Jeanette Erdmann

Jeanette Erdmann

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Jeanette Erdmann

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CARDIoGRAM celebrates its 10th Anniversary.

Eur Heart J 2019 Jun;40(21):1664-1666

Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK and National Institute for Health Research Leicester Cardiovascular Biomedical Research Centre, Leicester LE3 9QP, UK.

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http://dx.doi.org/10.1093/eurheartj/ehz347DOI Listing
June 2019

Genetically modulated educational attainment and coronary disease risk.

Eur Heart J 2019 Jun 6. Epub 2019 Jun 6.

Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Lazarettstr. 36, 80636 Munich, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehz328DOI Listing
June 2019

miRNAs and regulation of cardiometabolic phenotypes - novel insights into the complexity of GWAS loci.

Cardiovasc Res 2019 May 14. Epub 2019 May 14.

Institute for Cardiogenetics and University Heart Center Luebeck, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1093/cvr/cvz120DOI Listing
May 2019

Differentiation of human iPSCs into VSMCs and generation of VSMC-derived calcifying vascular cells.

Stem Cell Res 2018 08 17;31:62-70. Epub 2018 Jul 17.

Institute for Cardiogenetics, University of Luebeck, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Luebeck, Germany; University Heart Centre Luebeck, 23562 Luebeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.07.008DOI Listing
August 2018

A decade of genome-wide association studies for coronary artery disease: the challenges ahead.

Cardiovasc Res 2018 07;114(9):1241-1257

Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Lazarettstraβe 36, Munich, Germany.

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http://dx.doi.org/10.1093/cvr/cvy084DOI Listing
July 2018

Genome-Wide Association and Functional Studies Identify and as Novel Susceptibility Genes for Coronary Artery Disease.

Arterioscler Thromb Vasc Biol 2018 04 22;38(4):964-975. Epub 2018 Feb 22.

From the Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China (Y.L., J.G., K.X., C.S., F.Y., B.Z., H.Y., W.-J.W., C.W., J.D., G.Z., X.-L.T.); Beijing Anzhen Hospital (Y.L.), Department of Cardiology, Beijing Anzhen Hospital (Y.Y., C.W.), and Department of Cardiology, Beijing Chaoyang Hospital (F.J.), Capital Medical University, China; Beijing Institute of Heart, Lung, and Blood Vessel Disease, China (Y.L.); Department of Internal Medicine, Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (D.W.W., H.D., S.T.); Department of Cardiology, The General Hospital of Chinese People's Liberation Army, Beijing, China (Y.C., Z.S.); Cardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China (C.C., S.H., J.Z., Y.M., W.C., J.S., W.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing (S.Z., X.L., X.Y., D.G.); Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, China (L.Z.); Department of Internal Medicine, Hospital of Peking University, Beijing, China (Y.C.); Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, China (L.J.); Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, China (G.L.); Cardiovascular Department, Ningbo First Hospital, Ningbo University, China (H.C., S.W.); Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Germany (J.E.); German Research Centre for Cardiovascular Research, Partner Site Hamburg/Lübeck/Kiel (J.E.); Deutsches Herzzentrum München, Technische Universität München, Germany (L.Z., H.S.); German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance (L.Z., H.S.); Department of Human Population Genetics, Human Aging Research Institute and School of Life Science, Nanchang University, China (S.C., X.-L.T.); and Institute of Medical Systems Biology (S.R.) and School of Public Health (S.R.), Guangdong Medical University, Dongguan, China.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.117.310594
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http://dx.doi.org/10.1161/ATVBAHA.117.310594DOI Listing
April 2018

Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation.

Sci Rep 2018 Apr 11;8(1):5812. Epub 2018 Apr 11.

Institute for Cardiogenetics, Universität zu Lübeck; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany, University Heart Centre Lübeck, 23562, Lübeck, Germany.

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http://dx.doi.org/10.1038/s41598-018-24228-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895639PMC
April 2018

Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study.

BMC Med Genet 2017 11 13;18(1):128. Epub 2017 Nov 13.

Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box: 102, Khartoum, Sudan.

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
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http://dx.doi.org/10.1186/s12881-017-0491-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683550PMC
November 2017

Coronary artery disease associated gene Phactr1 modulates severity of vascular calcification in vitro.

Biochem Biophys Res Commun 2017 09 15;491(2):396-402. Epub 2017 Jul 15.

Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kie, University Heart Center Luebeck, 23562 Lübeck, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2017.07.090DOI Listing
September 2017

Functional Characterization of the Coronary Artery Disease Risk Locus.

Circulation 2017 Aug 9;136(5):476-489. Epub 2017 May 9.

From Deutsches Herzzentrum München, Klinik für Herz-und Kreislauferkrankungen, Technische Universität München, Munich, Germany (T.K., J.W., B.W., B.V., S.V.A., T.A.D., H.B.S., P.M.R., A.K., H.S.); Sektion für Funktionelle Genetik am Institut für Humangenetik, Universität zu Lübeck, Germany (J. Eckhold, R.H., F.J.K.); Center for Public Health Genomics, Department of Biomedical Engineering, University of Virginia, Charlottesville (R.A., M.C.); DZHK e.V. (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany (A.K., H.S.); Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (J.L.M.B.); Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia (J.L.M.B.); Institut für Integrative und Experimentelle Genomik and Universitäres Herzzentrum Lübeck, Universität zu Lübeck, Germany (J. Erdmann); DZHK e.V. (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany (J. Erdmann, F.J.K.); and Departments of Human Genetics and Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.J.L., M.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560301PMC
August 2017

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

Nat Genet 2017 Jul 22;49(7):1113-1119. Epub 2017 May 22.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555387PMC
July 2017

Genome-wide association study in takotsubo syndrome - Preliminary results and future directions.

Int J Cardiol 2017 Jun 15;236:335-339. Epub 2017 Jan 15.

University Heart Center of Lübeck, Medical Clinic II, Department of Cardiology, Angiology, Intensive Care Medicine, Lübeck, Germany; German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany; Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1016/j.ijcard.2017.01.093DOI Listing
June 2017

Loss of Cardioprotective Effects at the Locus as a Result of Gene-Smoking Interactions.

Circulation 2017 Jun 1;135(24):2336-2353. Epub 2017 May 1.

From Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (D.S., W.Z.); Center for Non-Communicable Diseases, Karachi, Pakistan (D.S., A.R., P.M.F., PROMIS); Department of Public Health and Primary Care, University of Cambridge, United Kingdom (R.Y., W.K.H., EPIC-CVD); Department of Cardiovascular Sciences, University of Leicester, United Kingdom (C.P.N., N.J.S.); Cardiology Division, Department of Medicine, Vanderbilt University, Nashville, TN (J.F.F., K.O.); Division of Cardiovascular Medicine, Radcliffe Department of Medicine & Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom (A.G., M.F.); The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY (R.D.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (R.D.); Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Canada (A.F.R.S., R.M.); Institute for Genetic Medicine and Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles (J.H., H.A.); Department of Epidemiology and Biostatistics, Imperial College London, United Kingdom (W.Z., J.C.C., J.K.); Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, United Kingdom (W.Z., J.C.C.); Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S.); Helsinki University Central Hospital HUCH Heart and Lung Center, Helsinki, Uusimaa, Finland (J.S.); Cardiology Division, Department of Medicine and the Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY (R.C.B., M.P.R.); William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.K., E.M., P.D.); Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands (S.S., A.D.); Department of Dietetics-Nutrition, Harokopio University, Athens, Greece (E.M., G.D.); National Institute for Health and Welfare, Helsinki, Finland (K.K., A.J., V.S., K.K., M.P.); MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, United Kingdom (J.H.Z., R.S.); INSERM, UMRS1138, Centre de Recherche des Cordeliers, Paris, France (D.G., N.W.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.H.S.); Icelandic Heart Association, Kopavogur, Iceland (A.V.S., V.G.); Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (N.v.Z., C.N.A.P.); Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC (A.J.C., D.W.B.); Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Germany (C.W., J.E.); DZHK (German Research Center for Cardiovascular Research) partner site Hamburg-Lübeck-Kiel, Germany (C.W., J.E.); Deutsches Herzzentrum München, Technische Universität München, Germany (T.K., L.Z., H.S.); Klinikum rechts der Isar, München, Germany (T.K.); DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Germany (L.Z., H.S.); Department of Genetics, Washington University School of Medicine, St. Louis, MO (M.A.P., M.F.F.); Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston (A.G.); Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (A.G.); Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Sweden (L.L.); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (N.L.P.); Department of Biostatistics Boston University School of Public Health Framingham Heart Study, MA (C.C.W.); Faculty of Medicine, University of Iceland, Reykjavik (A.V.S., V.G.); University of Helsinki, Institute for Molecular Medicine, Finland (FIMM) (A.J., M.P.); Department of Medicine, Mannheim Medical Faculty, Heidelberg University, Germany (M.E.K.); Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom (A.S.H.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany and Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria (W.M.); National Heart, Lung, and Blood Institute and the Framingham Heart Study, National Institutes of Health, Bethesda, MD (C.O'D.); Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Sweden (E.I.); Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, CA (E.I.); Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (U.D.F.); Lebanese American University, School of Medicine, Beirut (P.Z.); Department of Health Sciences, University of Leicester, United Kingdom (J.R.T.); Imperial College Healthcare NHS Trust, London, United Kingdom (J.C.C., J.K.); Cardiovascular Science, National Heart and Lung Institute, Imperial College London, United Kingdom (J.K.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia (P.D.); deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland (G.T., K.S.); University of Iceland, School of Medicine, Reykjavik, Iceland (G.T., K.S.); Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge (S.K.); Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.K.); Center for Human Genetic Research, Massachusetts General Hospital, Boston (S.K.); Department of Medicine, Harvard Medical School, Boston, MA (S.K.); Department of Genetics, University of Pennsylvania, Philadelphia (D.J.R.); and Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (S.T.N., D.J.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612779PMC
June 2017

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

J Am Coll Cardiol 2017 Apr 3;69(16):2054-2063. Epub 2017 Apr 3.

Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404817PMC
April 2017

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

Authors:
Thomas R Webb Jeanette Erdmann Kathleen E Stirrups Nathan O Stitziel Nicholas G D Masca Henning Jansen Stavroula Kanoni Christopher P Nelson Paola G Ferrario Inke R König John D Eicher Andrew D Johnson Stephen E Hamby Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Peter E Weeke Paul L Auer Ursula M Schick Yingchang Lu He Zhang Marie-Pierre Dube Anuj Goel Martin Farrall Gina M Peloso Hong-Hee Won Ron Do Erik van Iperen Jochen Kruppa Anubha Mahajan Robert A Scott Christina Willenborg Peter S Braund Julian C van Capelleveen Alex S F Doney Louise A Donnelly Rosanna Asselta Pier A Merlini Stefano Duga Nicola Marziliano Josh C Denny Christian Shaffer Nour Eddine El-Mokhtari Andre Franke Stefanie Heilmann Christian Hengstenberg Per Hoffmann Oddgeir L Holmen Kristian Hveem Jan-Håkan Jansson Karl-Heinz Jöckel Thorsten Kessler Jennifer Kriebel Karl L Laugwitz Eirini Marouli Nicola Martinelli Mark I McCarthy Natalie R Van Zuydam Christa Meisinger Tõnu Esko Evelin Mihailov Stefan A Escher Maris Alver Susanne Moebus Andrew D Morris Jarma Virtamo Majid Nikpay Oliviero Olivieri Sylvie Provost Alaa AlQarawi Neil R Robertson Karen O Akinsansya Dermot F Reilly Thomas F Vogt Wu Yin Folkert W Asselbergs Charles Kooperberg Rebecca D Jackson Eli Stahl Martina Müller-Nurasyid Konstantin Strauch Tibor V Varga Melanie Waldenberger Lingyao Zeng Rajiv Chowdhury Veikko Salomaa Ian Ford J Wouter Jukema Philippe Amouyel Jukka Kontto Børge G Nordestgaard Jean Ferrières Danish Saleheen Naveed Sattar Praveen Surendran Aline Wagner Robin Young Joanna M M Howson Adam S Butterworth John Danesh Diego Ardissino Erwin P Bottinger Raimund Erbel Paul W Franks Domenico Girelli Alistair S Hall G Kees Hovingh Adnan Kastrati Wolfgang Lieb Thomas Meitinger William E Kraus Svati H Shah Ruth McPherson Marju Orho-Melander Olle Melander Andres Metspalu Colin N A Palmer Annette Peters Daniel J Rader Muredach P Reilly Ruth J F Loos Alex P Reiner Dan M Roden Jean-Claude Tardif John R Thompson Nicholas J Wareham Hugh Watkins Cristen J Willer Nilesh J Samani Heribert Schunkert Panos Deloukas Sekar Kathiresan

J Am Coll Cardiol 2017 Feb;69(7):823-836

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2016.11.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314135PMC
February 2017

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Authors:
Georg B Ehret Teresa Ferreira Daniel I Chasman Anne U Jackson Ellen M Schmidt Toby Johnson Gudmar Thorleifsson Jian'an Luan Lousie A Donnelly Stavroula Kanoni Ann-Kristin Petersen Vasyl Pihur Rona J Strawbridge Dmitry Shungin Maria F Hughes Osorio Meirelles Marika Kaakinen Nabila Bouatia-Naji Kati Kristiansson Sonia Shah Marcus E Kleber Xiuqing Guo Leo-Pekka Lyytikäinen Cristiano Fava Niclas Eriksson Ilja M Nolte Patrik K Magnusson Elias L Salfati Loukianos S Rallidis Elizabeth Theusch Andrew J P Smith Lasse Folkersen Kate Witkowska Tune H Pers Roby Joehanes Stuart K Kim Lazaros Lataniotis Rick Jansen Andrew D Johnson Helen Warren Young Jin Kim Wei Zhao Ying Wu Bamidele O Tayo Murielle Bochud Devin Absher Linda S Adair Najaf Amin Dan E Arking Tomas Axelsson Damiano Baldassarre Beverley Balkau Stefania Bandinelli Michael R Barnes Inês Barroso Stephen Bevan Joshua C Bis Gyda Bjornsdottir Michael Boehnke Eric Boerwinkle Lori L Bonnycastle Dorret I Boomsma Stefan R Bornstein Morris J Brown Michel Burnier Claudia P Cabrera John C Chambers I-Shou Chang Ching-Yu Cheng Peter S Chines Ren-Hua Chung Francis S Collins John M Connell Angela Döring Jean Dallongeville John Danesh Ulf de Faire Graciela Delgado Anna F Dominiczak Alex S F Doney Fotios Drenos Sarah Edkins John D Eicher Roberto Elosua Stefan Enroth Jeanette Erdmann Per Eriksson Tonu Esko Evangelos Evangelou Alun Evans Tove Fall Martin Farrall Janine F Felix Jean Ferrières Luigi Ferrucci Myriam Fornage Terrence Forrester Nora Franceschini Oscar H Franco Duran Anders Franco-Cereceda Ross M Fraser Santhi K Ganesh He Gao Karl Gertow Francesco Gianfagna Bruna Gigante Franco Giulianini Anuj Goel Alison H Goodall Mark O Goodarzi Mathias Gorski Jürgen Gräßler Christopher Groves Vilmundur Gudnason Ulf Gyllensten Göran Hallmans Anna-Liisa Hartikainen Maija Hassinen Aki S Havulinna Caroline Hayward Serge Hercberg Karl-Heinz Herzig Andrew A Hicks Aroon D Hingorani Joel N Hirschhorn Albert Hofman Jostein Holmen Oddgeir Lingaas Holmen Jouke-Jan Hottenga Phil Howard Chao A Hsiung Steven C Hunt M Arfan Ikram Thomas Illig Carlos Iribarren Richard A Jensen Mika Kähönen Hyun Kang Sekar Kathiresan Brendan J Keating Kay-Tee Khaw Yun Kyoung Kim Eric Kim Mika Kivimaki Norman Klopp Genovefa Kolovou Pirjo Komulainen Jaspal S Kooner Gulum Kosova Ronald M Krauss Diana Kuh Zoltan Kutalik Johanna Kuusisto Kirsti Kvaløy Timo A Lakka Nanette R Lee I-Te Lee Wen-Jane Lee Daniel Levy Xiaohui Li Kae-Woei Liang Honghuang Lin Li Lin Jaana Lindström Stéphane Lobbens Satu Männistö Gabriele Müller Martina Müller-Nurasyid François Mach Hugh S Markus Eirini Marouli Mark I McCarthy Colin A McKenzie Pierre Meneton Cristina Menni Andres Metspalu Vladan Mijatovic Leena Moilanen May E Montasser Andrew D Morris Alanna C Morrison Antonella Mulas Ramaiah Nagaraja Narisu Narisu Kjell Nikus Christopher J O'Donnell Paul F O'Reilly Ken K Ong Fred Paccaud Cameron D Palmer Afshin Parsa Nancy L Pedersen Brenda W Penninx Markus Perola Annette Peters Neil Poulter Peter P Pramstaller Bruce M Psaty Thomas Quertermous Dabeeru C Rao Asif Rasheed N William N W R Rayner Frida Renström Rainer Rettig Kenneth M Rice Robert Roberts Lynda M Rose Jacques Rossouw Nilesh J Samani Serena Sanna Jouko Saramies Heribert Schunkert Sylvain Sebert Wayne H-H Sheu Young-Ah Shin Xueling Sim Johannes H Smit Albert V Smith Maria X Sosa Tim D Spector Alena Stančáková Alice Stanton Kathleen E Stirrups Heather M Stringham Johan Sundstrom Amy J Swift Ann-Christine Syvänen E-Shyong Tai Toshiko Tanaka Kirill V Tarasov Alexander Teumer Unnur Thorsteinsdottir Martin D Tobin Elena Tremoli Andre G Uitterlinden Matti Uusitupa Ahmad Vaez Dhananjay Vaidya Cornelia M van Duijn Erik P A van Iperen Ramachandran S Vasan Germaine C Verwoert Jarmo Virtamo Veronique Vitart Benjamin F Voight Peter Vollenweider Aline Wagner Louise V Wain Nicholas J Wareham Hugh Watkins Alan B Weder Harm-Jan Westra Rainford Wilks Tom Wilsgaard James F Wilson Tien Y Wong Tsun-Po Yang Jie Yao Loic Yengo Weihua Zhang Jing Hua Zhao Xiaofeng Zhu Pascal Bovet Richard S Cooper Karen L Mohlke Danish Saleheen Jong-Young Lee Paul Elliott Hinco J Gierman Cristen J Willer Lude Franke G Kees Hovingh Kent D Taylor George Dedoussis Peter Sever Andrew Wong Lars Lind Themistocles L Assimes Inger Njølstad Peter Eh Schwarz Claudia Langenberg Harold Snieder Mark J Caulfield Olle Melander Markku Laakso Juha Saltevo Rainer Rauramaa Jaakko Tuomilehto Erik Ingelsson Terho Lehtimäki Kristian Hveem Walter Palmas Winfried März Meena Kumari Veikko Salomaa Yii-Der I Chen Jerome I Rotter Philippe Froguel Marjo-Riitta Jarvelin Edward G Lakatta Kari Kuulasmaa Paul W Franks Anders Hamsten H-Erich Wichmann Colin N A Palmer Kari Stefansson Paul M Ridker Ruth J F Loos Aravinda Chakravarti Panos Deloukas Andrew P Morris Christopher Newton-Cheh Patricia B Munroe

Nat Genet 2016 10 12;48(10):1171-1184. Epub 2016 Sep 12.

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/ng.3667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042863PMC
October 2016

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.

Sci Rep 2016 10 12;6:35278. Epub 2016 Oct 12.

Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1038/srep35278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059659PMC
October 2016

Coronary Artery Ectasia Are Frequently Observed in Patients With Bicuspid Aortic Valves With and Without Dilatation of the Ascending Aorta.

Circ Cardiovasc Interv 2016 10;9(10)

From the Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, Germany (C. Meindl, B.A., D.H., A.B., U.H., S.B., L.M., K.D., M.F.); Helmholtz Zentrum München, Institute of Epidemiology II, Technische Universität München, Germany (C. Meisinger); Deutsches Herzzentrum München, Technische Universität München, Deutsches Zentrum für Herz-und Kreislaufforschung (DZHK), Partner site Munich Heart Alliance, Munich, Germany (C.H., H.S.); and Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Germany (J.E.).

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.116.004092DOI Listing
October 2016

Two polymorphisms in the Cx40 promoter are associated with hypertension and left ventricular hypertrophy preferentially in men.

Clin Exp Hypertens 2015 20;37(7):580-6. Epub 2015 May 20.

a Institut für Physiologie, Universität zu Lübeck , Lübeck , Germany .

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http://dx.doi.org/10.3109/10641963.2015.1026043DOI Listing
August 2016

Proatherosclerotic Effect of the α1-Subunit of Soluble Guanylyl Cyclase by Promoting Smooth Muscle Phenotypic Switching.

Am J Pathol 2016 08 15;186(8):2220-2231. Epub 2016 Jun 15.

Institute for Integrative and Experimental Genomics, University of Lübeck, DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, University Heart Centre Lübeck, Lübeck, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440163012
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http://dx.doi.org/10.1016/j.ajpath.2016.04.010DOI Listing
August 2016

Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study.

J Am Coll Cardiol 2016 08;68(9):934-45

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.05.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451109PMC
August 2016

Stimulators of the soluble guanylyl cyclase: promising functional insights from rare coding atherosclerosis-related GUCY1A3 variants.

Basic Res Cardiol 2016 07 24;111(4):51. Epub 2016 Jun 24.

Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany.

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July 2016

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.

Authors:
John D Eicher Nathalie Chami Tim Kacprowski Akihiro Nomura Ming-Huei Chen Lisa R Yanek Salman M Tajuddin Ursula M Schick Andrew J Slater Nathan Pankratz Linda Polfus Claudia Schurmann Ayush Giri Jennifer A Brody Leslie A Lange Ani Manichaikul W David Hill Raha Pazoki Paul Elliot Evangelos Evangelou Ioanna Tzoulaki He Gao Anne-Claire Vergnaud Rasika A Mathias Diane M Becker Lewis C Becker Amber Burt David R Crosslin Leo-Pekka Lyytikäinen Kjell Nikus Jussi Hernesniemi Mika Kähönen Emma Raitoharju Nina Mononen Olli T Raitakari Terho Lehtimäki Mary Cushman Neil A Zakai Deborah A Nickerson Laura M Raffield Rakale Quarells Cristen J Willer Gina M Peloso Goncalo R Abecasis Dajiang J Liu Panos Deloukas Nilesh J Samani Heribert Schunkert Jeanette Erdmann Myriam Fornage Melissa Richard Jean-Claude Tardif John D Rioux Marie-Pierre Dube Simon de Denus Yingchang Lu Erwin P Bottinger Ruth J F Loos Albert Vernon Smith Tamara B Harris Lenore J Launer Vilmundur Gudnason Digna R Velez Edwards Eric S Torstenson Yongmei Liu Russell P Tracy Jerome I Rotter Stephen S Rich Heather M Highland Eric Boerwinkle Jin Li Ethan Lange James G Wilson Evelin Mihailov Reedik Mägi Joel Hirschhorn Andres Metspalu Tõnu Esko Caterina Vacchi-Suzzi Mike A Nalls Alan B Zonderman Michele K Evans Gunnar Engström Marju Orho-Melander Olle Melander Michelle L O'Donoghue Dawn M Waterworth Lars Wallentin Harvey D White James S Floyd Traci M Bartz Kenneth M Rice Bruce M Psaty J M Starr David C M Liewald Caroline Hayward Ian J Deary Andreas Greinacher Uwe Völker Thomas Thiele Henry Völzke Frank J A van Rooij André G Uitterlinden Oscar H Franco Abbas Dehghan Todd L Edwards Santhi K Ganesh Sekar Kathiresan Nauder Faraday Paul L Auer Alex P Reiner Guillaume Lettre Andrew D Johnson

Am J Hum Genet 2016 Jul 23;99(1):40-55. Epub 2016 Jun 23.

Population Sciences Branch, National Heart Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005441PMC
July 2016

Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits.

Circ Cardiovasc Genet 2016 Jun 24;9(3):250-8. Epub 2016 Mar 24.

From the Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia (J.R.G.); Cardiovascular Division, Department of Medicine (N.O.S.), Department of Genetics and McDonnell Genome Institute (N.O.S.), Washington University School of Medicine, St. Louis, MO; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia (W.Z., C.X., D.S.); Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom (M.F., H.W.); Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (R.M.); Medizinische Klinik II, University of Lübeck, Lübeck, Germany (J.E.); William Harvey Research Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom (P.D.); Deutsches Herzzentrum München, Technische Universität München, DZHK, Munich Heart Alliance, München, Germany (H.S.); Department of Cardiovascular Sciences, University of Leicester & NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom (N.J.S.); Center for Human Genetic Research, Cardiovascular Research Center, Massachusetts General Hospital, Boston (S.K.); Department of Medicine, Harvard Medical School, Boston, MA (S.K.); Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (S.K.); and Department of Medicine, Columbia University, New York, NY (M.P.R.).

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015681PMC
June 2016

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.

Authors:
Robert A Scott Daniel F Freitag Li Li Audrey Y Chu Praveen Surendran Robin Young Niels Grarup Alena Stancáková Yuning Chen Tibor V Varga Hanieh Yaghootkar Jian'an Luan Jing Hua Zhao Sara M Willems Jennifer Wessel Shuai Wang Nisa Maruthur Kyriaki Michailidou Ailith Pirie Sven J van der Lee Christopher Gillson Ali Amin Al Olama Philippe Amouyel Larraitz Arriola Dominique Arveiler Iciar Aviles-Olmos Beverley Balkau Aurelio Barricarte Inês Barroso Sara Benlloch Garcia Joshua C Bis Stefan Blankenberg Michael Boehnke Heiner Boeing Eric Boerwinkle Ingrid B Borecki Jette Bork-Jensen Sarah Bowden Carlos Caldas Muriel Caslake L Adrienne Cupples Carlos Cruchaga Jacek Czajkowski Marcel den Hoed Janet A Dunn Helena M Earl Georg B Ehret Ele Ferrannini Jean Ferrieres Thomas Foltynie Ian Ford Nita G Forouhi Francesco Gianfagna Carlos Gonzalez Sara Grioni Louise Hiller Jan-Håkan Jansson Marit E Jørgensen J Wouter Jukema Rudolf Kaaks Frank Kee Nicola D Kerrison Timothy J Key Jukka Kontto Zsofia Kote-Jarai Aldi T Kraja Kari Kuulasmaa Johanna Kuusisto Allan Linneberg Chunyu Liu Gaëlle Marenne Karen L Mohlke Andrew P Morris Kenneth Muir Martina Müller-Nurasyid Patricia B Munroe Carmen Navarro Sune F Nielsen Peter M Nilsson Børge G Nordestgaard Chris J Packard Domenico Palli Salvatore Panico Gina M Peloso Markus Perola Annette Peters Christopher J Poole J Ramón Quirós Olov Rolandsson Carlotta Sacerdote Veikko Salomaa María-José Sánchez Naveed Sattar Stephen J Sharp Rebecca Sims Nadia Slimani Jennifer A Smith Deborah J Thompson Stella Trompet Rosario Tumino Daphne L van der A Yvonne T van der Schouw Jarmo Virtamo Mark Walker Klaudia Walter Jean E Abraham Laufey T Amundadottir Jennifer L Aponte Adam S Butterworth Josée Dupuis Douglas F Easton Rosalind A Eeles Jeanette Erdmann Paul W Franks Timothy M Frayling Torben Hansen Joanna M M Howson Torben Jørgensen Jaspal Kooner Markku Laakso Claudia Langenberg Mark I McCarthy James S Pankow Oluf Pedersen Elio Riboli Jerome I Rotter Danish Saleheen Nilesh J Samani Heribert Schunkert Peter Vollenweider Stephen O'Rahilly Panos Deloukas John Danesh Mark O Goodarzi Sekar Kathiresan James B Meigs Margaret G Ehm Nicholas J Wareham Dawn M Waterworth

Sci Transl Med 2016 06;8(341):341ra76

Genetics, PCPS, GlaxoSmithKline, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad3744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219001PMC
June 2016

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Authors:
Thomas W Winkler Anne E Justice Mariaelisa Graff Llilda Barata Mary F Feitosa Su Chu Jacek Czajkowski Tõnu Esko Tove Fall Tuomas O Kilpeläinen Yingchang Lu Reedik Mägi Evelin Mihailov Tune H Pers Sina Rüeger Alexander Teumer Georg B Ehret Teresa Ferreira Nancy L Heard-Costa Juha Karjalainen Vasiliki Lagou Anubha Mahajan Michael D Neinast Inga Prokopenko Jeannette Simino Tanya M Teslovich Rick Jansen Harm-Jan Westra Charles C White Devin Absher Tarunveer S Ahluwalia Shafqat Ahmad Eva Albrecht Alexessander Couto Alves Jennifer L Bragg-Gresham Anton J M de Craen Joshua C Bis Amélie Bonnefond Gabrielle Boucher Gemma Cadby Yu-Ching Cheng Charleston W K Chiang Graciela Delgado Ayse Demirkan Nicole Dueker Niina Eklund Gudny Eiriksdottir Joel Eriksson Bjarke Feenstra Krista Fischer Francesca Frau Tessel E Galesloot Frank Geller Anuj Goel Mathias Gorski Tanja B Grammer Stefan Gustafsson Saskia Haitjema Jouke-Jan Hottenga Jennifer E Huffman Anne U Jackson Kevin B Jacobs Åsa Johansson Marika Kaakinen Marcus E Kleber Jari Lahti Irene Mateo Leach Benjamin Lehne Youfang Liu Ken Sin Lo Mattias Lorentzon Jian'an Luan Pamela A F Madden Massimo Mangino Barbara McKnight Carolina Medina-Gomez Keri L Monda May E Montasser Gabriele Müller Martina Müller-Nurasyid Ilja M Nolte Kalliope Panoutsopoulou Laura Pascoe Lavinia Paternoster Nigel W Rayner Frida Renström Federica Rizzi Lynda M Rose Kathy A Ryan Perttu Salo Serena Sanna Hubert Scharnagl Jianxin Shi Albert Vernon Smith Lorraine Southam Alena Stančáková Valgerdur Steinthorsdottir Rona J Strawbridge Yun Ju Sung Ioanna Tachmazidou Toshiko Tanaka Gudmar Thorleifsson Stella Trompet Natalia Pervjakova Jonathan P Tyrer Liesbeth Vandenput Sander W van der Laan Nathalie van der Velde Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Efthymia Vlachopoulou Lindsay L Waite Sophie R Wang Zhaoming Wang Sarah H Wild Christina Willenborg James F Wilson Andrew Wong Jian Yang Loïc Yengo Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Ehm A Andersson Stephan J L Bakker Damiano Baldassarre Karina Banasik Matteo Barcella Cristina Barlassina Claire Bellis Paola Benaglio John Blangero Matthias Blüher Fabrice Bonnet Lori L Bonnycastle Heather A Boyd Marcel Bruinenberg Aron S Buchman Harry Campbell Yii-Der Ida Chen Peter S Chines Simone Claudi-Boehm John Cole Francis S Collins Eco J C de Geus Lisette C P G M de Groot Maria Dimitriou Jubao Duan Stefan Enroth Elodie Eury Aliki-Eleni Farmaki Nita G Forouhi Nele Friedrich Pablo V Gejman Bruna Gigante Nicola Glorioso Alan S Go Omri Gottesman Jürgen Gräßler Harald Grallert Niels Grarup Yu-Mei Gu Linda Broer Annelies C Ham Torben Hansen Tamara B Harris Catharina A Hartman Maija Hassinen Nicholas Hastie Andrew T Hattersley Andrew C Heath Anjali K Henders Dena Hernandez Hans Hillege Oddgeir Holmen Kees G Hovingh Jennie Hui Lise L Husemoen Nina Hutri-Kähönen Pirro G Hysi Thomas Illig Philip L De Jager Shapour Jalilzadeh Torben Jørgensen J Wouter Jukema Markus Juonala Stavroula Kanoni Maria Karaleftheri Kay Tee Khaw Leena Kinnunen Steven J Kittner Wolfgang Koenig Ivana Kolcic Peter Kovacs Nikolaj T Krarup Wolfgang Kratzer Janine Krüger Diana Kuh Meena Kumari Theodosios Kyriakou Claudia Langenberg Lars Lannfelt Chiara Lanzani Vaneet Lotay Lenore J Launer Karin Leander Jaana Lindström Allan Linneberg Yan-Ping Liu Stéphane Lobbens Robert Luben Valeriya Lyssenko Satu Männistö Patrik K Magnusson Wendy L McArdle Cristina Menni Sigrun Merger Lili Milani Grant W Montgomery Andrew P Morris Narisu Narisu Mari Nelis Ken K Ong Aarno Palotie Louis Pérusse Irene Pichler Maria G Pilia Anneli Pouta Myriam Rheinberger Rasmus Ribel-Madsen Marcus Richards Kenneth M Rice Treva K Rice Carlo Rivolta Veikko Salomaa Alan R Sanders Mark A Sarzynski Salome Scholtens Robert A Scott William R Scott Sylvain Sebert Sebanti Sengupta Bengt Sennblad Thomas Seufferlein Angela Silveira P Eline Slagboom Jan H Smit Thomas H Sparsø Kathleen Stirrups Ronald P Stolk Heather M Stringham Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Barbara Thorand Anke Tönjes Angelo Tremblay Emmanouil Tsafantakis Peter J van der Most Uwe Völker Marie-Claude Vohl Judith M Vonk Melanie Waldenberger Ryan W Walker Roman Wennauer Elisabeth Widén Gonneke Willemsen Tom Wilsgaard Alan F Wright M Carola Zillikens Suzanne C van Dijk Natasja M van Schoor Folkert W Asselbergs Paul I W de Bakker Jacques S Beckmann John Beilby David A Bennett Richard N Bergman Sven Bergmann Carsten A Böger Bernhard O Boehm Eric Boerwinkle Dorret I Boomsma Stefan R Bornstein Erwin P Bottinger Claude Bouchard John C Chambers Stephen J Chanock Daniel I Chasman Francesco Cucca Daniele Cusi George Dedoussis Jeanette Erdmann Johan G Eriksson Denis A Evans Ulf de Faire Martin Farrall Luigi Ferrucci Ian Ford Lude Franke Paul W Franks Philippe Froguel Ron T Gansevoort Christian Gieger Henrik Grönberg Vilmundur Gudnason Ulf Gyllensten Per Hall Anders Hamsten Pim van der Harst Caroline Hayward Markku Heliövaara Christian Hengstenberg Andrew A Hicks Aroon Hingorani Albert Hofman Frank Hu Heikki V Huikuri Kristian Hveem Alan L James Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Sekar Kathiresan Lambertus A L M Kiemeney Mika Kivimaki Paul B Knekt Heikki A Koistinen Jaspal S Kooner Seppo Koskinen Johanna Kuusisto Winfried Maerz Nicholas G Martin Markku Laakso Timo A Lakka Terho Lehtimäki Guillaume Lettre Douglas F Levinson Lars Lind Marja-Liisa Lokki Pekka Mäntyselkä Mads Melbye Andres Metspalu Braxton D Mitchell Frans L Moll Jeffrey C Murray Arthur W Musk Markku S Nieminen Inger Njølstad Claes Ohlsson Albertine J Oldehinkel Ben A Oostra Lyle J Palmer James S Pankow Gerard Pasterkamp Nancy L Pedersen Oluf Pedersen Brenda W Penninx Markus Perola Annette Peters Ozren Polašek Peter P Pramstaller Bruce M Psaty Lu Qi Thomas Quertermous Olli T Raitakari Tuomo Rankinen Rainer Rauramaa Paul M Ridker John D Rioux Fernando Rivadeneira Jerome I Rotter Igor Rudan Hester M den Ruijter Juha Saltevo Naveed Sattar Heribert Schunkert Peter E H Schwarz Alan R Shuldiner Juha Sinisalo Harold Snieder Thorkild I A Sørensen Tim D Spector Jan A Staessen Bandinelli Stefania Unnur Thorsteinsdottir Michael Stumvoll Jean-Claude Tardif Elena Tremoli Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa André L M Verbeek Sita H Vermeulen Jorma S Viikari Veronique Vitart Henry Völzke Peter Vollenweider Gérard Waeber Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins Eleftheria Zeggini Aravinda Chakravarti Deborah J Clegg L Adrienne Cupples Penny Gordon-Larsen Cashell E Jaquish D C Rao Goncalo R Abecasis Themistocles L Assimes Inês Barroso Sonja I Berndt Michael Boehnke Panos Deloukas Caroline S Fox Leif C Groop David J Hunter Erik Ingelsson Robert C Kaplan Mark I McCarthy Karen L Mohlke Jeffrey R O'Connell David Schlessinger David P Strachan Kari Stefansson Cornelia M van Duijn Joel N Hirschhorn Cecilia M Lindgren Iris M Heid Kari E North Ingrid B Borecki Zoltán Kutalik Ruth J F Loos

PLoS Genet 2016 06 29;12(6):e1006166. Epub 2016 Jun 29.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927064PMC
June 2016

Serum microRNA-1233 is a specific biomarker for diagnosing acute pulmonary embolism.

J Transl Med 2016 05 5;14(1):120. Epub 2016 May 5.

Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany.

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http://dx.doi.org/10.1186/s12967-016-0886-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858885PMC
May 2016

Classification of ADAMTS binding sites: The first step toward selective ADAMTS7 inhibitors.

Biochem Biophys Res Commun 2016 Mar 10;471(3):380-5. Epub 2016 Feb 10.

Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Maria-Goeppert-Str. 1, 23562 Lübeck, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, Germany; University Heart Center Luebeck, 23562 Lübeck, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2016.02.025DOI Listing
March 2016

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.

Authors:
Nathan O Stitziel Kathleen E Stirrups Nicholas G D Masca Jeanette Erdmann Paola G Ferrario Inke R König Peter E Weeke Thomas R Webb Paul L Auer Ursula M Schick Yingchang Lu He Zhang Marie-Pierre Dube Anuj Goel Martin Farrall Gina M Peloso Hong-Hee Won Ron Do Erik van Iperen Stavroula Kanoni Jochen Kruppa Anubha Mahajan Robert A Scott Christina Willenberg Peter S Braund Julian C van Capelleveen Alex S F Doney Louise A Donnelly Rosanna Asselta Piera A Merlini Stefano Duga Nicola Marziliano Josh C Denny Christian M Shaffer Nour Eddine El-Mokhtari Andre Franke Omri Gottesman Stefanie Heilmann Christian Hengstenberg Per Hoffman Oddgeir L Holmen Kristian Hveem Jan-Håkan Jansson Karl-Heinz Jöckel Thorsten Kessler Jennifer Kriebel Karl L Laugwitz Eirini Marouli Nicola Martinelli Mark I McCarthy Natalie R Van Zuydam Christa Meisinger Tõnu Esko Evelin Mihailov Stefan A Escher Maris Alver Susanne Moebus Andrew D Morris Martina Müller-Nurasyid Majid Nikpay Oliviero Olivieri Louis-Philippe Lemieux Perreault Alaa AlQarawi Neil R Robertson Karen O Akinsanya Dermot F Reilly Thomas F Vogt Wu Yin Folkert W Asselbergs Charles Kooperberg Rebecca D Jackson Eli Stahl Konstantin Strauch Tibor V Varga Melanie Waldenberger Lingyao Zeng Aldi T Kraja Chunyu Liu George B Ehret Christopher Newton-Cheh Daniel I Chasman Rajiv Chowdhury Marco Ferrario Ian Ford J Wouter Jukema Frank Kee Kari Kuulasmaa Børge G Nordestgaard Markus Perola Danish Saleheen Naveed Sattar Praveen Surendran David Tregouet Robin Young Joanna M M Howson Adam S Butterworth John Danesh Diego Ardissino Erwin P Bottinger Raimund Erbel Paul W Franks Domenico Girelli Alistair S Hall G Kees Hovingh Adnan Kastrati Wolfgang Lieb Thomas Meitinger William E Kraus Svati H Shah Ruth McPherson Marju Orho-Melander Olle Melander Andres Metspalu Colin N A Palmer Annette Peters Daniel Rader Muredach P Reilly Ruth J F Loos Alex P Reiner Dan M Roden Jean-Claude Tardif John R Thompson Nicholas J Wareham Hugh Watkins Cristen J Willer Sekkar Kathiresan Panos Deloukas Nilesh J Samani Heribert Schunkert

N Engl J Med 2016 03 2;374(12):1134-44. Epub 2016 Mar 2.

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http://dx.doi.org/10.1056/NEJMoa1507652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850838PMC
March 2016

Molecular variants of soluble guanylyl cyclase affecting cardiovascular risk.

Circ J 2015 6;79(3):463-9. Epub 2015 Feb 6.

Department of Cardiovascular Diseases, German Heart Center Munich, Technical University Munich.

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http://dx.doi.org/10.1253/circj.CJ-15-0025DOI Listing
November 2015

Genetics of coronary artery disease: Short people at risk?

Expert Rev Cardiovasc Ther 2015 Nov 28;13(11):1169-72. Epub 2015 Sep 28.

c 3 Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany.

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November 2015

Genetic variants associated with celiac disease and the risk for coronary artery disease.

Mol Genet Genomics 2015 Oct 18;290(5):1911-7. Epub 2015 Apr 18.

Deutsches Herzzentrum München and DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany.

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http://link.springer.com/content/pdf/10.1007/s00438-015-1045
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http://dx.doi.org/10.1007/s00438-015-1045-3DOI Listing
October 2015

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci.

Arterioscler Thromb Vasc Biol 2015 Oct 20;35(10):2207-17. Epub 2015 Aug 20.

From the Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany (I.B., B.R., J.E.); DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, Lübeck, Germany (I.B., B.R., J.E.); University Heart Center Lübeck, Lübeck, Germany (I.B., B.R., J.E.); Departments of Medicine (M.C., A.J.L.) and Integrative Biology and Physiology (Y.Z., X.Y.), University of California, Los Angeles; Deutsches Herzzentrum München, Klinik für Herz-und Kreislauferkrankungen, Technische Universität München, Munich, Germany (B.V., L.Z., H.S.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (A.D.N., K.H., E.E.S., J.L.M.B.); Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (A.D.N., K.H., E.E.S., J.L.M.B.); Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, The Framingham Heart Study, Framingham, MA (A.D.J.); Unité Mixte de Recherche en Santé (UMR_S) 1166, Institut National pour la Santé et la Recherche Médicale (INSERM), Paris, France (V.C., D.-A.T.); UMR_S 1166, Team Genomics and Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), Paris, France (V.C., D.-A.T.); Institute for Cardiometabolism and Nutrition (ICAN), Paris, France (V.C., D.-A.T.); Department of Cardiovascular Sciences, University of Leicester, and NIHR Leicester Cardiovascular Biomedical Research Unit, BHF Cardiovascular Research Centre, Leicester, United Kingdom (T.R.W., S.E.H., N.J.S.); Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden (H.F.A., J.L.M.B.); and Department of Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, CA (E.J.T.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583353PMC
October 2015

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.

Authors:
Majid Nikpay Anuj Goel Hong-Hee Won Leanne M Hall Christina Willenborg Stavroula Kanoni Danish Saleheen Theodosios Kyriakou Christopher P Nelson Jemma C Hopewell Thomas R Webb Lingyao Zeng Abbas Dehghan Maris Alver Sebastian M Armasu Kirsi Auro Andrew Bjonnes Daniel I Chasman Shufeng Chen Ian Ford Nora Franceschini Christian Gieger Christopher Grace Stefan Gustafsson Jie Huang Shih-Jen Hwang Yun Kyoung Kim Marcus E Kleber King Wai Lau Xiangfeng Lu Yingchang Lu Leo-Pekka Lyytikäinen Evelin Mihailov Alanna C Morrison Natalia Pervjakova Liming Qu Lynda M Rose Elias Salfati Richa Saxena Markus Scholz Albert V Smith Emmi Tikkanen Andre Uitterlinden Xueli Yang Weihua Zhang Wei Zhao Mariza de Andrade Paul S de Vries Natalie R van Zuydam Sonia S Anand Lars Bertram Frank Beutner George Dedoussis Philippe Frossard Dominique Gauguier Alison H Goodall Omri Gottesman Marc Haber Bok-Ghee Han Jianfeng Huang Shapour Jalilzadeh Thorsten Kessler Inke R König Lars Lannfelt Wolfgang Lieb Lars Lind Cecilia M Lindgren Marja-Liisa Lokki Patrik K Magnusson Nadeem H Mallick Narinder Mehra Thomas Meitinger Fazal-Ur-Rehman Memon Andrew P Morris Markku S Nieminen Nancy L Pedersen Annette Peters Loukianos S Rallidis Asif Rasheed Maria Samuel Svati H Shah Juha Sinisalo Kathleen E Stirrups Stella Trompet Laiyuan Wang Khan S Zaman Diego Ardissino Eric Boerwinkle Ingrid B Borecki Erwin P Bottinger Julie E Buring John C Chambers Rory Collins L Adrienne Cupples John Danesh Ilja Demuth Roberto Elosua Stephen E Epstein Tõnu Esko Mary F Feitosa Oscar H Franco Maria Grazia Franzosi Christopher B Granger Dongfeng Gu Vilmundur Gudnason Alistair S Hall Anders Hamsten Tamara B Harris Stanley L Hazen Christian Hengstenberg Albert Hofman Erik Ingelsson Carlos Iribarren J Wouter Jukema Pekka J Karhunen Bong-Jo Kim Jaspal S Kooner Iftikhar J Kullo Terho Lehtimäki Ruth J F Loos Olle Melander Andres Metspalu Winfried März Colin N Palmer Markus Perola Thomas Quertermous Daniel J Rader Paul M Ridker Samuli Ripatti Robert Roberts Veikko Salomaa Dharambir K Sanghera Stephen M Schwartz Udo Seedorf Alexandre F Stewart David J Stott Joachim Thiery Pierre A Zalloua Christopher J O'Donnell Muredach P Reilly Themistocles L Assimes John R Thompson Jeanette Erdmann Robert Clarke Hugh Watkins Sekar Kathiresan Ruth McPherson Panos Deloukas Heribert Schunkert Nilesh J Samani Martin Farrall

Nat Genet 2015 Oct 7;47(10):1121-1130. Epub 2015 Sep 7.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589895PMC
October 2015

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Authors:
Thomas W Winkler Anne E Justice Mariaelisa Graff Llilda Barata Mary F Feitosa Su Chu Jacek Czajkowski Tõnu Esko Tove Fall Tuomas O Kilpeläinen Yingchang Lu Reedik Mägi Evelin Mihailov Tune H Pers Sina Rüeger Alexander Teumer Georg B Ehret Teresa Ferreira Nancy L Heard-Costa Juha Karjalainen Vasiliki Lagou Anubha Mahajan Michael D Neinast Inga Prokopenko Jeannette Simino Tanya M Teslovich Rick Jansen Harm-Jan Westra Charles C White Devin Absher Tarunveer S Ahluwalia Shafqat Ahmad Eva Albrecht Alexessander Couto Alves Jennifer L Bragg-Gresham Anton J M de Craen Joshua C Bis Amélie Bonnefond Gabrielle Boucher Gemma Cadby Yu-Ching Cheng Charleston W K Chiang Graciela Delgado Ayse Demirkan Nicole Dueker Niina Eklund Gudny Eiriksdottir Joel Eriksson Bjarke Feenstra Krista Fischer Francesca Frau Tessel E Galesloot Frank Geller Anuj Goel Mathias Gorski Tanja B Grammer Stefan Gustafsson Saskia Haitjema Jouke-Jan Hottenga Jennifer E Huffman Anne U Jackson Kevin B Jacobs Åsa Johansson Marika Kaakinen Marcus E Kleber Jari Lahti Irene Mateo Leach Benjamin Lehne Youfang Liu Ken Sin Lo Mattias Lorentzon Jian'an Luan Pamela A F Madden Massimo Mangino Barbara McKnight Carolina Medina-Gomez Keri L Monda May E Montasser Gabriele Müller Martina Müller-Nurasyid Ilja M Nolte Kalliope Panoutsopoulou Laura Pascoe Lavinia Paternoster Nigel W Rayner Frida Renström Federica Rizzi Lynda M Rose Kathy A Ryan Perttu Salo Serena Sanna Hubert Scharnagl Jianxin Shi Albert Vernon Smith Lorraine Southam Alena Stančáková Valgerdur Steinthorsdottir Rona J Strawbridge Yun Ju Sung Ioanna Tachmazidou Toshiko Tanaka Gudmar Thorleifsson Stella Trompet Natalia Pervjakova Jonathan P Tyrer Liesbeth Vandenput Sander W van der Laan Nathalie van der Velde Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Efthymia Vlachopoulou Lindsay L Waite Sophie R Wang Zhaoming Wang Sarah H Wild Christina Willenborg James F Wilson Andrew Wong Jian Yang Loïc Yengo Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Ehm A Andersson Stephan J L Bakker Damiano Baldassarre Karina Banasik Matteo Barcella Cristina Barlassina Claire Bellis Paola Benaglio John Blangero Matthias Blüher Fabrice Bonnet Lori L Bonnycastle Heather A Boyd Marcel Bruinenberg Aron S Buchman Harry Campbell Yii-Der Ida Chen Peter S Chines Simone Claudi-Boehm John Cole Francis S Collins Eco J C de Geus Lisette C P G M de Groot Maria Dimitriou Jubao Duan Stefan Enroth Elodie Eury Aliki-Eleni Farmaki Nita G Forouhi Nele Friedrich Pablo V Gejman Bruna Gigante Nicola Glorioso Alan S Go Omri Gottesman Jürgen Gräßler Harald Grallert Niels Grarup Yu-Mei Gu Linda Broer Annelies C Ham Torben Hansen Tamara B Harris Catharina A Hartman Maija Hassinen Nicholas Hastie Andrew T Hattersley Andrew C Heath Anjali K Henders Dena Hernandez Hans Hillege Oddgeir Holmen Kees G Hovingh Jennie Hui Lise L Husemoen Nina Hutri-Kähönen Pirro G Hysi Thomas Illig Philip L De Jager Shapour Jalilzadeh Torben Jørgensen J Wouter Jukema Markus Juonala Stavroula Kanoni Maria Karaleftheri Kay Tee Khaw Leena Kinnunen Steven J Kittner Wolfgang Koenig Ivana Kolcic Peter Kovacs Nikolaj T Krarup Wolfgang Kratzer Janine Krüger Diana Kuh Meena Kumari Theodosios Kyriakou Claudia Langenberg Lars Lannfelt Chiara Lanzani Vaneet Lotay Lenore J Launer Karin Leander Jaana Lindström Allan Linneberg Yan-Ping Liu Stéphane Lobbens Robert Luben Valeriya Lyssenko Satu Männistö Patrik K Magnusson Wendy L McArdle Cristina Menni Sigrun Merger Lili Milani Grant W Montgomery Andrew P Morris Narisu Narisu Mari Nelis Ken K Ong Aarno Palotie Louis Pérusse Irene Pichler Maria G Pilia Anneli Pouta Myriam Rheinberger Rasmus Ribel-Madsen Marcus Richards Kenneth M Rice Treva K Rice Carlo Rivolta Veikko Salomaa Alan R Sanders Mark A Sarzynski Salome Scholtens Robert A Scott William R Scott Sylvain Sebert Sebanti Sengupta Bengt Sennblad Thomas Seufferlein Angela Silveira P Eline Slagboom Jan H Smit Thomas H Sparsø Kathleen Stirrups Ronald P Stolk Heather M Stringham Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Barbara Thorand Anke Tönjes Angelo Tremblay Emmanouil Tsafantakis Peter J van der Most Uwe Völker Marie-Claude Vohl Judith M Vonk Melanie Waldenberger Ryan W Walker Roman Wennauer Elisabeth Widén Gonneke Willemsen Tom Wilsgaard Alan F Wright M Carola Zillikens Suzanne C van Dijk Natasja M van Schoor Folkert W Asselbergs Paul I W de Bakker Jacques S Beckmann John Beilby David A Bennett Richard N Bergman Sven Bergmann Carsten A Böger Bernhard O Boehm Eric Boerwinkle Dorret I Boomsma Stefan R Bornstein Erwin P Bottinger Claude Bouchard John C Chambers Stephen J Chanock Daniel I Chasman Francesco Cucca Daniele Cusi George Dedoussis Jeanette Erdmann Johan G Eriksson Denis A Evans Ulf de Faire Martin Farrall Luigi Ferrucci Ian Ford Lude Franke Paul W Franks Philippe Froguel Ron T Gansevoort Christian Gieger Henrik Grönberg Vilmundur Gudnason Ulf Gyllensten Per Hall Anders Hamsten Pim van der Harst Caroline Hayward Markku Heliövaara Christian Hengstenberg Andrew A Hicks Aroon Hingorani Albert Hofman Frank Hu Heikki V Huikuri Kristian Hveem Alan L James Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Sekar Kathiresan Lambertus A L M Kiemeney Mika Kivimaki Paul B Knekt Heikki A Koistinen Jaspal S Kooner Seppo Koskinen Johanna Kuusisto Winfried Maerz Nicholas G Martin Markku Laakso Timo A Lakka Terho Lehtimäki Guillaume Lettre Douglas F Levinson Lars Lind Marja-Liisa Lokki Pekka Mäntyselkä Mads Melbye Andres Metspalu Braxton D Mitchell Frans L Moll Jeffrey C Murray Arthur W Musk Markku S Nieminen Inger Njølstad Claes Ohlsson Albertine J Oldehinkel Ben A Oostra Lyle J Palmer James S Pankow Gerard Pasterkamp Nancy L Pedersen Oluf Pedersen Brenda W Penninx Markus Perola Annette Peters Ozren Polašek Peter P Pramstaller Bruce M Psaty Lu Qi Thomas Quertermous Olli T Raitakari Tuomo Rankinen Rainer Rauramaa Paul M Ridker John D Rioux Fernando Rivadeneira Jerome I Rotter Igor Rudan Hester M den Ruijter Juha Saltevo Naveed Sattar Heribert Schunkert Peter E H Schwarz Alan R Shuldiner Juha Sinisalo Harold Snieder Thorkild I A Sørensen Tim D Spector Jan A Staessen Bandinelli Stefania Unnur Thorsteinsdottir Michael Stumvoll Jean-Claude Tardif Elena Tremoli Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa André L M Verbeek Sita H Vermeulen Jorma S Viikari Veronique Vitart Henry Völzke Peter Vollenweider Gérard Waeber Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins Eleftheria Zeggini Aravinda Chakravarti Deborah J Clegg L Adrienne Cupples Penny Gordon-Larsen Cashell E Jaquish D C Rao Goncalo R Abecasis Themistocles L Assimes Inês Barroso Sonja I Berndt Michael Boehnke Panos Deloukas Caroline S Fox Leif C Groop David J Hunter Erik Ingelsson Robert C Kaplan Mark I McCarthy Karen L Mohlke Jeffrey R O'Connell David Schlessinger David P Strachan Kari Stefansson Cornelia M van Duijn Joel N Hirschhorn Cecilia M Lindgren Iris M Heid Kari E North Ingrid B Borecki Zoltán Kutalik Ruth J F Loos

PLoS Genet 2015 Oct 1;11(10):e1005378. Epub 2015 Oct 1.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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October 2015

Identification of a novel ovine LH-beta promoter region, which dramatically enhances its promoter activity.

Springerplus 2015 1;4:466. Epub 2015 Sep 1.

Department of Biology, Faculty of Sciences, Moulay Ismail University, Zitoune, BP 11201, 50000 Meknes, Morocco.

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September 2015

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.

PLoS Genet 2015 Jul 1;11(7):e1005230. Epub 2015 Jul 1.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Estonian Genome Center, University of Tartu, Tartu, Estonia; Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom; Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.

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July 2015

The impact of low-frequency and rare variants on lipid levels.

Nat Genet 2015 Jun 11;47(6):589-97. Epub 2015 May 11.

1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] Department of Public Health, University of Helsinki, Helsinki, Finland. [3] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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June 2015

Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses.

Arterioscler Thromb Vasc Biol 2015 Apr 5;35(4):1011-21. Epub 2015 Feb 5.

From the National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., R.J., P.C., A.D.J., C.J.O., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., R.J., P.C., D.L.); Cardiovascular Epidemiology and Human Genomics Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (A.D.J., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (J.R., M.G.L.); Department of Medicine, University of Massachusetts Medical School, Worcester (K.T., D.D.M., J.E.F.); Department of Integrative Biology and Physiology, University of California, Los Angeles (Q.M., A.B., X.Y.); Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD (R.J., P.J.M); Department of Medicine, Harvard Medical School, Harvard University, Boston, MA (R.J.); Department of Medicine, Stanford University School of Medicine, Palo Alto, CA (T.L.A.); Departments of Medicine and Biochemistry, University of Ottawa, Ottawa, Ontario, Canada (R.M.); Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, United Kingdom (N.J.S.); National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Leicester, United Kingdom; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany (J.E.); DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany (J.E.); Deutsches Herzzentrum München, Technische Universität München, München, Germany (H.S.); DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany (H.S.); and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (B.Z.).

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April 2015

Shared genetic aetiology of coronary artery disease and atherosclerotic stroke - 2015.

Curr Atheroscler Rep 2015 Apr;17(4):498

Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany,

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April 2015

Role of sGC-dependent NO signalling and myocardial infarction risk.

J Mol Med (Berl) 2015 Apr 4;93(4):383-94. Epub 2015 Mar 4.

Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany.

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April 2015

ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.

Circulation 2015 Mar 20;131(13):1191-201. Epub 2015 Feb 20.

From Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Germany (T.K., H.S.); Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China (L.Z., Z.L.,Y.H.,Y.W., Y.F., X.W., W.K.); Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China (L.Z., Z.L., Y.H., Y.W., Y.F., X.W., W.K.); Cardiovascular Division, Kings College London BHF Centre, United Kingdom (X.Y., M.M., Q.X.); Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China (Q.G.); School of Basic Medical Sciences, Tianjin University, Beijing, China (Y.Z.); Institut für Physiologie, Universität zu Lübeck, Germany (K.S., C.d.W.); Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V. (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany (K.S., C.d.W., J.E., Z.A.); Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Germany (J.E., Z.A.); and Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V. (German Center for Cardiovascular Research), partner site Munich Heart Alliance (MHA), München, Germany (H.S.).

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March 2015

Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community.

J Am Heart Assoc 2015 Mar 11;4(3):e001544. Epub 2015 Mar 11.

National Heart, Blood, and Lung Institute's Framingham Heart Study, Framingham, MA (B.M.K., S.R.P., A.S.B., Q.Y., S.S., R.S.V.) Sections of Preventive Medicine and Epidemiology and Cardiology, Boston University School of Medicine, Boston, MA (R.S.V.).

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March 2015

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.

Nature 2015 Feb 10;518(7537):102-6. Epub 2014 Dec 10.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [2] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. [3] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA. [4] Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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February 2015

Genetic studies of body mass index yield new insights for obesity biology.

Authors:
Adam E Locke Bratati Kahali Sonja I Berndt Anne E Justice Tune H Pers Felix R Day Corey Powell Sailaja Vedantam Martin L Buchkovich Jian Yang Damien C Croteau-Chonka Tonu Esko Tove Fall Teresa Ferreira Stefan Gustafsson Zoltán Kutalik Jian'an Luan Reedik Mägi Joshua C Randall Thomas W Winkler Andrew R Wood Tsegaselassie Workalemahu Jessica D Faul Jennifer A Smith Jing Hua Zhao Wei Zhao Jin Chen Rudolf Fehrmann Åsa K Hedman Juha Karjalainen Ellen M Schmidt Devin Absher Najaf Amin Denise Anderson Marian Beekman Jennifer L Bolton Jennifer L Bragg-Gresham Steven Buyske Ayse Demirkan Guohong Deng Georg B Ehret Bjarke Feenstra Mary F Feitosa Krista Fischer Anuj Goel Jian Gong Anne U Jackson Stavroula Kanoni Marcus E Kleber Kati Kristiansson Unhee Lim Vaneet Lotay Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Sarah E Medland Michael A Nalls Cameron D Palmer Dorota Pasko Sonali Pechlivanis Marjolein J Peters Inga Prokopenko Dmitry Shungin Alena Stančáková Rona J Strawbridge Yun Ju Sung Toshiko Tanaka Alexander Teumer Stella Trompet Sander W van der Laan Jessica van Setten Jana V Van Vliet-Ostaptchouk Zhaoming Wang Loïc Yengo Weihua Zhang Aaron Isaacs Eva Albrecht Johan Ärnlöv Gillian M Arscott Antony P Attwood Stefania Bandinelli Amy Barrett Isabelita N Bas Claire Bellis Amanda J Bennett Christian Berne Roza Blagieva Matthias Blüher Stefan Böhringer Lori L Bonnycastle Yvonne Böttcher Heather A Boyd Marcel Bruinenberg Ida H Caspersen Yii-Der Ida Chen Robert Clarke E Warwick Daw Anton J M de Craen Graciela Delgado Maria Dimitriou Alex S F Doney Niina Eklund Karol Estrada Elodie Eury Lasse Folkersen Ross M Fraser Melissa E Garcia Frank Geller Vilmantas Giedraitis Bruna Gigante Alan S Go Alain Golay Alison H Goodall Scott D Gordon Mathias Gorski Hans-Jörgen Grabe Harald Grallert Tanja B Grammer Jürgen Gräßler Henrik Grönberg Christopher J Groves Gaëlle Gusto Jeffrey Haessler Per Hall Toomas Haller Goran Hallmans Catharina A Hartman Maija Hassinen Caroline Hayward Nancy L Heard-Costa Quinta Helmer Christian Hengstenberg Oddgeir Holmen Jouke-Jan Hottenga Alan L James Janina M Jeff Åsa Johansson Jennifer Jolley Thorhildur Juliusdottir Leena Kinnunen Wolfgang Koenig Markku Koskenvuo Wolfgang Kratzer Jaana Laitinen Claudia Lamina Karin Leander Nanette R Lee Peter Lichtner Lars Lind Jaana Lindström Ken Sin Lo Stéphane Lobbens Roberto Lorbeer Yingchang Lu François Mach Patrik K E Magnusson Anubha Mahajan Wendy L McArdle Stela McLachlan Cristina Menni Sigrun Merger Evelin Mihailov Lili Milani Alireza Moayyeri Keri L Monda Mario A Morken Antonella Mulas Gabriele Müller Martina Müller-Nurasyid Arthur W Musk Ramaiah Nagaraja Markus M Nöthen Ilja M Nolte Stefan Pilz Nigel W Rayner Frida Renstrom Rainer Rettig Janina S Ried Stephan Ripke Neil R Robertson Lynda M Rose Serena Sanna Hubert Scharnagl Salome Scholtens Fredrick R Schumacher William R Scott Thomas Seufferlein Jianxin Shi Albert Vernon Smith Joanna Smolonska Alice V Stanton Valgerdur Steinthorsdottir Kathleen Stirrups Heather M Stringham Johan Sundström Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Bamidele O Tayo Barbara Thorand Gudmar Thorleifsson Jonathan P Tyrer Hae-Won Uh Liesbeth Vandenput Frank C Verhulst Sita H Vermeulen Niek Verweij Judith M Vonk Lindsay L Waite Helen R Warren Dawn Waterworth Michael N Weedon Lynne R Wilkens Christina Willenborg Tom Wilsgaard Mary K Wojczynski Andrew Wong Alan F Wright Qunyuan Zhang Eoin P Brennan Murim Choi Zari Dastani Alexander W Drong Per Eriksson Anders Franco-Cereceda Jesper R Gådin Ali G Gharavi Michael E Goddard Robert E Handsaker Jinyan Huang Fredrik Karpe Sekar Kathiresan Sarah Keildson Krzysztof Kiryluk Michiaki Kubo Jong-Young Lee Liming Liang Richard P Lifton Baoshan Ma Steven A McCarroll Amy J McKnight Josine L Min Miriam F Moffatt Grant W Montgomery Joanne M Murabito George Nicholson Dale R Nyholt Yukinori Okada John R B Perry Rajkumar Dorajoo Eva Reinmaa Rany M Salem Niina Sandholm Robert A Scott Lisette Stolk Atsushi Takahashi Toshihiro Tanaka Ferdinand M van 't Hooft Anna A E Vinkhuyzen Harm-Jan Westra Wei Zheng Krina T Zondervan Andrew C Heath Dominique Arveiler Stephan J L Bakker John Beilby Richard N Bergman John Blangero Pascal Bovet Harry Campbell Mark J Caulfield Giancarlo Cesana Aravinda Chakravarti Daniel I Chasman Peter S Chines Francis S Collins Dana C Crawford L Adrienne Cupples Daniele Cusi John Danesh Ulf de Faire Hester M den Ruijter Anna F Dominiczak Raimund Erbel Jeanette Erdmann Johan G Eriksson Martin Farrall Stephan B Felix Ele Ferrannini Jean Ferrières Ian Ford Nita G Forouhi Terrence Forrester Oscar H Franco Ron T Gansevoort Pablo V Gejman Christian Gieger Omri Gottesman Vilmundur Gudnason Ulf Gyllensten Alistair S Hall Tamara B Harris Andrew T Hattersley Andrew A Hicks Lucia A Hindorff Aroon D Hingorani Albert Hofman Georg Homuth G Kees Hovingh Steve E Humphries Steven C Hunt Elina Hyppönen Thomas Illig Kevin B Jacobs Marjo-Riitta Jarvelin Karl-Heinz Jöckel Berit Johansen Pekka Jousilahti J Wouter Jukema Antti M Jula Jaakko Kaprio John J P Kastelein Sirkka M Keinanen-Kiukaanniemi Lambertus A Kiemeney Paul Knekt Jaspal S Kooner Charles Kooperberg Peter Kovacs Aldi T Kraja Meena Kumari Johanna Kuusisto Timo A Lakka Claudia Langenberg Loic Le Marchand Terho Lehtimäki Valeriya Lyssenko Satu Männistö André Marette Tara C Matise Colin A McKenzie Barbara McKnight Frans L Moll Andrew D Morris Andrew P Morris Jeffrey C Murray Mari Nelis Claes Ohlsson Albertine J Oldehinkel Ken K Ong Pamela A F Madden Gerard Pasterkamp John F Peden Annette Peters Dirkje S Postma Peter P Pramstaller Jackie F Price Lu Qi Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Paul M Ridker John D Rioux Marylyn D Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Heribert Schunkert Peter E H Schwarz Peter Sever Alan R Shuldiner Juha Sinisalo Ronald P Stolk Konstantin Strauch Anke Tönjes David-Alexandre Trégouët Angelo Tremblay Elena Tremoli Jarmo Virtamo Marie-Claude Vohl Uwe Völker Gérard Waeber Gonneke Willemsen Jacqueline C Witteman M Carola Zillikens Linda S Adair Philippe Amouyel Folkert W Asselbergs Themistocles L Assimes Murielle Bochud Bernhard O Boehm Eric Boerwinkle Stefan R Bornstein Erwin P Bottinger Claude Bouchard Stéphane Cauchi John C Chambers Stephen J Chanock Richard S Cooper Paul I W de Bakker George Dedoussis Luigi Ferrucci Paul W Franks Philippe Froguel Leif C Groop Christopher A Haiman Anders Hamsten Jennie Hui David J Hunter Kristian Hveem Robert C Kaplan Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Nicholas G Martin Winfried März Mads Melbye Andres Metspalu Susanne Moebus Patricia B Munroe Inger Njølstad Ben A Oostra Colin N A Palmer Nancy L Pedersen Markus Perola Louis Pérusse Ulrike Peters Chris Power Thomas Quertermous Rainer Rauramaa Fernando Rivadeneira Timo E Saaristo Danish Saleheen Naveed Sattar Eric E Schadt David Schlessinger P Eline Slagboom Harold Snieder Tim D Spector Unnur Thorsteinsdottir Michael Stumvoll Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa Pim van der Harst Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins David R Weir H-Erich Wichmann James F Wilson Pieter Zanen Ingrid B Borecki Panos Deloukas Caroline S Fox Iris M Heid Jeffrey R O'Connell David P Strachan Kari Stefansson Cornelia M van Duijn Gonçalo R Abecasis Lude Franke Timothy M Frayling Mark I McCarthy Peter M Visscher André Scherag Cristen J Willer Michael Boehnke Karen L Mohlke Cecilia M Lindgren Jacques S Beckmann Inês Barroso Kari E North Erik Ingelsson Joel N Hirschhorn Ruth J F Loos Elizabeth K Speliotes

Nature 2015 Feb;518(7538):197-206

Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.

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February 2015

Defining the role of common variation in the genomic and biological architecture of adult human height.

Authors:
Andrew R Wood Tonu Esko Jian Yang Sailaja Vedantam Tune H Pers Stefan Gustafsson Audrey Y Chu Karol Estrada Jian'an Luan Zoltán Kutalik Najaf Amin Martin L Buchkovich Damien C Croteau-Chonka Felix R Day Yanan Duan Tove Fall Rudolf Fehrmann Teresa Ferreira Anne U Jackson Juha Karjalainen Ken Sin Lo Adam E Locke Reedik Mägi Evelin Mihailov Eleonora Porcu Joshua C Randall André Scherag Anna A E Vinkhuyzen Harm-Jan Westra Thomas W Winkler Tsegaselassie Workalemahu Jing Hua Zhao Devin Absher Eva Albrecht Denise Anderson Jeffrey Baron Marian Beekman Ayse Demirkan Georg B Ehret Bjarke Feenstra Mary F Feitosa Krista Fischer Ross M Fraser Anuj Goel Jian Gong Anne E Justice Stavroula Kanoni Marcus E Kleber Kati Kristiansson Unhee Lim Vaneet Lotay Julian C Lui Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Michael A Nalls Dale R Nyholt Cameron D Palmer Dorota Pasko Sonali Pechlivanis Inga Prokopenko Janina S Ried Stephan Ripke Dmitry Shungin Alena Stancáková Rona J Strawbridge Yun Ju Sung Toshiko Tanaka Alexander Teumer Stella Trompet Sander W van der Laan Jessica van Setten Jana V Van Vliet-Ostaptchouk Zhaoming Wang Loïc Yengo Weihua Zhang Uzma Afzal Johan Arnlöv Gillian M Arscott Stefania Bandinelli Amy Barrett Claire Bellis Amanda J Bennett Christian Berne Matthias Blüher Jennifer L Bolton Yvonne Böttcher Heather A Boyd Marcel Bruinenberg Brendan M Buckley Steven Buyske Ida H Caspersen Peter S Chines Robert Clarke Simone Claudi-Boehm Matthew Cooper E Warwick Daw Pim A De Jong Joris Deelen Graciela Delgado Josh C Denny Rosalie Dhonukshe-Rutten Maria Dimitriou Alex S F Doney Marcus Dörr Niina Eklund Elodie Eury Lasse Folkersen Melissa E Garcia Frank Geller Vilmantas Giedraitis Alan S Go Harald Grallert Tanja B Grammer Jürgen Gräßler Henrik Grönberg Lisette C P G M de Groot Christopher J Groves Jeffrey Haessler Per Hall Toomas Haller Goran Hallmans Anke Hannemann Catharina A Hartman Maija Hassinen Caroline Hayward Nancy L Heard-Costa Quinta Helmer Gibran Hemani 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Ouwehand Gerard Pasterkamp Annette Peters Peter P Pramstaller Jackie F Price Lu Qi Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Marylyn Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Peter E H Schwarz Sylvain Sebert Peter Sever Alan R Shuldiner Juha Sinisalo Valgerdur Steinthorsdottir Ronald P Stolk Jean-Claude Tardif Anke Tönjes Angelo Tremblay Elena Tremoli Jarmo Virtamo Marie-Claude Vohl Philippe Amouyel Folkert W Asselbergs Themistocles L Assimes Murielle Bochud Bernhard O Boehm Eric Boerwinkle Erwin P Bottinger Claude Bouchard Stéphane Cauchi John C Chambers Stephen J Chanock Richard S Cooper Paul I W de Bakker George Dedoussis Luigi Ferrucci Paul W Franks Philippe Froguel Leif C Groop Christopher A Haiman Anders Hamsten M Geoffrey Hayes Jennie Hui David J Hunter Kristian Hveem J Wouter Jukema Robert C Kaplan Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Nicholas G Martin Winfried März Mads Melbye Susanne Moebus Patricia B Munroe 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Michael E Goddard Peter M Visscher Joel N Hirschhorn Timothy M Frayling

Nat Genet 2014 Nov 5;46(11):1173-86. Epub 2014 Oct 5.

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

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November 2014

Inactivating mutations in NPC1L1 and protection from coronary heart disease.

N Engl J Med 2014 Nov 12;371(22):2072-82. Epub 2014 Nov 12.

Cardiovascular Division, Department of Medicine, Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1056/NEJMoa1405386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335708PMC
November 2014

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.

N Engl J Med 2014 Jul 18;371(1):22-31. Epub 2014 Jun 18.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180269PMC
July 2014

SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes.

Cell Rep 2014 May 24;7(3):834-47. Epub 2014 Apr 24.

Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, ON K1Y, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address:

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May 2014

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.

PLoS Genet 2014 Mar 27;10(3):e1004263. Epub 2014 Mar 27.

Institut für Molekulare Medizin, Universität zu Lübeck, Lübeck, Germany; DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lubeck/Kiel, Lubeck, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967965PMC
March 2014

How to include chromosome X in your genome-wide association study.

Genet Epidemiol 2014 Feb 9;38(2):97-103. Epub 2014 Jan 9.

Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany; DZHK (German Centre for Cardiovascular Research), Lübeck, Germany.

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February 2014

Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.

Stroke 2014 Jan 21;45(1):24-36. Epub 2013 Nov 21.

From the Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität, Munich, Germany (M.D., R. Malik); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (M.D.); Institut für Medizinische Biometrie und Statistik (I.R.K.), and Institut für integrative und experimentelle Genomik (J.E.), Universität zu Lübeck, Lübeck, Germany; Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Germany (I.R.K.); Department of Neurology and Center for Human Genetic Research (J.R.), and Cardiology Division (C.J.O.D.), Massachusetts General Hospital, Boston; Harvard Medical School, Boston, MA (J.R.); Program in Medical and Population Genetics (J.R.), and Program in Medical and Population Genetics (S.K.), Broad Institute of Harvard and MIT, Cambridge, MA; Clinical Trial Service Unit and Epidemiological Studies Unit (R.C., J.C.H.), Wellcome Trust Centre for Human Genetics (H.W., M. Farrall), Department of Cardiovascular Medicine (M. Farrall), and Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience (P.M.R.), John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; deCODE Genetics, Reykjavik, Iceland (S.G., G.T., U.T., K.S.); Department of Medicine, University of Maryland School of Medicine, Baltimore (B.D.M.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (T.L.A.); Center for Translational Neuroscience and Mental Health Research, University of Newcastle, New South Wales, Australia (C.L.); Hunter Medical Research Institute, New South Wales, Australia (C.L.); National Heart, Lung and Blood Institute and NHLBI's Framingham Heart Study, MA (C.J.O.D., S.S.); University of Texas Health Science Center at Houston (M. Fornage); Cardiovascular Health Research Unit, Department of Epidemiology (B.M.P.), Department of Medicine (B.M.P.), Department of Health Services (B.M.P.), and Cardiovascular Health Research Unit, Department of Medicine (J.C.B.), University

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January 2014

Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia.

Arterioscler Thromb Vasc Biol 2013 Dec 26;33(12):2909-14. Epub 2013 Sep 26.

From the Cardiovascular Division, Department of Medicine (N.O.S.) and Division of Statistical Genomics (N.O.S.), Washington University School of Medicine, Saint Louis, MO; Department of Vascular Medicine (B.S., S.S., J.J.P.K., G.K.H.) Department of Experimental Vascular Medicine (S.W.F., J.C.D), and Radiology (A.J.N.), Academic Medical Center, Amsterdam, The Netherlands; Center for Human Genetic Research, Boston, MA (G.M.P., A.M.M., D.A., S.K.); Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (G.M.P., A.M.M., D.A., S.K.); Fred Hutchinson Cancer Research Center, Seattle, WA (P.L.A., C.K.); Wellcome Trust Centre for Human Genetics (A.G., M.F., H.W.) and Cardiovascular Medicine, Radcliffe Department of Medicine (A.G., M.F., H.W.), University of Oxford, Oxford, United Kingdom; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (B.G., U.d.F.); Department of Cardiovascular Sciences, University of Leicester and Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom (T.A.B., N.J.S.); Department of Clinical Sciences, Hypertension and Cardiovascular Diseases (O.M.) and Diabetes and Cardiovascular Disease Genetic Epidemiology (M.O.-M.), Skania University Hospital, Lund University, Malmö, Sweden; Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Milan, Italy (S.D.); Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (M.N.); Department of Medicine, University of Verona, Verona, Italy (N.M., D.G.); Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus (R.D.J.); Departments of Epidemiology, Genetics and Biostatistics, Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill (L.A.L.); Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy (D.A.); The John & Jennif

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002172PMC
December 2013

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.

Authors:
Maria Sabater-Lleal Jie Huang Daniel Chasman Silvia Naitza Abbas Dehghan Andrew D Johnson Alexander Teumer Alex P Reiner Lasse Folkersen Saonli Basu Alicja R Rudnicka Stella Trompet Anders Mälarstig Jens Baumert Joshua C Bis Xiuqing Guo Jouke J Hottenga So-Youn Shin Lorna M Lopez Jari Lahti Toshiko Tanaka Lisa R Yanek Tiphaine Oudot-Mellakh James F Wilson Pau Navarro Jennifer E Huffman Tatijana Zemunik Susan Redline Reena Mehra Drazen Pulanic Igor Rudan Alan F Wright Ivana Kolcic Ozren Polasek Sarah H Wild Harry Campbell J David Curb Robert Wallace Simin Liu Charles B Eaton Diane M Becker Lewis C Becker Stefania Bandinelli Katri Räikkönen Elisabeth Widen Aarno Palotie Myriam Fornage David Green Myron Gross Gail Davies Sarah E Harris David C Liewald John M Starr Frances M K Williams Peter J Grant Timothy D Spector Rona J Strawbridge Angela Silveira Bengt Sennblad Fernando Rivadeneira Andre G Uitterlinden Oscar H Franco Albert Hofman Jenny van Dongen Gonneke Willemsen Dorret I Boomsma Jie Yao Nancy Swords Jenny Talin Haritunians Barbara McKnight Thomas Lumley Kent D Taylor Jerome I Rotter Bruce M Psaty Annette Peters Christian Gieger Thomas Illig Anne Grotevendt Georg Homuth Henry Völzke Thomas Kocher Anuj Goel Maria Grazia Franzosi Udo Seedorf Robert Clarke Maristella Steri Kirill V Tarasov Serena Sanna David Schlessinger David J Stott Naveed Sattar Brendan M Buckley Ann Rumley Gordon D Lowe Wendy L McArdle Ming-Huei Chen Geoffrey H Tofler Jaejoon Song Eric Boerwinkle Aaron R Folsom Lynda M Rose Anders Franco-Cereceda Martina Teichert M Arfan Ikram Thomas H Mosley Steve Bevan Martin Dichgans Peter M Rothwell Cathie L M Sudlow Jemma C Hopewell John C Chambers Danish Saleheen Jaspal S Kooner John Danesh Christopher P Nelson Jeanette Erdmann Muredach P Reilly Sekar Kathiresan Heribert Schunkert Pierre-Emmanuel Morange Luigi Ferrucci Johan G Eriksson David Jacobs Ian J Deary Nicole Soranzo Jacqueline C M Witteman Eco J C de Geus Russell P Tracy Caroline Hayward Wolfgang Koenig Francesco Cucca J Wouter Jukema Per Eriksson Sudha Seshadri Hugh S Markus Hugh Watkins Nilesh J Samani Henri Wallaschofski Nicholas L Smith David Tregouet Paul M Ridker Weihong Tang David P Strachan Anders Hamsten Christopher J O'Donnell

Circulation 2013 Sep 22;128(12):1310-24. Epub 2013 Aug 22.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842025PMC
September 2013