Jeanine J Houwing-Duistermaat

Jeanine J Houwing-Duistermaat

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Jeanine J Houwing-Duistermaat

Jeanine J Houwing-Duistermaat

Publications by authors named "Jeanine J Houwing-Duistermaat"

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Powerful testing via hierarchical linkage disequilibrium in haplotype association studies.

Biom J 2019 May 28;61(3):747-768. Epub 2019 Jan 28.

Department of Biomedical Data Sciences, Section Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/bimj.201800053
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http://dx.doi.org/10.1002/bimj.201800053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637384PMC
May 2019

The mixed model for the analysis of a repeated-measurement multivariate count data.

Stat Med 2019 May 13;38(12):2248-2268. Epub 2019 Feb 13.

Department of Biostatistics and Research Support, UMC Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/sim.8101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594162PMC
May 2019

Estimating Constraints for Protection Factors from HDX-MS Data.

Biophys J 2019 Apr 5;116(7):1194-1203. Epub 2019 Mar 5.

Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom; School of Cellular and Molecular Biology, University of Leeds, Leeds, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2019.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451051PMC
April 2019

Subcortical brain volumes, cortical thickness and cortical surface area in families genetically enriched for social anxiety disorder - A multiplex multigenerational neuroimaging study.

EBioMedicine 2018 Oct 25;36:410-428. Epub 2018 Sep 25.

Department of Psychiatry, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.08.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197574PMC
October 2018

Genome-wide analysis in multiple-case families: assessing the relationship between triglyceride and methylation.

BMC Proc 2018 17;12(Suppl 9):33. Epub 2018 Sep 17.

2Department of Statistics, University of Leeds, Leeds, LS2 9JT UK.

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http://dx.doi.org/10.1186/s12919-018-0123-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157284PMC
September 2018

Survival analysis with delayed entry in selected families with application to human longevity.

Stat Methods Med Res 2018 03 13;27(3):933-954. Epub 2016 May 13.

1 Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1177/0962280216648356DOI Listing
March 2018

Delta-beta correlation as a candidate endophenotype of social anxiety: A two-generation family study.

J Affect Disord 2018 02 10;227:398-405. Epub 2017 Nov 10.

Developmental and Educational Psychology, Leiden University, The Netherlands; Leiden Institute for Brain and Cognition, Leiden University, The Netherlands.

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http://dx.doi.org/10.1016/j.jad.2017.11.019DOI Listing
February 2018

Estimation of metabolite networks with regard to a specific covariable: applications to plant and human data.

Metabolomics 2017 22;13(11):129. Epub 2017 Sep 22.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11306-017-1263-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610247PMC
September 2017

Secondary phenotype analysis in ascertained family designs: application to the Leiden longevity study.

Stat Med 2017 06 16;36(14):2288-2301. Epub 2017 Mar 16.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/sim.7281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485037PMC
June 2017

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.

Aging Cell 2016 Oct 21;15(5):811-24. Epub 2016 Jun 21.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.

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http://dx.doi.org/10.1111/acel.12490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013013PMC
October 2016

Vitamin D receptor polymorphisms and growth until adulthood after very premature birth.

J Bone Miner Metab 2016 Sep 28;34(5):564-70. Epub 2015 Jul 28.

Department of Pediatrics, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00774-015-0697-8DOI Listing
September 2016

Genetic Factors for the Severity of ACPA-negative Rheumatoid Arthritis in 2 Cohorts of Early Disease: A Genome-wide Study.

J Rheumatol 2015 Aug 15;42(8):1383-91. Epub 2015 Jun 15.

From the Department of Rheumatology, and the Department of Medical Statistics, Leiden University Medical Center, Leiden, the Netherlands; the Section of Rheumatology at the Institution of Clinical Science, Lund University, Skåne University Hospital, Lund, Sweden, for the BARFOT study group; the Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands; Center of Experimental Rheumatology, University Hospital Zurich, Schlieren, Switzerland; the Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.D.P. de Rooy, LLM, MD, PhD, Department of Rheumatology, Leiden University Medical Center; R. Tsonaka, PhD, Department of Medical Statistics, Leiden University Medical Center; M.L. Andersson, BMS, PhD; K. Forslind, Associate Professor, Senior Consultant, Section of Rheumatology at the Institution of Clinical Science, Lund University, Skåne University Hospital, for the BARFOT study group; A. Zhernakova, MD, PhD, Department of Rheumatology, Leiden University Medical Center, and Department of Genetics, University Medical Center Groningen and University of Groningen; M. Frank-Bertoncelj, MD, PhD, Center of Experimental Rheumatology, University Hospital Zurich; C.G. de Kovel, PhD; B.P. Koeleman, PhD, Department of Medical Genetics, University Medical Center Utrecht; D.M. van der Heijde, MD, PhD; T.W. Huizinga, MD, PhD; R.E. Toes, PhD, Department of Rheumatology, Leiden University Medical Center; J.J. Houwing-Duistermaat, PhD, PD, Department of Medical Statistics, Leiden University Medical Center; C. Ospelt, MD, PhD, Center of Experimental Rheumatology, University Hospital Zurich; B. Svensson, MD, PhD, Section of Rheumatology at the Institution of Clinical Science, Lund University, Skåne University Hospital, for the BARFOT study group; A.H. van der Helm-van Mil, MD, PhD, Department of Rheumatology, Leiden University Medical Center.

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http://dx.doi.org/10.3899/jrheum.140741DOI Listing
August 2015

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.

PLoS Genet 2015 Jul 1;11(7):e1005230. Epub 2015 Jul 1.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Estonian Genome Center, University of Tartu, Tartu, Estonia; Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1005230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488845PMC
July 2015

The impact of low-frequency and rare variants on lipid levels.

Nat Genet 2015 Jun 11;47(6):589-97. Epub 2015 May 11.

1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] Department of Public Health, University of Helsinki, Helsinki, Finland. [3] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757735PMC
June 2015

Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage.

Arthritis Rheumatol 2015 May;67(8):2108-16

Leiden University Medical Center, Leiden, The Netherlands, and The Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/art.39162DOI Listing
May 2015

Genotype-Based Score Test for Association Testing in Families.

Stat Biosci 2015;7(2):394-416. Epub 2015 Mar 17.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, S-5-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s12561-015-9128-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596911PMC
March 2015

Combining information from linkage and association mapping for next-generation sequencing longitudinal family data.

BMC Proc 2014 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S34. Epub 2014 Jun 17.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.

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http://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-
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http://dx.doi.org/10.1186/1753-6561-8-S1-S34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143620PMC
December 2014

Gene analysis for longitudinal family data using random-effects models.

BMC Proc 2014 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S88. Epub 2014 Jun 17.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1753-6561-8-S1-S88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143685PMC
December 2014

Defining the role of common variation in the genomic and biological architecture of adult human height.

Authors:
Andrew R Wood Tonu Esko Jian Yang Sailaja Vedantam Tune H Pers Stefan Gustafsson Audrey Y Chu Karol Estrada Jian'an Luan Zoltán Kutalik Najaf Amin Martin L Buchkovich Damien C Croteau-Chonka Felix R Day Yanan Duan Tove Fall Rudolf Fehrmann Teresa Ferreira Anne U Jackson Juha Karjalainen Ken Sin Lo Adam E Locke Reedik Mägi Evelin Mihailov Eleonora Porcu Joshua C Randall André Scherag Anna A E Vinkhuyzen Harm-Jan Westra Thomas W Winkler Tsegaselassie Workalemahu Jing Hua Zhao Devin Absher Eva Albrecht Denise Anderson Jeffrey Baron Marian Beekman Ayse Demirkan Georg B Ehret Bjarke Feenstra Mary F Feitosa Krista Fischer Ross M Fraser Anuj Goel Jian Gong Anne E Justice Stavroula Kanoni Marcus E Kleber Kati Kristiansson Unhee Lim Vaneet Lotay Julian C Lui Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Michael A Nalls Dale R Nyholt Cameron D Palmer Dorota Pasko Sonali Pechlivanis Inga Prokopenko Janina S Ried Stephan Ripke Dmitry Shungin Alena Stancáková Rona J Strawbridge Yun Ju Sung Toshiko Tanaka Alexander Teumer Stella Trompet Sander W van der Laan Jessica van Setten Jana V Van Vliet-Ostaptchouk Zhaoming Wang Loïc Yengo Weihua Zhang Uzma Afzal Johan Arnlöv Gillian M Arscott Stefania Bandinelli Amy Barrett Claire Bellis Amanda J Bennett Christian Berne Matthias Blüher Jennifer L Bolton Yvonne Böttcher Heather A Boyd Marcel Bruinenberg Brendan M Buckley Steven Buyske Ida H Caspersen Peter S Chines Robert Clarke Simone Claudi-Boehm Matthew Cooper E Warwick Daw Pim A De Jong Joris Deelen Graciela Delgado Josh C Denny Rosalie Dhonukshe-Rutten Maria Dimitriou Alex S F Doney Marcus Dörr Niina Eklund Elodie Eury Lasse Folkersen Melissa E Garcia Frank Geller Vilmantas Giedraitis Alan S Go Harald Grallert Tanja B Grammer Jürgen Gräßler Henrik Grönberg Lisette C P G M de Groot Christopher J Groves Jeffrey Haessler Per Hall Toomas Haller Goran Hallmans Anke Hannemann Catharina A Hartman Maija Hassinen Caroline Hayward Nancy L Heard-Costa Quinta Helmer Gibran Hemani Anjali K Henders Hans L Hillege Mark A Hlatky Wolfgang Hoffmann Per Hoffmann Oddgeir Holmen Jeanine J Houwing-Duistermaat Thomas Illig Aaron Isaacs Alan L James Janina Jeff Berit Johansen Åsa Johansson Jennifer Jolley Thorhildur Juliusdottir Juhani Junttila Abel N Kho Leena Kinnunen Norman Klopp Thomas Kocher Wolfgang Kratzer Peter Lichtner Lars Lind Jaana Lindström Stéphane Lobbens Mattias Lorentzon Yingchang Lu Valeriya Lyssenko Patrik K E Magnusson Anubha Mahajan Marc Maillard Wendy L McArdle Colin A McKenzie Stela McLachlan Paul J McLaren Cristina Menni Sigrun Merger Lili Milani Alireza Moayyeri Keri L Monda Mario A Morken Gabriele Müller Martina Müller-Nurasyid Arthur W Musk Narisu Narisu Matthias Nauck Ilja M Nolte Markus M Nöthen Laticia Oozageer Stefan Pilz Nigel W Rayner Frida Renstrom Neil R Robertson Lynda M Rose Ronan Roussel Serena Sanna Hubert Scharnagl Salome Scholtens Fredrick R Schumacher Heribert Schunkert Robert A Scott Joban Sehmi Thomas Seufferlein Jianxin Shi Karri Silventoinen Johannes H Smit Albert Vernon Smith Joanna Smolonska Alice V Stanton Kathleen Stirrups David J Stott Heather M Stringham Johan Sundström Morris A Swertz Ann-Christine Syvänen Bamidele O Tayo Gudmar Thorleifsson Jonathan P Tyrer Suzanne van Dijk Natasja M van Schoor Nathalie van der Velde Diana van Heemst Floor V A van Oort Sita H Vermeulen Niek Verweij Judith M Vonk Lindsay L Waite Melanie Waldenberger Roman Wennauer Lynne R Wilkens Christina Willenborg Tom Wilsgaard Mary K Wojczynski Andrew Wong Alan F Wright Qunyuan Zhang Dominique Arveiler Stephan J L Bakker John Beilby Richard N Bergman Sven Bergmann Reiner Biffar John Blangero Dorret I Boomsma Stefan R Bornstein Pascal Bovet Paolo Brambilla Morris J Brown Harry Campbell Mark J Caulfield Aravinda Chakravarti Rory Collins Francis S Collins Dana C Crawford L Adrienne Cupples John Danesh Ulf de Faire Hester M den Ruijter Raimund Erbel Jeanette Erdmann Johan G Eriksson Martin Farrall Ele Ferrannini Jean Ferrières Ian Ford Nita G Forouhi Terrence Forrester Ron T Gansevoort Pablo V Gejman Christian Gieger Alain Golay Omri Gottesman Vilmundur Gudnason Ulf Gyllensten David W Haas Alistair S Hall Tamara B Harris Andrew T Hattersley Andrew C Heath Christian Hengstenberg Andrew A Hicks Lucia A Hindorff Aroon D Hingorani Albert Hofman G Kees Hovingh Steve E Humphries Steven C Hunt Elina Hypponen Kevin B Jacobs Marjo-Riitta Jarvelin Pekka Jousilahti Antti M Jula Jaakko Kaprio John J P Kastelein Manfred Kayser Frank Kee Sirkka M Keinanen-Kiukaanniemi Lambertus A Kiemeney Jaspal S Kooner Charles Kooperberg Seppo Koskinen Peter Kovacs Aldi T Kraja Meena Kumari Johanna Kuusisto Timo A Lakka Claudia Langenberg Loic Le Marchand Terho Lehtimäki Sara Lupoli Pamela A F Madden Satu Männistö Paolo Manunta André Marette Tara C Matise Barbara McKnight Thomas Meitinger Frans L Moll Grant W Montgomery Andrew D Morris Andrew P Morris Jeffrey C Murray Mari Nelis Claes Ohlsson Albertine J Oldehinkel Ken K Ong Willem H Ouwehand Gerard Pasterkamp Annette Peters Peter P Pramstaller Jackie F Price Lu Qi Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Marylyn Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Peter E H Schwarz Sylvain Sebert Peter Sever Alan R Shuldiner Juha Sinisalo Valgerdur Steinthorsdottir Ronald P Stolk Jean-Claude Tardif Anke Tönjes Angelo Tremblay Elena Tremoli Jarmo Virtamo Marie-Claude Vohl Philippe Amouyel Folkert W Asselbergs Themistocles L Assimes Murielle Bochud Bernhard O Boehm Eric Boerwinkle Erwin P Bottinger Claude Bouchard Stéphane Cauchi John C Chambers Stephen J Chanock Richard S Cooper Paul I W de Bakker George Dedoussis Luigi Ferrucci Paul W Franks Philippe Froguel Leif C Groop Christopher A Haiman Anders Hamsten M Geoffrey Hayes Jennie Hui David J Hunter Kristian Hveem J Wouter Jukema Robert C Kaplan Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Nicholas G Martin Winfried März Mads Melbye Susanne Moebus Patricia B Munroe Inger Njølstad Ben A Oostra Colin N A Palmer Nancy L Pedersen Markus Perola Louis Pérusse Ulrike Peters Joseph E Powell Chris Power Thomas Quertermous Rainer Rauramaa Eva Reinmaa Paul M Ridker Fernando Rivadeneira Jerome I Rotter Timo E Saaristo Danish Saleheen David Schlessinger P Eline Slagboom Harold Snieder Tim D Spector Konstantin Strauch Michael Stumvoll Jaakko Tuomilehto Matti Uusitupa Pim van der Harst Henry Völzke Mark Walker Nicholas J Wareham Hugh Watkins H-Erich Wichmann James F Wilson Pieter Zanen Panos Deloukas Iris M Heid Cecilia M Lindgren Karen L Mohlke Elizabeth K Speliotes Unnur Thorsteinsdottir Inês Barroso Caroline S Fox Kari E North David P Strachan Jacques S Beckmann Sonja I Berndt Michael Boehnke Ingrid B Borecki Mark I McCarthy Andres Metspalu Kari Stefansson André G Uitterlinden Cornelia M van Duijn Lude Franke Cristen J Willer Alkes L Price Guillaume Lettre Ruth J F Loos Michael N Weedon Erik Ingelsson Jeffrey R O'Connell Goncalo R Abecasis Daniel I Chasman Michael E Goddard Peter M Visscher Joel N Hirschhorn Timothy M Frayling

Nat Genet 2014 Nov 5;46(11):1173-86. Epub 2014 Oct 5.

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

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http://kooperberg.fhcrc.org/papers/2014wood.pdf
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http://www.nature.com/doifinder/10.1038/ng.3097
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http://dx.doi.org/10.1038/ng.3097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250049PMC
November 2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Hum Mol Genet 2014 Aug 31;23(16):4420-32. Epub 2014 Mar 31.

Department of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing,

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http://dx.doi.org/10.1093/hmg/ddu139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103672PMC
August 2014

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers.

Int J Epidemiol 2014 Jun 14;43(3):878-86. Epub 2014 Jan 14.

Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, The Netherlands, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Estonian Genome Center, University of Tartu, Tartu, Estonia, Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands and Department of Medical Statistics, Leiden University Medical Center, Leiden, The NetherlandsDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, The Netherlands, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Estonian Genome Center, University of Tartu, Tartu, Estonia, Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands and Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.

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https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/
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http://dx.doi.org/10.1093/ije/dyt267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052133PMC
June 2014

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

Authors:
Eleonora Porcu Marco Medici Giorgio Pistis Claudia B Volpato Scott G Wilson Anne R Cappola Steffan D Bos Joris Deelen Martin den Heijer Rachel M Freathy Jari Lahti Chunyu Liu Lorna M Lopez Ilja M Nolte Jeffrey R O'Connell Toshiko Tanaka Stella Trompet Alice Arnold Stefania Bandinelli Marian Beekman Stefan Böhringer Suzanne J Brown Brendan M Buckley Clara Camaschella Anton J M de Craen Gail Davies Marieke C H de Visser Ian Ford Tom Forsen Timothy M Frayling Laura Fugazzola Martin Gögele Andrew T Hattersley Ad R Hermus Albert Hofman Jeanine J Houwing-Duistermaat Richard A Jensen Eero Kajantie Margreet Kloppenburg Ee M Lim Corrado Masciullo Stefano Mariotti Cosetta Minelli Braxton D Mitchell Ramaiah Nagaraja Romana T Netea-Maier Aarno Palotie Luca Persani Maria G Piras Bruce M Psaty Katri Räikkönen J Brent Richards Fernando Rivadeneira Cinzia Sala Mona M Sabra Naveed Sattar Beverley M Shields Nicole Soranzo John M Starr David J Stott Fred C G J Sweep Gianluca Usala Melanie M van der Klauw Diana van Heemst Alies van Mullem Sita H Vermeulen W Edward Visser John P Walsh Rudi G J Westendorp Elisabeth Widen Guangju Zhai Francesco Cucca Ian J Deary Johan G Eriksson Luigi Ferrucci Caroline S Fox J Wouter Jukema Lambertus A Kiemeney Peter P Pramstaller David Schlessinger Alan R Shuldiner Eline P Slagboom André G Uitterlinden Bijay Vaidya Theo J Visser Bruce H R Wolffenbuttel Ingrid Meulenbelt Jerome I Rotter Tim D Spector Andrew A Hicks Daniela Toniolo Serena Sanna Robin P Peeters Silvia Naitza

PLoS Genet 2013 7;9(2):e1003266. Epub 2013 Feb 7.

Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy.

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http://dx.doi.org/10.1371/journal.pgen.1003266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567175PMC
June 2013

Identification of seven loci affecting mean telomere length and their association with disease.

Authors:
Veryan Codd Christopher P Nelson Eva Albrecht Massimo Mangino Joris Deelen Jessica L Buxton Jouke Jan Hottenga Krista Fischer Tõnu Esko Ida Surakka Linda Broer Dale R Nyholt Irene Mateo Leach Perttu Salo Sara Hägg Mary K Matthews Jutta Palmen Giuseppe D Norata Paul F O'Reilly Danish Saleheen Najaf Amin Anthony J Balmforth Marian Beekman Rudolf A de Boer Stefan Böhringer Peter S Braund Paul R Burton Anton J M de Craen Matthew Denniff Yanbin Dong Konstantinos Douroudis Elena Dubinina Johan G Eriksson Katia Garlaschelli Dehuang Guo Anna-Liisa Hartikainen Anjali K Henders Jeanine J Houwing-Duistermaat Laura Kananen Lennart C Karssen Johannes Kettunen Norman Klopp Vasiliki Lagou Elisabeth M van Leeuwen Pamela A Madden Reedik Mägi Patrik K E Magnusson Satu Männistö Mark I McCarthy Sarah E Medland Evelin Mihailov Grant W Montgomery Ben A Oostra Aarno Palotie Annette Peters Helen Pollard Anneli Pouta Inga Prokopenko Samuli Ripatti Veikko Salomaa H Eka D Suchiman Ana M Valdes Niek Verweij Ana Viñuela Xiaoling Wang H-Erich Wichmann Elisabeth Widen Gonneke Willemsen Margaret J Wright Kai Xia Xiangjun Xiao Dirk J van Veldhuisen Alberico L Catapano Martin D Tobin Alistair S Hall Alexandra I F Blakemore Wiek H van Gilst Haidong Zhu Jeanette Erdmann Muredach P Reilly Sekar Kathiresan Heribert Schunkert Philippa J Talmud Nancy L Pedersen Markus Perola Willem Ouwehand Jaakko Kaprio Nicholas G Martin Cornelia M van Duijn Iiris Hovatta Christian Gieger Andres Metspalu Dorret I Boomsma Marjo-Riitta Jarvelin P Eline Slagboom John R Thompson Tim D Spector Pim van der Harst Nilesh J Samani

Nat Genet 2013 Apr;45(4):422-7, 427e1-2

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

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http://www.ideal-ageing.eu/uploads/publicaties/2013_codd_nat
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http://www.nature.com/doifinder/10.1038/ng.2528
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http://dx.doi.org/10.1038/ng.2528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006270PMC
April 2013

Clustering of child mortality in a contemporary polygamous population in Africa.

Biodemography Soc Biol 2012 ;58(2):162-72

Leyden Academy on Vitality and Ageing, Leiden, The Netherlands.

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http://dx.doi.org/10.1080/19485565.2012.720445DOI Listing
March 2013

Combining family and twin data in association studies to estimate the noninherited maternal antigens effect.

Genet Epidemiol 2012 Dec 31;36(8):811-9. Epub 2012 Jul 31.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/gepi.21667
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http://dx.doi.org/10.1002/gepi.21667DOI Listing
December 2012

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

Lancet 2012 Sep 3;380(9844):815-23. Epub 2012 Jul 3.

Wellcome Trust Sanger Institute, Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://linkinghub.elsevier.com/retrieve/pii/S014067361260681
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http://dx.doi.org/10.1016/S0140-6736(12)60681-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443899PMC
September 2012

A two-stage mixed-effects model approach for gene-set analyses in candidate gene studies.

Stat Med 2012 May 14;31(11-12):1190-202. Epub 2011 Oct 14.

Department of Medical Statistics and BioInformatics, Leiden University Medical Center, Postzone S5-P, PO Box 9600, 2300, RC, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/sim.4370DOI Listing
May 2012

Dealing with high dimensionality for the identification of common and rare variants as main effects and for gene-environment interaction.

Genet Epidemiol 2011 ;35 Suppl 1:S35-40

Department of Genetic Epidemiology, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1002/gepi.20647DOI Listing
May 2012

Does pathway analysis make it easier for common variants to tag rare ones?

BMC Proc 2011 Nov 29;5 Suppl 9:S90. Epub 2011 Nov 29.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1753-6561-5-S9-S90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287932PMC
November 2011

Pathway analysis for family data using nested random-effects models.

BMC Proc 2011 Nov 29;5 Suppl 9:S22. Epub 2011 Nov 29.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1753-6561-5-S9-S22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287857PMC
November 2011

Lipid metabolism in long-lived families: the Leiden Longevity Study.

Age (Dordr) 2011 Jun 3;33(2):219-27. Epub 2010 Sep 3.

Molecular Epidemiology Section, Department Medical Statistics and Bioinformatics, Leiden University Medical Centre, RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11357-010-9172-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127468PMC
June 2011

Polymorphisms in PARP, IL1B, IL4, IL10, C1INH, DEFB1, and DEFA4 in meningococcal disease in three populations.

Shock 2010 Jul;34(1):17-22

Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, University Medical Center, Dr Molewaterplein 60, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0b013e3181ce2c7dDOI Listing
July 2010

Testing for genetic association in the presence of linkage and gene-covariate interactions.

Biom J 2010 Feb;52(1):22-33

Department of Medical Statistics and Bioinformatics, Leiden University MC, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/bimj.200900057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410551PMC
February 2010

Model selection based on logistic regression in a highly correlated candidate gene region.

BMC Proc 2007 18;1 Suppl 1:S114. Epub 2007 Dec 18.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367469PMC
http://dx.doi.org/10.1186/1753-6561-1-s1-s114DOI Listing
December 2009

A new score statistic to test for association given linkage in affected sibling pair-control designs.

BMC Proc 2007 18;1 Suppl 1:S39. Epub 2007 Dec 18.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Postzone S-5-P, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367608PMC
http://dx.doi.org/10.1186/1753-6561-1-S1-S39DOI Listing
December 2009

Testing for genetic association taking into account phenotypic information of relatives.

BMC Proc 2009 Dec 15;3 Suppl 7:S123. Epub 2009 Dec 15.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, PO Box 9600, Leiden 2300RC, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795896PMC
http://dx.doi.org/10.1186/1753-6561-3-s7-s123DOI Listing
December 2009

Integration of gene ontology pathways with North American Rheumatoid Arthritis Consortium genome-wide association data via linear modeling.

BMC Proc 2009 Dec 15;3 Suppl 7:S94. Epub 2009 Dec 15.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, P,O, Box 9604, 2300 RC Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795998PMC
http://dx.doi.org/10.1186/1753-6561-3-s7-s94DOI Listing
December 2009

New score tests for age-at-onset linkage analysis in general pedigrees.

BMC Proc 2009 Dec 15;3 Suppl 7:S97. Epub 2009 Dec 15.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands Medical Center, PO Box 9600, 2300RC Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796001PMC
http://dx.doi.org/10.1186/1753-6561-3-s7-s97DOI Listing
December 2009

Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort.

Cancer Epidemiol Biomarkers Prev 2009 Nov 20;18(11):3062-7. Epub 2009 Oct 20.

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-0601DOI Listing
November 2009

Assessment of global phase uncertainty in case-control studies.

BMC Genet 2009 Sep 14;10:54. Epub 2009 Sep 14.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1471-2156-10-54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760579PMC
September 2009

IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

BMC Med Genet 2009 Mar 9;10:23. Epub 2009 Mar 9.

Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1186/1471-2350-10-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660301PMC
March 2009

Global tests for linkage.

Biom J 2009 Feb;51(1):70-83

Biometrics department, GCI, Organon, BH Oss, The Netherlands.

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http://dx.doi.org/10.1002/bimj.200810492DOI Listing
February 2009

Evaluation of regression methods when immunological measurements are constrained by detection limits.

BMC Immunol 2008 Oct 17;9:59. Epub 2008 Oct 17.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1186/1471-2172-9-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592244PMC
October 2008

Influence of genotyping error in linkage mapping for complex traits--an analytic study.

BMC Genet 2008 Aug 25;9:57. Epub 2008 Aug 25.

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Postzone S-05-P, PO Box 9600 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1471-2156-9-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533351PMC
August 2008