Jeffrey A Medin

Jeffrey A Medin

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Jeffrey A Medin

Publications by authors named "Jeffrey A Medin"

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Interleukin-15 in cancer immunotherapy: IL-15 receptor complex versus soluble IL-15 in a cancer cell-delivered murine leukemia model.

J Immunother Cancer 2019 Dec 19;7(1):355. Epub 2019 Dec 19.

Princess Margaret Cancer Centre, University Health Network, 610 University Avenue, Room 8-105, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1186/s40425-019-0777-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924073PMC
December 2019

Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency.

Lab Invest 2019 Oct 11;99(10):1572-1592. Epub 2019 Jun 11.

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1038/s41374-019-0271-4DOI Listing
October 2019

Inherited monogenic defects of ceramide metabolism: Molecular bases and diagnoses.

Clin Chim Acta 2019 Aug 22;495:457-466. Epub 2019 May 22.

Laboratoire de Biochimie Métabolique, Centre de Référence en Maladies Héréditaires du Métabolisme, Institut Fédératif de Biologie, CHU de Toulouse, Toulouse, France; INSERM UMR1037, CRCT (Cancer Research Center of Toulouse), Université Paul Sabatier, Toulouse, France. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2019.05.020DOI Listing
August 2019

An update on gene therapy for lysosomal storage disorders.

Expert Opin Biol Ther 2019 07 6;19(7):655-670. Epub 2019 May 6.

a Department of Medical Biophysics , University of Toronto , Toronto , Ontario , Canada.

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https://www.tandfonline.com/doi/full/10.1080/14712598.2019.1
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http://dx.doi.org/10.1080/14712598.2019.1607837DOI Listing
July 2019

Lentiviral interleukin-10 gene therapy: Safety and questions.

J Thorac Cardiovasc Surg 2019 02;157(2):818-819

Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, and Department of Surgery and Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00225223183285
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http://dx.doi.org/10.1016/j.jtcvs.2018.10.082DOI Listing
February 2019

Acid Ceramidase Deficiency in Mice Leads to Severe Ocular Pathology and Visual Impairment.

Am J Pathol 2019 02 23;189(2):320-338. Epub 2018 Nov 23.

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin; University Health Network, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183050
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http://dx.doi.org/10.1016/j.ajpath.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412726PMC
February 2019

Lentiviral interleukin-10 gene therapy: Safety and questions.

J Thorac Cardiovasc Surg 2019 02;157(2):818-819

Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, and Department of Surgery and Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00225223183285
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http://dx.doi.org/10.1016/j.jtcvs.2018.10.082DOI Listing
February 2019

A novel combined ex vivo and in vivo lentiviral interleukin-10 gene delivery strategy at the time of transplantation decreases chronic lung allograft rejection in mice.

J Thorac Cardiovasc Surg 2018 09 29;156(3):1305-1315. Epub 2018 May 29.

Latner Thoracic Surgery Research Laboratories, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2018.05.003DOI Listing
September 2018

Human mesenchymal stromal cells do not promote recurrence of soft tissue sarcomas in mouse xenografts after radiation and surgery.

Cytotherapy 2018 08 31;20(8):1001-1012. Epub 2018 Jul 31.

Cell Therapy Program, Princess Margaret Cancer Centre and Krembil Research Institute, University Health Network, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14653249183054
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http://dx.doi.org/10.1016/j.jcyt.2018.05.011DOI Listing
August 2018

Acid ceramidase deficiency: Farber disease and SMA-PME.

Orphanet J Rare Dis 2018 07 20;13(1):121. Epub 2018 Jul 20.

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/s13023-018-0845-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053731PMC
July 2018

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.

Mol Metab 2018 06 21;12:76-88. Epub 2018 Apr 21.

CHU Sainte-Justine Research Centre, Departments of Biochemistry and Pediatrics, University of Montreal, Montreal, Canada; Department of Anatomy and Cell Biology, McGill University, Montreal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001920PMC
June 2018

Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency.

Am J Physiol Lung Cell Mol Physiol 2018 03 22;314(3):L406-L420. Epub 2017 Nov 22.

Institute of Medical Science, University of Toronto , Toronto, Ontario , Canada.

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http://dx.doi.org/10.1152/ajplung.00223.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900354PMC
March 2018

Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency.

Sci Rep 2018 01 29;8(1):1808. Epub 2018 Jan 29.

Institute of Medical Science, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41598-018-20052-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789088PMC
January 2018

Yin and Yang of mesenchymal stem cells and aplastic anemia.

World J Stem Cells 2017 Dec;9(12):219-226

Departments of Pediatrics and Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, United States.

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http://www.wjgnet.com/1948-0210/full/v9/i12/219.htm
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http://dx.doi.org/10.4252/wjsc.v9.i12.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746642PMC
December 2017

Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system.

Redox Biol 2017 10 29;13:407-417. Epub 2017 Jun 29.

Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ward, Sendai, Miyagi 980-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498287PMC
October 2017

Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues.

Mol Genet Metab 2017 Jan - Feb;120(1-2):1-7. Epub 2016 Nov 12.

Department of Human Genetics and Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1016/j.ymgme.2016.10.010DOI Listing
August 2017

Practical considerations for chimeric antigen receptor design and delivery.

Expert Opin Biol Ther 2017 08 16;17(8):961-978. Epub 2017 Jun 16.

a Department of Pediatrics , The Medical College of Wisconsin , Milwaukee , USA.

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http://dx.doi.org/10.1080/14712598.2017.1339687DOI Listing
August 2017

Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice.

BBA Clin 2017 Jun 13;7:85-96. Epub 2017 Feb 13.

Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.

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http://dx.doi.org/10.1016/j.bbacli.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338723PMC
June 2017

Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy.

Biochim Biophys Acta Mol Basis Dis 2017 02 1;1863(2):386-394. Epub 2016 Dec 1.

Institute of Medical Science, University of Toronto, Toronto M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto M5G 1L7, Canada; University Health Network, Toronto M5G 1L7, Canada; Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.11.031DOI Listing
February 2017

Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.

Mol Ther Methods Clin Dev 2016 7;3:16074. Epub 2016 Dec 7.

University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/mtm.2016.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142463PMC
December 2016

Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion.

Future Sci OA 2016 Dec 13;2(4):FSO147. Epub 2016 Oct 13.

University Health Network, Toronto, Ontario, M5G 1L7, Canada; Department of Medical Biophysics, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; University Health Network, Toronto, Ontario, M5G 1L7, Canada; Department of Medical Biophysics, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

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http://dx.doi.org/10.4155/fsoa-2016-0027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242178PMC
December 2016

Roscoe Owen Brady: Passion for patients.

Authors:
Jeffrey A Medin

Proc Natl Acad Sci U S A 2016 10 7;113(42):11644-11645. Epub 2016 Oct 7.

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226

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http://dx.doi.org/10.1073/pnas.1614270113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081591PMC
October 2016

Engineering Hematopoietic Cells for Cancer Immunotherapy: Strategies to Address Safety and Toxicity Concerns.

J Immunother 2016 09;39(7):249-59

*Department of Medical Biophysics, University of Toronto †Centre for Innovation, Canadian Blood Services, Toronto, ON, Canada ‡Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; and Departments of Pediatrics and Biochemistry, Medical College of Wisconsin, Milwaukee, WI.

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http://dx.doi.org/10.1097/CJI.0000000000000134DOI Listing
September 2016

Relative distribution of Gb3 isoforms/analogs in NOD/SCID/Fabry mice tissues determined by tandem mass spectrometry.

Bioanalysis 2016 Sep 15;8(17):1793-807. Epub 2016 Aug 15.

Department of Pediatrics, Division of Medical Genetics, Faculty of Medicine & Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4 Canada.

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http://dx.doi.org/10.4155/bio-2016-0116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992964PMC
September 2016

Development of Novel Immunotherapies for Multiple Myeloma.

Int J Mol Sci 2016 Sep 8;17(9). Epub 2016 Sep 8.

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.3390/ijms17091506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037783PMC
September 2016

Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy.

World J Stem Cells 2015 Dec;7(11):1233-50

Murtaza S Nagree, Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.4252/wjsc.v7.i11.1233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691692PMC
December 2015

Lentiviral vectors in cancer immunotherapy.

Immunotherapy 2015 ;7(3):271-84

Department of Medical Biophysics, University of Toronto, 27 King's College Circle, Toronto, ON M5S, Canada.

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http://dx.doi.org/10.2217/imt.14.108DOI Listing
January 2016

Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy.

World J Stem Cells 2015 Dec;7(11):1233-50

Murtaza S Nagree, Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.4252/wjsc.v7.i11.1233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691692PMC
December 2015

Markedly perturbed hematopoiesis in acid ceramidase deficient mice.

Haematologica 2015 May 14;100(5):e162-5. Epub 2015 Feb 14.

Institute of Medical Science, University of Toronto, Canada University Health Network, Toronto, Canada Department of Medical Biophysics, University of Toronto, Canada

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http://dx.doi.org/10.3324/haematol.2014.108530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420221PMC
May 2015

Localized interleukin-12 delivery for immunotherapy of solid tumours.

J Cell Mol Med 2013 Nov 19;17(11):1465-74. Epub 2013 Nov 19.

Department of Immunology, University of Toronto, Toronto, ON, Canada; Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/jcmm.12121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117559PMC
November 2013

Murine splenic CD4⁺ T cells, induced by innate immune cell interactions and secreted factors, develop antileukemia cytotoxicity.

Cancer Immunol Res 2014 Nov 25;2(11):1113-24. Epub 2014 Aug 25.

Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0208DOI Listing
November 2014

Advances in haplo-identical stem cell transplantation in adults with high-risk hematological malignancies.

World J Stem Cells 2014 Sep;6(4):380-90

Michael J Ricci, Ronan S Foley, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8V 1C3, Canada.

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http://dx.doi.org/10.4252/wjsc.v6.i4.380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172667PMC
September 2014

On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.

Anal Chem 2014 Aug 8;86(16):8303-11. Epub 2014 Aug 8.

Department of Cell and Molecular Pharmacology and MUSC Proteomics Center, Medical University of South Carolina , 173 Ashley Avenue, Charleston, South Carolina 29425, United States.

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http://dx.doi.org/10.1021/ac501937dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139181PMC
August 2014

Localized interleukin-12 delivery for immunotherapy of solid tumours.

J Cell Mol Med 2013 Nov 19;17(11):1465-74. Epub 2013 Nov 19.

Department of Immunology, University of Toronto, Toronto, ON, Canada; Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/jcmm.12121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117559PMC
November 2013

Harnessing autophagy for cell fate control gene therapy.

Autophagy 2013 Jul 17;9(7):1069-79. Epub 2013 Apr 17.

Experimental Transplantation and Immunology Branch; National Cancer Institute; National Institutes of Health; Bethesda, MD USA.

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http://dx.doi.org/10.4161/auto.24639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722316PMC
July 2013

Engineering lentiviral vectors for modulation of dendritic cell apoptotic pathways.

Virol J 2013 Jul 20;10:240. Epub 2013 Jul 20.

University Health Network, Canadian Blood Services Building, 67 College St, Room 406, Toronto, Ontario M5G2M1, Canada.

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http://dx.doi.org/10.1186/1743-422X-10-240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723442PMC
July 2013

Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity.

Brain Behav Immun 2013 May 29;30:103-14. Epub 2013 Jan 29.

Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bbi.2013.01.079DOI Listing
May 2013

Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia.

Hum Gene Ther 2012 Dec 23;23(12):1280-9. Epub 2012 Nov 23.

University Health Network, Toronto, ON M5G 1L7, Canada.

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http://dx.doi.org/10.1089/hum.2012.063DOI Listing
December 2012

Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro.

J Cell Physiol 2012 May;227(5):2130-7

Centre LOEX de l'Université Laval, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Département de Chirurgie, Faculté de Médecine, Université Laval, Québec, Canada.

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http://dx.doi.org/10.1002/jcp.22943DOI Listing
May 2012

Local long-term expression of lentivirally delivered IL-10 in the lung attenuates obliteration of intrapulmonary allograft airways.

Hum Gene Ther 2011 Nov 12;22(11):1453-60. Epub 2011 Jul 12.

Latner Thoracic Surgery Research Laboratories, University Health Network, University of Toronto, Toronto, Ontario M5G 2C4, Canada.

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http://www.liebertpub.com/doi/10.1089/hum.2010.225
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http://dx.doi.org/10.1089/hum.2010.225DOI Listing
November 2011

The PDL1-PD1 axis converts human TH1 cells into regulatory T cells.

Sci Transl Med 2011 Nov;3(111):111ra120

Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/scitranslmed.3003130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235958PMC
November 2011

Sequencing and characterization of the porcine α-galactosidase A gene: towards the generation of a porcine model for Fabry disease.

Mol Biol Rep 2011 Jun 4;38(5):3145-52. Epub 2010 Feb 4.

Division of Cardiac Repair and Regeneration, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.

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http://dx.doi.org/10.1007/s11033-010-9985-5DOI Listing
June 2011

Identification of novel mutations in the α-galactosidase A gene in patients with Fabry disease: pitfalls of mutation analyses in patients with low α-galactosidase A activity.

J Cardiol 2011 May 17;57(3):345-53. Epub 2011 Feb 17.

Division of Cardiac Repair and Regeneration, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.

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http://dx.doi.org/10.1016/j.jjcc.2010.12.004DOI Listing
May 2011

Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production.

Cancer Immunol Immunother 2011 Mar 14;60(3):381-8. Epub 2010 Dec 14.

Department of Surgery, Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 950 West 28th Ave, Vancouver, BC V5Z4H4, Canada.

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http://dx.doi.org/10.1007/s00262-010-0948-4DOI Listing
March 2011

A novel tissue-engineered approach to problems of the postpneumonectomy space.

Ann Thorac Surg 2011 Mar;91(3):880-6

Latner Thoracic Surgery Research Laboratories, Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.athoracsur.2010.11.039DOI Listing
March 2011

Promoter-specific lentivectors for long-term, cardiac-directed therapy of Fabry disease.

J Cardiol 2011 Jan 16;57(1):115-22. Epub 2010 Sep 16.

University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jjcc.2010.08.003DOI Listing
January 2011

Isolation of cell surface proteins for mass spectrometry-based proteomics.

Expert Rev Proteomics 2010 Feb;7(1):141-54

Ontario Cancer Institute, University Health Network, Canada.

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http://dx.doi.org/10.1586/epr.09.97DOI Listing
February 2010

Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues.

Regul Pept 2010 Jan;159(1-3):44-53

Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, University Health Network (UHN), Toronto, Canada.

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http://dx.doi.org/10.1016/j.regpep.2009.09.007DOI Listing
January 2010

Vascular endothelial growth factor broadens lentivector distribution in the heart after neonatal injection.

J Cardiol 2009 Oct 1;54(2):245-54. Epub 2009 Jul 1.

Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

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http://dx.doi.org/10.1016/j.jjcc.2009.05.010DOI Listing
October 2009

Comparative impact of trastuzumab and cyclophosphamide on HER-2-positive human breast cancer xenografts.

Clin Cancer Res 2009 Oct 13;15(20):6358-66. Epub 2009 Oct 13.

Molecular and Cellular Biology Research, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-0931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788792PMC
October 2009

IL-12 immunotherapy of murine leukaemia: comparison of systemic versus gene modified cell therapy.

J Cell Mol Med 2009 Aug;13(8B):1962-76

Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/j.1582-4934.2008.00412.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512371PMC
August 2009

Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction.

Mol Ther 2009 Feb 11;17(2):262-8. Epub 2008 Nov 11.

Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2008.244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835055PMC
February 2009

IL-10 secretion increases signal persistence of HEMA-MMA-microencapsulated luciferase-modified CHO fibroblasts in mice.

Tissue Eng Part A 2009 Jan;15(1):127-36

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/ten.tea.2008.0028DOI Listing
January 2009

Fas-mediated killing of primary prostate cancer cells is increased by mitoxantrone and docetaxel.

Mol Cancer Ther 2008 Sep;7(9):3018-28

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0335DOI Listing
September 2008

Immuno-gene therapy approaches for cancer: from in vitro studies to clinical trials.

Front Biosci 2008 May 1;13:3202-14. Epub 2008 May 1.

Ontario Cancer Institute, University Health Network, 67 College Street, Toronto (ON) Canada M5G 2M1.

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http://dx.doi.org/10.2741/2921DOI Listing
May 2008

Implementation of high-throughput screening for Fabry disease in Toronto dialysis patients.

NDT Plus 2008 Apr 14;1(2):129-130. Epub 2008 Feb 14.

Department of Nephrology, Toronto Western Hospital, University Health Network.

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http://dx.doi.org/10.1093/ndtplus/sfn009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477914PMC
April 2008

A roadmap to safe, efficient, and stable lentivirus-mediated gene therapy with hematopoietic cell transplantation.

Biol Blood Marrow Transplant 2007 Dec;13(12):1407-16

Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbmt.2007.09.014DOI Listing
December 2007

Anti-CD25 targeted killing of bicistronically transduced cells: a novel safety mechanism against retroviral genotoxicity.

Mol Ther 2007 Jun 27;15(6):1174-81. Epub 2007 Mar 27.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.mt.6300147DOI Listing
June 2007

Anti-CD25 targeted killing of bicistronically transduced cells: a novel safety mechanism against retroviral genotoxicity.

Mol Ther 2007 Jun 27;15(6):1174-81. Epub 2007 Mar 27.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.mt.6300147DOI Listing
June 2007

Lentivirally transduced recipient-derived dendritic cells serve to ex vivo expand functional FcRgamma-sufficient double-negative regulatory T cells.

Mol Ther 2007 Apr 30;15(4):818-24. Epub 2007 Jan 30.

Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.mt.6300082DOI Listing
April 2007

Lentivirally Transduced Recipient-derived Dendritic Cells Serve to Ex Vivo Expand Functional FcRγ-sufficient Double-negative Regulatory T Cells.

Mol Ther 2007 Apr 7;15(4):818-824. Epub 2016 Dec 7.

Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1038/sj.mt.6300082DOI Listing
April 2007

Analog of H2 relaxin exhibits antagonistic properties and impairs prostate tumor growth.

FASEB J 2007 Mar 28;21(3):754-65. Epub 2006 Dec 28.

Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1096/fj.06-6847comDOI Listing
March 2007

Multiple reduced-intensity conditioning regimens facilitate correction of Fabry mice after transplantation of transduced cells.

Mol Ther 2007 Mar 16;15(3):618-27. Epub 2007 Jan 16.

Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S152500161631323
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http://dx.doi.org/10.1038/sj.mt.6300075DOI Listing
March 2007

Lentiviral vectors for gene therapy of heart disease.

J Cardiol 2007 Jan;49(1):1-11

Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.

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January 2007

Correction of cardiac abnormalities in fabry mice by direct intraventricular injection of a recombinant lentiviral vector that engineers expression of alpha-galactosidase A.

Circ J 2006 Nov;70(11):1503-8

Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2M1, Canada.

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http://dx.doi.org/10.1253/circj.70.1503DOI Listing
November 2006

Cancer immunotherapy using virally transduced dendritic cells: animal studies and human clinical trials.

Expert Rev Vaccines 2006 Oct;5(5):717-32

Department of Medical Biophysics, University of Toronto, 67 College Street, Room 426, Toronto, Ontario, M5G 2MI, Canada.

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http://dx.doi.org/10.1586/14760584.5.5.717DOI Listing
October 2006

Functional expression of mouse relaxin and mouse relaxin-3 in the lung from an Ebola virus glycoprotein-pseudotyped lentivirus via tracheal delivery.

Endocrinology 2006 Aug 18;147(8):3797-808. Epub 2006 May 18.

Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M1.

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http://dx.doi.org/10.1210/en.2006-0028DOI Listing
August 2006

Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts.

Clin Cancer Res 2006 Feb;12(3 Pt 1):904-16

Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1109DOI Listing
February 2006

Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction.

Proc Natl Acad Sci U S A 2006 Feb 7;103(7):2304-9. Epub 2006 Feb 7.

Toronto General Hospital Research Institute and Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C4.

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http://dx.doi.org/10.1073/pnas.0510997103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413746PMC
February 2006

H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis.

Int J Cancer 2006 Jan;118(1):62-73

Division of Stem Cell and Differentiation, Ontario Cancer Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1002/ijc.21288DOI Listing
January 2006

Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms.

FASEB J 2005 Oct 2;19(12):1752-4. Epub 2005 Aug 2.

Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1096/fj.05-4006fjeDOI Listing
October 2005

Cloning, sequencing and characterization of lentiviral-mediated expression of rhesus macaque (Macaca mulatta) interleukin-2 receptor alpha cDNA.

Dev Comp Immunol 2005 18;29(11):989-1002. Epub 2005 Apr 18.

Division of Experimental Therapeutics, Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Ont., Canada M5G-2M1.

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http://dx.doi.org/10.1016/j.dci.2005.02.007DOI Listing
September 2005

Efficient transfer of PSA and PSMA cDNAs into DCs generates antibody and T cell antitumor responses in vivo.

Cancer Gene Ther 2005 Jun;12(6):540-51

Division of Experimental Therapeutics, Ontario Cancer Institute, Toronto, Ontario, Canada M5G 2M1.

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http://www.nature.com/articles/7700810
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http://dx.doi.org/10.1038/sj.cgt.7700810DOI Listing
June 2005

Enhanced filter paper enzyme assay for high-throughput population screening for Fabry disease.

Anal Biochem 2005 Feb;337(1):161-3

Division of Experimental Therapeutics, Ontario Cancer Institute, Canada.

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http://dx.doi.org/10.1016/j.ab.2004.10.007DOI Listing
February 2005