Jeffrey I Weitz

Jeffrey I Weitz

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Jeffrey I Weitz

Jeffrey I Weitz

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Long-Term Management of Venous Thromboembolism: Lessons from EINSTEIN CHOICE and Other Extension Trials.

Thromb Haemost 2019 May 26;119(5):689-694. Epub 2019 Feb 26.

Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0039-1679906DOI Listing
May 2019

Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers.

N Engl J Med 2019 05 17;380(19):1825-1833. Epub 2019 Mar 17.

From the Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston (D.L.B.); the Department of Emergency Medicine, Thomas Jefferson University, Philadelphia (C.V.P.); McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada (J.I.W.); CirQuest Labs and the University of Tennessee Health Science Center, Memphis (L.K.J.); and PhaseBio Pharmaceuticals, Malvern, PA (S.X., S.E.A., B.R.U., M.C.M., J.S.L.).

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http://dx.doi.org/10.1056/NEJMoa1901778DOI Listing
May 2019

AB023, A Novel Antibody That Binds Factor XI and Blocks Its Activation by Factor XIIa.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):533-535

From the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.119.312459DOI Listing
April 2019

Factor XIII Prevents Pulmonary Emboli in Mice by Stabilizing Deep Vein Thrombi.

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0039-1685141DOI Listing
April 2019

Combination Antiplatelet and Oral Anticoagulant Therapy in Patients With Coronary and Peripheral Artery Disease.

Circulation 2019 Apr;139(18):2170-2185

Thrombosis and Atherosclerosis Research Institute and McMaster University, Hamilton, Canada (J.I.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033580DOI Listing
April 2019

Characteristics and Outcomes in Patients with Venous Thromboembolism Taking Concomitant Anti-Platelet Agents and Anticoagulants in the AMPLIFY Trial.

Thromb Haemost 2019 Mar 16;119(3):461-466. Epub 2019 Jan 16.

McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0038-1676983DOI Listing
March 2019

Rivaroxaban for prevention and treatment of venous thromboembolism.

Future Cardiol 2019 03 19;15(2):63-77. Epub 2019 Feb 19.

Thrombosis & Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

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https://www.futuremedicine.com/doi/10.2217/fca-2018-0076
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http://dx.doi.org/10.2217/fca-2018-0076DOI Listing
March 2019

MAA868 locks factor XIa in a zymogen-like state.

Blood 2019 Mar;133(13):1393-1394

Thrombosis and Atherosclerosis Research Institute.

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http://dx.doi.org/10.1182/blood-2019-02-900480DOI Listing
March 2019

Antithrombotic Agents.

Circ Res 2019 Feb;124(3):426-436

From the Thrombosis and Atherosclerosis Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313155DOI Listing
February 2019

Overview of Therapeutic Approaches for Cholesterol Lowering and Attenuation of Thrombosis for Prevention of Atherothrombosis.

Circ Res 2019 Feb;124(3):351-353

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland (S.F.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314576DOI Listing
February 2019

Synergy of Dual Pathway Inhibition in Chronic Cardiovascular Disease.

Circ Res 2019 Feb;124(3):416-425

McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada (J.I.W., J.W.A.E.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313141DOI Listing
February 2019

Advances in Antithrombotic Therapy.

Arterioscler Thromb Vasc Biol 2019 Jan;39(1):7-12

From the Thrombosis and Atherosclerosis Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.118.310960DOI Listing
January 2019

The Non-Vitamin K Antagonist Oral Anticoagulants in Heart Disease: Section V-Special Situations.

Thromb Haemost 2019 Jan 31;119(1):14-38. Epub 2018 Dec 31.

Thrombosis and Atherosclerosis Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0038-1675816DOI Listing
January 2019

Lubricant-Infused Surfaces with Built-In Functional Biomolecules Exhibit Simultaneous Repellency and Tunable Cell Adhesion.

ACS Nano 2018 Nov 24;12(11):10890-10902. Epub 2018 Oct 24.

School of Biomedical Engineering , McMaster University , Hamilton , Ontario L8S 4L7 , Canada.

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http://pubs.acs.org/doi/10.1021/acsnano.8b03938
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http://dx.doi.org/10.1021/acsnano.8b03938DOI Listing
November 2018

Effect of Different Doses of Acetylsalicylic Acid on the Antithrombotic Activity of Clopidogrel in a Mouse Arterial Thrombosis Model.

Arterioscler Thromb Vasc Biol 2018 Oct;38(10):2338-2344

From the Department of Medicine, McMaster University, Hamilton, Ontario, Canada (R.N., N.V., J.Z., J.I.W., P.L.G.).

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http://dx.doi.org/10.1161/ATVBAHA.118.311404DOI Listing
October 2018

Establishing Therapeutic Equivalence of Complex Pharmaceuticals: The Case of Dabigatran.

Can J Cardiol 2018 Sep 5;34(9):1116-1119. Epub 2018 Jun 5.

Department of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.cjca.2018.05.023DOI Listing
September 2018

Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness.

N Engl J Med 2018 Sep 26;379(12):1118-1127. Epub 2018 Aug 26.

From the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Feinstein Institute for Medical Research, and the Department of Medicine, Anticoagulation and Clinical Thrombosis Services, Northwell Health at Lenox Hill Hospital (A.C.S.), and the Cardiovascular Institute, Mount Sinai Medical Center (J.L.H.) - all in New York; the Department of Medicine and Surgery, University of Insubria, Varese, Italy (W.A.); the Stanford Stroke Center, Stanford University Medical Center, Stanford (G.W.A.), and the University of California at Davis, Sacramento (G.A.M.) - both in California; the Department of Medicine, Intermountain Medical Center, and Department of Medicine, University of Utah, Salt Lake City (C.G.E.); Division of Cardiology, University of Colorado School of Medicine, and CPC Clinical Research, Aurora (W.R.H.); Département Hospitalo-Universitaire FIRE (Fibrose Inflammation Remodelage), University Paris Diderot, Assistance Publique-Hôpitaux de Paris, and INSERM Unité 1148, Paris (P.G.S.); Imperial College, Royal Brompton Hospital, London (P.G.S.); McMaster University and the Thrombosis and Atherosclerosis Research Institute - both in Hamilton, ON, Canada (J.I.W.); Janssen Research and Development, Raritan (E.S., E.S.B.), and the Thrombosis and Hematology Therapeutic Area, Clinical Development, Pharmaceuticals, Bayer U.S., Whippany (T.E.S.) - both in New Jersey; and the College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City (G.E.R.).

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http://dx.doi.org/10.1056/NEJMoa1805090DOI Listing
September 2018

Screening and diagnostic clinical algorithm for paroxysmal nocturnal hemoglobinuria: Expert consensus.

Eur J Haematol 2018 Jul 16;101(1):3-11. Epub 2018 May 16.

McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada.

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http://dx.doi.org/10.1111/ejh.13059DOI Listing
July 2018

Antiplatelet therapy in the management of atherothrombosis: recent clinical advances.

Blood Adv 2018 07;2(14):1806

Department of Medicine and Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1182/bloodadvances.2018005074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058229PMC
July 2018

Peri-operative Adverse Outcomes in Patients with Atrial Fibrillation Taking Warfarin or Edoxaban: Analysis of the ENGAGE AF-TIMI 48 Trial.

Thromb Haemost 2018 06 3;118(6):1001-1008. Epub 2018 May 3.

Department of Medicine, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1055/s-0038-1645856DOI Listing
June 2018

Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source.

N Engl J Med 2018 Jun 16;378(23):2191-2201. Epub 2018 May 16.

From the Departments of Medicine-Neurology (R.G.H., M.S., A.S.), Health Research Methods, Evidence, and Impact (S.I.B.), Pathology and Molecular Medicine (G. Pare), and Medicine-Cardiology (S.J.C.), Population Health Research Institute (B.S., P.S., E.T.), and the Thrombosis and Atherosclerosis Research Institute and McMaster University (J.I.W.), Hamilton, ON, the Vancouver Stroke Program, University of British Columbia, Vancouver (O.R.B.), and Sunnybrook Health Sciences Centre, University of Toronto, Toronto (C.J.) - all in Canada; Bayer, Wuppertal (H.M.), Klinik für Neurologie, Charité-Universitätsmedizin Berlin (M.E.), and Bayer (B.K.), Berlin, and Bayer, Leverkusen (C.P.) - all in Germany; the Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.), and Janssen Research and Development, Spring House (G. Peters) - both in Pennsylvania; Bayer U.S., Pharmaceuticals Clinical Development Thrombosis, Whippany, NJ (S.D.B.); Clínica Alemana de Santiago, Santiago, Chile (P.L.); the Department of Neurology and Stroke Center, Beijing Tiantan Hospital, Beijing (Yongjun Wang, Yilong Wang); Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona (A.D.); Pirogov Russian National Research Medical University, Moscow (N.S.); International Clinical Research Center and Neurology Department, St. Anne's University Hospital, Brno, Czech Republic (R.M.); Centro Hospitalar e Universitário de Coimbra, Hospitais da Universidade de Coimbra, Coimbra, Portugal (L.C.); the Department of Clinical Sciences (Neurology), Lund University, and the Department of Neurology and Rehabilitation Medicine, Skåne University Hospital, Lund (A.L.), and the Department of Clinical Neuroscience-Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg (T.T.) - all in Sweden; Instituto Nacional de Neurología y Neurocirugía, Mexico City (A.A.); Hospital St. John of God, Sigmund Freud Private University, Medical Faculty, Vienna (W.L.); the 2nd Department of Neurology, Institute of Psychiatry and Neurology, and the Department of Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.); the Department of Internal Medicine, University Hospital Basel, Basel, Switzerland (J.E.); Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo (R.J.G.); Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris-Diderot, Sorbonne Paris Cité University, Paris (P.A.); Institute for Neurological Research-Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia, Buenos Aires (S.F.A.); the Department of Neurology, Helsinki University Central Hospital, Helsinki (T.T.); Imperial College London, London (R.V.); Medical School, University of Western Australia, and Sir Charles Gairdner Hospital, Perth, Australia (G.J.H.); the Department of Human Neurosciences, Sapienza University of Rome, Rome (D.T.); the Department of Neurology, Semmelweis University, Budapest, Hungary (D.B.); International University of Health and Welfare, Sanno Hospital and Sanno Medical Center, Tokyo (S.U.); the Department of Medicine, University of Thessaly, Larissa, Greece (G.N.); Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea (B.-W.Y.); the Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels (R.B.); the Department of Neurology, ZorgSaam Hospital, Terneuzen, the Netherlands (R.B.); Institute of Neuroscience and Psychology, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, United Kingdom (K.W.M.); Shaare Zedek Medical Center, Jerusalem (N.B.); the Department of Neurology, Selcuk University, Konya, Turkey (S.O.); Health Research Board Clinical Research Facility, National University of Ireland, Galway (M.J.O.); Tiervlei Trial Centre and Head of Internal Medicine Karl Bremer Hospital, Bellville, South Africa (M.M.D.V.B.); and Baylor College of Medicine, Houston (W.F.P.).

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http://dx.doi.org/10.1056/NEJMoa1802686DOI Listing
June 2018

Reversal agents for non-vitamin K antagonist oral anticoagulants.

Nat Rev Cardiol 2018 May 18;15(5):273-281. Epub 2018 Jan 18.

Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada.

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http://dx.doi.org/10.1038/nrcardio.2017.223DOI Listing
May 2018

Treatment Challenges in Venous Thromboembolism: An Appraisal of Rivaroxaban Studies.

Thromb Haemost 2018 May 22;118(S 01):S23-S33. Epub 2018 Mar 22.

Thrombosis and Atherosclerosis Research Institute and McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1160/TH17-09-0681DOI Listing
May 2018

Gastrointestinal Bleeding With Edoxaban Versus Warfarin: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis In Myocardial Infarction).

Circ Cardiovasc Qual Outcomes 2018 May;11(5):e003998

TIMI Study Group, Division of Cardiovascular Medicine and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.T.R., F.N., E.M.A., E.B., R.P.G.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.117.003998DOI Listing
May 2018

Non-vitamin K antagonist oral anticoagulants in atrial fibrillation patients with bioprosthetic valves.

Expert Rev Cardiovasc Ther 2018 May 23:1-6. Epub 2018 May 23.

f Department of Medicine and The Thrombosis and Atherosclerosis Research Institute , McMaster University , Hamilton , Canada.

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https://www.tandfonline.com/doi/full/10.1080/14779072.2018.1
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http://dx.doi.org/10.1080/14779072.2018.1475229DOI Listing
May 2018

Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism.

N Engl J Med 2018 Feb 12;378(7):615-624. Epub 2017 Dec 12.

From the University of Oklahoma Health Sciences Center, College of Public Health, Oklahoma City (G.E.R.); the Department of Vascular Medicine, Academic Medical Center, University of Amsterdam (N.E., H.R.B.), and ITREAS, Academic Research Organization (A.S.) - both in Amsterdam; the Department of Vascular Medicine and Hemostasis, University Hospitals Leuven, Leuven, Belgium (P.V.); Ottawa Hospital Research Institute, Ottawa (M.C.), London Health Sciences Centre-Victoria Hospital, London, ON (M.J.K.), University Health Network, University of Toronto, Toronto (E.Y.), and McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON (J.I.W.) - all in Canada; the Department of Medicine and Aging Sciences, University G. D'Annunzio, Chieti, Italy (M.D.N.); the Department of Medicine, Division of Hematology, University of Washington, Seattle (D.G.); Daiichi Sankyo Pharma Development, Basking Ridge, NJ (M.A.G., M.F.M., M.S., G.Z.); Thrombosis Research Institute and University College London, London (A.K.K.); the Department of Respiratory Disease, Hôpital Européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris, Paris (G.M.); the Department of Internal Medicine, Division of Hematology, Ohio State University Wexner Medical Center, Columbus (T.-F.W.); and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston (J.I.Z.).

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http://www.nejm.org/doi/10.1056/NEJMoa1711948
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http://dx.doi.org/10.1056/NEJMoa1711948DOI Listing
February 2018

2017 Scientific Sessions Sol Sherry Distinguished Lecture in Thrombosis: Factor XI as a Target for New Anticoagulants.

Arterioscler Thromb Vasc Biol 2018 02 21;38(2):304-310. Epub 2017 Dec 21.

From the Department of Medicine (J.I.W., J.C.F.) and Department of Biochemistry and Biomedical Sciences (J.I.W.), McMaster University, Hamilton, Ontario, Canada; and Thrombosis and Atherosclerosis Research Institute (J.I.W., J.C.F.), Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.117.309664DOI Listing
February 2018

Measuring Dabigatran Levels: What Tests Are Available and What Still Needs to Be Done?

Thromb Haemost 2017 12 6;117(12):2213-2214. Epub 2017 Dec 6.

Thrombosis and Atherosclerosis Research Institute, Hamilton, Canada.

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http://dx.doi.org/10.1160/TH17-10-0705DOI Listing
December 2017

A Test in Context: D-Dimer.

J Am Coll Cardiol 2017 Nov;70(19):2411-2420

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2017.09.024DOI Listing
November 2017

Dabigatran Reversal with Idarucizumab.

N Engl J Med 2017 10;377(17):1691-2

McMaster University, Hamilton, ON, Canada

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http://dx.doi.org/10.1056/NEJMc1711337DOI Listing
October 2017

Idarucizumab for Dabigatran Reversal - Full Cohort Analysis.

N Engl J Med 2017 08 11;377(5):431-441. Epub 2017 Jul 11.

From Thomas Jefferson University, Philadelphia (C.V.P.); Boehringer Ingelheim, Ridgefield, CT (P.A.R., R.D., B.W.); Boehringer Ingelheim, Biberach (J.R., S.G., J.S.), Boehringer Ingelheim, Ingelheim am Rhein (J.K.), Klinikum Frankfurt Höchst, Frankfurt (T.S.), and Heidelberg University Hospital, Heidelberg (T.S.) - all in Germany; McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada (J.W.E., J.I.W.); Feinberg School of Medicine, Northwestern University, Chicago (R.A.B.); Leiden University Medical Center, Leiden (M.V.H.), and Tergooi Hospital, Hilversum (P.W.K.) - both in the Netherlands; Boston University School of Medicine, Boston (E.M.H.); Tuen Mun Hospital, Hong Kong (C.-W.K.); Duke University School of Medicine, Durham, NC (J.H.L.); Middlemore Hospital (G.R.) and the University of Auckland (L.Y.) - both in Auckland, New Zealand; Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence (F.W.S.); and KU Leuven, Center for Molecular and Vascular Biology, Leuven, Belgium (P.V.).

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http://dx.doi.org/10.1056/NEJMoa1707278DOI Listing
August 2017

Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function.

PLoS One 2016 15;11(6):e0157471. Epub 2016 Jun 15.

Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157471PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909201PMC
July 2017

- a new ISTH publishing platform for the global thrombosis and hemostasis community.

Res Pract Thromb Haemost 2017 Jul 30;1(1):6-8. Epub 2017 May 30.

McMaster University and the Thrombosis and Atherosclerosis Research Institute Hamilton Ontario Canada.

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http://dx.doi.org/10.1002/rth2.12005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058212PMC
July 2017

Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential.

Thromb Haemost 2017 07 22;117(8):1509-1517. Epub 2017 Jun 22.

Paul Y. Kim, Thrombosis and Atherosclerosis Research Institute, 237 Barton St. East, Hamilton, Ontario, L8L 2X2, Canada, Tel.: +1 905 521 2100, Fax: +1 905 575 2646, E-mail:

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http://dx.doi.org/10.1160/TH17-01-0054DOI Listing
July 2017

Exosite 2-Directed Ligands Attenuate Protein C Activation by the Thrombin-Thrombomodulin Complex.

Biochemistry 2017 06 7;56(24):3119-3128. Epub 2017 Jun 7.

Department of Medicine, ‡Department of Biochemistry and Biomedical Sciences, and §Thrombosis and Atherosclerosis Research Institute, McMaster University , Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1021/acs.biochem.7b00250DOI Listing
June 2017

Evaluation of direct oral anticoagulants in superficial-vein thrombosis - Authors' reply.

Lancet Haematol 2017 06;4(6):e254-e255

Department of Vascular Medicine, Darmstadt Municipal Hospital, Darmstadt, Germany; Center of Thrombosis and Haemostasis, University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1016/S2352-3026(17)30086-8DOI Listing
June 2017

New developments in anticoagulants: Past, present and future.

Thromb Haemost 2017 06 8;117(7):1283-1288. Epub 2017 Jun 8.

Jeffrey I. Weitz, 237 Barton St E, Hamilton, Ontario L8L 2X2, Canada, Tel.: +1 905 574 8550, E-mail:

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http://dx.doi.org/10.1160/TH16-10-0807DOI Listing
June 2017

Extended Treatment of Venous Thromboembolism.

N Engl J Med 2017 06;376(25):2491-2492

University of Maastricht, Maastricht, the Netherlands

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http://dx.doi.org/10.1056/NEJMc1705484DOI Listing
June 2017

Recent advances in the treatment of venous thromboembolism in the era of the direct oral anticoagulants.

F1000Res 2017 23;6:985. Epub 2017 Jun 23.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.12688/f1000research.11174.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490483PMC
June 2017

Laboratory Monitoring of Non-Vitamin K Antagonist Oral Anticoagulant Use in Patients With Atrial Fibrillation: A Review.

JAMA Cardiol 2017 May;2(5):566-574

Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada3Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada4Hamilton Health Sciences, Hamilton, Ontario, Canada6Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1001/jamacardio.2017.0364DOI Listing
May 2017

Anticoagulant-Associated Intracranial Hemorrhage in the Era of Reversal Agents.

Stroke 2017 05 11;48(5):1432-1437. Epub 2017 Apr 11.

From the Department of Neurology, Klinikum Frankfurt Höchst, Germany (T.S.); Department of Neurology, Heidelberg University Hospital, Germany (T.S., R.V.); Thrombosis and Atherosclerosis Research Institute and the Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada (J.I.W.); and Department of Stroke, Medicine, Imperial College, London, United Kingdom (R.V.).

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http://dx.doi.org/10.1161/STROKEAHA.116.013343DOI Listing
May 2017

Anticoagulation for Mechanical Heart Valves: Will Oral Factor Xa Inhibitors Be Effective?

Arterioscler Thromb Vasc Biol 2017 05;37(5):743-745

From the Thrombosis and Atherosclerosis Research Institute, David Braley Research Institute, Hamilton, Canada (N.C.C., J.I.W., J.W.E.); and Department of Medicine, McMaster University, Hamilton, Canada (N.C.C., J.I.W., J.W.E.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309223DOI Listing
May 2017

Prevention of thromboembolic complications in patients with superficial-vein thrombosis given rivaroxaban or fondaparinux: the open-label, randomised, non-inferiority SURPRISE phase 3b trial.

Lancet Haematol 2017 Mar 16;4(3):e105-e113. Epub 2017 Feb 16.

Department of Vascular Medicine, Darmstadt Municipal Hospital, Darmstadt, Germany; Centre of Thrombosis and Haemostasis, University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1016/S2352-3026(17)30014-5DOI Listing
March 2017

Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism.

N Engl J Med 2017 03 18;376(13):1211-1222. Epub 2017 Mar 18.

From the Thrombosis and Atherosclerosis Research Institute and McMaster University, Hamilton, ON (J.I.W.), and the Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa (P.S.W.) - both in Canada; Bayer Pharmaceuticals, Leverkusen (A.W.A.L., M.C.S.F., G.H., A.F.P., S.D.B.), Vascular Medicine, Klinikum Darmstadt, Darmstadt (R.B.), the Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz (R.B.), and the Department of Hematology, Medical Clinic I, University Hospital Carl Gustav Carus, Dresden (J.B.-W.) - all in Germany; the Department of Epidemiology and Technology Assessment, University of Maastricht, Maastricht, the Netherlands (M.H.P.); the Division of Angiology and Hemostasis and the Faculty of Medicine, University of Geneva, Geneva (H.B.); the Department of Haematology, Prince of Wales Hospital, Sydney (T.A.B.); the Department of Haematology and Oncology, King's College London (J.B.-W.), the Department of Haematological Medicine, Guy's and St. Thomas' Hospitals, King's College Hospital (A.T.C.), and Thrombosis Research Institute and University College London (A.K.K.) - all in London; the University of Washington School of Medicine, Seattle (B.L.D.); Centre d'Investigation Clinique 1408, Sainbiose U1059, Investigation Network on Venous Thromboembolism, Service de Médecine Vasculaire et Thérapeutique, Centre Hospitalo-Universitaire, Hôpital Nord, Saint Etienne, France (H.D.); Janssen Research and Development, Raritan, NJ (L.H.); Hospital Beneficência Portuguesa, São Paulo (B.B.); Vascular Medicine and Hemostasis, University of Leuven, Leuven, Belgium (P.V.); and the Department of Cardiothoracic and Vascular Sciences, Vascular Medicine Unit, University of Padua, Padua, Italy (P.P.).

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http://dx.doi.org/10.1056/NEJMoa1700518DOI Listing
March 2017

Platelet polyphosphate: the long and the short of it.

Blood 2017 03;129(12):1574-1575

MCMASTER UNIVERSITY.

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http://dx.doi.org/10.1182/blood-2017-01-761593DOI Listing
March 2017

Reversal of Direct Oral Anticoagulants: Current Status and Future Directions.

Authors:
Jeffrey I Weitz

Semin Respir Crit Care Med 2017 02 16;38(1):40-50. Epub 2017 Feb 16.

Department of Medicine and Biochemistry and Biomedical Sciences, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0036-1597831DOI Listing
February 2017

Factors XI and XII as Targets for New Anticoagulants.

Front Med (Lausanne) 2017 24;4:19. Epub 2017 Feb 24.

Department of Medicine, McMaster University, Hamilton, ON, Canada; The Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.3389/fmed.2017.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323386PMC
February 2017

Emerging anticoagulant strategies.

Blood 2017 01 25;129(2):147-154. Epub 2016 Oct 25.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1182/blood-2016-09-692996DOI Listing
January 2017

Prosthetic Heart Valve Thrombosis.

J Am Coll Cardiol 2016 Dec;68(24):2670-2689

The Zena and Michael A. Wiener Cardiovascular Institute, The Icahn School of Medicine at Mount Sinai, New York, New York.

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https://eurheartj.oxfordjournals.org/content/ehj/14/4/447.fu
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http://dx.doi.org/10.1016/j.jacc.2016.09.958DOI Listing
December 2016

Clinical presentation and course of bleeding events in patients with venous thromboembolism, treated with apixaban or enoxaparin and warfarin. Results from the AMPLIFY trial.

Thromb Haemost 2016 Nov 1;116(6):1159-1164. Epub 2016 Sep 1.

Suzanne M. Bleker, Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands, Tel.: +31 20 5668274, Fax: +31 20 5669434, E-mail:

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http://dx.doi.org/10.1160/TH16-02-0137DOI Listing
November 2016

Global Anticoagulant Registry in the Field - Venous Thromboembolism (GARFIELD-VTE). Rationale and design.

Thromb Haemost 2016 Nov 22;116(6):1172-1179. Epub 2016 Sep 22.

Jeffrey I. Weitz, MD, Thrombosis and Atherosclerosis Research Institute, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada, Tel: +1 905 574 8550, Fax: +1 905 575 2646, E-mail:

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http://dx.doi.org/10.1160/TH16-04-0335DOI Listing
November 2016

Response by Weitz and Eikelboom to Letter Regarding Article, "Urgent Need to Measure Effects of Direct Oral Anticoagulants".

Circulation 2016 11;134(21):e498

From Department of Medicine, McMaster University, Hamilton, Ontario, Canada (J.I.W., J.W.E.; and Department of Biochemistry and Biomedical Sciences, Thrombosis & Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada (J.I.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.025545DOI Listing
November 2016

A PoTENtial Antidote: A Prohemostatic Factor Xa Variant for Reversal of Direct Oral Anticoagulants.

Circ Res 2016 11;119(11):1157-1160

From the Departments of Medicine (J.C.F., J.I.W.) and Biochemistry and Biomedical Sciences (J.I.W.) and The Thrombosis and Atherosclerosis Research Institute (J.C.F., J.I.W.), McMaster University, Hamilton, ON, Canada.

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November 2016

Ciraparantag for enoxaparin reversal: Adding to the evidence.

Thromb Res 2016 Oct 13;146:106-107. Epub 2016 Aug 13.

McMaster University, Canada; Thrombosis and Atherosclerosis Research Institute, Canada; Population Health Research Institute, Canada.

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http://dx.doi.org/10.1016/j.thromres.2016.08.013DOI Listing
October 2016

Idarucizumab for dabigatran overdose.

Clin Toxicol (Phila) 2016 Sep 25;54(8):644-6. Epub 2016 May 25.

a Department of Cardiovascular Sciences , University of Leuven , Leuven , Belgium ;

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http://dx.doi.org/10.1080/15563650.2016.1187737DOI Listing
September 2016

Dose reduction of edoxaban preserves efficacy and safety for the treatment of venous thromboembolism. An analysis of the randomised, double-blind HOKUSAI VTE trial.

Thromb Haemost 2016 Sep 21;116(4):747-53. Epub 2016 Jul 21.

Peter Verhamme, MD, KU Leuven Department of Cardiovascular Sciences, Vascular Medicine and Haemostasis, Leuven, Belgium, Tel.: + 32 16 34 35 32, Fax: + 32 16 34 34 93, E-mail:

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http://dx.doi.org/10.1160/TH16-03-0244DOI Listing
September 2016

Appropriate Apixaban Dosing: Prescribers Take Note.

JAMA Cardiol 2016 09;1(6):635-6

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1001/jamacardio.2016.1841DOI Listing
September 2016

Optimizing the safety of treatment for venous thromboembolism in the era of direct oral anticoagulants.

Pol Arch Med Wewn 2016 Sep 5;126(9):688-696. Epub 2016 Sep 5.

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http://dx.doi.org/10.20452/pamw.3547DOI Listing
September 2016

Spotlight on unmet needs in stroke prevention: The PIONEER AF-PCI, NAVIGATE ESUS and GALILEO trials.

Thromb Haemost 2016 Sep 14;116(Suppl. 2):S33-S40. Epub 2016 Sep 14.

Jeffrey Weitz, Thrombosis & Atherosclerosis Research Institute, 237 Barton Street East, C5-123, Hamilton, ON L8L 2X2, Canada, Tel.: +1 905 574 8550, E-mail:

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http://www.thieme-connect.de/DOI/DOI?10.1160/TH16-06-0487
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http://dx.doi.org/10.1160/TH16-06-0487DOI Listing
September 2016

A randomised, double blind comparison of tecarfarin, a novel vitamin K antagonist, with warfarin. The EmbraceAC Trial.

Thromb Haemost 2016 08 12;116(2):241-50. Epub 2016 May 12.

Richard Whitlock, Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada, E-mail:

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http://dx.doi.org/10.1160/TH15-11-0910DOI Listing
August 2016

Urgent Need to Measure Effects of Direct Oral Anticoagulants.

Circulation 2016 Jul;134(3):186-8

From The Thrombosis and Atherosclerosis Research Institute and McMaster University, Hamilton, Canada.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022307DOI Listing
July 2016

The MARINER trial of rivaroxaban after hospital discharge for medical patients at high risk of VTE. Design, rationale, and clinical implications.

Thromb Haemost 2016 06 4;115(6):1240-8. Epub 2016 Feb 4.

Gary E. Raskob, PhD, Dean, College of Public Health and Regents' Professor, Epidemiology and Medicine, University of Oklahoma Health Sciences Center, College of Public Health, 801 NE 13th Street, Oklahoma City, OK 73104, USA, Tel.: +1 405 271 2232, Fax: +1 405 271 3039, E-mail:

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http://dx.doi.org/10.1160/TH15-09-0756DOI Listing
June 2016

Factor XI and factor XII as targets for new anticoagulants.

Authors:
Jeffrey I Weitz

Thromb Res 2016 May;141 Suppl 2:S40-5

Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada; Thrombosis and Atherosclerosis Research Institute, Hamilton, Canada. Electronic address:

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http://dx.doi.org/10.1016/S0049-3848(16)30363-2DOI Listing
May 2016

Early time courses of recurrent thromboembolism and bleeding during apixaban or enoxaparin/warfarin therapy. A sub-analysis of the AMPLIFY trial.

Thromb Haemost 2016 Apr 10;115(4):809-16. Epub 2015 Dec 10.

Gary E. Raskob, PhD, College of Public Health, University of Oklahoma Health Sciences Center, 801 NE 13th Street, Oklahoma City, OK 73104, USA, Tel.: +1 405 271 2232, Fax: +1 405 271 3039, E-mail:

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http://www.thieme-connect.de/DOI/DOI?10.1160/TH15-09-0752
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http://dx.doi.org/10.1160/TH15-09-0752DOI Listing
April 2016

Advances in Thrombosis and Hemostasis: An Introduction to the Compendium.

Circ Res 2016 04;118(9):1337-9

From the Thrombosis and Atherosclerosis Research Institute and Departments of Medicine and Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308844DOI Listing
April 2016

Evolving Treatments for Arterial and Venous Thrombosis: Role of the Direct Oral Anticoagulants.

Circ Res 2016 Apr;118(9):1409-24

From the Population Health Research Institute (N.C.C., J.W.E.) and Department of Medicine (J.W.E., J.I.W.), McMaster University, Hamilton, Ontario, Canada; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada (J.W.E., J.I.W.); and Department of Medicine, Monash University, Clayton, Victoria, Australia (N.C.C.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.306925DOI Listing
April 2016

Zinc promotes clot stability by accelerating clot formation and modifying fibrin structure.

Thromb Haemost 2016 Mar 22;115(3):533-42. Epub 2015 Oct 22.

Jeffrey I. Weitz, Thrombosis and Atherosclerosis Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2, Canada, Tel.: +1 905 521 2100 ext. 40721, E-mail:

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http://dx.doi.org/10.1160/TH15-06-0462DOI Listing
March 2016

Incorporating edoxaban into the choice of anticoagulants for atrial fibrillation.

Thromb Haemost 2016 Jan 15;115(2):257-70. Epub 2015 Oct 15.

Jeffrey I. Weitz, MD, Thrombosis and Atherosclerosis Research Institute, 237 Barton Street East, Hamilton, ON, L8L 2X2 Canada, Tel: +1 905 574 8550, Fax: +1 905 575 2646, E-mail:

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http://www.thieme-connect.de/DOI/DOI?10.1160/th15-02-0181
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http://dx.doi.org/10.1160/TH15-02-0181DOI Listing
January 2016

Letter to the Editor: Managing Dabigatran-Related Bleeding.

J Intensive Care Med 2016 Jan;31(1):70-1

Pennsylvania Hospital, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1177/0885066614542758DOI Listing
January 2016

Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis.

Arterioscler Thromb Vasc Biol 2015 Dec 22;35(12):2544-53. Epub 2015 Oct 22.

From the Department of Medical Sciences (T.J.G., T.T.V.), Thrombosis and Atherosclerosis Research Institute (T.J.G., T.T.V., A.R.S., D.J.D., P.Y.K., A.E.F.-R., J.I.W., P.C.L.), and Department of Medicine (A.R.S., P.Y.K., A.E.F.-R., J.I.W., P.C.L.), McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.115.306035DOI Listing
December 2015

Idarucizumab: The Antidote for Reversal of Dabigatran.

Circulation 2015 Dec;132(25):2412-22

From Departments of Medicine (J.W.E., J.I.W.) and Biochemistry and Biomedical Sciences (J.I.W.), McMaster University, Hamilton, ON, Canada; Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, Canada (J.W.E., J.I.W.); Department of Radiology, King's College Hospital, London, UK (D.J.Q.); and CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany (J.v.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.019628DOI Listing
December 2015

Trends in Prescribing Oral Anticoagulants in Canada, 2008-2014.

Clin Ther 2015 Nov 16;37(11):2506-2514.e4. Epub 2015 Oct 16.

Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.clinthera.2015.09.008DOI Listing
November 2015