Jeffrey L Cummings

Jeffrey L Cummings

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Jeffrey L Cummings

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Efficacy and Safety of Brexpiprazole for the Treatment of Agitation in Alzheimer's Dementia: Two 12-Week, Randomized, Double-Blind, Placebo-Controlled Trials.

Am J Geriatr Psychiatry 2019 Oct 1. Epub 2019 Oct 1.

Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas (UNLV) (JLC), Las Vegas, NV; Cleveland Clinic Lou Ruvo Center for Brain Health (JLC), Las Vegas, NV.

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http://dx.doi.org/10.1016/j.jagp.2019.09.009DOI Listing
October 2019

Awareness of Psychiatric Symptoms in a Mixed Clinical Sample of Older Adults.

J Geriatr Psychiatry Neurol 2019 Aug 11:891988719868311. Epub 2019 Aug 11.

1 Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

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http://dx.doi.org/10.1177/0891988719868311DOI Listing
August 2019

Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease.

N Engl J Med 2019 Apr;380(15):1408-1420

From Merck, Kenilworth, NJ (M.F.E., J.K., T.V., Y. Mukai, Y.Z., W.L., C.F., E.M., L.H.M., Y. Mo, C.S., D.M.); the University of Southern California, San Diego (P.S.A.); Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas (J.L.C.); Banner Alzheimer's Institute, Phoenix, AZ (P.N.T.); Gerontopole, INSERM Unité 1027, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France (B.V.); Yale University School of Medicine, New Haven, CT (C.H.D.); and the Research Center and Memory Clínic, Fundació Alzheimer Centre Educacional, Institut Català de Neurociènces Aplicades-Universitat Internacional de Catalunya, Barcelona, and the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid - both in Spain (M.B.).

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http://dx.doi.org/10.1056/NEJMoa1812840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776078PMC
April 2019

Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options.

J Alzheimers Dis 2019 ;67(3):779-794

University of Exeter Medical School, St Luke's Campus, Exeter, UK.

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http://dx.doi.org/10.3233/JAD-180766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398562PMC
January 2019

Associations between Comorbid TDP-43, Lewy Body Pathology, and Neuropsychiatric Symptoms in Alzheimer's Disease.

J Alzheimers Dis 2019 ;69(4):953-961

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

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http://dx.doi.org/10.3233/JAD-181285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597983PMC
January 2019

Changes in regional cerebral blood flow associated with a 45 day course of the ketogenic agent, caprylidene, in patients with mild to moderate Alzheimer's disease: Results of a randomized, double-blinded, pilot study.

Exp Gerontol 2018 10 10;111:118-121. Epub 2018 Jul 10.

Ahmanson Translational Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at the University of California Los Angeles, 200 Medical Plaza, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2018.07.009DOI Listing
October 2018

Neurodegeneration research: Advances in clinical translational neuroscience infrastructure and methods.

Alzheimers Dement (N Y) 2018 1;4:326-329. Epub 2018 Jun 1.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

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http://dx.doi.org/10.1016/j.trci.2018.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111039PMC
June 2018

Statistical advances in clinical trials and clinical research.

Alzheimers Dement (N Y) 2018 14;4:366-371. Epub 2018 Jun 14.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23528737183002
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http://dx.doi.org/10.1016/j.trci.2018.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118095PMC
June 2018

ABBY: A phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease.

Neurology 2018 05 25;90(21):e1889-e1897. Epub 2018 Apr 25.

From the Cleveland Clinic Lou Ruvo Center for Brain Health (J.L.C.), Las Vegas, NV; Toronto Memory Program (S.C.), ON, Canada; Alzheimer's Disease Research Unit (C.H.v.D.), Yale University School of Medicine, New Haven, CT; Brain Matters Research Inc (M.B.), Delray Beach, FL; Compass Research, LLC (C.C.), Orlando, FL; Genentech (W.C., M.W., M.F., F.B., A.Q., L.A.H., R.N.F., D.C., D.M., C.H., R.P.), South San Francisco, CA; and Roche Diagnostics (C.R.), Penzberg, Germany.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000005550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962917PMC
May 2018

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease.

N Engl J Med 2018 05;378(18):1691-1703

From Merck Research Laboratories, Merck, Kenilworth, NJ (M.F.E., J.K., C.S., Y. Mukai, T.V., C.F., E.M., L.H.M., Y. Mo, D.M.); Banner Alzheimer's Institute, Phoenix, AZ (P.N.T.); University of Southern California, San Diego (P.S.A.); Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas (J.L.C.); Gerontopole, INSERM Unité 1027, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France (B.V.); and Leuven Institute of Neuroscience and Disease, Alzheimer Research Center, and the Laboratory for Cognitive Neurology, Department of Neurosciences, Katholieke Universiteit Leuven, and Neurology, University Hospitals - both in Leuven, Belgium (R.V.).

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http://dx.doi.org/10.1056/NEJMoa1706441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776074PMC
May 2018

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Neurology 2018 01 13;90(2):74-82. Epub 2017 Dec 13.

From Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology (F.K., G.K.W., W.P., K.S., N.S.), Medical University Innsbruck, Austria; National Institute of Neurological Disorders and Stroke (W.R.G., W.J.K.), NIH, Bethesda, MD; Department of Neurology (P.A.L.), Mayo Clinic, Rochester, MN; Brain and Mind Centre (G.H.), Sydney Medical School, the University of Sydney; UNSW Medicine & Neuroscience Research Australia (G.H.), Sydney; Queen Square Brain Bank (J.H.), UCL Institute of Neurology (N.P.Q.), London, UK; UPS, INSERM, and CHU de Toulouse (O.R.), University de Toulouse; Centre de Référence Maladie Rare contre l'AMS (O.R.), Centre d'Investigation Clinique CIC1436, Départments de Pharmacologie Clinique et de Neurosciences, NeuroToul/COEN Center of Excellence in Neurodegeneration, Toulouse, France; Department of Pathology & Laboratory Medicine (L.M.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Center for Neurosciences (D.E.), The Feinstein Institute for Medical Research, Manhasset, NY; The Multiple System Atrophy (MSA) Coalition, Inc. (P. B., J.B., P.F., L.K., C.L., C.R., S.S.), Charlotte, NC; Cleveland Clinic Lou Ruvo Center for Brain Health (J.L.C.), Las Vegas, NV; Medical Affairs (V.A.), Teva Pharmaceuticals, Frazer, PA; Department of Neurology (G.B.), David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California at Los Angeles; Institute of Neurology (D.J.B.), University of Newcastle upon Tyne, UK; Van Andel Research Institute (P. Brundin), Center for Neurodegenerative Science, Grand Rapids, MI; Center for Neurological Restoration (H.F.), Cleveland Clinic, OH; Defeat MSA (P.F.); MSA Shoe Charity (P.F., C.R.), Saint Clair Shores, MI; Department of Neurology (R.F.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Neurodegenerative Diseases (T.G.), Hertie Institute of Clinical Brain Research, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (T.G.), Tübingen, Germany; Lundbeck LLC (A.H.), Deerfield, IL; German Center for Neurodegenerative Diseases (DZNE) (G.U.H.), Munich; Department of Neurology (G.U.H.), Technical University of Munich, Germany; Neurogenomics Division (M.J.H.), The Translational Genomics Research Institute, Phoenix, AZ; Dandrite & Department of Biomedicine (P.H.J.), Aarhus University, Denmark; Quanterix (A.J.), Lexington, MA; Department of Neurology (U.J.K.), Columbia University Medical Center; Department of Neurology (H.K.), New York University School of Medicine, New York; Whitehead Institute for Biomedical Research (V.K.), Cambridge; Ann Romney Center for Neurologic Disease (V.K.), Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston; Harvard Stem Cell Institute (V.K.), Cambridge, MA; Department of Neurology (T.K.), University of Bonn; German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany; Brain and Mind Centre (W.S.K.), Sydney Medical School, University of Sydney, Australia; Department of Neurology (P.L.), Henry Ford Hospital; Department of Neurology (P.L.), Wayne State University School of Medicine, Detroit, MI; Division of Neurosciences (E.M.), National Institute on Aging/NIH, Bethesda, MD; Centre de Référence Maladie Rare AMS (W.M.), Hôpital Pellegrin, CHU de Bordeaux; Université de Bordeaux (W.M.), Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux; Paris Saclay Institute of Neuroscience (R.M.), CNRS, Gif-sur-Yvette, France; Genentech Inc. (S.O.), South San Francisco; Cedars-Sinai Medical Center (S.P.), Los Angeles, CA; Department of Neurology (D.R.), Vanderbilt University Medical Center, Nashville, TN; MSA NJ (C.R.), Howell, NJ; Prothena Biosciences (D.S.), South San Francisco, CA; Division of Neurology (M.S.), Department of Medicine, The Ottawa Hospital, Canada; Department of Neurology (J.D.S.), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Cure MSA Foundation (L.S.), Fremont, CA; Avid Radiopharmaceuticals (A.S.), Philadelphia, PA; Department of Neurological Sciences (G.T.S.), Rush University Medical Center, Chicago, IL; Department of Neurology (S.T.), Graduate School of Medicine, Tokyo University, Tokyo, Japan; and University of Washington (J.Z.), Seattle. W.R.G. is currently affiliated with Janssen Research and Development, Titusville, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000004798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772155PMC
January 2018

Moderating effects of sex on the impact of diagnosis and amyloid positivity on verbal memory and hippocampal volume.

Alzheimers Res Ther 2017 Sep 12;9(1):72. Epub 2017 Sep 12.

Cleveland Clinic Lou Ruvo Center for Brain Health, 888 West Bonneville Avenue, Las Vegas, NV, 89106, USA.

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http://dx.doi.org/10.1186/s13195-017-0300-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596932PMC
September 2017

Validation Study of the Korean Version of the Brief Clinical Form of the Neuropsychiatric Inventory.

Dement Geriatr Cogn Dis Extra 2016 May-Aug;6(2):214-21. Epub 2016 Jun 3.

Department of Neurology, Catholic University School of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1159/000445828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913765PMC
June 2016

Incidence of dementia and subtypes: A cohort study in four regions in China.

Alzheimers Dement 2016 Mar 15;12(3):262-71. Epub 2015 Jun 15.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

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http://dx.doi.org/10.1016/j.jalz.2015.02.011DOI Listing
March 2016

Dextromethorphan-Quinidine for Agitation in Alzheimer Disease--Reply.

JAMA 2016 Mar;315(11):1166-7

Avanir Pharmaceuticals, Aliso Viejo, California.

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http://dx.doi.org/10.1001/jama.2015.18289DOI Listing
March 2016

Alzheimer's disease.

Nat Rev Dis Primers 2015 10 15;1:15056. Epub 2015 Oct 15.

Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, Nevada, USA.

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http://dx.doi.org/10.1038/nrdp.2015.56DOI Listing
October 2015

Concordance of the Montreal cognitive assessment with standard neuropsychological measures.

Alzheimers Dement (Amst) 2015 Sep 28;1(3):289-94. Epub 2015 Jun 28.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

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http://dx.doi.org/10.1016/j.dadm.2015.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877929PMC
September 2015

Values of the Minimal Clinically Important Difference for the Neuropsychiatric Inventory Questionnaire in Individuals with Dementia.

J Am Geriatr Soc 2015 Jul 5;63(7):1448-52. Epub 2015 Jun 5.

Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1111/jgs.13473DOI Listing
July 2015

Higher working memory predicts slower functional decline in autopsy-confirmed Alzheimer's disease.

Dement Geriatr Cogn Disord 2014 4;38(3-4):224-33. Epub 2014 Jun 4.

Department of Neurology, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1159/000362715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140977PMC
May 2015

A practical algorithm for managing Alzheimer's disease: what, when, and why?

Ann Clin Transl Neurol 2015 Mar 23;2(3):307-23. Epub 2015 Jan 23.

Novartis Pharmaceuticals Corporation East Hanover, New Jersey.

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http://dx.doi.org/10.1002/acn3.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369281PMC
March 2015

Utility of the functional activities questionnaire for distinguishing mild cognitive impairment from very mild Alzheimer disease.

Alzheimer Dis Assoc Disord 2010 Oct-Dec;24(4):348-53

*Neurobehavior Unit †Geriatric Research Education and Clinical Center, Veterans Affairs Greater Los Angeles Healthcare System ‡Departments of Neurology ∥Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA §Department of Neurology, Mayo Clinic.

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http://dx.doi.org/10.1097/WAD.0b013e3181e2fc84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997338PMC
February 2015

Sensitivity to change of composite and frequency scores of the neuropsychiatric inventory in mild cognitive impairment.

Int Psychogeriatr 2014 Nov 3;26(11):1871-4. Epub 2014 Jul 3.

Dr. Willmar Schwabe GmbH & Co. KG,Karlsruhe,Germany.

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http://dx.doi.org/10.1017/S1041610214001185DOI Listing
November 2014

Alzheimer's disease drug-development pipeline: few candidates, frequent failures.

Alzheimers Res Ther 2014 3;6(4):37. Epub 2014 Jul 3.

Cleveland Clinic Lou Ruvo Center for Brain Health, 888 West Bonneville Avenue, Las Vegas, Nevada 89106, USA.

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http://dx.doi.org/10.1186/alzrt269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095696PMC
July 2014

Randomized controlled trials in frontotemporal dementia: cognitive and behavioral outcomes.

Transl Neurodegener 2014 5;3:12. Epub 2014 Jun 5.

Cleveland Clinic, Lou Ruvo Center for Brain Health, 888 W. Bonneville Ave, Las Vegas, Nevada 89106, USA.

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http://dx.doi.org/10.1186/2047-9158-3-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052335PMC
June 2014

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study.

Alzheimers Res Ther 2012 29;4(5):43. Epub 2012 Oct 29.

Mary S. Easton Center for Alzheimer's Disease Research, David Geffen School of Medicine at UCLA, 10911 Weyburn Ave., #200, Los Angeles, CA 90095-7226, USA ; UCLA Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA ; UCLA Department of Medicine, 757 Westwood Plaza, Los Angeles, CA 90095, USA ; Geriatric Research Education and Clinical Center, W LA Veterans Administration Medical Center, 11301 Wilshire Blvd., Bldg. 113, Room 312, Los Angeles, CA 90073, USA.

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http://dx.doi.org/10.1186/alzrt146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580400PMC
May 2014

Discovering new treatments for Alzheimer's disease by repurposing approved medications.

Curr Top Med Chem 2013 ;13(18):2306-27

Cleveland Clinic Lou Ruvo Center for Brain Health, 9500 Euclid Avenue/U10, Cleveland, OH 44195.

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http://dx.doi.org/10.2174/15680266113136660162DOI Listing
April 2014

The "Alzheimer's type" profile of semantic clustering in amnestic mild cognitive impairment.

J Int Neuropsychol Soc 2014 Apr 13;20(4):402-12. Epub 2014 Feb 13.

1 Department of Neurology, University of California, Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1017/S135561771400006XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086918PMC
April 2014

Neuropathologic correlates of trial-related instruments for Alzheimer's disease.

Am J Neurodegener Dis 2014 28;3(1):45-9. Epub 2014 Mar 28.

Department of Pathology & Laboratory Medicine (Neuropathology), The Mary S Easton Center for Alzheimer's Disease Research at The David Geffen School of Medicine at UCLA Los Angeles, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986610PMC
April 2014

Repackaging FDA-approved drugs for degenerative diseases: promises and challenges.

Expert Rev Clin Pharmacol 2014 Mar 6;7(2):161-5. Epub 2014 Feb 6.

Cleveland Clinic Lou Ruvo Center for Brain Health, 888 W Bonneville Ave, Las Vegas, NV 89106, USA.

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http://dx.doi.org/10.1586/17512433.2014.884923DOI Listing
March 2014

Memory performance and fMRI signal in presymptomatic familial Alzheimer's disease.

Hum Brain Mapp 2013 Dec 17;34(12):3308-19. Epub 2012 Jul 17.

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California; Laboratory of Neuro Imaging, David Geffen School of Medicine at UCLA, Los Angeles, California.

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http://dx.doi.org/10.1002/hbm.22141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812259PMC
December 2013

Toward a more precise, clinically--informed pathophysiology of pathological laughing and crying.

Neurosci Biobehav Rev 2013 Sep 18;37(8):1893-916. Epub 2013 Mar 18.

Departments of Psychiatry and Internal Medicine (Neurology), Mercer University School of Medicine, 655 First Street, Macon, GA 31201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2013.03.002DOI Listing
September 2013

A review: treatment of Alzheimer's disease discovered in repurposed agents.

Dement Geriatr Cogn Disord 2013 9;35(1-2):1-22. Epub 2013 Jan 9.

Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland, OH, USA.

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http://dx.doi.org/10.1159/000345791DOI Listing
August 2013

Alzheimer's disease biomarkers: correspondence between human studies and animal models.

Neurobiol Dis 2013 Aug 28;56:116-30. Epub 2013 Apr 28.

Behavioral Neuroscience Laboratory, University of Nevada, Las Vegas, NV, USA.

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http://dx.doi.org/10.1016/j.nbd.2013.04.010DOI Listing
August 2013

Alzheimer's disease biomarkers in animal models: closing the translational gap.

Am J Neurodegener Dis 2013 21;2(2):108-20. Epub 2013 Jun 21.

Behavioral Neuroscience Laboratory, University of Nevada Las Vegas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703123PMC
July 2013

Alzheimer's disease drug development: translational neuroscience strategies.

CNS Spectr 2013 Jun 11;18(3):128-38. Epub 2013 Mar 11.

Cleveland Clinic, Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

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http://dx.doi.org/10.1017/S1092852913000023DOI Listing
June 2013

International Work Group criteria for the diagnosis of Alzheimer disease.

Med Clin North Am 2013 May 16;97(3):363-8. Epub 2013 Feb 16.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

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http://dx.doi.org/10.1016/j.mcna.2013.01.001DOI Listing
May 2013

Clinical trials in predementia stages of Alzheimer disease.

Med Clin North Am 2013 May 22;97(3):439-57. Epub 2013 Feb 22.

Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/j.mcna.2013.01.002DOI Listing
May 2013

Medical Clinics of North America. Early diagnosis and intervention in predementia Alzheimer's disease. Preface.

Med Clin North Am 2013 May 22;97(3):xiii-xv. Epub 2013 Feb 22.

Neurology Service, ICN Hospital Clinic i Universitari and Pasqual Maragall Foundation, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.mcna.2013.01.003DOI Listing
May 2013

Sensitivity to change of composite and frequency scores of the Neuropsychiatric Inventory in mild to moderate dementia.

Int Psychogeriatr 2013 Mar 30;25(3):431-8. Epub 2012 Nov 30.

Lou Ruvo Center for Brain Health, The Andrea L. and Joseph F. Hahn MD Chair of Neurotherapeutics, Cleveland Clinic, Las Vegas, NV, USA.

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http://dx.doi.org/10.1017/S1041610212001974DOI Listing
March 2013

Animal systems in the development of treatments for Alzheimer's disease: challenges, methods, and implications.

Neurobiol Aging 2013 Jan 1;34(1):169-83. Epub 2012 Apr 1.

Behavioral Neuroscience Laboratory, University of Nevada, Las Vegas, NV, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.02.027DOI Listing
January 2013

Estimating sample sizes for predementia Alzheimer's trials based on the Alzheimer's Disease Neuroimaging Initiative.

Neurobiol Aging 2013 Jan 13;34(1):62-72. Epub 2012 Apr 13.

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412892PMC
January 2013

Food for thought: Souvenaid in mild Alzheimer’s disease.

J Alzheimers Dis 2012 ;31(1):237-8

Cleveland Clinic Lou Ruvo Center for Brain Health, Neurological Institute, Las Vegas, NV 89106, USA.

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http://dx.doi.org/10.3233/JAD-2012-120245DOI Listing
December 2012

Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations.

Dement Geriatr Cogn Disord 2012 14;33(4):219-25. Epub 2012 May 14.

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095-7334, USA.

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http://dx.doi.org/10.1159/000338546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568669PMC
November 2012

Reviewing the role of donepezil in the treatment of Alzheimer's disease.

Curr Alzheimer Res 2012 Sep;9(7):773-81

Department of Neurology, Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX 07730, USA.

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http://dx.doi.org/10.2174/156720512802455412DOI Listing
September 2012

Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease.

Dement Geriatr Cogn Disord 2012 13;33(1):1-5. Epub 2012 Feb 13.

Mary S. Easton Center for Alzheimer's Disease Research at UCLA, Los Angeles, Calif., USA.

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http://dx.doi.org/10.1159/000335729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696356PMC
July 2012

Novel late-onset Alzheimer disease loci variants associate with brain gene expression.

Authors:
Mariet Allen Fanggeng Zou High Seng Chai Curtis S Younkin Julia Crook V Shane Pankratz Minerva M Carrasquillo Christopher N Rowley Asha A Nair Sumit Middha Sooraj Maharjan Thuy Nguyen Li Ma Kimberly G Malphrus Ryan Palusak Sarah Lincoln Gina Bisceglio Constantin Georgescu Debra Schultz Fariborz Rakhshan Christopher P Kolbert Jin Jen Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg Ronald C Petersen Neill R Graff-Radford Dennis W Dickson Steven G Younkin Nilüfer Ertekin-Taner Liana G Apostolova Steven E Arnold Clinton T Baldwin Robert Barber Michael M Barmada Thomas Beach Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Jacqueline Buros Joseph D Buxbaum Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Paul K Crane Carlos Cruchaga Jeffrey L Cummings Philip L De Jager Charles DeCarli Steven T DeKosky F Yesim Demirci Ramon Diaz-Arrastia Malcolm Dick Beth A Dombroski Ranjan Duara William D Ellis Denis Evans Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Tatiana M Foroud Matthew Frosch Douglas R Galasko Paul J Gallins Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass Alison M Goate Robert C Green John H Growdon Hakon Hakonarson Ronald L Hamilton John Hardy Lindy E Harrell Elizabeth Head Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun M Ilyas Kamboh Jason Karlawish Anna Karydas John S K Kauwe Jeffrey A Kaye Nancy Kennedy Ronald Kim Edward H Koo Neil W Kowall Patricia Kramer Walter A Kukull James J Lah Eric B Larson Allan I Levey Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Amanda J Myers Adam C Naj Petra Nowotny Joseph E Parisi Daniel P Perl Elaine Peskind Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Ruchita A Rajbhandary Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Peter St George-Hyslop Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Badri Narayan Vardarajan Harry V Vinters Jean Paul Vonsattel Li-San Wang Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer

Neurology 2012 Jul 20;79(3):221-8. Epub 2012 Jun 20.

Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA.

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http://dx.doi.org/10.1212/WNL.0b013e3182605801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398432PMC
July 2012

Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype.

Arch Neurol 2012 Jun;69(6):757-64

Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, David Geffen School of Medicine at UCLA, 10911 Weyburn Ave, Ste 200, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1001/archneurol.2012.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668092PMC
June 2012

Propositional density and apolipoprotein E genotype among persons at risk for familial Alzheimer's disease.

Dement Geriatr Cogn Disord 2011 30;32(3):188-92. Epub 2011 Aug 30.

SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, Calif., USA. MedinaL @ rohan.sdsu.edu

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http://dx.doi.org/10.1159/000333023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542946PMC
April 2012

Increased fMRI signal with age in familial Alzheimer's disease mutation carriers.

Neurobiol Aging 2012 Feb 3;33(2):424.e11-21. Epub 2010 Dec 3.

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097258PMC
February 2012

Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease.

Dement Geriatr Cogn Disord 2011 23;32(2):118-25. Epub 2011 Sep 23.

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, UCLA School of Medicine, Los Angeles, Calif., USA.

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http://dx.doi.org/10.1159/000330471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222115PMC
February 2012

[123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography brain imaging in the diagnosis of dementia with Lewy bodies.

Alzheimers Dement 2012 Jan 22;8(1):74-83. Epub 2011 Oct 22.

UCL Mental Health Sciences Unit, University College London, United Kingdom.

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http://dx.doi.org/10.1016/j.jalz.2011.08.003DOI Listing
January 2012

Alzheimer's disease clinical trials: changing the paradigm.

Curr Psychiatry Rep 2011 Dec;13(6):437-42

Cleveland Clinic Lou Ruvo Center for Brain Health, 888 West Bonneville Avenue, Las Vegas, NV 89106, USA.

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http://dx.doi.org/10.1007/s11920-011-0234-yDOI Listing
December 2011

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:
Adam C Naj Gyungah Jun Gary W Beecham Li-San Wang Badri Narayan Vardarajan Jacqueline Buros Paul J Gallins Joseph D Buxbaum Gail P Jarvik Paul K Crane Eric B Larson Thomas D Bird Bradley F Boeve Neill R Graff-Radford Philip L De Jager Denis Evans Julie A Schneider Minerva M Carrasquillo Nilufer Ertekin-Taner Steven G Younkin Carlos Cruchaga John S K Kauwe Petra Nowotny Patricia Kramer John Hardy Matthew J Huentelman Amanda J Myers Michael M Barmada F Yesim Demirci Clinton T Baldwin Robert C Green Ekaterina Rogaeva Peter St George-Hyslop Steven E Arnold Robert Barber Thomas Beach Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Chris S Carlson Regina M Carney Steven L Carroll Helena C Chui David G Clark Jason Corneveaux Carl W Cotman Jeffrey L Cummings Charles DeCarli Steven T DeKosky Ramon Diaz-Arrastia Malcolm Dick Dennis W Dickson William G Ellis Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Sid Gilman Bruno Giordani Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Nancy Johnson Jason Karlawish Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall James J Lah Allan I Levey Andrew P Lieberman Oscar L Lopez Wendy J Mack Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Joseph E Parisi Daniel P Perl Elaine Peskind Ronald C Petersen Wayne W Poon Joseph F Quinn Ruchita A Rajbhandary Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Roger N Rosenberg Mary Sano Lon S Schneider William Seeley Michael L Shelanski Michael A Slifer Charles D Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Randall L Woltjer Laura B Cantwell Beth A Dombroski Duane Beekly Kathryn L Lunetta Eden R Martin M Ilyas Kamboh Andrew J Saykin Eric M Reiman David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Jonathan L Haines Richard Mayeux Margaret A Pericak-Vance Lindsay A Farrer Gerard D Schellenberg

Nat Genet 2011 May 3;43(5):436-41. Epub 2011 Apr 3.

The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.

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http://dx.doi.org/10.1038/ng.801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090745PMC
May 2011

Biomarkers in Alzheimer's disease drug development.

Alzheimers Dement 2011 May 6;7(3):e13-44. Epub 2011 May 6.

Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic Neurological Institute, Las Vegas, NV, USA.

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http://dx.doi.org/10.1016/j.jalz.2010.06.004DOI Listing
May 2011

Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task.

Cereb Cortex 2011 Apr 20;21(4):877-83. Epub 2010 Aug 20.

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1093/cercor/bhq158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059887PMC
April 2011

Subtle deficits in instrumental activities of daily living in subtypes of mild cognitive impairment.

Dement Geriatr Cogn Disord 2010 26;30(3):189-97. Epub 2010 Aug 26.

Neurobehavior Unit, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.

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http://dx.doi.org/10.1159/000313540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948658PMC
January 2011

Effects of rivastigmine transdermal patch and capsule on aspects of clinical global impression of change in Alzheimer's disease: a retrospective analysis.

Dement Geriatr Cogn Disord 2010 21;29(5):406-12. Epub 2010 May 21.

Mary S. Easton Center for Alzheimer's Disease Research at UCLA, Los Angeles, CA 90095-7226, USA.

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http://dx.doi.org/10.1159/000296073DOI Listing
September 2010

Integrating ADNI results into Alzheimer's disease drug development programs.

Neurobiol Aging 2010 Aug 5;31(8):1481-92. Epub 2010 May 5.

Mary S. Easton Center for Alzheimer's Disease Research at UCLA, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-7226, United States.

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http://dx.doi.org/10.1016/j.neurobiolaging.2010.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902618PMC
August 2010

Effects of oral rivastigmine on cognitive domains in mild-to-moderate Alzheimer's disease.

Am J Alzheimers Dis Other Demen 2010 Jun 14;25(4):347-52. Epub 2010 Apr 14.

Indiana University School of Medicine, Indianapolis, USA.

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http://dx.doi.org/10.1177/1533317510365344DOI Listing
June 2010

Current therapeutic targets for the treatment of Alzheimer's disease.

Expert Rev Neurother 2010 May;10(5):711-28

Mary S. Easton Center for Alzheimer's Disease Research, Deane F. Johnson Center for Neurotherapeutics, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

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http://dx.doi.org/10.1586/ern.10.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140224PMC
May 2010

Mary S. Easton Center of Alzheimer's Disease Research at UCLA: advancing the therapeutic imperative.

J Alzheimers Dis 2010 ;19(2):375-88

Department of Neurology, The Mary S Easton Center for Alzheimer's Disease Research at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.3233/JAD-2010-1286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855886PMC
April 2010

Rivastigmine transdermal patch skin tolerability: results of a 1-year clinical trial in patients with mild-to-moderate Alzheimer's disease.

Clin Drug Investig 2010 ;30(1):41-9

Mary S. Easton Center for Alzheimer's Disease Research at UCLA, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095-7226, USA.

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http://dx.doi.org/10.2165/11531270-000000000-00000DOI Listing
March 2010

Commentary on: L-methylfolate, methylcobolamine, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline.

CNS Spectr 2010 Jan;15(1 Suppl 1)

Department of Neurology and Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, USA.

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http://dx.doi.org/10.1017/s1092852900027607DOI Listing
January 2010