Jeffrey A Bluestone

Jeffrey A Bluestone

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Jeffrey A Bluestone

Publications by authors named "Jeffrey A Bluestone"

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New Frontiers in the Treatment of Type 1 Diabetes.

Cell Metab 2020 Jan 12;31(1):46-61. Epub 2019 Dec 12.

Endocrine Division, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.11.017DOI Listing
January 2020

Cutting Edge: IL-6-Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression.

J Immunol 2020 Jan 10. Epub 2020 Jan 10.

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.

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http://dx.doi.org/10.4049/jimmunol.1900876DOI Listing
January 2020

T cell-based therapies: challenges and perspectives.

Nat Rev Immunol 2019 Dec 6. Epub 2019 Dec 6.

Sean N. Parker Autoimmune Research Laboratory, Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41577-019-0232-6DOI Listing
December 2019

Next-generation regulatory T cell therapy.

Nat Rev Drug Discov 2019 10 20;18(10):749-769. Epub 2019 Sep 20.

Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.

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http://www.nature.com/articles/s41573-019-0041-4
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http://dx.doi.org/10.1038/s41573-019-0041-4DOI Listing
October 2019

Thymically-derived Foxp3+ regulatory T cells are the primary regulators of type 1 diabetes in the non-obese diabetic mouse model.

PLoS One 2019 24;14(10):e0217728. Epub 2019 Oct 24.

Diabetes Center, University of California, San Francisco, San Francisco, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217728PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812862PMC
October 2019

NextGen cell-based immunotherapies in cancer and other immune disorders.

Curr Opin Immunol 2019 Aug 6;59:79-87. Epub 2019 May 6.

Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA; UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2019.03.007DOI Listing
August 2019

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.

N Engl J Med 2019 08 9;381(7):603-613. Epub 2019 Jun 9.

From the Departments of Immunobiology and Internal Medicine, Yale University, New Haven, CT (K.C.H.); the Departments of Epidemiology and Pediatrics, University of South Florida, Tampa (B.N.B., J.P.K., H.R.), the Department of Medicine, University of Miami, Miami (J.B.M., J.S.S.), and the Department of Pediatrics, University of Florida, Gainesville (D.S.) - all in Florida; Benaroya Research Institute, Seattle (S.A.L., M.J.D., P.S.L., C.J.G.); the Diabetes Center, University of California at San Francisco, San Francisco (J.A.B., S.E.G.); the Department of Pediatrics, Indiana University, Indianapolis (L.A.D.); the Barbara Davis Diabetes Center, University of Colorado, Anschultz (P.A.G.); Children's Mercy Hospital, Kansas City, MO (W.M.); the Department of Pediatrics, University of Minnesota, Minneapolis (A.M.); the Department of Pediatrics and Cell and Developmental Biology, Vanderbilt University, Nashville (W.E.R.); the Department of Pediatrics, University of Iowa, Iowa City (E.T.); the Hospital for Sick Children, University of Toronto, Toronto (D.K.W.); and Forschergruppe Diabetes, Technical University Munich, at Klinikum rechts der Isar, Munich, Germany (A.-G.Z.).

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http://dx.doi.org/10.1056/NEJMoa1902226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776880PMC
August 2019

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.

Immunity 2019 02 29;50(2):362-377.e6. Epub 2019 Jan 29.

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Sean N. Parker Autoimmune Research Laboratory, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183056
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http://dx.doi.org/10.1016/j.immuni.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476426PMC
February 2019

Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier.

J Allergy Clin Immunol 2018 12 25;142(6):1710-1718. Epub 2018 Oct 25.

Department of Surgery at the University of California, San Francisco, Calif; Diabetes Center at the University of California, San Francisco, Calif. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183148
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http://dx.doi.org/10.1016/j.jaci.2018.10.015DOI Listing
December 2018

The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy.

Cancer Immunol Res 2018 12;6(12):1445-1452

Diabetes Center and Sean N. Parker Autoimmune Research Laboratory, University of California San Francisco, San Francisco, California.

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-18-0487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281171PMC
December 2018

Cytokines, Chemokines, and Other Biomarkers of Response for Checkpoint Inhibitor Therapy in Skin Cancer.

Front Med (Lausanne) 2018 12;5:351. Epub 2018 Dec 12.

Sean N. Parker Autoimmune Research Laboratory, Diabetes Center, University of California, San Francisco, San Francisco, CA, United States.

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https://www.frontiersin.org/article/10.3389/fmed.2018.00351/
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http://dx.doi.org/10.3389/fmed.2018.00351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315146PMC
December 2018

T cells-the next frontier of cell therapy.

Science 2018 10;362(6411):154-155

Department of Surgery, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/science.aau2688DOI Listing
October 2018

Recent advances in immunotherapies: from infection and autoimmunity, to cancer, and back again.

Genome Med 2018 10 31;10(1):79. Epub 2018 Oct 31.

Parker Institute of Cancer Immunotherapy, 1 Letterman Drive, San Francisco, CA, USA.

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https://genomemedicine.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13073-018-0588-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208073PMC
October 2018

Chance favours the prepared mind.

Nat Rev Immunol 2018 09;18(9):541

Diabetes Center, University of California, San Francisco, USA.

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http://www.nature.com/articles/s41577-018-0043-1
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http://dx.doi.org/10.1038/s41577-018-0043-1DOI Listing
September 2018

Revisiting IL-2: Biology and therapeutic prospects.

Sci Immunol 2018 07;3(25)

Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.

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http://immunology.sciencemag.org/lookup/doi/10.1126/sciimmun
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http://dx.doi.org/10.1126/sciimmunol.aat1482DOI Listing
July 2018

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.

Cell Stem Cell 2018 Jun;22(6):810-823

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007036PMC
June 2018

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity.

Cell Rep 2018 06;23(11):3262-3274

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94129, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183079
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http://dx.doi.org/10.1016/j.celrep.2018.05.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094952PMC
June 2018

Pathological conversion of regulatory T cells is associated with loss of allotolerance.

Sci Rep 2018 05 4;8(1):7059. Epub 2018 May 4.

Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41598-018-25384-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935752PMC
May 2018

Is autoimmunity the Achilles' heel of cancer immunotherapy?

Nat Med 2017 05;23(5):540-547

Parker Institute for Cancer Immunotherapy, San Francisco, California, USA.

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http://dx.doi.org/10.1038/nm.4321DOI Listing
May 2017

Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.

Cell Metab 2017 Apr;25(4):883-897.e8

Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Lung Biology Center, University of California, San Francisco, San Francisco, CA 94143, USA; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497784PMC
April 2017

FOXP3, the Transcription Factor at the Heart of the Rebirth of Immune Tolerance.

J Immunol 2017 02;198(3):979-980

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143

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http://dx.doi.org/10.4049/jimmunol.1602060DOI Listing
February 2017

The therapeutic potential of regulatory T cells for the treatment of autoimmune disease.

Expert Opin Ther Targets 2015 16;19(8):1091-103. Epub 2015 Apr 16.

University of California San Francisco, Diabetes Center , San Francisco, CA 94143 , USA +1 415 476 4451 ;

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http://www.tandfonline.com/doi/full/10.1517/14728222.2015.10
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http://dx.doi.org/10.1517/14728222.2015.1037282DOI Listing
January 2017

Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials.

Annu Rev Pathol 2017 Jan 5;12:305-330. Epub 2016 Dec 5.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94158-2517; email:

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http://dx.doi.org/10.1146/annurev-pathol-052016-100304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557092PMC
January 2017

Regulatory T cell therapy for type 1 diabetes: May the force be with you.

J Autoimmun 2016 07 28;71:78-87. Epub 2016 Apr 28.

Diabetes Center, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.jaut.2016.03.011DOI Listing
July 2016

CD28 Costimulation: From Mechanism to Therapy.

Immunity 2016 05;44(5):973-88

Diabetes Center and Department of Medicine, University of California, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932896PMC
May 2016

Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease.

Nat Rev Immunol 2016 Mar 15;16(3):149-63. Epub 2016 Feb 15.

Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nri.2015.18DOI Listing
March 2016

Inducing and Administering Tregs to Treat Human Disease.

Front Immunol 2015 22;6:654. Epub 2016 Jan 22.

Department of Immunobiology, Yale University, New Haven, CT, USA; Department of Internal Medicine, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.3389/fimmu.2015.00654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722090PMC
February 2016

Targeting Treg signaling for the treatment of autoimmune diseases.

Curr Opin Immunol 2015 Dec 29;37:11-20. Epub 2015 Sep 29.

Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2015.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679451PMC
December 2015

Aberrant innate immune activation following tissue injury impairs pancreatic regeneration.

PLoS One 2014 10;9(7):e102125. Epub 2014 Jul 10.

Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102125PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092101PMC
November 2015

Shifting the Evolving CAR T Cell Platform into Higher Gear.

Cancer Cell 2015 Oct;28(4):401-402

UCSF Diabetes Center and Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0540, San Francisco, CA 94143, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108150034
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http://dx.doi.org/10.1016/j.ccell.2015.09.014DOI Listing
October 2015

The immune system in Duchenne muscular dystrophy: Friend or foe.

Rare Dis 2015 23;3(1):e1010966. Epub 2015 Feb 23.

Diabetes Center; University of California, San Francisco ; San Francisco, CA USA ; Department of Medicine; University of California, San Francisco ; San Francisco, CA USA.

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https://www.tandfonline.com/doi/full/10.1080/21675511.2015.1
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http://dx.doi.org/10.1080/21675511.2015.1010966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588155PMC
October 2015

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

Proc Natl Acad Sci U S A 2015 Aug 27;112(33):10437-42. Epub 2015 Jul 27.

Diabetes Center, University of California, San Francisco, CA 94143; Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA 94143; Innovative Genomics Initiative, University of California, Berkeley, CA 94720;

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http://dx.doi.org/10.1073/pnas.1512503112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547290PMC
August 2015

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.

Immunity 2015 Jul 16;43(1):161-74. Epub 2015 Jun 16.

Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143-0795, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-0795, USA; Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143-0795, USA. Electronic address:

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http://www.cell.com/cms/attachment/2035042614/2050341150/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S107476131500217
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http://dx.doi.org/10.1016/j.immuni.2015.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512852PMC
July 2015

IL-2: Change Structure … Change Function.

Immunity 2015 May;42(5):779-81

Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613150018
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http://dx.doi.org/10.1016/j.immuni.2015.05.002DOI Listing
May 2015

Immunotherapy: making the case for precision medicine.

Sci Transl Med 2015 Mar;7(280):280ed3

Jeffrey A. Bluestone is Director, Hormone Research Institute, and holds the A. W. and Mary Margaret Clausen Distinguished Professorship in Metabolism and Endocrinology at the University of California, San Francisco, San Francisco, CA 94143, USA. E-mail: Tang is Associate Professor of Surgery and Director of the UCSF Transplantation Research Laboratory, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa9846DOI Listing
March 2015

Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm.

Cell Stem Cell 2015 Feb 18;16(2):148-57. Epub 2014 Dec 18.

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.12.001DOI Listing
February 2015

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.

Nat Immunol 2015 Feb 5;16(2):188-96. Epub 2015 Jan 5.

1] Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA. [2] Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297515PMC
February 2015

Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling.

Mol Cell 2014 Dec;56(6):723-37

Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Cell and Tissue Biology, University of California at San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273650PMC
December 2014

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy.

Sci Transl Med 2014 Oct;6(258):258ra142

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/scitranslmed.3009925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889432PMC
October 2014

Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function.

Eur J Immunol 2014 Jun 15;44(6):1737-46. Epub 2014 Apr 15.

Diabetes Center and the Department of Medicine, University of California, San Francisco, CA, USA; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.

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http://doi.wiley.com/10.1002/eji.201343891
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http://dx.doi.org/10.1002/eji.201343891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051436PMC
June 2014

DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability.

PLoS One 2013 31;8(5):e66282. Epub 2013 May 31.

Diabetes Center and the Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066282PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669207PMC
January 2014

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.

Nat Med 2014 Jan 22;20(1):62-8. Epub 2013 Dec 22.

1] Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. [2] Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Bunkyo-ku, Tokyo, Japan. [3] Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Nedlands, Western Australia, Australia.

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http://www.nature.com/articles/nm.3432
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http://dx.doi.org/10.1038/nm.3432DOI Listing
January 2014

Regulatory T-cell therapy in transplantation: moving to the clinic.

Cold Spring Harb Perspect Med 2013 Nov 1;3(11). Epub 2013 Nov 1.

Department of Surgery, University of California, San Francisco, San Francisco, California 94143.

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http://dx.doi.org/10.1101/cshperspect.a015552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808774PMC
November 2013

Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background.

J Autoimmun 2013 Sep 12;45:58-67. Epub 2013 Jul 12.

University of California in San Francisco, 513 Parnassus Avenue, Box 0400, San Francisco, CA 94143-0400, USA.

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http://dx.doi.org/10.1016/j.jaut.2013.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156399PMC
September 2013

The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.

Nat Immunol 2013 Aug 30;14(8):840-8. Epub 2013 Jun 30.

Department of Microbiology & Immunology, Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/ni.2642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720769PMC
August 2013

microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis.

J Immunol 2013 Aug 15;191(4):1594-605. Epub 2013 Jul 15.

Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.4049/jimmunol.1203567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160833PMC
August 2013

Peripherally induced tregs - role in immune homeostasis and autoimmunity.

Front Immunol 2013 7;4:232. Epub 2013 Aug 7.

Diabetes Center, University of California San Francisco , San Francisco, CA , USA.

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http://dx.doi.org/10.3389/fimmu.2013.00232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736167PMC
August 2013

Production of α-galactosylceramide by a prominent member of the human gut microbiota.

PLoS Biol 2013 Jul 16;11(7):e1001610. Epub 2013 Jul 16.

Department of Bioengineering and Therapeutic Sciences and the California Institute for Quantitative Biosciences, University of California, San Francisco, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712910PMC
July 2013

Immune therapy and β-cell death in type 1 diabetes.

Diabetes 2013 May 19;62(5):1676-80. Epub 2013 Feb 19.

Departments of Immunobiology and Internal Medicine and Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.2337/db12-1207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636605PMC
May 2013

MicroRNA regulation of T-cell differentiation and function.

Immunol Rev 2013 May;253(1):65-81

Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1111/imr.12061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621017PMC
May 2013

Type 1 diabetes: translating mechanistic observations into effective clinical outcomes.

Nat Rev Immunol 2013 Apr;13(4):243-56

Department of Immunobiology, Yale University, New Haven, Connecticut 06520, USA.

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http://www.nature.com/articles/nri3422
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http://dx.doi.org/10.1038/nri3422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172461PMC
April 2013

Cell-based therapeutics: the next pillar of medicine.

Sci Transl Med 2013 Apr;5(179):179ps7

UCSF Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA. fischbach@f schbach-group.org

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http://dx.doi.org/10.1126/scitranslmed.3005568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772767PMC
April 2013

The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes.

J Immunol 2013 Feb 4;190(3):961-9. Epub 2013 Jan 4.

Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568535PMC
February 2013

MicroRNA 10a marks regulatory T cells.

PLoS One 2012 18;7(5):e36684. Epub 2012 May 18.

Diabetes Center and the Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356350PMC
December 2012

Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipients.

Transpl Int 2012 Dec 21;25(12):1257-67. Epub 2012 Sep 21.

Department of Surgery, University of California-San Francisco, 513 Parnassus Ave., San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1111/j.1432-2277.2012.01565.xDOI Listing
December 2012

Current and future immunomodulation strategies to restore tolerance in autoimmune diseases.

Cold Spring Harb Perspect Biol 2012 Nov 1;4(11). Epub 2012 Nov 1.

UCSF Diabetes Center, University of California at San Francisco, 94143, USA.

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http://dx.doi.org/10.1101/cshperspect.a007542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536337PMC
November 2012

NK cells are not required for spontaneous autoimmune diabetes in NOD mice.

PLoS One 2012 25;7(4):e36011. Epub 2012 Apr 25.

Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338490PMC
September 2012

Single step isolation and activation of primary CD3+ T lymphocytes using alcohol-dispersed electrospun magnetic nanofibers.

Nano Lett 2012 Aug 26;12(8):4018-24. Epub 2012 Jul 26.

Global Research Lab, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136-713, Korea.

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http://dx.doi.org/10.1021/nl301388dDOI Listing
August 2012

The future of cancer treatment: will it include immunotherapy?

Cancer Cell 2012 Jul;22(1):7-8

Diabetes Center, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.06.009DOI Listing
July 2012

Breakdown in peripheral tolerance in type 1 diabetes in mice and humans.

Cold Spring Harb Perspect Med 2012 Mar;2(3):a007807

UCSF Diabetes Center, University of California at San Francisco, San Francisco, California 94143, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282496PMC
March 2012

CD4(+)Foxp3(+) regulatory T cell therapy in transplantation.

J Mol Cell Biol 2012 Feb 14;4(1):11-21. Epub 2011 Dec 14.

Division of Transplantation, Department of Surgery, University of California San Francisco, San Francisco, CA 94143-0780, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695644PMC
February 2012

The yin and yang of interleukin-2-mediated immunotherapy.

N Engl J Med 2011 Dec;365(22):2129-31

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http://dx.doi.org/10.1056/NEJMe1110900DOI Listing
December 2011

A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse.

J Immunol 2011 Nov 3;187(10):4947-53. Epub 2011 Oct 3.

Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.

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November 2011