Jeffrey J Legos

Jeffrey J Legos

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Jeffrey J Legos

Jeffrey J Legos

Publications by authors named "Jeffrey J Legos"

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Inhibition of phosphodiesterase type 4 decreases stress-induced defecation in rats and mice.

Pharmacology 2008 28;81(1):11-7. Epub 2007 Aug 28.

Discovery Research, High Throughput Biology, GlaxoSmithKline, King of Prussia, PA 19406, USA.

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https://www.karger.com/Article/FullText/107662
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http://dx.doi.org/10.1159/000107662DOI Listing
December 2007

Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study.

Am J Physiol Endocrinol Metab 2007 Nov 28;293(5):E1256-64. Epub 2007 Aug 28.

Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, UW2510, King of Prussia, PA 19406, USA.

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http://dx.doi.org/10.1152/ajpendo.00218.2007DOI Listing
November 2007

Update on pharmacological strategies for stroke: prevention, acute intervention and regeneration.

Curr Opin Investig Drugs 2003 Jul;4(7):847-58

GlaxoSmithKline, PO Box 1539, 709 Swedeland Road, King of Prussia, PA 19406-0939, USA.

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July 2003

Caspase 3 activation is essential for neuroprotection in preconditioning.

Proc Natl Acad Sci U S A 2003 Jan 9;100(2):715-20. Epub 2003 Jan 9.

Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1073/pnas.0232966100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC141062PMC
January 2003

The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injury.

Eur J Pharmacol 2002 Jun;447(1):37-42

High Throughput Biology, Discovery Research, GlaxoSmithKline, PO Box 1539, Mail Code UW 2523, 709 Swedeland Road, 19406, King of Prussia, PA, USA.

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http://dx.doi.org/10.1016/s0014-2999(02)01890-3DOI Listing
June 2002

LEX032, a novel recombinant serpin, protects the brain after transient focal ischemia.

Microvasc Res 2002 May;63(3):327-34

Department of Physiology, Temple University School of Medicine, 3420 N. Broad St., Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1006/mvre.2002.2405DOI Listing
May 2002

Pharmacological interventions for stroke: failures and future.

Expert Opin Investig Drugs 2002 May;11(5):603-14

High Throughput Biology, Discovery Research, GlaxoSmithKline, King of Prussia, PA, USA.

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http://dx.doi.org/10.1517/13543784.11.5.603DOI Listing
May 2002

Non-surgical management of spinal cord injury.

Expert Opin Investig Drugs 2002 Apr;11(4):469-82

Hign Throughput Biology, Discovery Research, GlaxoSmithKline, King of Prussia, PA, USA.

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http://dx.doi.org/10.1517/13543784.11.4.469DOI Listing
April 2002

Programmable microchip monitoring of post-stroke pyrexia: effects of aspirin and paracetamol on temperature and infarct size in the rat.

J Neurosci Methods 2002 Jan;113(2):159-66

GlaxoSmithKline, High Throughput Biology, Discovery Research, 709 Swedeland Road, PO Box 1539, King of Prussia, PA 19406, USA.

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http://dx.doi.org/10.1016/s0165-0270(01)00488-5DOI Listing
January 2002