Publications by authors named "Jeffrey L Brodsky"

186Publications

Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control.

Authors:
Amanjot Singh Nidhi Vashistha Jarrod Heck Xin Tang Peter Wipf Jeffrey L Brodsky Randolph Y Hampton

Mol Biol Cell 2020 11 23;31(24):2669-2686. Epub 2020 Sep 23.

Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92103.

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November 2020

The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.

Authors:
Teresa M Buck Xuemei Zeng Pamela S Cantrell Richard T Cattley Zikri Hasanbasri Megan E Yates Diep Nguyen Nathan A Yates Jeffrey L Brodsky

Mol Cell Proteomics 2020 11 31;19(11):1896-1909. Epub 2020 Aug 31.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

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November 2020

Ubiquitination of disease-causing CFTR variants in a microsome-based assay.

Authors:
Samuel K Estabrooks Jeffrey L Brodsky

Anal Biochem 2020 09 1;604:113829. Epub 2020 Jul 1.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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September 2020

Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with Efficacy in a Model of Huntington's Disease.

Authors:
Leila Terrab Christopher J Rosenker Lisa Johnstone Linh K Ngo Li Zhang Nathaniel F Ware Bettina Miller Andrea Z Topacio Sara Sannino Jeffrey L Brodsky Peter Wipf

ACS Med Chem Lett 2020 May 20;11(5):984-990. Epub 2020 Feb 20.

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

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May 2020

Complementary computational and experimental evaluation of missense variants in the ROMK potassium channel.

Authors:
Luca Ponzoni Nga H Nguyen Ivet Bahar Jeffrey L Brodsky

PLoS Comput Biol 2020 04 6;16(4):e1007749. Epub 2020 Apr 6.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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April 2020

Unlocking the door for ERAD.

Authors:
Miguel Betegon Jeffrey L Brodsky

Nat Cell Biol 2020 03;22(3):263-265

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

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March 2020

Regulation of CFTR Biogenesis by the Proteostatic Network and Pharmacological Modulators.

Authors:
Samuel Estabrooks Jeffrey L Brodsky

Int J Mol Sci 2020 Jan 10;21(2). Epub 2020 Jan 10.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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January 2020

-Nitrosylation of CHIP Enhances F508Del-CFTR Maturation.

Authors:
Khalequz Zaman Julia Knight Faraaz Hussain Ruofan Cao Samuel K Estabrooks Ghaith Altawallbeh Kristopher Holloway Anjum Jafri Victoria Sawczak Yuejin Li Paulina Getsy Fei Sun Thomas Raffay Calvin Cotton Jeffrey L Brodsky Ammasi Periasamy Stephen J Lewis Benjamin Gaston

Am J Respir Cell Mol Biol 2019 12;61(6):765-775

Pediatric Pulmonology Division, Department of Pediatrics, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio.

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December 2019

Protein quality control in the secretory pathway.

Authors:
Zhihao Sun Jeffrey L Brodsky

J Cell Biol 2019 10 19;218(10):3171-3187. Epub 2019 Sep 19.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA

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October 2019

Harmonizing Experimental Data with Modeling to Predict Membrane Protein Insertion in Yeast.

Authors:
Christopher J Guerriero Yessica K Gomez Grant J Daskivich Karl-Richard Reutter Andrew A Augustine Kurt F Weiberth Kunio Nakatsukasa Michael Grabe Jeffrey L Brodsky

Biophys J 2019 08 16;117(4):668-678. Epub 2019 Jul 16.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania.

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August 2019

A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation.

Authors:
Yixian Cui Smriti Parashar Muhammad Zahoor Patrick G Needham Muriel Mari Ming Zhu Shuliang Chen Hsuan-Chung Ho Fulvio Reggiori Hesso Farhan Jeffrey L Brodsky Susan Ferro-Novick

Science 2019 07;365(6448):53-60

Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

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July 2019

Exploring the Functional Consequences of Protein Backbone Alteration in Ubiquitin through Native Chemical Ligation.

Authors:
Halina M Werner Samuel K Estabrooks G Michael Preston Jeffrey L Brodsky W Seth Horne

Chembiochem 2019 09 23;20(18):2346-2350. Epub 2019 Aug 23.

Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA, 15260, USA.

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September 2019

Hsp104 facilitates the endoplasmic-reticulum-associated degradation of disease-associated and aggregation-prone substrates.

Authors:
Lynley M Doonan Christopher J Guerriero G Michael Preston Teresa M Buck Netaly Khazanov Edward A Fisher Hanoch Senderowitz Jeffrey L Brodsky

Protein Sci 2019 07 20;28(7):1290-1306. Epub 2019 May 20.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260.

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July 2019

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.

Authors:
Jacob R Mann Amanda M Gleixner Jocelyn C Mauna Edward Gomes Michael R DeChellis-Marks Patrick G Needham Katie E Copley Bryan Hurtle Bede Portz Noah J Pyles Lin Guo Christopher B Calder Zachary P Wills Udai B Pandey Julia K Kofler Jeffrey L Brodsky Amantha Thathiah James Shorter Christopher J Donnelly

Neuron 2019 04 27;102(2):321-338.e8. Epub 2019 Feb 27.

Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; LiveLikeLou Center for ALS Research, University of Pittsburgh Brain Institute, Pittsburgh, PA 15213, USA; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Protein Conformational Diseases, Kenneth P. Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address:

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April 2019

Chaperoning Endoplasmic Reticulum-Associated Degradation (ERAD) and Protein Conformational Diseases.

Authors:
Patrick G Needham Christopher J Guerriero Jeffrey L Brodsky

Cold Spring Harb Perspect Biol 2019 08 1;11(8). Epub 2019 Aug 1.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.

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August 2019

Predicting protein targets for drug-like compounds using transcriptomics.

Authors:
Nicolas A Pabon Yan Xia Samuel K Estabrooks Zhaofeng Ye Amanda K Herbrand Evelyn Süß Ricardo M Biondi Victoria A Assimon Jason E Gestwicki Jeffrey L Brodsky Carlos J Camacho Ziv Bar-Joseph

PLoS Comput Biol 2018 12 7;14(12):e1006651. Epub 2018 Dec 7.

Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America.

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December 2018

Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.

Authors:
Annette N Chiang Mary Liang Antonio Dominguez-Meijide Caterina Masaracchia Jennifer L Goeckeler-Fried Carly S Mazzone David W Newhouse Nathan M Kendsersky Megan E Yates Alexandra Manos-Turvey Patrick G Needham Tiago F Outeiro Peter Wipf Jeffrey L Brodsky

Bioorg Med Chem 2019 01 15;27(1):79-91. Epub 2018 Nov 15.

Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA. Electronic address:

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January 2019

Thumb domains of the three epithelial Na channel subunits have distinct functions.

Authors:
Shaohu Sheng Jingxin Chen Anindit Mukherjee Megan E Yates Teresa M Buck Jeffrey L Brodsky Michael A Tolino Rebecca P Hughey Thomas R Kleyman

J Biol Chem 2018 11 18;293(45):17582-17592. Epub 2018 Sep 18.

From the Renal-Electrolyte Division, Department of Medicine and

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November 2018

Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells.

Authors:
Sara Sannino Christopher J Guerriero Amit J Sabnis Donna Beer Stolz Callen T Wallace Peter Wipf Simon C Watkins Trever G Bivona Jeffrey L Brodsky

J Cell Sci 2018 09 5;131(17). Epub 2018 Sep 5.

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA

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September 2018

Investigating Potassium Channels in Budding Yeast: A Genetic Sandbox.

Authors:
Timothy D Mackie Jeffrey L Brodsky

Genetics 2018 07;209(3):637-650

Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260

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July 2018