Publications by authors named "Jeffery D Molkentin"

100Publications

Resident macrophages keep mitochondria running in the heart.

Cell Res 2020 Nov 2. Epub 2020 Nov 2.

Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/s41422-020-00427-zDOI Listing
November 2020

A specialized population of Periostin-expressing cardiac fibroblasts contributes to postnatal cardiomyocyte maturation and innervation.

Proc Natl Acad Sci U S A 2020 09 17;117(35):21469-21479. Epub 2020 Aug 17.

The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267;

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http://dx.doi.org/10.1073/pnas.2009119117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474678PMC
September 2020

A 20/20 view of ANT function in mitochondrial biology and necrotic cell death.

J Mol Cell Cardiol 2020 07 23;144:A3-A13. Epub 2020 May 23.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA; Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2020.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483807PMC
July 2020

MCUb Induction Protects the Heart From Postischemic Remodeling.

Circ Res 2020 Jul 17;127(3):379-390. Epub 2020 Apr 17.

From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (J.H., M.J.B., K.M.G., M.A.S., J.D.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.316369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367751PMC
July 2020

Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion.

Circulation 2020 Mar 23;141(12):1037-1039. Epub 2020 Mar 23.

Department of Pediatrics (R.J.V., M.A.S., J.D.M.), Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122064PMC
March 2020

Cysteine 202 of Cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection.

Cardiovasc Res 2020 Mar 4. Epub 2020 Mar 4.

Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1093/cvr/cvaa053DOI Listing
March 2020

MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure.

EBioMedicine 2020 Jan 3;51:102571. Epub 2020 Jan 3.

Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970 Campinas, Sao Paulo, Brazil; Department of Internal Medicine, University of Campinas, Campinas, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.11.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948164PMC
January 2020

An acute immune response underlies the benefit of cardiac stem cell therapy.

Nature 2020 01 27;577(7790):405-409. Epub 2019 Nov 27.

Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/s41586-019-1802-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962570PMC
January 2020

Hippo signaling does it again: arbitrating cardiac fibroblast identity and activation.

Genes Dev 2019 11;33(21-22):1457-1459

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1101/gad.332791.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824471PMC
November 2019

CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart.

Mol Ther 2019 11 1;27(11):1869-1871. Epub 2019 Oct 1.

Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838878PMC
November 2019

The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.

Nat Commun 2019 09 12;10(1):4143. Epub 2019 Sep 12.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1038/s41467-019-12226-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742632PMC
September 2019

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD.

Sci Adv 2019 08 28;5(8):eaaw4597. Epub 2019 Aug 28.

Department of Pediatrics, Cincinnati Children's Hospital and University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.1126/sciadv.aaw4597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713508PMC
August 2019

Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease.

Circ Res 2019 04;124(9):1294-1296

INSERM U060, CarMeN Laboratory, Claude Bernard Lyon 1 University, France and Service d'explorations fonctionnelles Cardiovasculaires, Hôpital Louis Pradel, Hospices Civils de Lyon, France (M.O.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485951PMC
April 2019

Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis.

J Biol Chem 2019 05 21;294(22):8918-8929. Epub 2019 Apr 21.

From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229-3039,

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http://dx.doi.org/10.1074/jbc.RA119.007585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552413PMC
May 2019

ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity.

JCI Insight 2019 04 9;5. Epub 2019 Apr 9.

Division of Molecular and Cardiovascular Biology, Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://insight.jci.org/articles/view/127356
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http://dx.doi.org/10.1172/jci.insight.127356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542606PMC
April 2019

Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart.

Sci Rep 2019 02 14;9(1):2059. Epub 2019 Feb 14.

Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, USA.

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http://www.nature.com/articles/s41598-019-39515-5
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http://dx.doi.org/10.1038/s41598-019-39515-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375966PMC
February 2019

Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve.

J Mol Cell Cardiol 2019 02 4;127:223-231. Epub 2019 Jan 4.

Cardiovascular Translational Science Institute and the Department of Pediatrics, 423 Heritage Medical Research Building, University of Alberta, Edmonton, Alberta T6G 2S2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2018.12.019DOI Listing
February 2019

Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell.

Circulation 2018 08;138(8):806-808

University of Cincinnati and Cincinnati Children's Hospital Medical Center, OH (B.D.M., J.D.M.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205190PMC
August 2018

New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications.

Circ Res 2018 07;123(2):159-176

Cincinnati Children's Hospital Medical Center, OH; and the Lewis Katz School of Medicine, Cardiovascular Research Center, Temple University, Philadelphia, PA (S.R.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.311208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051429PMC
July 2018

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart.

J Clin Invest 2018 05 16;128(5):2127-2143. Epub 2018 Apr 16.

Cincinnati Children's Hospital Medical Center (CCHMC), Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.

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https://www.jci.org/articles/view/98215
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http://dx.doi.org/10.1172/JCI98215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957472PMC
May 2018

van Berlo et al. reply.

Nature 2018 03;555(7697):E18

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1038/nature25772DOI Listing
March 2018

Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects.

Circ Genom Precis Med 2018 03;11(3):e001901

From the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.H., M.P.M., J.B., K.B.M., T.P.C.); Cardiovascular Research Center (N.R.T., V.A.P., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, Boston; Department of Statistics, University of Illinois at Urbana-Champaign (S.D.Z.); Heidelberg University Hospital, Germany (B.M., H.A.K.); Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Germany (F.R., M.S.); INSERM UMRS1166-IACN, Hôpital Pitié-Salpêtrière, Paris, France (E.V., F.C.); Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, MA (H.L.); Department of Epidemiology, University of Washington, Seattle (N.L.S.); Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands (J.F.F.); Boston University School of Medicine, MA (R.S.V.); Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (P.v.d.H.); Medical and Population Genetics Program, Broad Institute, Cambridge, MA (C.N.-C.); Center for Applied Genomics, Children's Hospital of Philadelphia, PA (J.L., C.E.K., H.H.); Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.); Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, CA (E.A.A.); Department of Cardiovascular Medicine, Cleveland Clinic, OH (C.S.M., W.H.W.T.); and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center, OH (M.M., J.D.M.).

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http://dx.doi.org/10.1161/CIRCGEN.117.001901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858599PMC
March 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Increasing T-type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates.

J Physiol 2018 04 24;596(7):1137-1151. Epub 2018 Jan 24.

Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, USA.

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http://doi.wiley.com/10.1113/JP274756
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http://dx.doi.org/10.1113/JP274756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878229PMC
April 2018

BEX1 is an RNA-dependent mediator of cardiomyopathy.

Nat Commun 2017 11 30;8(1):1875. Epub 2017 Nov 30.

Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1038/s41467-017-02005-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709413PMC
November 2017

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak.

Elife 2017 11 17;6. Epub 2017 Nov 17.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Ohio, United States.

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http://dx.doi.org/10.7554/eLife.30543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697932PMC
November 2017

Identity Crisis for Regenerative Cardiac cKit Cells.

Circ Res 2017 10;121(10):1130-1132

From the Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center and Howard Hughes Medical Institute, OH (O.K., R.J.V., J.D.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687275PMC
October 2017

Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX.

Circulation 2017 10;136(15):1410-1411

From Department of Pediatrics, University of Cincinnati (H.K., M.M., J.D.M.), and Howard Hughes Medical Institute (J.D.M.), Cincinnati Children's Hospital Medical Center, OH.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.030625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679745PMC
October 2017

Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis.

J Clin Invest 2017 Oct 11;127(10):3770-3783. Epub 2017 Sep 11.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1172/JCI94753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617658PMC
October 2017

Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression.

J Am Coll Cardiol 2017 Aug;70(8):958-971

Department of Pediatrics, Division of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.06.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564231PMC
August 2017

TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury.

PLoS One 2017 27;12(7):e0181945. Epub 2017 Jul 27.

From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181945PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531541PMC
September 2017

Mitsugumin 29 regulates t-tubule architecture in the failing heart.

Sci Rep 2017 07 13;7(1):5328. Epub 2017 Jul 13.

Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, USA.

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http://dx.doi.org/10.1038/s41598-017-05284-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509714PMC
July 2017

Cardiomyocyte Regeneration: A Consensus Statement.

Circulation 2017 08 6;136(7):680-686. Epub 2017 Jul 6.

From Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany (T.E.); DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany (T.E.) and partner site Rhein/Main, Bad Nauheim, Germany (T.B.); Institute of Molecular Cardiology, University of Louisville, Louisville, KY (R.B.); Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany (T.B.); Department of Internal Medicine II, University of Giessen, Germany (T.B.); German Center for Lung Research (DZHL), Giessen/Marburg Bad Nauheim, Bad Nauheim, Germany (T.B.); Krannert Institute of Cardiology and Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis (L.J.F.); Institute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Germany (B.K.F.); Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden (J.F.); International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy (M.G.); Donald Soffer Endowed Program in Regenerative Medicine, Miller School of Medicine, Miami, FL (J.M.H.); Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (J.M.H.); Department of Physiology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (S.H.); Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA (R.T.L.); Cedars-Sinai Heart Institute, Los Angeles, CA (E.M.); Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston (J.F.M.); Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX (J.F.M.); Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (J.D.M.); Departments of Pathology, Bioengineering, and Medicine/Cardiology, Institute for Stem Cell and Regenerative Medicine, and Center for Cardiovascular Biology, University of Washington, Seattle (C.E.M.); University of Oxford, Department of Physiology, Anatomy and Genetics, United Kingdom (P.R.R.) Regencor, Inc, Los Altos, CA (P.R.-L.); Departments of Internal Medicine (Division of Cardiology) and Molecular Biology, UT Southwestern Medical Center, Dallas, TX (H.A.S., J.A.H.); and Heart Institute, Integrated Regenerative Research Institute, and Biology Department, San Diego State University, CA (M.S.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557671PMC
August 2017

An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels.

Circ Res 2017 Sep 27;121(6):604-616. Epub 2017 Jun 27.

From the Division of Molecular Cardiovascular Biology, Heart Institute, Cincinnati Children's Hospital Medical Center, OH (P.M.M., G.D., J.G., S.R.S., N.X., J.D.M., J.R.); Division of Biomedical Informatics, Cincinnati Children's Hospital, OH (N.S.); and UES, Inc, Dayton, OH (P.M.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581213PMC
September 2017

Preexisting endothelial cells mediate cardiac neovascularization after injury.

J Clin Invest 2017 Aug 26;127(8):2968-2981. Epub 2017 Jun 26.

The State Key Laboratory of Cell Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology.

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http://dx.doi.org/10.1172/JCI93868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531398PMC
August 2017

Redefining the identity of cardiac fibroblasts.

Nat Rev Cardiol 2017 Aug 24;14(8):484-491. Epub 2017 Apr 24.

Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3026, USA.

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http://dx.doi.org/10.1038/nrcardio.2017.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329009PMC
August 2017

Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart.

Cardiovasc Res 2017 Jun;113(7):749-759

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 240 Albert Sabin Way, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1093/cvr/cvx046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852617PMC
June 2017

Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis.

Circulation 2017 Aug 29;136(6):549-561. Epub 2017 Mar 29.

From Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, OH (J.D.M., N.G., L.E.D., M.A.S.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, OH (J.D.M); Department of Bioengineering, University of Washington, Seattle (D.B., P.K., J.G. J.D.); and Cardiovascular Division, King's College London British Heart Foundation Centre of Research Excellence, United Kingdom (K.O.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548661PMC
August 2017

The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away.

Circ Res 2017 Jan;120(2):400-406

From the Department of Developmental and Regenerative Biology, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY (C.-L.C.); and Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center and Howard Hughes Medical Institute, OH (J.D.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260844PMC
January 2017

Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast.

JACC Basic Transl Sci 2016 Dec 26;1(7):603-605. Epub 2016 Dec 26.

Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center and Howard Hughes Medical Institute, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.jacbts.2016.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113558PMC
December 2016

RCANs regulate the convergent roles of NFATc1 in bone homeostasis.

Sci Rep 2016 12 5;6:38526. Epub 2016 Dec 5.

Department of Pharmacology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.

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http://dx.doi.org/10.1038/srep38526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137032PMC
December 2016

Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart.

PLoS One 2016 20;11(10):e0164897. Epub 2016 Oct 20.

Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164897PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072578PMC
June 2017

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.

Cell Death Differ 2016 12 2;23(12):1995-2006. Epub 2016 Sep 2.

ULB Center for Diabetes Research, Université Libre de Bruxelles, 1070 Brussels, Belgium.

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http://dx.doi.org/10.1038/cdd.2016.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136495PMC
December 2016

Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs).

J Mol Cell Cardiol 2016 Dec 27;101:44-49. Epub 2016 Aug 27.

Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2016.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154921PMC
December 2016

Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes.

Cardiovasc Res 2016 10 5;112(1):491-501. Epub 2016 Aug 5.

Department of Internal Medicine, Cardiology, University Hospital Würzburg, Oberdürrbacherstr. 6, 97080 Würzburg, Germany Comprehensive Heart Failure Center, University of Würzburg, Straubmühlweg 2a, 97078 Würzburg, Germany Medizinische Hochschule Brandenburg, Campus Klinikum Brandenburg/Havel, Abteilung für Kardiologie und Pneumologie, Hochstr. 29, 14770 Brandenburg an der Havel, Germany.

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http://dx.doi.org/10.1093/cvr/cvw185DOI Listing
October 2016

Genetic lineage tracing defines myofibroblast origin and function in the injured heart.

Nat Commun 2016 07 22;7:12260. Epub 2016 Jul 22.

Department of Pediatrics and Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1038/ncomms12260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512625PMC
July 2016

DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling.

Circ Res 2016 07 25;119(2):249-60. Epub 2016 May 25.

From the Department of Pediatrics, University of Cincinnati (R.L., J.H.v.B., A.J.Y., R.J.V., M.M., J.D.M.) and Howard Hughes Medical Institute (J.D.M.), Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and Division of Cardiology, Department of Medicine, Lillehei Heart Institute, University of Minnesota, St. Paul (J.H.v.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.308238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938738PMC
July 2016

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.

Cell 2016 May 21;165(5):1147-1159. Epub 2016 Apr 21.

Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati 45247, OH, USA; Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, Cincinnati 45247, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874838PMC
May 2016

Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice.

J Biol Chem 2016 May 10;291(19):9920-8. Epub 2016 Mar 10.

From the Department of Pediatrics and Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229

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http://dx.doi.org/10.1074/jbc.M116.719054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858995PMC
May 2016

Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils.

Am J Physiol Gastrointest Liver Physiol 2016 04 18;310(8):G609-17. Epub 2016 Feb 18.

Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio; and

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http://dx.doi.org/10.1152/ajpgi.00389.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836130PMC
April 2016

Most of the Dust Has Settled: cKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo.

Circ Res 2016 Jan;118(1):17-9

From the Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis (J.H.v.B.); Department of Pediatrics, Cincinnati Children's Hospital Medical Center, OH (J.D.M.); and Howard Hughes Medical Institute, Cincinnati, OH (J.D.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329000PMC
January 2016

Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice.

Hum Mol Genet 2016 Mar 6;25(6):1192-202. Epub 2016 Jan 6.

Department of Pediatrics, University of Cincinnati and Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, MLC7020, Cincinnati, OH 45229, USA

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http://dx.doi.org/10.1093/hmg/ddw005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764199PMC
March 2016

Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings.

Circ Res 2016 Mar 28;118(5):834-41. Epub 2015 Dec 28.

From the Department of Pharmacology, University of California, Davis (X.L., D.M.B.); Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (J.Q.K., J.D.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.308093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779382PMC
March 2016

MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response.

Nat Commun 2015 Dec 16;6:10084. Epub 2015 Dec 16.

Cincinnati Children's Hospital Medical Center, Department of Pediatrics, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1038/ncomms10084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703843PMC
December 2015

Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling.

Arterioscler Thromb Vasc Biol 2016 Jan 12;36(1):60-8. Epub 2015 Nov 12.

From the Department of Pediatrics (J.A.S., A.L., R.J.V., D.V., J.D.M.) and Howard Hughes Medical Institute (J.D.M.), Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH.

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http://dx.doi.org/10.1161/ATVBAHA.115.306397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690815PMC
January 2016

TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways.

Sci Rep 2015 Nov 13;5:16626. Epub 2015 Nov 13.

Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1038/srep16626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643217PMC
November 2015

Calcineurin Links Mitochondrial Elongation with Energy Metabolism.

Cell Metab 2015 Nov 24;22(5):838-50. Epub 2015 Sep 24.

Helmholtz Diabetes Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Technische Universität München, 80333 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.08.022DOI Listing
November 2015

Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.

J Mol Cell Cardiol 2015 Oct 31;87:204-13. Epub 2015 Aug 31.

Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, Cincinnati, OH 45229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637224PMC
October 2015

STIM1 elevation in the heart results in aberrant Ca²⁺ handling and cardiomyopathy.

J Mol Cell Cardiol 2015 Oct 1;87:38-47. Epub 2015 Aug 1.

Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637225PMC
October 2015

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart.

Cell Rep 2015 Jul 25;12(1):15-22. Epub 2015 Jun 25.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA; Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497842PMC
July 2015

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death.

PLoS One 2015 10;10(6):e0130520. Epub 2015 Jun 10.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America; Howard Hughes Medical Institute, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130520PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465034PMC
April 2016

Regulated necrotic cell death: the passive aggressive side of Bax and Bak.

Circ Res 2015 May;116(11):1800-9

From the Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, OH (J.K., J.D.M.); and Howard Hughes Medical Institute, Cincinnati, OH (J.D.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.305421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443748PMC
May 2015

Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin.

Gastroenterology 2015 Sep 14;149(3):753-64.e11. Epub 2015 May 14.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550538PMC
September 2015

Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling.

Mol Cell Biol 2015 Jun 13;35(12):2154-64. Epub 2015 Apr 13.

Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Howard Hughes Medical Institute, Cincinnati, Ohio, USA

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http://dx.doi.org/10.1128/MCB.00199-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438237PMC
June 2015

Sarcolipin overexpression improves muscle energetics and reduces fatigue.

J Appl Physiol (1985) 2015 Apr 19;118(8):1050-8. Epub 2015 Feb 19.

Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, Ohio; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio;

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http://dx.doi.org/10.1152/japplphysiol.01066.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398885PMC
April 2015

SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.

Am J Physiol Cell Physiol 2015 05 4;308(9):C699-709. Epub 2015 Feb 4.

Department of Kinesiology, School of Public Health, University of Maryland, College Park, Maryand; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryand; and Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

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http://dx.doi.org/10.1152/ajpcell.00341.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420794PMC
May 2015

Physiological and pathological roles of the mitochondrial permeability transition pore in the heart.

Cell Metab 2015 Feb;21(2):206-214

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA; Howard Hughes Medical Institute, Cincinnati, OH 45229, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131140055
Publisher Site
http://dx.doi.org/10.1016/j.cmet.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616258PMC
February 2015

An emerging consensus on cardiac regeneration.

Nat Med 2014 Dec;20(12):1386-93

1] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. [2] Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1038/nm.3764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418535PMC
December 2014

Targeting latent TGFβ release in muscular dystrophy.

Sci Transl Med 2014 Oct;6(259):259ra144

Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1126/scitranslmed.3010018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337885PMC
October 2014

RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.

Sci Signal 2014 Oct 21;7(348):ra100. Epub 2014 Oct 21.

Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.2005262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300109PMC
October 2014

Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling.

Circulation 2014 Dec 2;130(24):2162-72. Epub 2014 Oct 2.

From the Department of Physiology and Biophysics, University of Washington, Seattle, WA (L.L., Y.C., J.D., J.M., Q.L.); and Howard Hughes Medical Institute, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.011195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302054PMC
December 2014

Letter by Molkentin regarding article, "The absence of evidence is not evidence of absence: the pitfalls of Cre Knock-Ins in the c-Kit Locus".

Circ Res 2014 Sep;115(8):e21-3

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, OH.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.305011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278750PMC
September 2014

Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice.

Hum Mol Genet 2014 Dec 8;23(25):6903-15. Epub 2014 Aug 8.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, 240 Albert Sabin Way, Cincinnati, OH 45229, USA Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229, USA

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http://dx.doi.org/10.1093/hmg/ddu413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271062PMC
December 2014

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes.

Circ Res 2014 Sep 5;115(8):721-9. Epub 2014 Aug 5.

From the Heart Institute, Department of Pediatrics, The Cincinnati Children's Hospital Medical Center, OH (M.K.G., J.G., R.L., J.D.M., J.R.); and Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion (X.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.304760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180728PMC
September 2014