Publications by authors named "Jeanne M Nerbonne"

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Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.
Circ Res 2018 Apr 13;122(8):1052-1068. Epub 2018 Mar 13.
From the Department and Graduate Institute of Pharmacology (Y.-C.S., C.-L.C., H.-C.W., C.-T.H., J.-Y.N., H.-J.C., T.-H.L., Y.-S.T., K.-C.Y.), Department and Graduate Institute of Medical Education and Bioethics (C.-C.W.), and Department and Graduate Institute of Physiology (S.-L.L.), National Taiwan University College of Medicine, Taipei; Department of Developmental Biology (J.M.N.) and Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine (Y.Z., R.L.M., E.M.K., K.A.Y., J.M.N.), Washington University School of Medicine, St Louis, MO; Department of Medicine, University of Chicago, IL (Y.F.); Department of Surgery (C.-N.C.), Division of Nephrology, Department of Internal Medicine (S.-L.L.), and Division of Cardiology, Department of Internal Medicine (C.-C.W., K.-C.Y.), National Taiwan University Hospital, Taipei.

Differential Expression and Remodeling of Transient Outward Potassium Currents in Human Left Ventricles.
Circ Arrhythm Electrophysiol 2018 Jan;11(1):e005914
From the Cardiovascular Division, Department of Medicine (E.K.J., S.J.S., W.W., E.J.D., Y.Z., E.M.K., K.A.Y., J.M.N.) and Department of Developmental Biology (J.M.N.), Washington University School of Medicine, St. Louis, MO.

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics.
J Physiol 2017 Apr 5;595(7):2229-2252. Epub 2017 Jan 5.
Departments of Developmental Biology and Internal Medicine, Cardiovascular Division, Washington University Medical School, St Louis, MO, 63110, USA.

Mechanisms contributing to myocardial potassium channel diversity, regulation and remodeling.
Trends Cardiovasc Med 2016 Apr 17;26(3):209-18. Epub 2015 Jul 17.
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO; Internal Medicine, Washington University School of Medicine, St. Louis, MO; Cardiovascular Division, Washington University School of Medicine, St. Louis, MO. Electronic address:

Cardiac Mechano-Gated Ion Channels and Arrhythmias.
Circ Res 2016 Jan;118(2):311-29
From the National Heart and Lung Institute, Imperial College London, United Kingdom (R.P., P.K.); Departments of Developmental Biology and Internal Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO (J.M.N.); Institute for Experimental Cardiovascular Medicine, University Heart Centre Freiburg/Bad Krozingen, Freiburg, Germany (R.P., P.K.).

Characterization of SEMA3A-encoded semaphorin as a naturally occurring Kv4.3 protein inhibitor and its contribution to Brugada syndrome.
Circ Res 2014 Aug 24;115(4):460-9. Epub 2014 Jun 24.
From the Center for Clinical and Translational Science (N.J.B.) and Mayo Graduate School (N.J.B.), Department Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (D.Y., D.J.T., J.R.G., M.J.A.), Department of Medicine (J.R.G.), Division of Cardiovascular Diseases (M.J.A.), and Division of Pediatric Cardiology (M.J.A.), Mayo Clinic, Rochester, MN; Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO (E.K.J., W.W., J.M.N.); Department of Molecular Medicine, University of Pavia, Pavia, Italy (L.C.); Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milan, Italy (L.C., F.D., M.T., P.J.S.); Institute of Human Genetics, Helmholtz Zentrum Munich, Neuherberg, Germany (L.C.); and Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands (Y.M., M.A., A.A.M.W.).

Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support.
Circulation 2014 Mar 15;129(9):1009-21. Epub 2014 Jan 15.
Department of Developmental Biology (K.-C.Y., J.M.N.) and Center for Cardiovascular Research, Division of Cardiology, Department of Internal Medicine (K.A.Y., A.Y.P., V.K.T., G.A.E., D.L.M.), Washington University Medical School, St. Louis, MO; Division of Cardiothoracic Surgery, New York Presbyterian Hospital, Columbia University College of Physicians and Surgeons, New York, NY (I.G.); and Department of Surgery, University of Maryland School of Medicine, Baltimore (F.H.C.). Dr Yang's current affiliation is the Department of Pharmacology, National Taiwan University School of Medicine, Taipei, Taiwan.

Distinct balance of excitation and inhibition in an interareal feedforward and feedback circuit of mouse visual cortex.
J Neurosci 2013 Oct;33(44):17373-84
Department of Anatomy and Neurobiology and Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, and Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147.

Stabilization of Kv4 protein by the accessory K(+) channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K(+) currents.
J Physiol 2013 Sep 27;591(17):4149-66. Epub 2013 May 27.
J. M. Nerbonne: Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St. Louis, MO 63110, USA.


Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk.
Circ Res 2012 Sep 9;111(7):863-75. Epub 2012 Jul 9.
Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.



MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts.
Circ Res 2010 Jan 5;106(1):166-75. Epub 2009 Nov 5.
Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellum.
Proc Natl Acad Sci U S A 2009 Sep 4;106(38):16475-80. Epub 2009 Sep 4.
National Institute of Neuroscience and Department of Neurological and Visual Sciences, Section of Physiology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy.

Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy.
Circ Res 2009 Jan 20;104(1):95-103. Epub 2008 Nov 20.
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA.




A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.
Proc Natl Acad Sci U S A 2003 Feb 27;100(3):1226-31. Epub 2003 Jan 27.
Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO 63110, USA.


Early remodeling of repolarizing K currents in the αMHC mouse model of familial hypertrophic cardiomyopathy.
J Mol Cell Cardiol 2017 02 13;103:93-101. Epub 2017 Jan 13.
Department of Developmental Biology, Washington University Medical School, St. Louis, MO 63110-1093, USA; Department of Medicine, Washington University Medical School, St. Louis, MO 63110-1093, USA. Electronic address:

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