Jeanne M Nerbonne

Jeanne M Nerbonne

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Jeanne M Nerbonne

Jeanne M Nerbonne

Publications by authors named "Jeanne M Nerbonne"

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99Publications

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Circulating long noncoding RNA DKFZP434I0714 predicts adverse cardiovascular outcomes in patients with end-stage renal disease.

Int J Cardiol 2018 Aug 7. Epub 2018 Aug 7.

Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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August 2018

Voltage-gated sodium currents in cerebellar Purkinje neurons: functional and molecular diversity.

Cell Mol Life Sci 2018 Jul 7. Epub 2018 Jul 7.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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July 2018

Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.

Circ Res 2018 Apr 13;122(8):1052-1068. Epub 2018 Mar 13.

From the Department and Graduate Institute of Pharmacology (Y.-C.S., C.-L.C., H.-C.W., C.-T.H., J.-Y.N., H.-J.C., T.-H.L., Y.-S.T., K.-C.Y.), Department and Graduate Institute of Medical Education and Bioethics (C.-C.W.), and Department and Graduate Institute of Physiology (S.-L.L.), National Taiwan University College of Medicine, Taipei; Department of Developmental Biology (J.M.N.) and Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine (Y.Z., R.L.M., E.M.K., K.A.Y., J.M.N.), Washington University School of Medicine, St Louis, MO; Department of Medicine, University of Chicago, IL (Y.F.); Department of Surgery (C.-N.C.), Division of Nephrology, Department of Internal Medicine (S.-L.L.), and Division of Cardiology, Department of Internal Medicine (C.-C.W., K.-C.Y.), National Taiwan University Hospital, Taipei.

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April 2018

Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior.

eNeuro 2017 May-Jun;4(3). Epub 2017 May 23.

Departments of Developmental Biology and Internal Medicine Washington University School of Medicine, Washington University, St. Louis, MO 63130.

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March 2018

Differential Expression and Remodeling of Transient Outward Potassium Currents in Human Left Ventricles.

Circ Arrhythm Electrophysiol 2018 Jan;11(1):e005914

From the Cardiovascular Division, Department of Medicine (E.K.J., S.J.S., W.W., E.J.D., Y.Z., E.M.K., K.A.Y., J.M.N.) and Department of Developmental Biology (J.M.N.), Washington University School of Medicine, St. Louis, MO.

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January 2018

Mechanisms of noncovalent β subunit regulation of Na channel gating.

J Gen Physiol 2017 Jul 18. Epub 2017 Jul 18.

Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO

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July 2017

Loss of Navβ4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance.

Cell Rep 2017 04;19(3):532-544

Departments of Developmental Biology and Internal Medicine , Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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April 2017

Early remodeling of repolarizing K currents in the αMHC mouse model of familial hypertrophic cardiomyopathy.

J Mol Cell Cardiol 2017 02 13;103:93-101. Epub 2017 Jan 13.

Department of Developmental Biology, Washington University Medical School, St. Louis, MO 63110-1093, USA; Department of Medicine, Washington University Medical School, St. Louis, MO 63110-1093, USA. Electronic address:

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February 2017

Notch-Mediated Epigenetic Regulation of Voltage-Gated Potassium Currents.

Circ Res 2016 Dec 3;119(12):1324-1338. Epub 2016 Oct 3.

Department of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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December 2016

Proteomic analysis of native cerebellar iFGF14 complexes.

Channels (Austin) 2016 Jul 18;10(4):297-312. Epub 2016 Feb 18.

e L'Institut du Thorax, INSERM UMR1087, CNRS UMR6291, Université de Nantes , Nantes , France.

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July 2016

Molecular Basis of Functional Myocardial Potassium Channel Diversity.

Card Electrophysiol Clin 2016 Jun 24;8(2):257-73. Epub 2016 Mar 24.

Department of Internal Medicine, Washington University Medical School, 660 South Euclid Avenue, Box 8086, St Louis, MO 63110, USA; Department of Developmental Biology, Washington University Medical School, St Louis, MO 63110, USA. Electronic address:

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June 2016

Mechanisms contributing to myocardial potassium channel diversity, regulation and remodeling.

Trends Cardiovasc Med 2016 Apr 17;26(3):209-18. Epub 2015 Jul 17.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO; Internal Medicine, Washington University School of Medicine, St. Louis, MO; Cardiovascular Division, Washington University School of Medicine, St. Louis, MO. Electronic address:

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April 2016

Distinct Firing Properties of Vasoactive Intestinal Peptide-Expressing Neurons in the Suprachiasmatic Nucleus.

J Biol Rhythms 2016 Feb 27;31(1):57-67. Epub 2015 Dec 27.

Departments of Developmental Biology and Medicine, Washington University School of Medicine, Saint Louis, MO

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February 2016

Cardiac Mechano-Gated Ion Channels and Arrhythmias.

Circ Res 2016 Jan;118(2):311-29

From the National Heart and Lung Institute, Imperial College London, United Kingdom (R.P., P.K.); Departments of Developmental Biology and Internal Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO (J.M.N.); Institute for Experimental Cardiovascular Medicine, University Heart Centre Freiburg/Bad Krozingen, Freiburg, Germany (R.P., P.K.).

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January 2016

IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus.

J Biol Rhythms 2015 Oct 6;30(5):396-407. Epub 2015 Jul 6.

Department of Biology, Washington University, St. Louis, MO, USA.

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October 2015

Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo.

PLoS One 2014 5;9(8):e104062. Epub 2014 Aug 5.

Developmental Biology, Washington University School of Medicine, Saint Louis, Missouri, United States of America.

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April 2015

Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance.

J Neurosci 2015 Apr;35(17):6752-69

Department of Developmental Biology and Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri 63110

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April 2015

A fully implantable pacemaker for the mouse: from battery to wireless power.

PLoS One 2013 23;8(10):e76291. Epub 2013 Oct 23.

Department of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, Missouri, United States of America.

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February 2015

Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts.

Neuron 2014 Oct 22;84(2):311-23. Epub 2014 Oct 22.

Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

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October 2014

Characterization of SEMA3A-encoded semaphorin as a naturally occurring Kv4.3 protein inhibitor and its contribution to Brugada syndrome.

Circ Res 2014 Aug 24;115(4):460-9. Epub 2014 Jun 24.

From the Center for Clinical and Translational Science (N.J.B.) and Mayo Graduate School (N.J.B.), Department Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (D.Y., D.J.T., J.R.G., M.J.A.), Department of Medicine (J.R.G.), Division of Cardiovascular Diseases (M.J.A.), and Division of Pediatric Cardiology (M.J.A.), Mayo Clinic, Rochester, MN; Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO (E.K.J., W.W., J.M.N.); Department of Molecular Medicine, University of Pavia, Pavia, Italy (L.C.); Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milan, Italy (L.C., F.D., M.T., P.J.S.); Institute of Human Genetics, Helmholtz Zentrum Munich, Neuherberg, Germany (L.C.); and Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands (Y.M., M.A., A.A.M.W.).

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August 2014

IA channels: diverse regulatory mechanisms.

Neuroscientist 2014 Apr 8;20(2):104-11. Epub 2013 Oct 8.

1Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.

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April 2014

Mouse models of arrhythmogenic cardiovascular disease: challenges and opportunities.

Curr Opin Pharmacol 2014 Apr 13;15:107-14. Epub 2014 Mar 13.

Department of Developmental Biology, Washington University Medical School, St. Louis, MO 63110, USA; Department of Internal Medicine, Washington University Medical School, St. Louis, MO 63110, USA. Electronic address:

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April 2014

Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support.

Circulation 2014 Mar 15;129(9):1009-21. Epub 2014 Jan 15.

Department of Developmental Biology (K.-C.Y., J.M.N.) and Center for Cardiovascular Research, Division of Cardiology, Department of Internal Medicine (K.A.Y., A.Y.P., V.K.T., G.A.E., D.L.M.), Washington University Medical School, St. Louis, MO; Division of Cardiothoracic Surgery, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, NY (I.G.); and Department of Surgery, University of Maryland School of Medicine, Baltimore (F.H.C.). Dr Yang's current affiliation is the Department of Pharmacology, National Taiwan University School of Medicine, Taipei, Taiwan.

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March 2014

Distinct balance of excitation and inhibition in an interareal feedforward and feedback circuit of mouse visual cortex.

J Neurosci 2013 Oct;33(44):17373-84

Department of Anatomy and Neurobiology and Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, and Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147.

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October 2013

Kv4.2 potassium channels segregate to extrasynaptic domains and influence intrasynaptic NMDA receptor NR2B subunit expression.

Brain Struct Funct 2013 Sep 30;218(5):1115-32. Epub 2012 Aug 30.

Department of Pharmacology, Innsbruck Medical University, Peter-Mayr Strasse 1a, 6020 Innsbruck, Austria.

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September 2013

Stabilization of Kv4 protein by the accessory K(+) channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K(+) currents.

J Physiol 2013 Sep 27;591(17):4149-66. Epub 2013 May 27.

J. M. Nerbonne: Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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September 2013

FGF14 localization and organization of the axon initial segment.

Mol Cell Neurosci 2013 Sep 26;56:393-403. Epub 2013 Jul 26.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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September 2013

Gender differences in electrophysiological gene expression in failing and non-failing human hearts.

PLoS One 2013 23;8(1):e54635. Epub 2013 Jan 23.

Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America.

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June 2013

How to build an integrated biobank: the Washington University Translational Cardiovascular Biobank & Repository experience.

Clin Transl Sci 2013 Jun 18;6(3):226-31. Epub 2013 Apr 18.

Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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June 2013

Mass spectrometry-based identification of native cardiac Nav1.5 channel α subunit phosphorylation sites.

J Proteome Res 2012 Dec 9;11(12):5994-6007. Epub 2012 Nov 9.

INSERM, UMR1087, CNRS, UMR6291, LUNAM Université, Nantes, France.

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December 2012

Exercise training and PI3Kα-induced electrical remodeling is independent of cellular hypertrophy and Akt signaling.

J Mol Cell Cardiol 2012 Oct 21;53(4):532-41. Epub 2012 Jul 21.

Department of Developmental Biology, Washington University Medical School, St Louis, MO 63110-1093, USA.

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October 2012

A-type K+ channels encoded by Kv4.2, Kv4.3 and Kv1.4 differentially regulate intrinsic excitability of cortical pyramidal neurons.

J Physiol 2012 Aug 21;590(16):3877-90. Epub 2012 May 21.

Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St Louis, MO 63110, USA.

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August 2012

Combined deep microRNA and mRNA sequencing identifies protective transcriptomal signature of enhanced PI3Kα signaling in cardiac hypertrophy.

J Mol Cell Cardiol 2012 Jul 11;53(1):101-12. Epub 2012 May 11.

Department of Developmental Biology, Washington University Medical School, St Louis, MO 63110-1093, USA.

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July 2012

I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity.

J Neurosci 2012 Jul;32(29):10045-52

Department of Biology, School of Medicine, Washington University, St. Louis, Missouri 63130-4899, USA.

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July 2012

Characterization of a novel, dominant negative KCNJ2 mutation associated with Andersen-Tawil syndrome.

Channels (Austin) 2011 Nov-Dec;5(6):500-9. Epub 2011 Nov 1.

Washington University School of Medicine; St. Louis, MO, USA.

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June 2012

ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling.

Blood 2012 Apr 17;119(14):3295-305. Epub 2012 Feb 17.

Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA.

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April 2012

Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization.

J Biol Chem 2012 Mar 6;287(12):9640-50. Epub 2012 Feb 6.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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March 2012

Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure.

Cardiovasc Res 2012 Feb 27;93(2):252-62. Epub 2011 Oct 27.

Department of Developmental Biology, Washington University Medical School, 660 South Euclid Avenue Box 8103, St Louis, MO 63110-1093, USA.

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February 2012

Repolarizing cardiac potassium channels: multiple sites and mechanisms for CaMKII-mediated regulation.

Heart Rhythm 2011 Jun 11;8(6):938-41. Epub 2011 Jan 11.

Department of Developmental Biology and Center for the Investigation of Membrane Excitability Diseases, Washington University Medical School, St. Louis, Missouri, USA.

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June 2011

Mechanisms linking short- and long-term electrical remodeling in the heart...is it a stretch?

Channels (Austin) 2008 Mar-Apr;2(2):117-24. Epub 2008 Mar 6.

Department of Internal Medicine, Washington University Medical School, Saint Louis, Missouri, USA.

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May 2011

Proteomic analysis highlights the molecular complexities of native Kv4 channel macromolecular complexes.

Semin Cell Dev Biol 2011 Apr 17;22(2):145-52. Epub 2010 Oct 17.

L'Institut du Thorax, INSERM UMR-915, Institut de Recherche Thérapeutique-Université de Nantes, Nantes, France.

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April 2011

Neuronal voltage-gated K+ (Kv) channels function in macromolecular complexes.

Neurosci Lett 2010 Dec 9;486(2):73-7. Epub 2010 Sep 9.

Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St. Louis, MO 63110, United States.

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December 2010

Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy.

J Physiol 2010 Dec 25;588(Pt 24):5015-32. Epub 2010 Oct 25.

Department of Developmental Biology, Washington University Medical School, St Louis, MO 63110-1093, USA.

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December 2010

Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes.

J Biol Chem 2010 Oct 13;285(43):33413-22. Epub 2010 Aug 13.

Department of Developmental Biology, Washington University Medical School, St Louis, Missouri 63110, USA.

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October 2010

Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons.

J Neurosci 2010 Oct;30(41):13644-55

Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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October 2010

Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits.

J Neurosci 2010 Apr;30(14):5092-101

Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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April 2010

Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents.

J Mol Cell Cardiol 2010 Feb 24;48(2):395-405. Epub 2009 Oct 24.

Pfizer Global Research and Development, Chesterfield, MO 63017, USA.

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February 2010

Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation.

J Mol Cell Cardiol 2010 Jan 18;48(1):12-25. Epub 2009 Jul 18.

Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8103, St. Louis, MO 63110-1093, USA.

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January 2010

MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts.

Circ Res 2010 Jan 5;106(1):166-75. Epub 2009 Nov 5.

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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January 2010

Proteomic analyses of native brain K(V)4.2 channel complexes.

Channels (Austin) 2009 Jul-Aug;3(4):284-94. Epub 2009 Jul 16.

Department of Developmental Biology, Washington University, St. Louis, MO, USA.

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December 2009

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

Mol Cell Neurosci 2009 Oct 22;42(2):90-101. Epub 2009 May 22.

Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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October 2009

Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels.

J Biol Chem 2009 Sep 1;284(38):25553-9. Epub 2009 Jul 1.

Department of Medicine and Public Health, Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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September 2009

Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum.

Proc Natl Acad Sci U S A 2009 Sep 4;106(38):16475-80. Epub 2009 Sep 4.

National Institute of Neuroscience and Department of Neurological and Visual Sciences, Section of Physiology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy.

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September 2009

In vivo effect of a dominant negative Kv4.2 loss-of-function mutation eliminating I(to,f) on atrial refractoriness and atrial fibrillation in mice.

Circ J 2009 Mar 15;73(3):461-7. Epub 2009 Jan 15.

Universitätsklinikum Freiburg, Innere Medizin III, Kardiologie, Freiburg, Germany.

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March 2009

FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons.

Neurobiol Dis 2009 Jan 1;33(1):81-8. Epub 2008 Oct 1.

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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January 2009

Calmodulin kinase II inhibition enhances ischemic preconditioning by augmenting ATP-sensitive K+ current.

Channels (Austin) 2007 Sep-Oct;1(5):387-94. Epub 2007 Dec 17.

Departments of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242-1081, USA.

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November 2008

Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs.

Cell Stem Cell 2008 Jul;3(1):55-68

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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July 2008

Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy.

Circ Res 2008 Jun 1;102(11):1406-15. Epub 2008 May 1.

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA.

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June 2008

PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy.

J Mol Cell Cardiol 2008 Jun 9;44(6):1002-15. Epub 2008 Apr 9.

Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, MO 63110, USA.

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June 2008

Electrical remodelling maintains firing properties in cortical pyramidal neurons lacking KCND2-encoded A-type K+ currents.

J Physiol 2008 Mar 10;586(6):1565-79. Epub 2008 Jan 10.

Department of Molecular Biology and Pharmacology, Box 8103, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110-1093, USA.

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March 2008

Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventricles.

J Mol Cell Cardiol 2008 Jan 18;44(1):95-104. Epub 2007 Oct 18.

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8103, St. Louis, MO 63110-1093, USA.

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January 2008

The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability.

J Neurosci 2007 Oct;27(44):12033-44

Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110, USA.

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October 2007

Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT.

J Physiol 2007 Jan 16;578(Pt 1):115-29. Epub 2006 Nov 16.

University of Pittsburgh, Cardiovascular Institute, Pittsburgh, PA 15213, USA.

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January 2007

Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents.

Circ Res 2006 Nov 12;99(10):1092-9. Epub 2006 Oct 12.

Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, USA.

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November 2006

Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.

J Neurosci 2006 Nov;26(47):12274-82

Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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November 2006

The kv4.2 potassium channel subunit is required for pain plasticity.

Neuron 2006 Apr;50(1):89-100

Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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April 2006

Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels.

J Physiol 2005 Nov 15;569(Pt 1):179-93. Epub 2005 Sep 15.

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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November 2005

Molecular physiology of cardiac repolarization.

Physiol Rev 2005 Oct;85(4):1205-53

Dept. of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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October 2005

Functional role of the fast transient outward K+ current IA in pyramidal neurons in (rat) primary visual cortex.

J Neurosci 2005 Oct;25(40):9185-94

Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri 63110, USA.

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October 2005

KChIP2 modulates the cell surface expression of Kv 1.5-encoded K(+) channels.

J Mol Cell Cardiol 2005 Jul;39(1):121-32

Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.

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July 2005

Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes.

Circ Res 2005 Mar 20;96(4):451-8. Epub 2005 Jan 20.

Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110-1093, USA.

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March 2005

Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles.

J Physiol 2004 Aug 11;559(Pt 1):103-20. Epub 2004 Jun 11.

Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, Box 8103, St Louis, MO 63110-1093, USA.

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August 2004

Differential depression of inhibitory synaptic responses in feedforward and feedback circuits between different areas of mouse visual cortex.

J Comp Neurol 2004 Jul;475(3):361-73

Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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July 2004

Studying cardiac arrhythmias in the mouse--a reasonable model for probing mechanisms?

Trends Cardiovasc Med 2004 Apr;14(3):83-93

Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, Missouri, USA.

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April 2004

Selective elimination of I(K,slow1) in mouse ventricular myocytes expressing a dominant negative Kv1.5alpha subunit.

Am J Physiol Heart Circ Physiol 2004 Jan 2;286(1):H319-28. Epub 2003 Oct 2.

Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

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January 2004

Attenuation of I(K,slow1) and I(K,slow2) in Kv1/Kv2DN mice prolongs APD and QT intervals but does not suppress spontaneous or inducible arrhythmias.

Am J Physiol Heart Circ Physiol 2004 Jan;286(1):H368-74

Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.

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January 2004

Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels.

J Neurosci 2003 Jun;23(12):4798-802

Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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June 2003

Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle.

J Physiol 2003 May 21;548(Pt 3):815-22. Epub 2003 Feb 21.

Department of Physiology and Biophysics, Institute of Molecular Cardiology, State University of New York at Stony Brook, NY 11794, USA.

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May 2003

Regional upregulation of Kv2.1-encoded current, IK,slow2, in Kv1DN mice is abolished by crossbreeding with Kv2DN mice.

Am J Physiol Heart Circ Physiol 2003 Feb;284(2):H491-500

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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February 2003

A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.

Proc Natl Acad Sci U S A 2003 Feb 27;100(3):1226-31. Epub 2003 Jan 27.

Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO 63110, USA.

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February 2003

Delayed rectifier K+ currents, IK, are encoded by Kv2 alpha-subunits and regulate tonic firing in mammalian sympathetic neurons.

J Neurosci 2002 Dec;22(23):10094-105

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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December 2002

Modulation of Kv4-encoded K(+) currents in the mammalian myocardium by neuronal calcium sensor-1.

J Biol Chem 2002 Jul 6;277(29):26436-43. Epub 2002 May 6.

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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July 2002

Heterogeneous expression of voltage-gated potassium channels in the heart: roles in normal excitation and arrhythmias.

J Cardiovasc Electrophysiol 2002 Apr;13(4):406-9

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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April 2002

Role of heteromultimers in the generation of myocardial transient outward K+ currents.

Circ Res 2002 Mar;90(5):586-93

Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Mo 63110, USA.

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March 2002