Jeffrey D Rothstein

Jeffrey D Rothstein

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Jeffrey D Rothstein

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Prospective natural history study of ALS clinical characteristics and biomarkers.

Neurology 2019 Oct 2. Epub 2019 Oct 2.

From the Department of Neurology (A.J.C., T.H., C.D., J.J.-B., A.M., S.B., A.S., T.J.E., C.C., T.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Neurology (N.A., H.Y., A.V.S., M.C.), Neurological Clinical Research Institute, Massachusetts General Hospital, Boston; Department of Neurology (L.H.v.d.B., M.A.v.E., J.H.V., B.S.d.V.), Brain Center Rudolf Magnus, University Medical Center Utrecht, University Utrecht, the Netherlands; Department of Neurology (M.H.), Columbia University, New York, NY; Department of Neurology (R.H. Baloh), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (R.H. Brown, N.W., D.M.-Y., M.A.O., C.D.), University of Massachusetts, Worcester; Department of Neurology (J.D.R.), Johns Hopkins University, Baltimore, MD; and Biogen Inc. (A.M., T.F.), Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000008359DOI Listing
October 2019

The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model.

Fluids Barriers CNS 2019 Jul 15;16(1):20. Epub 2019 Jul 15.

Institute for Nanobiotechnology, Johns Hopkins University, 100 Croft Hall, 3400 North Charles Street, Baltimore, MD, 21218, USA.

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http://dx.doi.org/10.1186/s12987-019-0139-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628493PMC
July 2019

Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model.

J Neurogenet 2018 12 6;32(4):322-335. Epub 2018 Nov 6.

a Department of Neurology , Johns Hopkins School of Medicine , Baltimore , MD , USA.

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https://www.tandfonline.com/doi/full/10.1080/01677063.2018.1
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http://dx.doi.org/10.1080/01677063.2018.1513508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444185PMC
December 2018

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.

Cell 2018 05 5;173(4):958-971.e17. Epub 2018 Apr 5.

Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Cellular and Molecular Medicine Program, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183030
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http://dx.doi.org/10.1016/j.cell.2018.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083872PMC
May 2018

Astroglial transcriptome dysregulation in early disease of an ALS mutant SOD1 mouse model.

J Neurogenet 2017 Mar - Jun;31(1-2):37-48. Epub 2016 Dec 25.

a Department of Neurology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/01677063.2016.1260128DOI Listing
March 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Edaravone: A new drug approved for ALS.

Cell 2017 Nov;171(4):725

Brain Science Institute and Dept of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173119
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http://dx.doi.org/10.1016/j.cell.2017.10.011DOI Listing
November 2017

Oligodendroglia: metabolic supporters of neurons.

J Clin Invest 2017 Sep 1;127(9):3271-3280. Epub 2017 Sep 1.

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http://dx.doi.org/10.1172/JCI90610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669561PMC
September 2017

Astroglia in Thick Tissue with Super Resolution and Cellular Reconstruction.

PLoS One 2016 5;11(8):e0160391. Epub 2016 Aug 5.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160391PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975496PMC
July 2017

3D Printer Generated Tissue iMolds for Cleared Tissue Using Single- and Multi-Photon Microscopy for Deep Tissue Evaluation.

Biol Proced Online 2017 5;19. Epub 2017 Jul 5.

Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Univ., 855 N Wolfe Street, Room 250.18, Baltimore, MD 21205 USA.

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http://dx.doi.org/10.1186/s12575-017-0057-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497344PMC
July 2017

Mutant Huntingtin Disrupts the Nuclear Pore Complex.

Neuron 2017 Apr;94(1):93-107.e6

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595097PMC
April 2017

Neurodegenerative disease: Two-for-one on potential therapies.

Nature 2017 04 12;544(7650):302-303. Epub 2017 Apr 12.

Brain Science Institute, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature21911DOI Listing
April 2017

Poly(GP) proteins are a useful pharmacodynamic marker for -associated amyotrophic lateral sclerosis.

Sci Transl Med 2017 03;9(383)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1126/scitranslmed.aai7866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576451PMC
March 2017

c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA.

Cell Chem Biol 2017 Feb 26;24(2):141-148. Epub 2017 Jan 26.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316317PMC
February 2017

The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons.

Sci Rep 2016 10 19;6:35592. Epub 2016 Oct 19.

Department of Neurology, Johns Hopkins School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland, 21205, USA.

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http://dx.doi.org/10.1038/srep35592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069678PMC
October 2016

The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease.

Nat Rev Neurosci 2016 06 6;17(6):383-95. Epub 2016 May 6.

Brain Science Institute, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nrn.2016.38DOI Listing
June 2016

C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC.

Neuron 2016 05;90(3):427-31

Brain Science Institute, Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.04.026DOI Listing
May 2016

Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex.

Elife 2016 Mar 16;5. Epub 2016 Mar 16.

Institut des Neurosciences Cellulaires et Intégratives, CNRS, Université de Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.7554/eLife.09862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805550PMC
March 2016

The transcription factor Pax6 contributes to the induction of GLT-1 expression in astrocytes through an interaction with a distal enhancer element.

J Neurochem 2016 Jan 24;136(2):262-75. Epub 2015 Nov 24.

Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/jnc.13406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837027PMC
January 2016

A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells.

PLoS One 2015 11;10(3):e0118266. Epub 2015 Mar 11.

Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, 21205, United States of America; Brain Science Institute, Johns Hopkins University, Baltimore, Maryland, 21205, United States of America; Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, Maryland, 21205, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118266PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356618PMC
December 2015

Rodent Models of Amyotrophic Lateral Sclerosis.

Curr Protoc Pharmacol 2015 Jun 1;69:5.67.1-21. Epub 2015 Jun 1.

Brain Science Institute and Department of Neurology, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1002/0471141755.ph0567s69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562058PMC
June 2015

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush.

Exp Neurol 2015 Jan 29;263:325-38. Epub 2014 Oct 29.

Department of Neurology, School of Medicine, The Johns Hopkins University, 855 North Wolfe Street, Baltimore, MD 21205, USA; Brain Science Institute, School of Medicine, The Johns Hopkins University, 855 North Wolfe Street, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2014.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292924PMC
January 2015

Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study.

Acta Neuropathol Commun 2014 Dec 14;2:165. Epub 2014 Dec 14.

Département des Maladies du Système Nerveux, APHP, Reseau SLA IDF Groupe Hospitalier Pitié-Salpêtrière, Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), Paris, F-75005, France.

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http://dx.doi.org/10.1186/s40478-014-0165-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297389PMC
December 2014

Preclinical models: needed in translation? A Pro/Con debate.

Mov Disord 2014 Sep;29(11):1391-6

Johns Hopkins University, Brain Science Institute, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/mds.26010DOI Listing
September 2014

Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies.

Trends Neurosci 2014 Aug 11;37(8):433-42. Epub 2014 Jun 11.

Neurosciences Research Australia, Sydney, Australia; Brain and Mind Research Institute, University of Sydney, Sydney, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S01662236140008
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http://dx.doi.org/10.1016/j.tins.2014.05.006DOI Listing
August 2014

C9orf72 nucleotide repeat structures initiate molecular cascades of disease.

Nature 2014 Mar 5;507(7491):195-200. Epub 2014 Mar 5.

1] Department of Biochemistry and Molecular Biology, Johns Hopkins University Baltimore, Maryland 21205, USA [2] Department of Neuroscience, Johns Hopkins University Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature13124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046618PMC
March 2014

Oligodendroglia: metabolic supporters of axons.

Trends Cell Biol 2013 Dec 27;23(12):644-51. Epub 2013 Aug 27.

Brain Science Institute, Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.tcb.2013.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842360PMC
December 2013

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.

Proc Natl Acad Sci U S A 2013 Dec 18;110(51):E4968-77. Epub 2013 Nov 18.

Department of Molecular Genetics and Microbiology, Department of Neurology, and Department of Neuroscience, Center for NeuroGenetics, Genetics Institute, College of Medicine, University of Florida, Gainesville, FL 32610.

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http://dx.doi.org/10.1073/pnas.1315438110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870665PMC
December 2013

RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.

Neuron 2013 Oct;80(2):415-28

Department of Neurology, Johns Hopkins University, 855 N Wolfe Street, Rangos 2-270, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University, 855 N Wolfe Street, Rangos 2-270, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098943PMC
October 2013

The blood-brain barrier: an engineering perspective.

Front Neuroeng 2013 Aug 30;6. Epub 2013 Aug 30.

Department of Materials Science and Engineering, Johns Hopkins University Baltimore, MD, USA ; Institute for Nanobiotechnology, Johns Hopkins University Baltimore, MD, USA.

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http://dx.doi.org/10.3389/fneng.2013.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757302PMC
August 2013

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis.

Nat Neurosci 2013 May 31;16(5):571-9. Epub 2013 Mar 31.

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://www.nature.com/articles/nn.3357
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http://dx.doi.org/10.1038/nn.3357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637847PMC
May 2013

Derivation of glial restricted precursors from E13 mice.

J Vis Exp 2012 Jun 20(64). Epub 2012 Jun 20.

Hugo W. Moser Research Institute at Kennedy Krieger, Johns Hopkins University.

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http://dx.doi.org/10.3791/3462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399460PMC
June 2012

Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.

Exp Neurol 2011 Dec 16;232(2):203-11. Epub 2011 Sep 16.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.expneurol.2011.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220936PMC
December 2011

Plasticity of astroglial networks in olfactory glomeruli.

Proc Natl Acad Sci U S A 2011 Nov 13;108(45):18442-6. Epub 2011 Oct 13.

Collège de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241/Institut National de la Santé et de la Recherche Médicale U1050, 75231 Paris Cedex 05, France.

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http://dx.doi.org/10.1073/pnas.1107386108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214998PMC
November 2011

β-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis.

J Neurosci 2011 Nov;31(46):16581-90

Department of Neurology and Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3332-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374928PMC
November 2011

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Neuron 2011 Oct 21;72(2):257-68. Epub 2011 Sep 21.

Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200438PMC
October 2011

GLT-1 Promoter Activity in Astrocytes and Neurons of Mouse Hippocampus and Somatic Sensory Cortex.

Front Neuroanat 2010 11;3:31. Epub 2010 Jan 11.

Dipartimento di Neuroscienze, Università Politecnica delle Marche Ancona, Italy.

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http://dx.doi.org/10.3389/neuro.05.031.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813724PMC
July 2011

Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury.

J Neurosci Res 2011 Jul 12;89(7):1001-17. Epub 2011 Apr 12.

Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1002/jnr.22624DOI Listing
July 2011

John W. "Jack" Griffin, MD.

Ann Neurol 2011 Jun;69(6):A11-3

Johns Hopkins University School of Medicine Department of Neurology, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/ana.22481DOI Listing
June 2011

Nuclear factor-κB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes.

J Neurosci 2011 Jun;31(25):9159-69

Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0302-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138498PMC
June 2011

New treatments in amyotrophic lateral sclerosis.

Neuropsychopharmacology 2011 Jan;36(1):370-2

Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2010.140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055527PMC
January 2011

NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.

Neuron 2010 Nov;68(4):668-81

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.neuron.2010.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989827PMC
November 2010

A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis.

Amyotroph Lateral Scler 2010 May;11(3):266-71

Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.3109/17482960903307805DOI Listing
May 2010

Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum.

J Neurosci 2010 May;30(21):7290-9

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5118-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894469PMC
May 2010

Quantitative analysis of EAAT4 promoter activity in neurons and astrocytes of mouse somatic sensory cortex.

Neurosci Lett 2010 Apr 6;474(1):42-5. Epub 2010 Mar 6.

Dipartimento di Neuroscienze, Università Politecnica delle Marche, Ancona, Italy.

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http://dx.doi.org/10.1016/j.neulet.2010.03.003DOI Listing
April 2010

Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1.

Glia 2010 Feb;58(3):277-86

Department of Neurology, Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1002/glia.20922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794958PMC
February 2010

Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis.

Brain Res 2009 Mar 3;1263:143-54. Epub 2009 Feb 3.

Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.brainres.2009.01.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952353PMC
March 2009

ALS--motor neuron disease: mechanism and development of new therapies.

J Vis Exp 2007 29(6):245. Epub 2007 Jul 29.

Department of Neurology, John Hopkins University, USA.

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http://www.jove.com/index/Details.stp?ID=245
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http://dx.doi.org/10.3791/245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557107PMC
February 2009

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis.

Ann Neurol 2009 Jan;65 Suppl 1:S3-9

Department of Neurology and Neuroscience, Brain Science Institute, Johns Hopkins University, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1002/ana.21543DOI Listing
January 2009

Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease.

Nat Neurosci 2008 Nov 19;11(11):1294-301. Epub 2008 Oct 19.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1038/nn.2210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656686PMC
November 2008

Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.

J Biol Chem 2008 Mar 20;283(10):6561-71. Epub 2007 Dec 20.

Departments of Neurology and Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1074/jbc.M708096200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581797PMC
March 2008

Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS.

Brain Res 2007 Dec 22;1185:256-65. Epub 2007 Sep 22.

Department of Neurology, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Meyer 6-109, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.brainres.2007.09.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265207PMC
December 2007

TDP-43 in amyotrophic lateral sclerosis: pathophysiology or patho-babel?

Ann Neurol 2007 May;61(5):382-4

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http://dx.doi.org/10.1002/ana.21155DOI Listing
May 2007

Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS.

Neurobiol Dis 2007 Apr 30;26(1):146-52. Epub 2006 Dec 30.

Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.nbd.2006.12.013DOI Listing
April 2007

Glucocorticoid regulation of GLT-1 glutamate transporter isoform expression in the rat hippocampus.

Neuroendocrinology 2006 6;83(5-6):371-9. Epub 2006 Oct 6.

Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29208, USA.

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http://dx.doi.org/10.1159/000096092DOI Listing
January 2007

Targeting an old mechanism in a new disease-protection of glutamatergic dysfunction in depression.

Biol Psychiatry 2007 Jan;61(2):137-8

Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.biopsych.2006.11.011DOI Listing
January 2007

Mechanisms of Disease: astrocytes in neurodegenerative disease.

Nat Clin Pract Neurol 2006 Dec;2(12):679-89

Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 6-119, Baltimore, MD 21287, USA.

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December 2006

Models of amyotrophic lateral sclerosis.

Curr Protoc Neurosci 2002 Nov;Chapter 9:Unit 9.13

Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/0471142301.ns0913s20DOI Listing
November 2002