Publications by authors named "Jeffrey D Parvin"

72Publications

Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity.

PLoS Genet 2019 03 29;15(3):e1008049. Epub 2019 Mar 29.

Department of Biomedical Informatics, Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1008049
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http://dx.doi.org/10.1371/journal.pgen.1008049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457558PMC
March 2019

F-Box Protein-Mediated Resistance to PARP Inhibitor Therapy.

Mol Cell 2019 01;73(2):195-196

Department of Biomedical Informatics, The Ohio State University and The OSU Comprehensive Cancer Center, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.12.019DOI Listing
January 2019

A Multiplex Homology-Directed DNA Repair Assay Reveals the Impact of More Than 1,000 BRCA1 Missense Substitution Variants on Protein Function.

Am J Hum Genet 2018 10 12;103(4):498-508. Epub 2018 Sep 12.

Department of Biomedical Informatics, Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183024
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http://dx.doi.org/10.1016/j.ajhg.2018.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174279PMC
October 2018

Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.

Dev Cell 2017 05;41(4):392-407.e6

Solid Tumor Biology Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA; Department of Cancer Biology and Genetics, McGill University, Montreal, QC H3A 1A1, Canada; Hollings Cancer Center, Medical University of South Carolina, Hollings Cancer Center 124J, 86 Jonathan Lucas Street, Charleston, SC 29425, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508591PMC
May 2017

Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanisms.

Genes Chromosomes Cancer 2017 08 31;56(8):617-631. Epub 2017 May 31.

Department of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, Ohio.

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http://dx.doi.org/10.1002/gcc.22465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170175PMC
August 2017

HDAC10 as a potential therapeutic target in ovarian cancer.

Gynecol Oncol 2017 03 7;144(3):613-620. Epub 2017 Jan 7.

Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2017.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020686PMC
March 2017

Integrative analysis of somatic mutations and transcriptomic data to functionally stratify breast cancer patients.

BMC Genomics 2016 08 22;17 Suppl 7:513. Epub 2016 Aug 22.

Department of Biomedical Informatics, The Ohio State University, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1186/s12864-016-2902-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001235PMC
August 2016

RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins.

Nucleic Acids Res 2016 Mar 17;44(5):2136-44. Epub 2015 Nov 17.

Department of Biomedical Informatics, OSU Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA

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http://nar.oxfordjournals.org/content/early/2015/11/16/nar.g
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkv1223
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http://dx.doi.org/10.1093/nar/gkv1223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797268PMC
March 2016

Roles for SUMO in pre-mRNA processing.

Wiley Interdiscip Rev RNA 2016 Jan-Feb;7(1):105-12. Epub 2015 Nov 13.

Department of Biomedical Informatics and the Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1002/wrna.1318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005391PMC
October 2016

Functional Analysis of BARD1 Missense Variants in Homology-Directed Repair of DNA Double Strand Breaks.

Hum Mutat 2015 Dec 22;36(12):1205-14. Epub 2015 Sep 22.

Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

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http://dx.doi.org/10.1002/humu.22902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005381PMC
December 2015

Massively Parallel Functional Analysis of BRCA1 RING Domain Variants.

Genetics 2015 Jun 30;200(2):413-22. Epub 2015 Mar 30.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195 Department of Medicine, University of Washington, Seattle, Washington 98195 Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195

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http://dx.doi.org/10.1534/genetics.115.175802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492368PMC
June 2015

The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing.

Nucleic Acids Res 2015 Apr 23;43(7):3605-13. Epub 2015 Mar 23.

Department of Biomedical Informatics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA

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http://dx.doi.org/10.1093/nar/gkv246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402547PMC
April 2015

Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells.

PLoS One 2014 1;9(8):e103819. Epub 2014 Aug 1.

Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103819PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118958PMC
April 2015

Small ubiquitin-like modifier (SUMO) isoforms and conjugation-independent function in DNA double-strand break repair pathways.

J Biol Chem 2014 Aug 25;289(31):21289-95. Epub 2014 Jun 25.

From the Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio 43210

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http://dx.doi.org/10.1074/jbc.C114.582122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118090PMC
August 2014

NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels.

Cancer Biol Ther 2014 May 12;15(5):533-43. Epub 2014 Feb 12.

Department of Biomedical Informatics; The Ohio State University Comprehensive Cancer Center; The Ohio State University; Columbus, OH USA.

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http://dx.doi.org/10.4161/cbt.28019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026076PMC
May 2014

MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples.

Bioinformatics 2014 Mar 1;30(5):682-9. Epub 2013 Oct 1.

Division of Medical Oncology, Department of Internal Medicine, Department of Biomedical Informatics and Comprehensive Cancer Center, Biomedical Informatics Shared Resource, The Ohio State University, Columbus OH 43210, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933869PMC
March 2014

BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade.

Proc Natl Acad Sci U S A 2013 Aug 30;110(33):13558-63. Epub 2013 Jul 30.

Basic Biomedical Science Division, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.

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http://dx.doi.org/10.1073/pnas.1306534110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746927PMC
August 2013

Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver.

Pharmacogenet Genomics 2013 May;23(5):269-78

Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32835ff536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132188PMC
May 2013

Gene Co-expression analysis predicts genetic aberration loci associated with colon cancer metastasis.

Int J Comput Biol Drug Des 2013 21;6(1-2):60-71. Epub 2013 Feb 21.

The Ohio State University, Columbus, OH 43201, USA.

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http://dx.doi.org/10.1504/IJCBDD.2013.052202DOI Listing
July 2013

DFI: gene feature discovery in RNA-seq experiments from multiple sources.

BMC Genomics 2012 17;13 Suppl 8:S11. Epub 2012 Dec 17.

The Department of Biomedical Informatics and The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1186/1471-2164-13-S8-S11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535702PMC
June 2013

Analysis of BRCA1 variants in double-strand break repair by homologous recombination and single-strand annealing.

Hum Mutat 2013 Mar 12;34(3):439-45. Epub 2012 Dec 12.

Department of Biomedical Informatics and the Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1002/humu.22251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906639PMC
March 2013

Weighted frequent gene co-expression network mining to identify genes involved in genome stability.

PLoS Comput Biol 2012 30;8(8):e1002656. Epub 2012 Aug 30.

Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1002656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431293PMC
December 2012

Promoters active in interphase are bookmarked during mitosis by ubiquitination.

Nucleic Acids Res 2012 Nov 31;40(20):10187-202. Epub 2012 Aug 31.

Department of Biomedical Informatics and the Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/nar/gks820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488253PMC
November 2012

Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes.

Nucleic Acids Res 2012 Nov 31;40(20):10172-86. Epub 2012 Aug 31.

The Department of Biomedical Informatics and the Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/nar/gks819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488252PMC
November 2012

KIAA0101 interacts with BRCA1 and regulates centrosome number.

Mol Cancer Res 2011 Aug 14;9(8):1091-9. Epub 2011 Jun 14.

Molecular, Cellular, and Development Program, Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157549PMC
August 2011

Comparing multiple ChIP-sequencing experiments.

J Bioinform Comput Biol 2011 Apr;9(2):269-82

Department of Biomedical Informatics, The Ohio State University , Columbus, OH, 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289603PMC
http://dx.doi.org/10.1142/s0219720011005483DOI Listing
April 2011

Fanconi anemia protein FANCD2 inhibits TRF1 polyADP-ribosylation through tankyrase1-dependent manner.

Genome Integr 2011 Feb 12;2(1). Epub 2011 Feb 12.

Department of Genetics and Microbiology, Universitat Autonoma de Barcelona, Edifici C, Bellaterra, Barcelona 08193, Spain.

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http://dx.doi.org/10.1186/2041-9414-2-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048478PMC
February 2011

Histone deacetylases 9 and 10 are required for homologous recombination.

J Biol Chem 2011 Mar 18;286(10):7722-6. Epub 2011 Jan 18.

Department of Biomedical Informatics, Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C110.194233
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http://dx.doi.org/10.1074/jbc.C110.194233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048658PMC
March 2011

BRCA1 represses amphiregulin gene expression.

Cancer Res 2010 Feb 26;70(3):996-1005. Epub 2010 Jan 26.

Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816672PMC
February 2010

BRCA1/BARD1 E3 ubiquitin ligase can modify histones H2A and H2B in the nucleosome particle.

J Biomol Struct Dyn 2010 Feb;27(4):399-406

Dept of Molecular Biology University of Wyoming, Laramie, WY 82071, USA.

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http://dx.doi.org/10.1080/07391102.2010.10507326DOI Listing
February 2010

The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes.

Authors:
Jeffrey D Parvin

Environ Mol Mutagen 2009 Oct;50(8):649-53

Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://doi.wiley.com/10.1002/em.20475
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http://dx.doi.org/10.1002/em.20475DOI Listing
October 2009

Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase.

Cancer Biol Ther 2008 Oct 19;7(10):1540-3. Epub 2008 Oct 19.

Department of Biomedical Informatics, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628548PMC
http://dx.doi.org/10.4161/cbt.7.10.7053DOI Listing
October 2008

Multiple mechanisms contribute to inhibit transcription in response to DNA damage.

J Biol Chem 2008 Apr 15;283(15):9555-61. Epub 2008 Feb 15.

Department of Biomedical Informatics and the Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M707700200
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http://dx.doi.org/10.1074/jbc.M707700200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442283PMC
April 2008

BRCA1 regulates gamma-tubulin binding to centrosomes.

Cancer Biol Ther 2007 Dec 13;6(12):1853-7. Epub 2007 Oct 13.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643382PMC
http://dx.doi.org/10.4161/cbt.6.12.5164DOI Listing
December 2007

Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation.

Cancer Res 2007 Dec;67(23):11186-94

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2578DOI Listing
December 2007

BRCA1 control of steroid receptor ubiquitination.

Sci STKE 2007 Jun 19;2007(391):pe34. Epub 2007 Jun 19.

Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1126/stke.3912007pe34DOI Listing
June 2007

A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase.

Proc Natl Acad Sci U S A 2007 Apr 9;104(16):6614-9. Epub 2007 Apr 9.

Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0610481104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871834PMC
April 2007

The BRCA1 E3 ubiquitin ligase controls centrosome dynamics.

Cell Cycle 2006 Sep 1;5(17):1946-50. Epub 2006 Sep 1.

Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.4161/cc.5.17.3208DOI Listing
September 2006

Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity.

Hum Mol Genet 2006 Oct 7;15(20):3012-23. Epub 2006 Sep 7.

Department of Pathology, Brigham and Women's Hospital, Program in Neuroscience, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/hmg/ddl243DOI Listing
October 2006

Centrosome function in normal and tumor cells.

J Cell Biochem 2006 Dec;99(5):1240-50

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/jcb.21003DOI Listing
December 2006

Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.

Cancer Res 2006 Jun;66(11):5574-81

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3293DOI Listing
June 2006

Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function.

Cancer Res 2006 Apr;66(8):4100-7

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4430DOI Listing
April 2006

BRCA1 DNA-binding activity is stimulated by BARD1.

Cancer Res 2006 Feb;66(4):2012-8

Graduate Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3296DOI Listing
February 2006

Substrates of the BRCA1-dependent ubiquitin ligase.

Cancer Biol Ther 2006 Feb 4;5(2):137-41. Epub 2006 Feb 4.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.4161/cbt.5.2.2479DOI Listing
February 2006

Direct stimulation of transcription initiation by BRCA1 requires both its amino and carboxyl termini.

J Biol Chem 2006 Mar 10;281(13):8317-20. Epub 2006 Feb 10.

Program in Biology and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.C500475200DOI Listing
March 2006

Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells.

Genes Dev 2005 Dec;19(23):2827-36

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.1369805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315390PMC
December 2005

Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination.

Mol Cell Biol 2005 Oct;25(19):8656-68

Department of Pathology, Brigham and Women's Hospital, NRB 630, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1128/MCB.25.19.8656-8668.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265743PMC
October 2005

BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.

J Biol Chem 2005 Jul 10;280(26):24498-505. Epub 2005 May 10.

Program in Biology and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M414020200DOI Listing
July 2005

Degradation of Cdt1 during S phase is Skp2-independent and is required for efficient progression of mammalian cells through S phase.

J Biol Chem 2005 Jun 25;280(24):23416-23. Epub 2005 Apr 25.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M501208200DOI Listing
June 2005

Direct DNA binding activity of the Fanconi anemia D2 protein.

J Biol Chem 2005 Jun 23;280(25):23593-8. Epub 2005 Apr 23.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M503730200
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http://dx.doi.org/10.1074/jbc.M503730200DOI Listing
June 2005

The tumor suppressor protein p53 functions similarly to p63 and p73 in activating transcription in vitro.

Cancer Biol Ther 2005 Apr 21;4(4):414-8. Epub 2005 Apr 21.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachussetts 02115, USA.

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http://dx.doi.org/10.4161/cbt.4.4.1619DOI Listing
April 2005

BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.

Mol Cell Biol 2004 Oct;24(19):8457-66

Brigham and Women's Hospital, Department of Pathology, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.

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http://dx.doi.org/10.1128/MCB.24.19.8457-8466.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516733PMC
October 2004

Overview of history and progress in BRCA1 research: the first BRCA1 decade.

Authors:
Jeffrey D Parvin

Cancer Biol Ther 2004 Jun 20;3(6):505-8. Epub 2004 Jun 20.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.4161/cbt.3.6.839DOI Listing
June 2004

Expression of an amino-terminal BRCA1 deletion mutant causes a dominant growth inhibition in MCF10A cells.

Oncogene 2004 Jul;23(34):5792-8

Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/sj.onc.1207739DOI Listing
July 2004

Phosphorylation of histone H2A inhibits transcription on chromatin templates.

J Biol Chem 2004 May 9;279(21):21866-72. Epub 2004 Mar 9.

Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M400099200DOI Listing
May 2004

Elongation by RNA polymerase II on chromatin templates requires topoisomerase activity.

Nucleic Acids Res 2003 Sep;31(17):5016-24

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC212805PMC
http://dx.doi.org/10.1093/nar/gkg705DOI Listing
September 2003

Transcription from the perspective of the DNA: twists and bumps in the road.

Crit Rev Eukaryot Gene Expr 2003 ;13(1):1-8

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA 02115, USA.

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http://dx.doi.org/10.1615/critreveukaryotgeneexpr.v13.i1.10DOI Listing
February 2004

The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair.

Curr Opin Cell Biol 2003 Jun;15(3):345-50

Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0955-0674(03)00042-5DOI Listing
June 2003

Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells.

Oncogene 2003 Feb;22(7):983-91

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/sj.onc.1206195DOI Listing
February 2003

Creating a tool-kit for exploring BRCA1 function.

Authors:
Jeffrey D Parvin

Cancer Biol Ther 2002 Sep-Oct;1(5):509-10

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts USA.

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http://dx.doi.org/10.4161/cbt.1.5.166DOI Listing
August 2003

The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme.

Cancer Res 2002 Aug;62(15):4222-8

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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August 2002