Jean-Yves Douillard

Jean-Yves Douillard

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Jean-Yves Douillard

Jean-Yves Douillard

Publications by authors named "Jean-Yves Douillard"

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3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation.

Eur J Med Chem 2019 Sep 29;178:195-213. Epub 2019 May 29.

Université de Nantes, CNRS, Chimie et Interdisciplinarité: Synthèse, Analyse, Modélisation (CEISAM), UMR CNRS 6230, Faculté des Sciences et des Techniques, 2 rue de la Houssinière, BP 92208, 44322, Nantes Cedex 3, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.05.069DOI Listing
September 2019

RE: Magnitude of Clinical Benefit of Cancer Drugs Approved by the US Food and Drug Administration.

J Natl Cancer Inst 2018 10;110(10):1142-1143

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1093/jnci/djy029DOI Listing
October 2018

Effect of Primary Tumor Location on Second- or Later-line Treatment Outcomes in Patients With RAS Wild-type Metastatic Colorectal Cancer and All Treatment Lines in Patients With RAS Mutations in Four Randomized Panitumumab Studies.

Clin Colorectal Cancer 2018 09 8;17(3):170-178.e3. Epub 2018 Mar 8.

Center for Oncological Research, University of Antwerp, Wilrijk, Belgium; Department of Oncology, Antwerp University Hospital, Edegem, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2018.03.005DOI Listing
September 2018

Efficacy and Safety of Nintedanib Plus Docetaxel in Patients with Advanced Lung Adenocarcinoma: Complementary and Exploratory Analyses of the Phase III LUME-Lung 1 Study.

Target Oncol 2017 08;12(4):475-485

Department of Thoracic Oncology, LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), 22927, Grosshansdorf, Germany.

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http://dx.doi.org/10.1007/s11523-017-0517-2DOI Listing
August 2017

Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database.

J Clin Oncol 2017 Jun 17;35(17):1929-1937. Epub 2017 Apr 17.

Lindsay A. Renfro, Axel Grothey, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Richard M. Goldberg, The Ohio State University, Columbus, OH; Alberto Sobrero, Ospedale San Martino, Genoa; Alfredo Falcone, University Hospital of Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil; Christophe Tournigand, Assistance Hopitaux Publique de Paris Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs; Dana-Farber Cancer Institute, Boston, MA; Eduardo Diaz-Rubio, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Paulo M. Hoff, Hospital Sírio-Libanês and University of São Paulo, São Paulo, Brazil; Fairooz F. Kabbinavar and J. Randolph Hecht, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, University of Amsterdam, Amsterdam, the Netherlands; John Souglakos, University of Crete, Heraklion, Greece; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; and Leonard Saltz, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.71.5771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466009PMC
June 2017

Pooled Analysis of the Prognostic and Predictive Effects of TP53 Comutation Status Combined With KRAS or EGFR Mutation in Early-Stage Resected Non-Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy.

J Clin Oncol 2017 Jun 28;35(18):2018-2027. Epub 2017 Apr 28.

Frances A. Shepherd and Ming-Sound Tsao, Princess Margaret Cancer Centre; University of Toronto, Toronto; Lesley Seymour, Queen's University, Kingston, Ontario, Canada; Benjamin Lacas, Gwénaël Le Teuff, Jean-Pierre Pignon, Thierry Le Chevalier, and Jean-Charles Soria, Institut Gustave-Roussy; Benjamin Lacas, Gwénaël Le Teuff, Jean-Pierre Pignon, Thierry Le Chevalier, and Jean-Charles Soria, University Paris XI, Paris; Pierre Hainaut, International Agency for Research on Cancer, Lyon; Jean-Yves Douillard, R Gauducheau, St Herblain; Elizabeth Brambilla, Inserm U823, Institut Albert Bonniot, Département de Pathologie CHU, Albert Michallon University Joseph Fourrier, Grenoble, France; Pasi A. Jänne, Dana-Farber Cancer Institute, Boston, MA; Stephen Graziano, State University of New York Upstate Medical University, Syracuse, NY; Robert Kratzke, University of Minnesota Medical School, Minneapolis, MN; and Robert Pirker and Martin Filipits, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1200/JCO.2016.71.2893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075828PMC
June 2017

ESMO Copenhagen 2016: a lung cancer 'grand cru'.

ESMO Open 2017 28;2(2):e000196. Epub 2017 May 28.

Chief Medical Officer, European Society for Medical Oncology, Viganello, TI, Switzerland.

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http://dx.doi.org/10.1136/esmoopen-2017-000196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519794PMC
May 2017

A study-level meta-analysis of efficacy data from head-to-head first-line trials of epidermal growth factor receptor inhibitors versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer.

Eur J Cancer 2016 11 1;67:11-20. Epub 2016 Sep 1.

Department of Medical Oncology, Institut de Cancérologie de l'Ouest (ICO) René Gauducheau, 44805, St Herblain, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.07.019DOI Listing
November 2016

Prognostic and Predictive Effect of TP53 Mutations in Patients with Non-Small Cell Lung Cancer from Adjuvant Cisplatin-Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis.

J Thorac Oncol 2016 06 17;11(6):850-61. Epub 2016 Feb 17.

International Agency for Research on Cancer, Lyon, France; Department of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada; Department of Pathology, Centre Hospitalier Universitaire, Grenoble, France; International Prevention Research Institute, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.02.002DOI Listing
June 2016

Prognostic Effect of Tumor Lymphocytic Infiltration in Resectable Non-Small-Cell Lung Cancer.

J Clin Oncol 2016 Apr 1;34(11):1223-30. Epub 2016 Feb 1.

Elisabeth Brambilla and Sylvie Lantuejoul, Institut Albert Bonniot-Institut National de la Santé et de la Recherche Médicale U823; and Centre Hospitalier Universitaire Albert Michallon, Grenoble; Gwénaël Le Teuff, Sophie Marguet, Ariane Dunant, Thierry Le Chevalier, and Jean-Charles Soria, Institut Gustave Roussy, Villejuif; Gwénaël Le Teuff, Sophie Marguet, Ariane Dunant, Thierry Le Chevalier, and Jean-Charles Soria, Université Paris-Sud, Orsay; Gwénaël Le Teuff, Université Paris-Saclay, Saint-Aubin; Jean-Yves Douillard, Centre René Gauducheau Institut de Cancerologie de l'Ouest, Saint-Herblain, France; Stephen Graziano, State University of New York Upstate Medical University, Syracuse, NY; Robert Pirker and Martin Filipits, Medical University of Vienna, Vienna; Helmut Popper, Medical University of Graz, Graz, Austria; Rafael Rosell, Catalan Institute of Oncology, Barcelona, Spain; Robert Kratzke, University of Minnesota, Minneapolis, MN; Frances A. Shepherd and Ming Sound Tsao, Princess Margaret Cancer Centre; Frances A. Shepherd and Ming Sound Tsao, University of Toronto, Toronto; and Lesley Seymour, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2015.63.0970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872323PMC
April 2016

Body Mass Index Is Prognostic in Metastatic Colorectal Cancer: Pooled Analysis of Patients From First-Line Clinical Trials in the ARCAD Database.

J Clin Oncol 2016 Jan 26;34(2):144-50. Epub 2015 Oct 26.

Lindsay A. Renfro and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Fotios Loupakis and Alfredo Falcone, Azienda Ospedaliero-Universitaria Pisana and Università di Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital Cancer Center, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Institut de Cancerologie, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil, Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs, Dana-Farber Cancer Institute Boston, MA; Eduardo Diaz-Rubio, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; J. Randolph Hecht, David Geffen School of Medicine at the University of California at Los Angeles; Heinz-Josef Lenz, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; Richard M. Goldberg, Ohio State University, Columbus, OH; and Leonard B. Saltz, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2015.61.6441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070548PMC
January 2016

Subtype Classification of Lung Adenocarcinoma Predicts Benefit From Adjuvant Chemotherapy in Patients Undergoing Complete Resection.

J Clin Oncol 2015 Oct 27;33(30):3439-46. Epub 2015 Apr 27.

Ming-Sound Tsao and Frances A. Shepherd, Princess Margaret Cancer Centre, University Health Network, and University of Toronto, Toronto; Lesley Seymour, NCIC Clinical Trials Group and Queen's University, Kingston, Ontario, Canada; Sophie Marguet, Gwénaël Le Teuff, Thierry Le-Chevalier, Jean-Pierre Pignon, and Jean-Charles Soria, Gustave Roussy, Villejuif; Sylvie Lantuejoul and Elisabeth M. Brambilla, Inserm U823, Centre Hospitalier Universitaire de Grenoble, Institut Albert Bonniot, Université Joseph Fourier, Grenoble; Jean-Yves Douillard, Centre René Gauducheau, Saint-Herblain, Nantes, France; Robert Kratzke, University of Minnesota, Minneapolis, MN; Stephen L. Graziano, SUNY Upstate Medical University, Syracuse, NY; Helmut H. Popper, Institute of Pathology, University Medical School of Graz, Graz, Austria; and Rafael Rosell, Catalan Institute of Oncology, Barcelona, Spain.

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http://dx.doi.org/10.1200/JCO.2014.58.8335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606061PMC
October 2015

Safety and Immunogenicity of MAGE-A3 Cancer Immunotherapeutic with or without Adjuvant Chemotherapy in Patients with Resected Stage IB to III MAGE-A3-Positive Non-Small-Cell Lung Cancer.

J Thorac Oncol 2015 Oct;10(10):1458-67

*Thoracic Oncology Unit, Arnaud de Villeneuve Hospital/CHRU Montpellier, Montpellier, France; †Department of Pneumology, University Hospital, KU Leuven, Leuven, Belgium; ‡Medical Oncology, European Institute of Oncology, Milan, Italy; §Division of Hematology and Hematologic Malignancies, University of Utah Huntsman Cancer Institute, Salt Lake City, Utah; ¶Department of Thoracic Oncology, Hospital Grosshansdorf, Grosshansdorf, Germany; ‖Department of Respiratory Medicine, Ziekenhuis Oost Limburg, Genk and LCRP Oncology Cluster, University of Hasselt, Hasselt, Belgium; #Department of Medical Oncologie, ICO R. Gauducheau, St-Herblain, France; **Department of Oncology, University Hospital S. Maria della misericordia, Udine, Italy; ††Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom; ‡‡Northwest Lung Centre, University Hospitals of South Manchester, Manchester, United Kingdom; §§Thoracic Oncology-Pneumology Service, André Renard Clinic, Herstal, Belgium; ¶¶Clinic of Thoracic Surgery, Waldburg-Zeil Clinic, Wangen im Allgäu, Germany; and ‖‖GSK Vaccines, Rixensart, Belgium.

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http://dx.doi.org/10.1097/JTO.0000000000000653DOI Listing
October 2015

Impact of early tumour shrinkage and resection on outcomes in patients with wild-type RAS metastatic colorectal cancer.

Eur J Cancer 2015 Jul 5;51(10):1231-42. Epub 2015 May 5.

Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2015.03.026DOI Listing
July 2015

Panitumumab in Metastatic Colorectal Cancer: The Importance of Tumour RAS Status.

Drugs 2015 May;75(7):731-48

Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium,

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http://dx.doi.org/10.1007/s40265-015-0386-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419154PMC
May 2015

Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: findings from the analysis and research in cancers of the digestive system database.

J Clin Oncol 2015 Jan 10;33(1):22-8. Epub 2014 Nov 10.

Qian Shi, Axel Grothey, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Aimery de Gramont and Benoist Chibaudel, Hospital Saint Antoine; Christophe Tournigand, Université Paris Est Créteil, Paris; Jean-Yves Douillard, Institute of Cancer Research in Western, St Herblain, France; John Zalcberg, Monash University; Niall C. Tebbutt, Austin Health, Melbourne, Victoria, Australia; Hans-Joachim Schmoll, Martin-Luther University, Halle; Rainer Porschen, Klinikum Bremen-Ost, Bremen; Volker Heinemann, University of Munich, München; Carsten Bokemeyer, University Hospital, Hamburg-Eppendorf, Germany; Matthew T. Seymour, Cancer Research UK Clincal Center, Leeds; Richard Adams, Cardiff University, Cardiff, United Kingdom; Leonard Saltz, Memorial Sloan-Kettering Cancer Center, New York, NY; Richard M. Goldberg, Ohio State University, Columbus, OH; Cornelis J.A. Punt, Academic Medical Center, Amsterdam, the Netherlands; Paulo M. Hoff, Hospital Sírio-Libanês, Sao Paulo, Brazil; Joel Randolph Hecht and Fairooz F. Kabbinavar, University of California at Los Angeles, Los Angeles, CA; Herbert Hurwitz, Duke University, Durham, NC; Eduardo Díaz-Rubio, Hospital Clinico San Carlos, Madrid, Spain; Charles Fuchs, Dana-Farber Cancer Institute, Boston, MA; John Souglakos, University of Crete, Heraklion, Greece; Alfredo Falcone, University of Pisa, Pisa, Italy; Eric Van Cutsem, University Hospital Gasthuisberg, Leuven; and Marc Buyse, International Drug Development Institute, Louvain-la-Neuve, Belgium.

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http://dx.doi.org/10.1200/JCO.2014.56.5887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482837PMC
January 2015

Gefitinib treatment in EGFR mutated caucasian NSCLC: circulating-free tumor DNA as a surrogate for determination of EGFR status.

J Thorac Oncol 2014 Sep;9(9):1345-53

*Institut de Cancerologie, Centre René Gauducheau, Nantes, France; †National Koranyi Institute of Pulmonology, Budapest, Hungary; ‡Hospital Regional Universitario, Malaga, Spain; §Institutul Oncologic Prof. Dr. Ion Chiricuta and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania; and ‖AstraZeneca, Macclesfield, United Kingdom.

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http://dx.doi.org/10.1097/JTO.0000000000000263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224589PMC
September 2014

Relationship between EGFR expression, EGFR mutation status, and the efficacy of chemotherapy plus cetuximab in FLEX study patients with advanced non-small-cell lung cancer.

J Thorac Oncol 2014 May;9(5):717-24

*Department of Medical Oncology, Institut de Cancerologie de l'Ouest, Centre René Gauducheau, Saint-Herblain, France; †Department of Medicine I, Medical University of Vienna, Vienna, Austria; ‡HOPE Directorate, St James's Hospital, Dublin, Ireland; §Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom; ‖Institute of Pathology, University of Witten/Herdecke and HELIOS Hospital Wuppertal, Wuppertal, Germany; ¶Global Biostatistics, #Biomarker Technologies & Operations, and **Translational Innovation Platform Oncology, Merck KGaA, Darmstadt, Germany; and ††University Health Network, Department of Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1097/JTO.0000000000000141DOI Listing
May 2014

RAS mutations in colorectal cancer.

N Engl J Med 2013 11;369(22):2159-60

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http://dx.doi.org/10.1056/NEJMc1312697DOI Listing
November 2013

[Immunotherapy for non-small cell lung cancer--novel approaches to improve patient outcome].

Zhongguo Fei Ai Za Zhi 2013 Apr;16(4):C9-20

Department of Medical Oncology and Hematology, University Health Network, Princess Margaret Hospital and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3779/j.issn.1009-3419.2013.04.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123568PMC
April 2013

[Optimizing good use and costs of anticancer drugs: A French inter regional study of the Observatory of Cancer].

Bull Cancer 2013 Mar;100(3):271-82

Observatoire dédié au Cancer Bretagne et Pays-de-la-Loire, Siège médical Paul-Papin, 49000 Angers, France.

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http://dx.doi.org/10.1684/bdc.2013.1715DOI Listing
March 2013

Panitumumab in combination with cytotoxic chemotherapy for the treatment of metastatic colorectal carcinoma.

Clin Colorectal Cancer 2012 Mar 16;11(1):14-23. Epub 2011 Sep 16.

Antwerp University Hospital, Antwerp, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S15330028110010
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http://dx.doi.org/10.1016/j.clcc.2011.06.010DOI Listing
March 2012

3-fluoro- and 3,3-difluoro-3,4-dideoxy-KRN7000 analogues as new potent immunostimulator agents: total synthesis and biological evaluation in human invariant natural killer T cells and mice.

J Med Chem 2012 Feb 1;55(3):1227-41. Epub 2012 Feb 1.

Université de Nantes, CNRS, Chimie et Interdisciplinarité: Synthèse, Analyse, Modélisation (CEISAM), UMR CNRS 6230, Faculté des Sciences et des Techniques, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.

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http://dx.doi.org/10.1021/jm201368mDOI Listing
February 2012

Immunotherapy for non-small cell lung cancer: novel approaches to improve patient outcome.

J Thorac Oncol 2011 Oct;6(10):1763-73

Department of Medical Oncology and Hematology, University Health Network, Princess Margaret Hospital and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JTO.0b013e31822e28fcDOI Listing
October 2011

Adjuvant chemotherapy for non-small-cell lung cancer: it does not always fade with time.

J Clin Oncol 2010 Jan 23;28(1):3-5. Epub 2009 Nov 23.

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http://dx.doi.org/10.1200/JCO.2009.25.5109DOI Listing
January 2010

Focus on the controversial activation of human iNKT cells by 4-deoxy analogue of KRN7000.

J Med Chem 2009 Aug;52(15):4960-3

Université de Nantes, CNRS, Chimie et Interdisciplinarité: Synthèse, Analyse, Modélisation (CEISAM), UMR CNRS 6230, Faculté des Sciences et des Techniques, 2 Rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.

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http://dx.doi.org/10.1021/jm900290rDOI Listing
August 2009

The role of UFT in metastatic colorectal cancer.

Oncology 2009 20;76(5):301-10. Epub 2009 Mar 20.

Centre R Gauducheau, St Herblain, France.

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http://dx.doi.org/10.1159/000209334DOI Listing
May 2009

Is XELOX equivalent to FOLFOX or other continuous-infusion 5-fluorouracil chemotherapy in metastatic colorectal cancer?

Clin Colorectal Cancer 2008 May;7(3):206-11

Department of Medical Oncology, Centre R. Gauducheau, St. Herblain, France.

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http://dx.doi.org/10.3816/CCC.2008.n.029DOI Listing
May 2008

Endpoints in adjuvant treatment trials: a systematic review of the literature in colon cancer and proposed definitions for future trials.

J Natl Cancer Inst 2007 Jul 27;99(13):998-1003. Epub 2007 Jun 27.

Department of Medical Oncology, Radboud University Nijmegen Medical Center, PO Box 9101 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/jnci/djm024DOI Listing
July 2007