Jeffrey C Rathmell

Jeffrey C Rathmell

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Jeffrey C Rathmell

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Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer.

J Immunother Cancer 2019 Aug 14;7(1):218. Epub 2019 Aug 14.

Department of Radiation Oncology, Vanderbilt University Medical Center, B1003 PRB, 2220 Pierce Avenue, Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1186/s40425-019-0704-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694548PMC
August 2019

Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade.

Cancer Discov 2019 Jul;9(7):831-833

Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0510DOI Listing
July 2019

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.

Cell 2018 12 1;175(7):1780-1795.e19. Epub 2018 Nov 1.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Immunobiology, Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183130
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http://dx.doi.org/10.1016/j.cell.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361668PMC
December 2018

Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions.

J Clin Oncol 2018 Oct 29:JCO2018792309. Epub 2018 Oct 29.

W. Kimryn Rathmell and Jeffrey C. Rathmell, Vanderbilt-Ingram Cancer Center and Vanderbilt University Medical Center, Nashville, TN; W. Marston Linehan, National Institutes of Health, Bethesda, MD.

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http://ascopubs.org/doi/10.1200/JCO.2018.79.2309
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http://dx.doi.org/10.1200/JCO.2018.79.2309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488445PMC
October 2018

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.

Oncogene 2018 09 23;37(36):5007-5019. Epub 2018 May 23.

Cancer Early Detection and Prevention Initiative, Vanderbilt Ingram Cancer Center, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.

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http://www.nature.com/articles/s41388-018-0307-z
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http://dx.doi.org/10.1038/s41388-018-0307-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127081PMC
September 2018

Metabolic Barriers to T Cell Function in Tumors.

J Immunol 2018 01;200(2):400-407

Vanderbilt Institute of Infection, Immunology, and Inflammation, Vanderbilt-Ingram Cancer Center, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232

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http://dx.doi.org/10.4049/jimmunol.1701041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777533PMC
January 2018

Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway.

Cell Rep 2018 01 28;22(4):860-868. Epub 2018 Jan 28.

Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806629PMC
January 2018

MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.

Cell Metab 2017 Oct;26(4):633-647.e7

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650077PMC
October 2017

Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.

Cell Metab 2017 Jul;26(1):49-70

Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center and Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555084PMC
July 2017

Dysfunctional T cell metabolism in the tumor microenvironment.

Cytokine Growth Factor Rev 2017 Jun 23;35:7-14. Epub 2017 Apr 23.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1211 Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2017.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710836PMC
June 2017

Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate.

Curr Opin Immunol 2017 06 3;46:viii-xi. Epub 2017 Jul 3.

Vanderbilt Center for Immunobiology, Departments of Pathology, Microbiology, and Immunology, Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, United States.

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http://dx.doi.org/10.1016/j.coi.2017.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648598PMC
June 2017

Fine tuning of immunometabolism for the treatment of rheumatic diseases.

Nat Rev Rheumatol 2017 May 6;13(5):313-320. Epub 2017 Apr 6.

Division of Molecular Pathology, Department of Pathology, Microbiology, and Immunology, and the Vanderbilt Center for Immunobiology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1038/nrrheum.2017.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502208PMC
May 2017

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.

Immunity 2017 05;46(5):703-713

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660630PMC
May 2017

Foxp3 and Toll-like receptor signaling balance T cell anabolic metabolism for suppression.

Nat Immunol 2016 Dec 3;17(12):1459-1466. Epub 2016 Oct 3.

Department of Pathology, Microbiology, and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/ni.3577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215903PMC
December 2016

Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.

Cell Rep 2016 12;17(12):3142-3152

Department of Microbiology and Immunology and Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189677PMC
December 2016

Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes.

J Immunol Methods 2016 11 2;438:51-58. Epub 2016 Sep 2.

Department of Pathology, Microbiology, and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37323, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065394PMC
http://dx.doi.org/10.1016/j.jim.2016.08.013DOI Listing
November 2016

Metabolic Signaling Drives IFN-γ.

Cell Metab 2016 11;24(5):651-652

Department of Pathology, Microbiology and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232-2363, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292925PMC
November 2016

Nutrients and the microenvironment to feed a T cell army.

Semin Immunol 2016 10 3;28(5):505-513. Epub 2016 Oct 3.

Department of Pathology, Microbiology, and Immunology, and Cancer Biology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232, United States. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2016.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154770PMC
October 2016

Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.

J Immunol 2016 09 10;197(6):2532-40. Epub 2016 Aug 10.

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710; Department of Pathology, Microbiology, and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232; Department of Cancer Biology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232;

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http://dx.doi.org/10.4049/jimmunol.1502464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010978PMC
September 2016

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.

Cell Rep 2016 Apr 31;15(2):323-35. Epub 2016 Mar 31.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833658PMC
April 2016

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

Cell Metab 2016 Apr;23(4):649-62

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA; Department of Immunology, Duke University, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University, Durham, NC 27710, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832577PMC
April 2016

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.

Dev Cell 2016 Mar;36(5):540-9

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2016.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766004PMC
March 2016

Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.

Proc Natl Acad Sci U S A 2016 Feb 22;113(6):E782-90. Epub 2016 Jan 22.

Department of Molecular Genetics and Microbiology, Center for Virology, Duke University School of Medicine, Durham, NC 27710;

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http://dx.doi.org/10.1073/pnas.1517141113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760815PMC
February 2016

IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF.

J Immunol 2016 Jan 30;196(1):196-206. Epub 2015 Nov 30.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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http://dx.doi.org/10.4049/jimmunol.1402527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684997PMC
January 2016

AIF Is "Always In Fashion" for T Cells.

Immunity 2016 Jan;44(1):11-13

Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660629PMC
January 2016

Novel therapeutic targets of tumor metabolism.

Cancer J 2015 Mar-Apr;21(2):62-9

From the Departments of *Pharmacology and Cancer Biology and †Immunology and ‡Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC.

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http://dx.doi.org/10.1097/PPO.0000000000000099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380246PMC
December 2015

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.

Cell Metab 2015 Dec 17;22(6):1009-19. Epub 2015 Sep 17.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818967PMC
December 2015

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819002PMC
December 2015

Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.

PLoS One 2014 4;9(8):e104104. Epub 2014 Aug 4.

Department of Pharmacology and Cancer Biology, Department of Immunology, Sarah W. Stedman Center for Nutrition and Metabolism, Duke University, Durham, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104104PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121309PMC
November 2015

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

Cell 2015 Sep 27;162(6):1217-28. Epub 2015 Aug 27.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567953PMC
September 2015

PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1.

Mol Cell 2015 Jun;58(5):711-2

Department of Pharmacology and Cancer Biology, Department of Immunology, Duke Molecular Physiology Institute, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704109PMC
June 2015

T cell metabolic fitness in antitumor immunity.

Trends Immunol 2015 Apr 12;36(4):257-64. Epub 2015 Mar 12.

Department of Pharmacology and Cancer Biology, Department of Immunology, Duke Molecular Physiology Institute, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2015.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393792PMC
April 2015

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.

Nat Immunol 2015 Feb 5;16(2):188-96. Epub 2015 Jan 5.

1] Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA. [2] Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297515PMC
February 2015

HIF1α and HIF2α exert distinct nutrient preferences in renal cells.

PLoS One 2014 30;9(5):e98705. Epub 2014 May 30.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Genetics Department, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Department of Medicine, Division of Hematology and Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098705PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039535PMC
January 2015

Glucose availability and glycolytic metabolism dictate glycosphingolipid levels.

J Cell Biochem 2015 Jan;116(1):67-80

Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky.

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http://dx.doi.org/10.1002/jcb.24943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229434PMC
January 2015

The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

Cell Metab 2014 Jul 12;20(1):61-72. Epub 2014 Jun 12.

Department of Pharmacology and Cancer Biology, Immunology, Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.cmet.2014.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079750PMC
July 2014

Leptin metabolically licenses T cells for activation to link nutrition and immunity.

J Immunol 2014 Jan 22;192(1):136-44. Epub 2013 Nov 22.

Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, NC 27710;

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http://dx.doi.org/10.4049/jimmunol.1301158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872216PMC
January 2014

Metabolic regulation of T lymphocytes.

Annu Rev Immunol 2013 3;31:259-83. Epub 2013 Jan 3.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1146/annurev-immunol-032712-095956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606674PMC
June 2013

Metabolic reprogramming of the immune response in the tumor microenvironment.

Cancer Biol Ther 2013 Apr 28;14(4):315-8. Epub 2013 Jan 28.

Cancer Immunology and Hematology Branch, Division of Cancer Biology, NCI, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/cbt.23616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667870PMC
April 2013

Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.

Proc Natl Acad Sci U S A 2013 Feb 16;110(6):2300-5. Epub 2013 Jan 16.

Department of Pharmacology and Toxicology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1073/pnas.1206551110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568344PMC
February 2013

Activated lymphocytes as a metabolic model for carcinogenesis.

Cancer Metab 2013 Jan 23;1(1). Epub 2013 Jan 23.

Department of Pharmacology and Cancer Biology, Department of Immunology, Sarah W, Stedman Nutrition and Metabolism Center, Duke University, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1186/2049-3002-1-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834493PMC
January 2013

Matched and mismatched metabolic fuels in lymphocyte function.

Semin Immunol 2012 Dec 3;24(6):405-13. Epub 2013 Jan 3.

Department of Pharmacology and Cancer Biology, Sarah W Stedman Nutrition and Metabolism Center, Duke University, Durham, NC 27710, United States.

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http://dx.doi.org/10.1016/j.smim.2012.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582857PMC
December 2012

Metabolism and autophagy in the immune system: immunometabolism comes of age.

Immunol Rev 2012 Sep;249(1):5-13

Department of Pharmacology and Cancer Biology, Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2012.01158.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576876PMC
September 2012

Metabolic stress in autophagy and cell death pathways.

Cold Spring Harb Perspect Biol 2012 Sep 1;4(9):a008763. Epub 2012 Sep 1.

Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1101/cshperspect.a008763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428762PMC
September 2012

Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.

Proc Natl Acad Sci U S A 2012 Jul 29;109(29):11818-23. Epub 2012 Jun 29.

Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1205995109
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http://dx.doi.org/10.1073/pnas.1205995109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406848PMC
July 2012

Metabolic pathways in T cell fate and function.

Trends Immunol 2012 Apr 17;33(4):168-73. Epub 2012 Feb 17.

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.

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http://www.cell.com/trends/immunology/pdf/S1471-4906(12)0001
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April 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra Sasnauskiene Miklós Sass Ken Sato Miyuki Sato Anthony H V Schapira Michael Scharl Hermann M Schätzl Wiep Scheper Stefano Schiaffino Claudio Schneider Marion E Schneider Regine Schneider-Stock Patricia V Schoenlein Daniel F Schorderet Christoph Schüller Gary K Schwartz Luca Scorrano Linda Sealy Per O Seglen Juan Segura-Aguilar Iban Seiliez Oleksandr Seleverstov Christian Sell Jong Bok Seo Duska Separovic Vijayasaradhi Setaluri Takao Setoguchi Carmine Settembre John J Shacka Mala Shanmugam Irving M Shapiro Eitan Shaulian Reuben J Shaw James H Shelhamer Han-Ming Shen Wei-Chiang Shen Zu-Hang Sheng Yang Shi Kenichi Shibuya Yoshihiro Shidoji Jeng-Jer Shieh Chwen-Ming Shih Yohta Shimada Shigeomi Shimizu Takahiro Shintani Orian S Shirihai Gordon C Shore Andriy A Sibirny Stan B Sidhu Beata Sikorska Elaine C M Silva-Zacarin Alison Simmons Anna Katharina Simon Hans-Uwe Simon Cristiano Simone Anne Simonsen David A Sinclair Rajat Singh Debasish Sinha Frank A Sinicrope Agnieszka Sirko Parco M Siu Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang Hong-Gang Wang Horng-Dar Wang Jin Wang Ke Wang Mei Wang Richard C Wang Xinglong Wang Xuejun Wang Ying-Jan Wang Yipeng Wang Zhen Wang Zhigang Charles Wang Zhinong Wang Derick G Wansink Diane M Ward Hirotaka Watada Sarah L Waters Paul Webster Lixin Wei Conrad C Weihl William A Weiss Scott M Welford Long-Ping Wen Caroline A Whitehouse J Lindsay Whitton Alexander J Whitworth Tom Wileman John W Wiley Simon Wilkinson Dieter Willbold Roger L Williams Peter R Williamson Bradly G Wouters Chenghan Wu Dao-Cheng Wu William K K Wu Andreas Wyttenbach Ramnik J Xavier Zhijun Xi Pu Xia Gengfu Xiao Zhiping Xie Zhonglin Xie Da-zhi Xu Jianzhen Xu Liang Xu Xiaolei Xu Ai Yamamoto Akitsugu Yamamoto Shunhei Yamashina Michiaki Yamashita Xianghua Yan Mitsuhiro Yanagida Dun-Sheng Yang Elizabeth Yang Jin-Ming Yang Shi Yu Yang Wannian Yang Wei Yuan Yang Zhifen Yang Meng-Chao Yao Tso-Pang Yao Behzad Yeganeh Wei-Lien Yen Jia-jing Yin Xiao-Ming Yin Ook-Joon Yoo Gyesoon Yoon Seung-Yong Yoon Tomohiro Yorimitsu Yuko 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Autophagy 2012 Apr;8(4):445-544

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April 2012

T cell Myc-tabolism.

Immunity 2011 Dec;35(6):845-6

Department of Pharmacology and Cancer Biology, Department of Immunology, Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC 27710, USA.

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December 2011

The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.

J Immunol 2011 Oct 19;187(8):4187-98. Epub 2011 Sep 19.

Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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October 2011

Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.

Cancer Res 2011 Aug 13;71(15):5204-13. Epub 2011 Jun 13.

Departments of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.

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August 2011

PKM2 and the tricky balance of growth and energy in cancer.

Mol Cell 2011 Jun;42(6):713-4

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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June 2011

Cell metabolism: an essential link between cell growth and apoptosis.

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Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.

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April 2011

ER stress modulates cellular metabolism.

Biochem J 2011 Apr;435(1):285-96

Molecular Targets Program, James Graham Brown Cancer Center, 529 S. Jackson Street, Louisville, KY 40202, USA.

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April 2011

Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl.

Cancer Res 2010 Oct 28;70(20):8066-76. Epub 2010 Sep 28.

Departments of Pharmacology and Cancer Biology and Immunology and Sarah W. Stedman Center for Nutrition and Metabolism, Duke University Medical Center, Durham, NC 27710, USA.

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October 2010

The metabolic life and times of a T-cell.

Immunol Rev 2010 Jul;236:190-202

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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July 2010

IL-7 is essential for homeostatic control of T cell metabolism in vivo.

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Department of Pharmacology, Sarah W Stedman Center for Nutrition and Metabolism, Duke University Medical Center, Durham, NC 27710, USA.

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April 2010

TGF-beta: a new role for an old AktTOR.

Dev Cell 2009 Jul;17(1):6-8

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.

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July 2009

Autophagy: not good OR bad, but good AND bad.

Autophagy 2009 May;5(4):569-70

Department of Pharmacology and Cancer Biology, Sarah W. Stedman Center for Nutrition and Metabolism, Durham, NC, USA

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Biochemistry. A glucose-to-gene link.

Science 2009 May;324(5930):1021-2

Department of Pharmacology and Cancer Biology, Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1126/science.1174665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788238PMC
May 2009

Glucose metabolism as a target of histone deacetylase inhibitors.

Mol Endocrinol 2009 Mar 23;23(3):388-401. Epub 2008 Dec 23.

Duke University Medical Center, Pharmacology and Cancer Biology, Box 3813, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1210/me.2008-0179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654518PMC
March 2009

Mechanisms and methods in glucose metabolism and cell death.

Methods Enzymol 2008 ;442:439-57

Department of Pharmacology, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1016/S0076-6879(08)01422-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605583PMC
January 2009

Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation.

J Biol Chem 2008 Dec 6;283(52):36344-53. Epub 2008 Nov 6.

Department of Pharmacology and Cancer Biology, Sarah W. Stedman Center for Nutrition and Metabolism, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1074/jbc.M803580200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606014PMC
December 2008

Methed-up FOXOs can't in-Akt-ivate.

Mol Cell 2008 Oct;32(2):160-2

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603568PMC
October 2008

New roles for pyruvate kinase M2: working out the Warburg effect.

Trends Biochem Sci 2008 Aug 4;33(8):359-62. Epub 2008 Jul 4.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.tibs.2008.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590867PMC
August 2008

Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

J Immunol 2008 Apr;180(7):4476-86

Department of Pharmacology and Cancer Biology, Sarah W Stedman Center for Nutrition and Metabolism, Duke University Medical Center, Durham, NC 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593791PMC
http://dx.doi.org/10.4049/jimmunol.180.7.4476DOI Listing
April 2008

IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.

Blood 2008 Feb 27;111(4):2101-11. Epub 2007 Nov 27.

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.1182/blood-2007-06-096297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234050PMC
February 2008

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

Proc Natl Acad Sci U S A 2007 Jul 3;104(29):12105-10. Epub 2007 Jul 3.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0705285104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924580PMC
July 2007

Filling a GAP(DH) in caspase-independent cell death.

Cell 2007 Jun;129(5):861-3

Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740700669
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http://dx.doi.org/10.1016/j.cell.2007.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592604PMC
June 2007