Publications by authors named "Jeffrey A Toretsky"

68Publications

Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis.

J Mol Med (Berl) 2019 07 25;97(7):957-972. Epub 2019 Apr 25.

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 4005B Wahl Hall East, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.

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http://dx.doi.org/10.1007/s00109-019-01782-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584050PMC
July 2019

A probable primary malignant bone tumor in a pre-Columbian human humerus from Cerro Brujo, Bocas del Toro, Panamá.

Int J Paleopathol 2018 06 26;21:138-146. Epub 2017 May 26.

Smithsonian Tropical Research Institute, Ancón, Panamá, Panama.

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https://linkinghub.elsevier.com/retrieve/pii/S18799817163017
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http://dx.doi.org/10.1016/j.ijpp.2017.05.005DOI Listing
June 2018

Synovial sarcoma is a gateway to the role of chromatin remodeling in cancer.

Cancer Metastasis Rev 2015 Sep;34(3):417-28

Department of Oncology, Georgetown University, Research Building, Suite E501, 3970 Reservoir Road, N.W., Washington, DC, 20057, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs10555-015-95
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http://link.springer.com/10.1007/s10555-015-9575-z
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http://dx.doi.org/10.1007/s10555-015-9575-zDOI Listing
September 2015

RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1.

Nucleic Acids Res 2015 Jan 6;43(2):1069-80. Epub 2015 Jan 6.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, New Research Building E316, Washington, DC 20007, USA.

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http://dx.doi.org/10.1093/nar/gku1328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333382PMC
January 2015

Systemic levels of neuropeptide Y and dipeptidyl peptidase activity in patients with Ewing sarcoma--associations with tumor phenotype and survival.

Cancer 2015 Mar 11;121(5):697-707. Epub 2014 Nov 11.

Department of Nursing, School of Nursing and Health Studies, Georgetown University, Washington, District of Columbia; Department of Human Science, School of Nursing and Health Studies, Georgetown University, Washington, District of Columbia.

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http://dx.doi.org/10.1002/cncr.29090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339539PMC
March 2015

Assemblages: functional units formed by cellular phase separation.

J Cell Biol 2014 Sep;206(5):579-88

Department of Integrative Structural and Computational Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037 Department of Integrative Structural and Computational Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.

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http://dx.doi.org/10.1083/jcb.201404124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151146PMC
September 2014

Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma.

Bioorg Med Chem 2014 Jan 14;22(1):478-87. Epub 2013 Nov 14.

Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, 3970 Reservoir Road, NW, The Research Building, Washington, DC 20057, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349528PMC
January 2014

Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: a children's oncology group study.

Pediatr Blood Cancer 2014 Apr 31;61(4):749-52. Epub 2013 Oct 31.

Department of Pediatrics, Division of Pediatric Hematology/Oncology, Vanderbilt University, Nashville, TN, Tennessee.

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http://dx.doi.org/10.1002/pbc.24778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946315PMC
April 2014

Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage.

Mol Cancer Ther 2013 Nov 21;12(11):2591-600. Epub 2013 Aug 21.

Corresponding Author: Sam S. Yoon, Department of Surgery, Memorial Sloan-Kettering Cancer Center, H-1209, 1275 York Avenue, New York, NY 10065.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823674PMC
November 2013

Loss of SS18-SSX1 inhibits viability and induces apoptosis in synovial sarcoma.

Clin Orthop Relat Res 2014 Mar;472(3):874-82

MedStar Georgetown Orthopaedic Institute, 110 Irving Street, NW C-2173, Washington, DC, 20010, USA,

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http://dx.doi.org/10.1007/s11999-013-3065-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916608PMC
March 2014

Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1.

Exp Cell Res 2013 Jan 24;319(1):1-11. Epub 2012 Sep 24.

Departments of Oncology and Pediatrics, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.yexcr.2012.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638858PMC
January 2013

YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion.

PLoS One 2011 Apr 29;6(4):e19343. Epub 2011 Apr 29.

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D. C., United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019343PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084826PMC
April 2011

High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition.

PLoS One 2010 Nov 11;5(11):e13943. Epub 2010 Nov 11.

Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013943PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978678PMC
November 2010

Oncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma.

Clin Cancer Res 2010 Aug 14;16(16):4077-83. Epub 2010 Jun 14.

Department of Oncology and Pediatrics, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-2261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682924PMC
August 2010

IGF-1R targeted treatment of sarcoma.

Lancet Oncol 2010 Feb 23;11(2):105-6. Epub 2009 Dec 23.

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http://dx.doi.org/10.1016/S1470-2045(09)70391-2DOI Listing
February 2010

Juvenile xanthogranuloma in a child with previously unsuspected neurofibromatosis type 1 and juvenile myelomonocytic leukemia.

Pediatr Blood Cancer 2010 Jan;54(1):173-5

Eunice Kennedy Shriver National Institute of Child Health and Human Development, Section on Developmental Genetics, Bethesda, MD 20892-1831, USA.

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http://dx.doi.org/10.1002/pbc.22297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783853PMC
January 2010

The role of IGF-1R in pediatric malignancies.

Oncologist 2009 Jan 6;14(1):83-91. Epub 2009 Jan 6.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1634/theoncologist.2008-0189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721475PMC
January 2009

Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival.

Pediatr Blood Cancer 2008 Sep;51(3):349-55

Georgetown University School of Medicine, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1002/pbc.21595DOI Listing
September 2008

PTPL1: a large phosphatase with a split personality.

Cancer Metastasis Rev 2008 Jun;27(2):205-14

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1007/s10555-008-9114-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682929PMC
June 2008

Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.

Mol Cell Biol 2008 Apr 22;28(7):2368-79. Epub 2008 Jan 22.

National Cancer Institute, Bldg. 37, Room 2042, 37 Convent Drive, MSC 4256, Bethesda, MD 20892-4256, USA.

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http://dx.doi.org/10.1128/MCB.01780-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268413PMC
April 2008

Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.

Cancer Res 2006 Jun;66(11):5574-81

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3293DOI Listing
June 2006

Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

Future Oncol 2005 Aug;1(4):521-8

Georgetown University School of Medicine, Lombardi Comprehensive Cancer Center, 3970 Reservoir Road North West, New Research Building, Room W316, Washington DC, WA 20057, USA.

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http://dx.doi.org/10.2217/14796694.1.4.521DOI Listing
August 2005

Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression.

Cancer Res 2005 Jul;65(14):6199-206

Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, District of Columbia 20057, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-0455DOI Listing
July 2005

PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis.

Oncogene 2005 Apr;24(16):2715-22

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1038/sj.onc.1208247DOI Listing
April 2005

Differential effects of neuropeptide Y on the growth and vascularization of neural crest-derived tumors.

Cancer Res 2005 Mar;65(5):1719-28

Department of Physiology, Lombardi Cancer Center, Georgetown University Medical Center, Washington, District of Columbia 20057, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2192DOI Listing
March 2005

Pediatric malignancies provide unique cancer therapy targets.

Curr Opin Pediatr 2005 Feb;17(1):14-9

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

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http://dx.doi.org/10.1097/01.mop.0000147904.84978.aeDOI Listing
February 2005

Recombinant EWS-FLI1 oncoprotein activates transcription.

Biochemistry 2004 Oct;43(42):13579-89

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Research Building, Room W316, 3970 Reservoir Road, N.W., Box 571469, Washington, DC 20057-1469, USA.

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http://dx.doi.org/10.1021/bi048776qDOI Listing
October 2004

Wnt/Frizzled signaling in Ewing sarcoma.

Pediatr Blood Cancer 2004 Sep;43(3):243-9

Georgetown University Medical Center, Lombardi Cancer Center, Research Building, Washington, DC 20057-1469, USA.

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http://dx.doi.org/10.1002/pbc.20124DOI Listing
September 2004

Forced expression of the H11 heat shock protein can be regulated by DNA methylation and trigger apoptosis in human cells.

J Biol Chem 2003 Sep 26;278(39):37600-9. Epub 2003 Jun 26.

Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M303834200
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http://dx.doi.org/10.1074/jbc.M303834200DOI Listing
September 2003

Novel translocation in acute megakaryoblastic leukemia (AML-M7).

J Pediatr Hematol Oncol 2003 May;25(5):396-402

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA.

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http://dx.doi.org/10.1097/00043426-200305000-00009DOI Listing
May 2003