Publications by authors named "Jeffrey L Brodsky"

186Publications

Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control.

Mol Biol Cell 2020 11 23;31(24):2669-2686. Epub 2020 Sep 23.

Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92103.

View Article and Find Full Text PDF
November 2020

The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.

Mol Cell Proteomics 2020 11 31;19(11):1896-1909. Epub 2020 Aug 31.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

View Article and Find Full Text PDF
November 2020

Ubiquitination of disease-causing CFTR variants in a microsome-based assay.

Anal Biochem 2020 09 1;604:113829. Epub 2020 Jul 1.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

View Article and Find Full Text PDF
September 2020

Complementary computational and experimental evaluation of missense variants in the ROMK potassium channel.

PLoS Comput Biol 2020 04 6;16(4):e1007749. Epub 2020 Apr 6.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

View Article and Find Full Text PDF
April 2020

Unlocking the door for ERAD.

Nat Cell Biol 2020 03;22(3):263-265

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

View Article and Find Full Text PDF
March 2020

Regulation of CFTR Biogenesis by the Proteostatic Network and Pharmacological Modulators.

Int J Mol Sci 2020 Jan 10;21(2). Epub 2020 Jan 10.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

View Article and Find Full Text PDF
January 2020

Protein quality control in the secretory pathway.

J Cell Biol 2019 10 19;218(10):3171-3187. Epub 2019 Sep 19.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA

View Article and Find Full Text PDF
October 2019

Exploring the Functional Consequences of Protein Backbone Alteration in Ubiquitin through Native Chemical Ligation.

Chembiochem 2019 09 23;20(18):2346-2350. Epub 2019 Aug 23.

Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA, 15260, USA.

View Article and Find Full Text PDF
September 2019

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.

Neuron 2019 04 27;102(2):321-338.e8. Epub 2019 Feb 27.

Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA 15213, USA; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Protein Conformational Diseases, Kenneth P. Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address:

View Article and Find Full Text PDF
April 2019

Chaperoning Endoplasmic Reticulum-Associated Degradation (ERAD) and Protein Conformational Diseases.

Cold Spring Harb Perspect Biol 2019 08 1;11(8). Epub 2019 Aug 1.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.

View Article and Find Full Text PDF
August 2019

Predicting protein targets for drug-like compounds using transcriptomics.

PLoS Comput Biol 2018 12 7;14(12):e1006651. Epub 2018 Dec 7.

Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America.

View Article and Find Full Text PDF
December 2018

Investigating Potassium Channels in Budding Yeast: A Genetic Sandbox.

Genetics 2018 07;209(3):637-650

Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260

View Article and Find Full Text PDF
July 2018