M5G 1X5.

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http://dx.doi.org/10.1073/pnas.0906796106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729014PMC
August 2009

The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning.

Biochem J 2009 Jun 12;421(1):119-31. Epub 2009 Jun 12.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital and the Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G1X5, Canada.

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http://dx.doi.org/10.1042/BJ20081131DOI Listing
June 2009

Regulation of planar cell polarity by Smurf ubiquitin ligases.

Cell 2009 Apr;137(2):295-307

Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada, M5G 1X5.

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http://dx.doi.org/10.1016/j.cell.2009.02.025DOI Listing
April 2009

UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.

Nat Neurosci 2009 Feb 25;12(2):150-5. Epub 2009 Jan 25.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1038/nn.2256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745997PMC
February 2009

Dynamic modularity in protein interaction networks predicts breast cancer outcome.

Nat Biotechnol 2009 Feb 1;27(2):199-204. Epub 2009 Feb 1.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1038/nbt.1522DOI Listing
February 2009

The secret life of Smad4.

Authors:
Jeffrey L Wrana

Cell 2009 Jan;136(1):13-4

Center for Systems Biology, Mount Sinai Hospital, Toronto M5G 1X5, Canada.

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http://dx.doi.org/10.1016/j.cell.2008.12.028DOI Listing
January 2009

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.

Nat Cell Biol 2008 Jul 22;10(7):837-48. Epub 2008 Jun 22.

Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.

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http://dx.doi.org/10.1038/ncb1748DOI Listing
July 2008

Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA.

J Biol Chem 2008 May 14;283(20):13834-41. Epub 2008 Mar 14.

Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6600, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M710607200
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http://dx.doi.org/10.1074/jbc.M710607200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376225PMC
May 2008

SnapShot: The TGFbeta pathway interactome.

Cell 2008 Apr;133(2):378.e1

Samuel Lunenfeld Research Institute and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada.

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http://dx.doi.org/10.1016/j.cell.2008.04.007DOI Listing
April 2008

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization.

Apoptosis 2008 Mar;13(3):413-22

Ontario Cancer Institute, Princess Margaret Hospital, 610 University Ave, M5G 2M9, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s10495-007-0175-4DOI Listing
March 2008

A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis.

Cancer Res 2007 Sep;67(17):8307-15

Ontario Cancer Institute, Princess Margaret Hospital, Mt Sinai Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1687DOI Listing
September 2007

The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.

Science 2007 Sep;317(5846):1934-8

Samuel Lunenfeld Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1126/science.1144874DOI Listing
September 2007

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.

Cell 2007 Aug;130(4):651-62

Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740700900
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http://dx.doi.org/10.1016/j.cell.2007.06.050DOI Listing
August 2007

Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.

EMBO J 2007 Jul 14;26(13):3132-43. Epub 2007 Jun 14.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.emboj.7601753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914101PMC
July 2007

Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans.

Curr Biol 2007 Jan;17(2):159-64

Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1016/j.cub.2006.11.065DOI Listing
January 2007

An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2.

J Biol Chem 2006 Jun 26;281(25):17069-75. Epub 2006 Apr 26.

Program in Structural Biology and Biochemistry, Hospital for Sick Children, Toronto M5G 1X8.

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http://dx.doi.org/10.1074/jbc.M601493200DOI Listing
June 2006