Publications by authors named "Jeewanjot S Grewal"

7 Publications

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The unilateral cleft lip repair.

Am J Otolaryngol 2021 Jan 13;42(3):102908. Epub 2021 Jan 13.

SUNY Upstate Medical University, Department of Otolaryngology and Communication Sciences, United States of America.

Objective: To determine if there is a benefit of 2-stage cleft lip repair in regard to improving facial symmetry and facilitating definitive lip, nose, and palate repair.

Study Design: Retrospective chart review of patients born with complete, unilateral cleft lip deformity that underwent a two-stage repair described as a stage 1 straight line repair and a stage 2 modified Millard repair, for which a complete set of records, and peri-operative and post-operative photos were available. All cases were performed by a single surgeon.

Setting: Tertiary care center craniofacial team.

Methods: Measurements were taken from intraoperative, perioperative, and postoperative images of patients before and after each stage. Ratios were then created comparing the affected size to the unaffected side, and these were averaged between observers.

Results: A 19% increase in the width of area of the presumptive C flap was obtained between the unrepaired and the post-stage I images. The nostril width of the cleft side was 1.2× the width of the unaffected side, demonstrating a 140% decrease in nostril width at the completion of stage II. The cleft side nostril width was maintained slightly larger than the noncleft side as desired. Symmetry of the upper lip length was achieved, as the length of the cleft side lateral lip after stage II was 92% of the unaffected side.

Conclusion: We believe this study provides evidence for our observations that a two-stage repair can be performed with functionally and aesthetically pleasing outcomes as an alternative to presurgical nasoalveolar molding.
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http://dx.doi.org/10.1016/j.amjoto.2021.102908DOI Listing
January 2021

Comparing Caliper versus Computed Tomography Measurements of Cranial Dimensions in Children.

Laryngoscope 2020 Sep 12. Epub 2020 Sep 12.

Department of Otolaryngology-Head and Neck Surgery, State University of New York Upstate Medical University, Syracuse, New York, U.S.A.

Objectives/hypothesis: We have found no study assessing the accuracy of caliper cranium measurements compared to computed tomography (CT) measurements of the head. The objective of this study was to assess the reliability of caliper measurements in comparison to CT measurements.

Study Design: Retrospective chart review.

Methods: This study includes all patients evaluated for head shape abnormality between 2010 and 2019 at a single academic medical center. Eighty-nine patients who had CT head scans were identified, and their caliper measurements of anterior-posterior and transverse head dimensions were documented.

Results: There was no statistically significant difference between the CT and caliper measurements.

Conclusion: Caliper measurements are a simple and reliable way to assess cranial vault proportionality with growth after cranial vault reconstruction.

Level Of Evidence: 4 Laryngoscope, 2020.
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http://dx.doi.org/10.1002/lary.29086DOI Listing
September 2020

An Unlikely Cause of Headaches and Temporomandibular Joint Pain in a Young Woman.

JAMA Otolaryngol Head Neck Surg 2020 Aug 27. Epub 2020 Aug 27.

SUNY Upstate, Department of Otolaryngology-Head and Neck Surgery, Syracuse, New York.

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http://dx.doi.org/10.1001/jamaoto.2020.2182DOI Listing
August 2020

Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma.

J Surg Oncol 2019 Aug 16;120(2):101-108. Epub 2019 May 16.

Department of Head and Neck and Plastic Surgery, Erie County Medical Center, SUNY Buffalo, Buffalo, New York.

Background And Objectives: The management of the clinically N0 (cN0) neck is controversial for early stage squamous cell carcinoma of the oral cavity (OSCC). This paper represents a single institution series analyzing the efficacy of sentinel lymph node biopsy (SNB) for early stage oral cavity cancers.

Methods: From 2005 to 2017, 108 patients with cN0 OSCC were treated with primary resection and SNB. Patients with positive biopsy results proceeded to neck dissection with or without adjuvant chemoradiotherapy. Mean follow-up for the entire cohort was 50.8 months (range: 8-147 months). Clinically, 56 patients were T1N0, 49 patients were T2N0, and three patients were T3N0 or greater.

Results: Disease-specific survival was 93% within the entire cohort. Sentinel lymph nodes were identified in 95.4% of patients. Twenty one patients had a positive biopsy. There were seven false-negative biopsies. The overall rate of nodal disease was 26%. Accuracy of node biopsy was 93%, with sensitivity of 75%, and negative predictive value of 91%. Recurrence rate was 19% (20/108), with an overall survival of 60% in this subgroup.

Conclusion: SNB is a safe, effective, and well tolerated method for staging cN0 OSCC.
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http://dx.doi.org/10.1002/jso.25494DOI Listing
August 2019

Complex and non-redundant signals from individual odor receptors that underlie chemotaxis behavior in Drosophila melanogaster larvae.

Biol Open 2014 Sep 19;3(10):947-57. Epub 2014 Sep 19.

Department of Biological Sciences, Dominican University, 7900 West Division Street, Parmer Hall 244, River Forest, IL 60305, USA

The rules by which odor receptors encode odors and allow behavior are still largely unexplored. Although large data sets of electrophysiological responses of receptors to odors have been generated, few hypotheses have been tested with behavioral assays. We use a data set on odor responses of Drosophila larval odor receptors coupled with chemotaxis behavioral assays to examine rules of odor coding. Using mutants of odor receptors, we have found that odor receptors with similar electrophysiological responses to odors across concentrations play non-redundant roles in odor coding at specific odor concentrations. We have also found that high affinity receptors for odors determine behavioral response thresholds, but the rules for determining peak behavioral responses are more complex. While receptor mutants typically show loss of attraction to odors, some receptor mutants result in increased attraction at specific odor concentrations. The odor receptor mutants were rescued using transgenic expression of odor receptors, validating assignment of phenotypes to the alleles. Vapor pressures alone cannot fully explain behavior in our assay. Finally, some odors that did not elicit strong electrophysiological responses are associated with behavioral phenotypes upon examination of odor receptor mutants. This result is consistent with the role of sensory neurons in lateral inhibition via local interneurons in the antennal lobe. Taken together, our results suggest a complexity of odor coding rules even in a simple olfactory sensory system.
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http://dx.doi.org/10.1242/bio.20148573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197443PMC
September 2014