Jeffrey Barrett

Jeffrey Barrett

UNVERIFIED PROFILE

Are you Jeffrey Barrett?   Register this Author

Register author
Jeffrey Barrett

Jeffrey Barrett

Publications by authors named "Jeffrey Barrett"

Are you Jeffrey Barrett?   Register this Author

100Publications

3660Reads

25Profile Views

Real-World Data: An Unrealized Opportunity in Global Health?

Clin Pharmacol Ther 2019 Jul 12;106(1):57-59. Epub 2019 Jun 12.

Bill & Melinda Gates Medical Research Institute, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1476DOI Listing
July 2019

A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children.

AAPS J 2019 Jun 27;21(5):81. Epub 2019 Jun 27.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-019-0351-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597607PMC
June 2019

Propositional content in signals.

Stud Hist Philos Biol Biomed Sci 2019 Apr 28;74:34-39. Epub 2019 Jan 28.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.shpsc.2019.01.005DOI Listing
April 2019

Challenges and Opportunities With Oncology Drug Development in China.

Clin Pharmacol Ther 2019 Feb 8;105(2):363-375. Epub 2018 Mar 8.

Bristol-Myers Squibb, Princeton, New Jersey, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1017DOI Listing
February 2019

Multiomics Analyses to Deliver the Most Effective Treatment to Every Patient With Inflammatory Bowel Disease.

Gastroenterology 2018 11 2;155(5):e1-e4. Epub 2018 Aug 2.

Genomics plc, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2018.07.039DOI Listing
November 2018

Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults.

JCI Insight 2017 10 5;2(19). Epub 2017 Oct 5.

Department of Pediatrics, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.95893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841871PMC
October 2017

Linear-In-Flux-Expressions Methodology: Toward a Robust Mathematical Framework for Quantitative Systems Pharmacology Simulators.

Gene Regul Syst Bio 2017 26;11:1177625017711414. Epub 2017 Jul 26.

Translational Informatics Department, Sanofi US, Bridgewater, NJ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1177625017711414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862386PMC
July 2017

Safety, dosing, and pharmaceutical quality for studies that evaluate medicinal products (including biological products) in neonates.

Pediatr Res 2017 May 3;81(5):692-711. Epub 2016 Nov 3.

Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/pr.2016.221DOI Listing
May 2017

Returning genome sequences to research participants: Policy and practice.

Wellcome Open Res 2017 Feb 24;2:15. Epub 2017 Feb 24.

The Ethox Centre, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/wellcomeopenres.10942.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351846PMC
February 2017

Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development.

J Clin Pharmacol 2016 11;56(11):1326-1334

Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482171PMC
November 2016

Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families.

Gastroenterology 2016 10 1;151(4):698-709. Epub 2016 Jul 1.

Division of Medicine, University College London (UCL), London, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2016.06.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643259PMC
October 2016

A reference panel of 64,976 haplotypes for genotype imputation.

Authors:
Shane McCarthy Sayantan Das Warren Kretzschmar Olivier Delaneau Andrew R Wood Alexander Teumer Hyun Min Kang Christian Fuchsberger Petr Danecek Kevin Sharp Yang Luo Carlo Sidore Alan Kwong Nicholas Timpson Seppo Koskinen Scott Vrieze Laura J Scott He Zhang Anubha Mahajan Jan Veldink Ulrike Peters Carlos Pato Cornelia M van Duijn Christopher E Gillies Ilaria Gandin Massimo Mezzavilla Arthur Gilly Massimiliano Cocca Michela Traglia Andrea Angius Jeffrey C Barrett Dorrett Boomsma Kari Branham Gerome Breen Chad M Brummett Fabio Busonero Harry Campbell Andrew Chan Sai Chen Emily Chew Francis S Collins Laura J Corbin George Davey Smith George Dedoussis Marcus Dorr Aliki-Eleni Farmaki Luigi Ferrucci Lukas Forer Ross M Fraser Stacey Gabriel Shawn Levy Leif Groop Tabitha Harrison Andrew Hattersley Oddgeir L Holmen Kristian Hveem Matthias Kretzler James C Lee Matt McGue Thomas Meitinger David Melzer Josine L Min Karen L Mohlke John B Vincent Matthias Nauck Deborah Nickerson Aarno Palotie Michele Pato Nicola Pirastu Melvin McInnis J Brent Richards Cinzia Sala Veikko Salomaa David Schlessinger Sebastian Schoenherr P Eline Slagboom Kerrin Small Timothy Spector Dwight Stambolian Marcus Tuke Jaakko Tuomilehto Leonard H Van den Berg Wouter Van Rheenen Uwe Volker Cisca Wijmenga Daniela Toniolo Eleftheria Zeggini Paolo Gasparini Matthew G Sampson James F Wilson Timothy Frayling Paul I W de Bakker Morris A Swertz Steven McCarroll Charles Kooperberg Annelot Dekker David Altshuler Cristen Willer William Iacono Samuli Ripatti Nicole Soranzo Klaudia Walter Anand Swaroop Francesco Cucca Carl A Anderson Richard M Myers Michael Boehnke Mark I McCarthy Richard Durbin

Nat Genet 2016 10 22;48(10):1279-83. Epub 2016 Aug 22.

Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388176PMC
October 2016

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.

Nat Genet 2016 09 1;48(9):1060-5. Epub 2016 Aug 1.

Wellcome Trust Sanger Institute, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988037PMC
September 2016

Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV.

J Transl Med 2016 05 26;14(1):148. Epub 2016 May 26.

Division of Allergy and Immunology, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12967-016-0904-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880976PMC
May 2016

Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents.

Br J Clin Pharmacol 2015 Nov 10;80(5):1185-96. Epub 2015 Sep 10.

Division of Clinical Pharmacology, Children's National Medical Center, Washington DC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.12693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631191PMC
November 2015

Understanding inflammatory bowel disease via immunogenetics.

J Autoimmun 2015 Nov 7;64:91-100. Epub 2015 Aug 7.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1HH, United Kingdom; European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1HH, United Kingdom; Centre for Therapeutic Target Validation, Wellcome Genome Campus, Hinxton, Cambridge CB10 1HH, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2015.07.013DOI Listing
November 2015

Strategies for fine-mapping complex traits.

Hum Mol Genet 2015 Oct 8;24(R1):R111-9. Epub 2015 Jul 8.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1HH, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddv260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572002PMC
October 2015

Using human genetics to make new medicines.

Nat Rev Genet 2015 10 15;16(10):561-2. Epub 2015 Sep 15.

European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrg3998DOI Listing
October 2015

Malabsorption blood test: Assessing fat absorption in patients with cystic fibrosis and pancreatic insufficiency.

J Clin Pharmacol 2015 Aug 23;55(8):854-65. Epub 2015 Mar 23.

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496318PMC
August 2015

Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation.

Antimicrob Agents Chemother 2015 Jul 20;59(7):3935-43. Epub 2015 Apr 20.

Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00102-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468733PMC
July 2015

Population Pharmacokinetic Model of Sublingual Buprenorphine in Neonatal Abstinence Syndrome.

Pharmacotherapy 2015 Jul 14;35(7):670-80. Epub 2015 Jul 14.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.1610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119858PMC
July 2015

Evaluation of sodium nitroprusside for controlled hypotension in children during surgery.

Front Pharmacol 2015 6;6:136. Epub 2015 Jul 6.

Department of Anesthesia and Perioperative Care, University of California, San Francisco San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2015.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491614PMC
July 2015

ABCB1 polymorphism and gender affect the pharmacokinetics of amlodipine in Chinese patients with essential hypertension: a population analysis.

Drug Metab Pharmacokinet 2014 11;29(4):305-11. Epub 2014 Feb 11.

Center of Clinical Pharmacology and Pharmacy Department, The Third Xiangya Hospital, Central South University.

View Article

Download full-text PDF

Source
May 2015

Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers: phase 1B trial of aprepitant in HIV-1-infected adults.

AIDS 2015 May;29(8):931-9

aDepartment of Medicine bDepartment of Pediatrics cDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania dThe Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania eWestat, Rockville, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0000000000000638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472318PMC
May 2015

Novel method to predict body weight in children based on age and morphological facial features.

J Clin Pharmacol 2015 Apr 6;55(4):447-51. Epub 2015 Jan 6.

Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jcph.422
Publisher Site
http://dx.doi.org/10.1002/jcph.422DOI Listing
April 2015

Modeling and simulation approach to support dosing and study design requirements for treating HIV-related neuropsychiatric disease with the NK1-R antagonist aprepitant.

Curr HIV Res 2014 ;12(2):121-31

Divisions of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
March 2015

Challenges and considerations for development of therapeutic proteins in pediatric patients.

J Clin Pharmacol 2015 Mar;55 Suppl 3:S103-15

Former employee of Clinical Pharmacology, Genentech, South San Francisco, USA; Oncology Clinical Pharmacology, Novartis, East Hanover, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.382DOI Listing
March 2015

Characterization of expression quantitative trait loci in the human colon.

Inflamm Bowel Dis 2015 Feb;21(2):251-6

*Medical Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom; †Division of Medicine, University College London, London, United Kingdom; ‡Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, United Kingdom; and §Eastman Dental Institute, University College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/ibdjournal/2015/02000/Character
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/MIB.0000000000000265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345969PMC
February 2015

Paediatric models in motion: requirements for model-based decision support at the bedside.

Br J Clin Pharmacol 2015 Jan;79(1):85-96

Department of Pediatrics, Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.12287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294079PMC
January 2015

Adjuvant therapies for HIV-associated neurocognitive disorders.

Ann Clin Transl Neurol 2014 Nov 23;1(11):938-52. Epub 2014 Oct 23.

The Children's Hospital of Philadelphia Research Institute Philadelphia, Pennsylvania ; Division of Allergy & Immunology, The Children's Hospital of Philadelphia Philadelphia, Pennsylvania ; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265066PMC
November 2014

Predictors of arterial blood pressure control during deliberate hypotension with sodium nitroprusside in children.

Anesth Analg 2014 Oct;119(4):867-74

From the *Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina; †Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania; ‡Department of Anesthesia, Stanford School of Medicine, Stanford, California; and §Duke Clinical Research Institute, Durham, North Carolina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0000000000000376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169308PMC
October 2014

Using genetic prediction from known complex disease Loci to guide the design of next-generation sequencing experiments.

PLoS One 2013 18;8(10):e76328. Epub 2013 Oct 18.

Medical Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom ; Wellcome Trust Centre for Human Genetics, Univeristy of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076328PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799779PMC
August 2014

Practical considerations for dose selection in pediatric patients to ensure target exposure requirements.

AAPS J 2014 Jul 20;16(4):749-55. Epub 2014 May 20.

Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, 709 Swedeland Rd. UW2431, King of Prussia, Pennsylvania, 19406, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-014-9603-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070253PMC
July 2014

Distribution and medical impact of loss-of-function variants in the Finnish founder population.

PLoS Genet 2014 Jul 31;10(7):e1004494. Epub 2014 Jul 31.

Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117444PMC
July 2014

Effect of CYP3A5*3 polymorphism on pharmacokinetic drug interaction between tacrolimus and amlodipine.

Drug Metab Pharmacokinet 2013 26;28(5):398-405. Epub 2013 Feb 26.

Clinical Pharmacy and Pharmacology Research Institute, The Third Xiangya Hospital, Central South University.

View Article

Download full-text PDF

Source
June 2014

Busulfan in infant to adult hematopoietic cell transplant recipients: a population pharmacokinetic model for initial and Bayesian dose personalization.

Clin Cancer Res 2014 Feb 11;20(3):754-63. Epub 2013 Nov 11.

Authors' Affiliations: University of Washington Schools of Pharmacy and Medicine; Fred Hutchinson Cancer Research Center; Seattle Children's Hospital, Seattle, Washington; Division of Clinical Pharmacology & Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Children's Mercy Hospitals and Clinics, Kansas City, Missouri; and Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-13-1960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946385PMC
February 2014

A sensitive and selective liquid chromatography/tandem mass spectrometry method for quantitative analysis of efavirenz in human plasma.

PLoS One 2013 5;8(6):e63305. Epub 2013 Jun 5.

Division of Clinical Pharmacology & Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063305PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673986PMC
January 2014

The grand challenges in obstetric and pediatric pharmacology.

Front Pharmacol 2013 30;4:170. Epub 2013 Dec 30.

Interdisciplinary Pharmacometrics Program, Pediatric Clinical Pharmacology Sanofi, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2013.00170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874543PMC
January 2014

PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: are we asking the right questions?

J Clin Psychopharmacol 2013 Dec;33(6):725-8

From the *Laboratory for Applied PK/PD, Division of Clinical Pharmacology and Therapeutics, Divisions of †Neurology, and ‡Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JCP.0b013e3182a88654DOI Listing
December 2013

Identifying novel phenotypes of vulnerability and resistance to activity-based anorexia in adolescent female rats.

Int J Eat Disord 2013 Nov 13;46(7):737-46. Epub 2013 Jul 13.

Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York; Department of Psychiatry, New York State Psychiatric Institute, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eat.22149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783190PMC
November 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary Dose-Exposure Relationships to Define Clinical Development Strategies.

Clin Pharmacol Drug Dev 2013 Oct 25;2(4):379-86. Epub 2013 Jul 25.

Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpdd.47DOI Listing
October 2013

A Modeling and Simulations Framework to Support Global Regulatory Strategies for Pediatric Drug Development Programs.

Ther Innov Regul Sci 2013 Sep;47(5):550-556

3 The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2168479013500289DOI Listing
September 2013

Considerations for the prediction of survival time in pancreatic cancer based on registry data.

J Pharmacokinet Pharmacodyn 2013 Aug 12;40(4):527-36. Epub 2013 Jul 12.

Laboratory of Applied PK/PD, Department of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Colket Translational Research Building, Room 4012, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10928-013-9327-zDOI Listing
August 2013

Risk assessment of drug interaction potential and concomitant dosing pattern on targeted toxicities in pediatric cancer patients.

AAPS J 2013 Jul 18;15(3):775-86. Epub 2013 Apr 18.

Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, The Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-013-9489-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691430PMC
July 2013

Strategic biomarkers for drug development in treating rare diseases and diseases in neonates and infants.

AAPS J 2013 Apr 19;15(2):447-54. Epub 2013 Jan 19.

Office of Clinical Pharmacology, Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1208/s12248-013-9452-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675740PMC
April 2013

The zebrafish reference genome sequence and its relationship to the human genome.

Authors:
Kerstin Howe Matthew D Clark Carlos F Torroja James Torrance Camille Berthelot Matthieu Muffato John E Collins Sean Humphray Karen McLaren Lucy Matthews Stuart McLaren Ian Sealy Mario Caccamo Carol Churcher Carol Scott Jeffrey C Barrett Romke Koch Gerd-Jörg Rauch Simon White William Chow Britt Kilian Leonor T Quintais José A Guerra-Assunção Yi Zhou Yong Gu Jennifer Yen Jan-Hinnerk Vogel Tina Eyre Seth Redmond Ruby Banerjee Jianxiang Chi Beiyuan Fu Elizabeth Langley Sean F Maguire Gavin K Laird David Lloyd Emma Kenyon Sarah Donaldson Harminder Sehra Jeff Almeida-King Jane Loveland Stephen Trevanion Matt Jones Mike Quail Dave Willey Adrienne Hunt John Burton Sarah Sims Kirsten McLay Bob Plumb Joy Davis Chris Clee Karen Oliver Richard Clark Clare Riddle David Elliot David Eliott Glen Threadgold Glenn Harden Darren Ware Sharmin Begum Beverley Mortimore Beverly Mortimer Giselle Kerry Paul Heath Benjamin Phillimore Alan Tracey Nicole Corby Matthew Dunn Christopher Johnson Jonathan Wood Susan Clark Sarah Pelan Guy Griffiths Michelle Smith Rebecca Glithero Philip Howden Nicholas Barker Christine Lloyd Christopher Stevens Joanna Harley Karen Holt Georgios Panagiotidis Jamieson Lovell Helen Beasley Carl Henderson Daria Gordon Katherine Auger Deborah Wright Joanna Collins Claire Raisen Lauren Dyer Kenric Leung Lauren Robertson Kirsty Ambridge Daniel Leongamornlert Sarah McGuire Ruth Gilderthorp Coline Griffiths Deepa Manthravadi Sarah Nichol Gary Barker Siobhan Whitehead Michael Kay Jacqueline Brown Clare Murnane Emma Gray Matthew Humphries Neil Sycamore Darren Barker David Saunders Justene Wallis Anne Babbage Sian Hammond Maryam Mashreghi-Mohammadi Lucy Barr Sancha Martin Paul Wray Andrew Ellington Nicholas Matthews Matthew Ellwood Rebecca Woodmansey Graham Clark James D Cooper James Cooper Anthony Tromans Darren Grafham Carl Skuce Richard Pandian Robert Andrews Elliot Harrison Andrew Kimberley Jane Garnett Nigel Fosker Rebekah Hall Patrick Garner Daniel Kelly Christine Bird Sophie Palmer Ines Gehring Andrea Berger Christopher M Dooley Zübeyde Ersan-Ürün Cigdem Eser Horst Geiger Maria Geisler Lena Karotki Anette Kirn Judith Konantz Martina Konantz Martina Oberländer Silke Rudolph-Geiger Mathias Teucke Christa Lanz Günter Raddatz Kazutoyo Osoegawa Baoli Zhu Amanda Rapp Sara Widaa Cordelia Langford Fengtang Yang Stephan C Schuster Nigel P Carter Jennifer Harrow Zemin Ning Javier Herrero Steve M J Searle Anton Enright Robert Geisler Ronald H A Plasterk Charles Lee Monte Westerfield Pieter J de Jong Leonard I Zon John H Postlethwait Christiane Nüsslein-Volhard Tim J P Hubbard Hugues Roest Crollius Jane Rogers Derek L Stemple

Nature 2013 Apr 17;496(7446):498-503. Epub 2013 Apr 17.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703927PMC
April 2013