Jeffrey L Brodsky

Jeffrey L Brodsky

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Jeffrey L Brodsky

Publications by authors named "Jeffrey L Brodsky"

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Protein quality control in the secretory pathway.

J Cell Biol 2019 Oct 19;218(10):3171-3187. Epub 2019 Sep 19.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA

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http://dx.doi.org/10.1083/jcb.201906047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781448PMC
October 2019

Exploring the Functional Consequences of Protein Backbone Alteration in Ubiquitin through Native Chemical Ligation.

Chembiochem 2019 Sep 23;20(18):2346-2350. Epub 2019 Aug 23.

Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA, 15260, USA.

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http://dx.doi.org/10.1002/cbic.201900225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752966PMC
September 2019

Chaperoning Endoplasmic Reticulum-Associated Degradation (ERAD) and Protein Conformational Diseases.

Cold Spring Harb Perspect Biol 2019 Aug 1;11(8). Epub 2019 Aug 1.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.

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http://dx.doi.org/10.1101/cshperspect.a033928DOI Listing
August 2019

A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation.

Science 2019 07;365(6448):53-60

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/science.aau9263DOI Listing
July 2019

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.

Neuron 2019 04 27;102(2):321-338.e8. Epub 2019 Feb 27.

Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA 15213, USA; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Protein Conformational Diseases, Kenneth P. Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08966273193007
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http://dx.doi.org/10.1016/j.neuron.2019.01.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472983PMC
April 2019

Predicting protein targets for drug-like compounds using transcriptomics.

PLoS Comput Biol 2018 12 7;14(12):e1006651. Epub 2018 Dec 7.

Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300300PMC
December 2018

Adapting to stress - chaperome networks in cancer.

Nat Rev Cancer 2018 09;18(9):562-575

Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41568-018-0020-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108944PMC
September 2018

Epithelial sodium channel biogenesis and quality control in the early secretory pathway.

Curr Opin Nephrol Hypertens 2018 09;27(5):364-372

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MNH.0000000000000438DOI Listing
September 2018

Can modulators of apolipoproteinB biogenesis serve as an alternate target for cholesterol-lowering drugs?

Biochim Biophys Acta Mol Cell Biol Lipids 2018 07 6;1863(7):762-771. Epub 2018 Apr 6.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953829PMC
July 2018

Investigating Potassium Channels in Budding Yeast: A Genetic Sandbox.

Genetics 2018 07;209(3):637-650

Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260

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http://dx.doi.org/10.1534/genetics.118.301026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028241PMC
July 2018

The degradation pathway of a model misfolded protein is determined by aggregation propensity.

Mol Biol Cell 2018 06 24;29(12):1422-1434. Epub 2018 Apr 24.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260.

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http://dx.doi.org/10.1091/mbc.E18-02-0117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014095PMC
June 2018

Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic-Reticulum-Associated Degradation.

Mol Cell 2018 04;70(2):242-253.e6

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912696PMC
April 2018

N-linked glycans are required on epithelial Na channel subunits for maturation and surface expression.

Am J Physiol Renal Physiol 2018 03 29;314(3):F483-F492. Epub 2017 Nov 29.

Renal Electrolyte Division, Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1152/ajprenal.00195.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899221PMC
March 2018

Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100.

Circ Res 2018 02 4;122(4):568-582. Epub 2018 Jan 4.

From the Division of Cardiology (J.A., L.G., H.W., E.A.F.), Department of Medicine (J.A., L.G., H.W., E.A.F.), and Marc and Ruti Bell Program in Vascular Biology (J.A., E.A.F., L.G, H.W.), NYU School of Medicine; Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (A.S., D.J.R.); Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York (J.M.-M., S.K., A.M.C.); and Department of Biological Sciences, University of Pittsburgh, PA (J.L.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815905PMC
February 2018

Linking chanelopathies with endoplasmic reticulum associated degradation.

Channels (Austin) 2017 11 18;11(6):499-501. Epub 2017 Aug 18.

a Department of Biological Sciences , University of Pittsburgh , Pittsburgh , PA , USA.

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http://dx.doi.org/10.1080/19336950.2017.1357944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786258PMC
November 2017

-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione.

Mol Pharmacol 2017 11 22;92(5):564-575. Epub 2017 Aug 22.

Division of Pharmaceutical Sciences, School of Pharmacy, Duquesne University, Pittsburgh, Pennsylvania (A.M.G., D.F.H., T.N.B., L.C.L., P.T.F., R.K.L.); and Departments of Biological Sciences (S.S., J.L.B.) and Chemistry and Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania (P.W.)

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http://dx.doi.org/10.1124/mol.117.109926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635514PMC
November 2017

Targeting protein quality control pathways in breast cancer.

BMC Biol 2017 11 16;15(1):109. Epub 2017 Nov 16.

Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, 4249 Fifth Ave, Pittsburgh, PA, 15260, USA.

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http://dx.doi.org/10.1186/s12915-017-0449-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689203PMC
November 2017

Guardians of the ERAD Galaxy.

Cell 2017 10;171(2):267-268

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.023DOI Listing
October 2017

Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE.

Dis Model Mech 2017 09 2;10(9):1129-1140. Epub 2017 Aug 2.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, 5117 Centre Avenue, UPCI Research Pavilion, 2.42e, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1242/dmm.029926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611967PMC
September 2017

Regulation of the epithelial Na channel by paraoxonase-2.

J Biol Chem 2017 09 2;292(38):15927-15938. Epub 2017 Aug 2.

From the Renal-Electrolyte Division, Department of Medicine,

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http://dx.doi.org/10.1074/jbc.M117.785253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612122PMC
September 2017

Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome.

J Biol Chem 2017 08 19;292(31):12813-12827. Epub 2017 Jun 19.

From the Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 and

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http://dx.doi.org/10.1074/jbc.M117.786376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546024PMC
August 2017

Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase.

Sci Rep 2017 05 11;7(1):1789. Epub 2017 May 11.

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15206, USA.

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http://dx.doi.org/10.1038/s41598-017-01880-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431976PMC
May 2017

UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase.

J Biol Chem 2017 02 21;292(6):2470-2484. Epub 2016 Dec 21.

From the Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261,

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http://dx.doi.org/10.1074/jbc.M116.766824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313114PMC
February 2017

The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation.

Biochem J 2017 02;474(4):445-469

Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, U.S.A.

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http://dx.doi.org/10.1042/BCJ20160582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425155PMC
February 2017

Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications.

Am J Physiol Lung Cell Mol Physiol 2016 Oct 29;311(4):L719-L733. Epub 2016 Jul 29.

Department of Pediatrics, Emory University, Atlanta, Georgia

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http://dx.doi.org/10.1152/ajplung.00431.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142128PMC
October 2016

Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members.

Bioorg Med Chem Lett 2016 10 25;26(20):5087-5091. Epub 2016 Aug 25.

Department of Biological Science, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050167PMC
http://dx.doi.org/10.1016/j.bmcl.2016.08.080DOI Listing
October 2016

Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.

Proc Natl Acad Sci U S A 2016 08 22;113(32):9015-20. Epub 2016 Jul 22.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143; Department of Medicine, University of California, San Francisco, CA 94143;

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http://dx.doi.org/10.1073/pnas.1603883113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987817PMC
August 2016

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

Mol Biol Cell 2016 Feb;27(3):424-33

Department of Physiology, McGill University, Montréal, QC H3G 1Y6, Canada Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada GRASP, McGill University, Montréal, QC H3G 1Y6, Canada

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http://dx.doi.org/10.1091/mbc.E14-04-0935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751594PMC
February 2016

α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis.

J Cell Sci 2015 Nov 12;128(22):4220-34. Epub 2015 Oct 12.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA Division of Biochemistry, Biophysics and Structural Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA

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http://dx.doi.org/10.1242/jcs.175372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712785PMC
November 2015

Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.

J Mol Biol 2015 Sep 23;427(18):2948-65. Epub 2015 Apr 23.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569534PMC
September 2015

A combination therapy for cystic fibrosis.

Cell 2015 Sep;163(1):17

Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.cell.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865247PMC
September 2015

Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations.

Structure 2015 Aug 25;23(8):1526-1537. Epub 2015 Jun 25.

Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527966PMC
August 2015

Heat shock protein responses to aging and proteotoxicity in the olfactory bulb.

J Neurochem 2015 Jun 5;133(6):780-794. Epub 2015 Mar 5.

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh PA.

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http://dx.doi.org/10.1111/jnc.13041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464935PMC
June 2015

Synthesis of -inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).

Tetrahedron Lett 2015 Jun;56(23):3097-3100

Division of Pediatric Surgery, Children's Hospital of Pittsburgh of University of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh PA 15224, USA ; Division of Pediatric Surgery, Bloomberg Children's Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00404039140194
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http://dx.doi.org/10.1016/j.tetlet.2014.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518473PMC
June 2015

The conserved core enzymatic activities and the distinct dynamics of polyomavirus large T antigens.

Arch Biochem Biophys 2015 May 6;573:23-31. Epub 2015 Mar 6.

Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, PA 15260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2015.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865250PMC
May 2015

Heat shock protein defenses in the neocortex and allocortex of the telencephalon.

Neurobiol Aging 2015 May 18;36(5):1924-37. Epub 2015 Feb 18.

Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417007PMC
May 2015

Intracellular complexes of the early-onset torsion dystonia-associated AAA+ ATPase TorsinA.

Springerplus 2014 16;3:743. Epub 2014 Dec 16.

Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506 USA.

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http://dx.doi.org/10.1186/2193-1801-3-743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320221PMC
February 2015

Escaping the endoplasmic reticulum: why does a molecular chaperone leave home for greener pastures?

EMBO J 2015 Jan 25;34(1):1-3. Epub 2014 Nov 25.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.15252/embj.201490462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291476PMC
January 2015

Protein folding in the cell, from atom to organism.

FASEB J 2014 Dec;28(12):5034-8

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA

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http://dx.doi.org/10.1096/fj.14-1202ufmDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190966PMC
December 2014

Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation.

J Biol Chem 2014 Nov 25;289(45):31591-604. Epub 2014 Sep 25.

From the Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282 and

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http://dx.doi.org/10.1074/jbc.M114.581157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223355PMC
November 2014

Recent technical developments in the study of ER-associated degradation.

Curr Opin Cell Biol 2014 Aug 24;29:82-91. Epub 2014 May 24.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2014.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130770PMC
August 2014

The Cdc48-Vms1 complex maintains 26S proteasome architecture.

Biochem J 2014 Mar;458(3):459-67

*Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, U.S.A.

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http://dx.doi.org/10.1042/BJ20131161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135392PMC
March 2014

Organelle and proteome quality control mechanisms: how cells are able to keep calm and carry on.

Mol Biol Cell 2014 Mar;25(6):733-4

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260 Departments of Biochemistry and Physiology and Biophysics, University of Washington, Seattle, WA 98195-3750 Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721.

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http://dx.doi.org/10.1091/mbc.E13-11-0672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952841PMC
March 2014

A regulator of secretory vesicle size, Kelch-like protein 12, facilitates the secretion of apolipoprotein B100 and very-low-density lipoproteins--brief report.

Arterioscler Thromb Vasc Biol 2014 Feb 12;34(2):251-4. Epub 2013 Dec 12.

From the Department of Medicine, Leon H. Charney Division of Cardiology, Department of Cell Biology, and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine (C.B., L.G., B.R., A.W., K.J.M., E.A.F.); and Department of Biological Sciences, University of Pittsburgh, PA (J.L.B.). C.B. is currently affiliated with Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.113.302728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919549PMC
February 2014

Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.

J Med Chem 2014 Feb 18;57(4):1188-207. Epub 2014 Feb 18.

Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center , New York, New York 10021, United States.

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http://dx.doi.org/10.1021/jm401551nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983365PMC
February 2014

Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors.

PLoS One 2013 12;8(6):e65779. Epub 2013 Jun 12.

Division of Pediatric Surgery Children's Hospital of Pittsburgh and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065779PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680486PMC
January 2014

ESCRT regulates surface expression of the Kir2.1 potassium channel.

Mol Biol Cell 2014 Jan 13;25(2):276-89. Epub 2013 Nov 13.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15261 Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.

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http://dx.doi.org/10.1091/mbc.E13-07-0394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890348PMC
January 2014

The threads that tie protein-folding diseases.

Dis Model Mech 2014 Jan;7(1):3-4

Department of Biological Sciences, A320 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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http://dx.doi.org/10.1242/dmm.014985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882041PMC
January 2014

The proteolytic landscape of the yeast vacuole.

Cell Logist 2014 Jan 12;4(1):e28023. Epub 2014 Feb 12.

Department of Biological Sciences; University of Pittsburgh; Pittsburgh, PA USA.

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http://dx.doi.org/10.4161/cl.28023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022603PMC
January 2014

How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD.

Biochim Biophys Acta 2013 Nov 2;1833(11):2447-57. Epub 2013 Apr 2.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2013.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723753PMC
November 2013

Characterization of an M28 metalloprotease family member residing in the yeast vacuole.

FEMS Yeast Res 2013 Aug 3;13(5):471-84. Epub 2013 Jun 3.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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http://dx.doi.org/10.1111/1567-1364.12050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708649PMC
August 2013

Just a trim, please: refining ER degradation through deubiquitination.

Cell 2013 Aug 25;154(3):479-81. Epub 2013 Jul 25.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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http://dx.doi.org/10.1016/j.cell.2013.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423715PMC
August 2013

Chemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells.

ACS Chem Biol 2013 Jul 1;8(7):1460-8. Epub 2013 May 1.

Departments of †Chemical and Biomolecular Engineering, ∥Bioengineering, and ⊥Biochemistry and Cell Biology, Rice University , Houston, Texas 77005, United States.

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http://dx.doi.org/10.1021/cb400017hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532326PMC
July 2013

A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation.

Mol Biol Cell 2013 Jun 27;24(11):1765-75, S1-8. Epub 2013 Mar 27.

Division of Biological Sciences, Graduate School of Science, Nagoya University, Nagoya, Aichi 464-8602 Japan.

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http://www.molbiolcell.org/doi/10.1091/mbc.e12-12-0907
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http://dx.doi.org/10.1091/mbc.E12-12-0907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667728PMC
June 2013

Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase.

J Biol Chem 2013 Jun 7;288(25):18506-20. Epub 2013 May 7.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

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http://dx.doi.org/10.1074/jbc.M113.475905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689992PMC
June 2013

Cleaning up: ER-associated degradation to the rescue.

Cell 2012 Dec;151(6):1163-7

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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http://dx.doi.org/10.1016/j.cell.2012.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521611PMC
December 2012

The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin.

Genetics 2012 Nov 24;192(3):889-903. Epub 2012 Aug 24.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

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http://www.genetics.org/cgi/doi/10.1534/genetics.112.143487
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http://dx.doi.org/10.1534/genetics.112.143487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522165PMC
November 2012

The unfolded protein response: a multifaceted regulator of lipid and lipoprotein metabolism.

Cell Metab 2012 Oct;16(4):407-8

Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.09.008DOI Listing
October 2012

Assays to measure ER-associated degradation in yeast.

Methods Mol Biol 2012 ;832:505-18

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/978-1-61779-474-2_36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334846PMC
July 2012

The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology.

Physiol Rev 2012 Apr;92(2):537-76

Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA.

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http://www.physiology.org/doi/10.1152/physrev.00027.2011
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http://dx.doi.org/10.1152/physrev.00027.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162396PMC
April 2012

Characterization of inhibitors of glucocorticoid receptor nuclear translocation: a model of cytoplasmic dynein-mediated cargo transport.

Assay Drug Dev Technol 2012 Feb 15;10(1):46-60. Epub 2011 Sep 15.

Department of Structural Biology, University of Pittsburgh , Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1089/adt.2010.0367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277738PMC
February 2012

Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101.

J Oncol 2011 29;2011:232037. Epub 2011 Sep 29.

Division of Hematology/Oncology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.

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http://dx.doi.org/10.1155/2011/232037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184436PMC
November 2011

Expression of a malarial Hsp70 improves defects in chaperone-dependent activities in ssa1 mutant yeast.

PLoS One 2011 19;6(5):e20047. Epub 2011 May 19.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020047PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098276PMC
October 2011

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems.

Curr Opin Cell Biol 2011 Aug 12;23(4):464-75. Epub 2011 Jun 12.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S095506741100073
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http://dx.doi.org/10.1016/j.ceb.2011.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154734PMC
August 2011

Saccharomyces cerivisiae as a model system for kidney disease: what can yeast tell us about renal function?

Am J Physiol Renal Physiol 2011 Jul 13;301(1):F1-11. Epub 2011 Apr 13.

University of Pittsburgh, 4249 Fifth Ave., A320 Langley Hall, Pittsburgh, PA 15260, USA.

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http://www.physiology.org/doi/10.1152/ajprenal.00141.2011
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http://dx.doi.org/10.1152/ajprenal.00141.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129885PMC
July 2011

Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence.

Biochem J 2011 Jun;436(2):291-303

Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, ON, Canada, L8N 3Z5.

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http://dx.doi.org/10.1042/BJ20101865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095691PMC
June 2011