Jeffrey G Supko

Jeffrey G Supko

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Jeffrey G Supko

Jeffrey G Supko

Publications by authors named "Jeffrey G Supko"

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Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model.

Theranostics 2019 14;9(21):6284-6299. Epub 2019 Aug 14.

Department of Medical Oncology, Dana-Farber Cancer Institute; Department of Medicine, Brigham and Women's Hospital; Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.7150/thno.35892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735504PMC
August 2019

Phase I study of RO4929097 with bevacizumab in patients with recurrent malignant glioma.

J Neurooncol 2016 12 8;130(3):571-579. Epub 2016 Nov 8.

Neuro-Oncology Branch, CCR, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s11060-016-2263-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571739PMC
December 2016

Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib.

Cancer Discov 2014 May 13;4(5):546-53. Epub 2014 Mar 13.

Departments of 1Medical Oncology and 2Biostatistics and Computational Biology, 3Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute; Departments of 4Medicine and 5Pathology, Brigham and Women's Hospital, Harvard Medical School; 6Division of Hematology/Oncology, Massachusetts General Hospital, Boston; 7Broad Institute of Harvard and MIT; 8Department of Biology, Whitehead Institute for Biomedical Research; 9Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts; and 10Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122326PMC
May 2014

A phase II trial of oral gimatecan for recurrent glioblastoma.

J Neurooncol 2013 Feb 12;111(3):347-53. Epub 2012 Dec 12.

Johnnie L. Cochran Jr. Brain Tumor Center, 8631 West Third St, Suite 410E, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1007/s11060-012-1023-0DOI Listing
February 2013

Phase I study of terameprocol in patients with recurrent high-grade glioma.

Neuro Oncol 2012 Apr 8;14(4):511-7. Epub 2012 Feb 8.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1093/neuonc/nor230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309850PMC
April 2012

Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma.

J Neurooncol 2010 Oct 8;100(1):95-103. Epub 2010 Mar 8.

The New Approaches to Brain Tumor Therapy Consortium, NABTT Central Office, 1550 Orleans Street, Suite 1M-16, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1007/s11060-010-0143-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811025PMC
October 2010

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.

Proc Natl Acad Sci U S A 2010 Aug 21;107(32):14093-8. Epub 2010 Jul 21.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1002713107
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http://dx.doi.org/10.1073/pnas.1002713107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922607PMC
August 2010

Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme.

J Neurooncol 2010 Apr 19;97(2):241-5. Epub 2009 Sep 19.

Brain Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Cancer Research Building II, Suite 1 M-16 1550 Orleans Street, Baltimore, MD, 21231, USA.

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http://dx.doi.org/10.1007/s11060-009-0008-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927643PMC
April 2010

Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study.

J Neurooncol 2009 Jan 12;91(1):51-8. Epub 2008 Sep 12.

Johns Hopkins University School of Medicine, Cancer Research Building II, 1550 Orleans Street, Suite 1M16, Baltimore, MD, 21231, USA.

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http://dx.doi.org/10.1007/s11060-008-9678-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029102PMC
January 2009

Phase I and pharmacokinetic study of gimatecan given orally once a week for 3 of 4 weeks in patients with advanced solid tumors.

Clin Cancer Res 2009 Jan;15(1):374-81

Massachusetts General Hospital, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1024DOI Listing
January 2009

Phase I and pharmacokinetic study of karenitecin in patients with recurrent malignant gliomas.

Neuro Oncol 2008 Aug 24;10(4):608-16. Epub 2008 Jun 24.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231-1000, USA.

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http://dx.doi.org/10.1215/15228517-2008-030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666235PMC
August 2008

Exposure to phytoestrogens in the perinatal period affects androgen secretion by testicular Leydig cells in the adult rat.

Endocrinology 2007 Sep 14;148(9):4475-88. Epub 2007 Jun 14.

Department of Anatomy, Physiology and Pharmacology, 109 Greene Hall, Auburn University, Auburn, Alabama 36849, USA.

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http://dx.doi.org/10.1210/en.2007-0327DOI Listing
September 2007

Pharmacokinetic factors contribute to the inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome.

J Clin Endocrinol Metab 2007 Apr 30;92(4):1347-52. Epub 2007 Jan 30.

Reproductive Endocrine Unit, BHX-5, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1210/jc.2006-2716DOI Listing
April 2007

Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors.

Clin Cancer Res 2007 Jan;13(2 Pt 1):584-90

Beth Israel Deaconess Medical Center, and Harvard Cancer Center, Boston, MA, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-0964DOI Listing
January 2007

The effect of enzyme-inducing antiseizure drugs on the pharmacokinetics and tolerability of procarbazine hydrochloride.

Clin Cancer Res 2006 Sep;12(17):5174-81

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231-1000, and Massachusetts General Hospital, Boston, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-0932DOI Listing
September 2006

Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 administered as a weekly 24 h continuous intravenous infusion in patients with advanced solid tumors.

Cancer Chemother Pharmacol 2006 Jul 13;58(1):107-16. Epub 2005 Dec 13.

Dana-Farber Cancer Institute, Department of Medical Oncology and Brigham and Women's Hospital, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Shields-Warren Building 460, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s00280-005-0134-0DOI Listing
July 2006

Case records of the Massachusetts General Hospital. Case 11-2006. A 54-year-old woman with a mass in the pelvis.

N Engl J Med 2006 Apr;354(15):1615-25

Gillette Center for Women's Cancers, Massachusetts General Hospital, USA.

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http://dx.doi.org/10.1056/NEJMcpc069002DOI Listing
April 2006

Prolonged stabilization of platinum-resistant ovarian cancer in a single patient consuming a fermented soy therapy.

Gynecol Oncol 2006 Jan 19;100(1):205-9. Epub 2005 Sep 19.

Division of Medical Oncology, Massachusetts General Hospital, Cox 640, 100 Blossom Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.ygyno.2005.08.006DOI Listing
January 2006

Increased endothelial uptake of paclitaxel as a potential mechanism for its antiangiogenic effects: potentiation by Cox-2 inhibition.

Int J Cancer 2005 Jan;113(3):490-8

Division of Hematology-Oncology, Department of Medicine, the Center for Study of the Tumor Microenvironment, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/ijc.20595DOI Listing
January 2005

Phase I clinical trial and pharmacokinetic study of the spicamycin analog KRN5500 administered as a 1-hour intravenous infusion for five consecutive days to patients with refractory solid tumors.

Clin Cancer Res 2003 Nov;9(14):5178-86

Massachusetts General Hospital, Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.

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November 2003

Phase I clinical and pharmacokinetic study of irinotecan in adults with recurrent malignant glioma.

Clin Cancer Res 2003 Aug;9(8):2940-9

Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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August 2003

A Phase I study of 9-nitrocamptothecin given concurrently with capecitabine in patients with refractory, metastatic solid tumors.

Cancer 2003 Jan;97(1):148-54

Department of Hematology/Oncology, Massachusetts General Hospital, Cox Building Room 640, 100 Blossom Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/cncr.11038DOI Listing
January 2003

Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins.

Clin Cancer Res 2002 Mar;8(3):641-61

Division of Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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March 2002

A phase I clinical trial of sequentially administered doxorubicin and topotecan in refractory solid tumors.

Clin Cancer Res 2002 Mar;8(3):691-7

Department of Medicine, Massachusetts General Hospital, Boston 02114, USA.

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March 2002