Jean-Pierre J Issa

Jean-Pierre J Issa

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Jean-Pierre J Issa

Publications by authors named "Jean-Pierre J Issa"

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Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology.

Mol Psychiatry 2019 Aug 27. Epub 2019 Aug 27.

Alzheimer's Center at Temple, Lewis Katz School of Medicine Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41380-019-0489-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044032PMC
August 2019

Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia.

Clin Epigenetics 2019 07 22;11(1):106. Epub 2019 Jul 22.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/s13148-019-0704-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647096PMC
July 2019

Introduction: Cancer as an Epigenetic Disease.

Cancer J 2017 Sep/Oct;23(5):255-256

From the Fels Institute, Temple University School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1097/PPO.0000000000000285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708861PMC
March 2019

Demethylator phenotypes in acute myeloid leukemia.

Leukemia 2018 10 7;32(10):2178-2188. Epub 2018 Mar 7.

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1038/s41375-018-0084-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128790PMC
October 2018

TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer.

Cancer Res 2018 08 11;78(15):4126-4137. Epub 2018 Jun 11.

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-2082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072603PMC
August 2018

Digital Restriction Enzyme Analysis of Methylation (DREAM).

Methods Mol Biol 2018 ;1708:247-265

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/978-1-4939-7481-8_13DOI Listing
July 2018

Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion.

J Neurosci 2018 07 6;38(27):6090-6101. Epub 2018 Jun 6.

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140 and

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http://dx.doi.org/10.1523/JNEUROSCI.2616-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031579PMC
July 2018

Epigenetics and Precision Oncology.

Cancer J 2017 Sep/Oct;23(5):262-269

From the *Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

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http://dx.doi.org/10.1097/PPO.0000000000000281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708865PMC
May 2018

Caloric restriction delays age-related methylation drift.

Nat Commun 2017 09 14;8(1):539. Epub 2017 Sep 14.

Fels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, 19140, USA.

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http://dx.doi.org/10.1038/s41467-017-00607-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599616PMC
September 2017

A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer.

Nucleic Acids Res 2017 Aug;45(14):8269-8281

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1093/nar/gkx435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737541PMC
August 2017

DNA Hypomethylating Drugs in Cancer Therapy.

Cold Spring Harb Perspect Med 2017 May 1;7(5). Epub 2017 May 1.

Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania 19111.

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http://dx.doi.org/10.1101/cshperspect.a026948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411681PMC
May 2017

Repositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome.

Mol Cancer Ther 2017 02 15;16(2):397-407. Epub 2016 Dec 15.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292054PMC
February 2017

The promise of epigenetic therapy: reprogramming the cancer epigenome.

Curr Opin Genet Dev 2017 Feb 14;42:68-77. Epub 2017 Apr 14.

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X173003
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http://dx.doi.org/10.1016/j.gde.2017.03.015DOI Listing
February 2017

Transcriptional Selectivity of Epigenetic Therapy in Cancer.

Cancer Res 2017 01 22;77(2):470-481. Epub 2016 Nov 22.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243171PMC
January 2017

Healthcare utilization and costs associated with tyrosine kinase inhibitor switching in patients with chronic myeloid leukemia.

Leuk Lymphoma 2016 20;57(4):935-41. Epub 2015 Nov 20.

c Fels Institute for Cancer Research , Temple University School of Medicine , Philadelphia , PA , USA.

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http://dx.doi.org/10.3109/10428194.2015.1088654DOI Listing
December 2016

Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells.

Epigenetics 2015 ;10(11):1006-13

a Fels Institute for Cancer Research and Molecular Biology; Temple University ; Philadelphia , PA USA.

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http://dx.doi.org/10.1080/15592294.2015.1091145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844212PMC
October 2016

Targeting the cancer epigenome for therapy.

Nat Rev Genet 2016 09;17(10):630-41

Van Andel Research Institute, Grand Rapids, Michigan 49503, USA.

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http://dx.doi.org/10.1038/nrg.2016.93DOI Listing
September 2016

Zebrafish embryos as a screen for DNA methylation modifications after compound exposure.

Toxicol Appl Pharmacol 2016 Jan 19;291:84-96. Epub 2015 Dec 19.

Center for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2015.12.012DOI Listing
January 2016

Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.

J Clin Oncol 2015 Dec 12;33(34):4032-8. Epub 2015 Oct 12.

Scott Kopetz, Dipen Maru, Van Morris, Filip Janku, and Arvind Dasari, The University of Texas MD Anderson Cancer Center, Houston, TX; Emily Chan, Vanderbilt-Ingram Cancer Center, Nashville, TN; Joel Randolph Hecht, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Brian James and Garth Powis, Sanford Burnham Institute, La Jolla; Keith B. Nolop, Plexxikon, Berkeley; Suman Bhattacharya, Genentech, South San Francisco, CA; Peter J. O'Dwyer, Abramson Cancer Center at University of Pennsylvania, Philadelphia, PA; Woonbook Chung and Jean-Pierre J. Issa, Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA; Leonard Saltz, Memorial Sloan-Kettering Cancer Center, New York, NY; and Jayesh Desai and Peter Gibbs, Royal Melbourne Hospital, Parkville, Victoria, Australia.

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http://jco.ascopubs.org/content/early/2015/10/12/JCO.2015.63
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http://jco.ascopubs.org/content/suppl/2015/11/23/33.34.4032.
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.63.2497
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http://dx.doi.org/10.1200/JCO.2015.63.2497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669589PMC
December 2015

Hypomethylation of TET2 Target Genes Identifies a Curable Subset of Acute Myeloid Leukemia.

J Natl Cancer Inst 2015 Nov 13;108(2). Epub 2015 Nov 13.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA (JY, JJ, NJMR, MC, JPJI); Department of Leukemia (JY, RT, JJ, NJMR, SAP, SMK, FR, HMK, JPJI) and Department of Hematopathology (CEBR), The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1093/jnci/djv323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862435PMC
November 2015

Will next-generation agents deliver on the promise of epigenetic hypomethylation therapy?

Epigenomics 2015 Oct 6;7(7):1083-8. Epub 2015 Nov 6.

Fels Institute, Temple University School of Medicine & Cancer Epigenetics Program, Fox Chase Cancer Center, Temple Health, 3307 North Broad Street, Room 154, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.2217/epi.15.66DOI Listing
October 2015

Regulation of AURKC expression by CpG island methylation in human cancer cells.

Tumour Biol 2015 Sep 20;36(10):8147-58. Epub 2015 May 20.

Department of Translational Molecular Pathology, UT MD Anderson Cancer Center, Unit 2951, Life Science Plaza Building, 2130 W. Holcombe Blvd., Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s13277-015-3553-5DOI Listing
September 2015

Epigenetic synergy between decitabine and platinum derivatives.

Clin Epigenetics 2015 11;7:97. Epub 2015 Sep 11.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.

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http://dx.doi.org/10.1186/s13148-015-0131-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567801PMC
September 2015

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.

Cancer Res 2015 Jul 13;75(14):2833-43. Epub 2015 May 13.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506197PMC
July 2015

Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties.

Sci Rep 2013 ;3:2687

1] Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA [2] Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA [3] Center for Stem Cells & Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1038/srep02687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776231PMC
June 2014

TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells.

Nucleic Acids Res 2014 Jun 29;42(11):6956-71. Epub 2014 May 29.

Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140, USA

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http://dx.doi.org/10.1093/nar/gku372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066785PMC
June 2014

Age-related epigenetic drift in the pathogenesis of MDS and AML.

Genome Res 2014 Apr 10;24(4):580-91. Epub 2014 Jan 10.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania 19140, USA;

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http://dx.doi.org/10.1101/gr.157529.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975058PMC
April 2014

Fusobacterium in colonic flora and molecular features of colorectal carcinoma.

Cancer Res 2014 Mar 2;74(5):1311-8. Epub 2014 Jan 2.

Authors' Affiliations: Fels Institute for Cancer Research & Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania; Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake; First Departments of Internal Medicine and Molecular Biology, Sapporo Medical University, Sapporo; Department of Gastroenterology, Akita Red Cross Hospital, Akita; Department of Pathology, Iwate Medical University, Morioka; Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan; Division of OVP, Department of Clinical Cancer Prevention, Cancer Prevention and Population Sciences; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston; and Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396185PMC
March 2014

Hepatitis virus infection affects DNA methylation in mice with humanized livers.

Gastroenterology 2014 Feb 30;146(2):562-72. Epub 2013 Oct 30.

Division of Epigenomics, Aichi Cancer Center, Nagoya, Japan; Division of Molecular Oncology, Aichi Cancer Center, Nagoya, Japan; Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, Japan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2013.10.056DOI Listing
February 2014

Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.

Gastroenterology 2014 Feb 6;146(2):530-38.e5. Epub 2013 Nov 6.

Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085130157
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http://dx.doi.org/10.1053/j.gastro.2013.10.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918446PMC
February 2014

Examination of whole blood DNA methylation as a potential risk marker for gastric cancer.

Cancer Prev Res (Phila) 2013 Oct 13;6(10):1093-100. Epub 2013 Aug 13.

Temple University School of Medicine, 3307 N. Broad Street, Room 154 PAHB, Philadelphia, PA 19140.

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http://dx.doi.org/10.1158/1940-6207.CAPR-13-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337829PMC
October 2013

Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma.

Cancer Res 2013 Jul 29;73(14):4559-70. Epub 2013 May 29.

Department of Neurosurgery, Nagoya University School of Medicine, Divisions of Epigenomics and Molecular Oncology, Aichi Cancer Center Research Institute.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0109DOI Listing
July 2013

The myelodysplastic syndrome as a prototypical epigenetic disease.

Blood 2013 May;121(19):3811-7

Fels Institute, Temple University School of Medicine, Philadelphia, PA 19140,

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http://dx.doi.org/10.1182/blood-2013-02-451757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650703PMC
May 2013

Epigenetic aspects of MDS and its molecular targeted therapy.

Int J Hematol 2013 Feb 10;97(2):175-82. Epub 2012 Oct 10.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1007/s12185-012-1197-4DOI Listing
February 2013

The epigenome of AML stem and progenitor cells.

Epigenetics 2013 Jan 18;8(1):92-104. Epub 2012 Dec 18.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.4161/epi.23243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549884PMC
January 2013

Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique.

Epigenetics 2012 Dec 17;7(12):1368-78. Epub 2012 Oct 17.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/epi.22552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528692PMC
December 2012

SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters.

Mol Cancer Res 2012 Oct 4;10(10):1332-42. Epub 2012 Sep 4.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-12-0351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475755PMC
October 2012

Metabolic, hormonal and immunological associations with global DNA methylation among postmenopausal women.

Epigenetics 2012 Sep 7;7(9):1020-8. Epub 2012 Aug 7.

Division of Preventive Oncology, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.4161/epi.21464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515011PMC
September 2012

Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island.

Nucleic Acids Res 2012 Aug 17;40(15):7257-68. Epub 2012 May 17.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gks429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424568PMC
August 2012

Dissecting DNA hypermethylation in cancer.

FEBS Lett 2011 Jul 10;585(13):2078-86. Epub 2010 Dec 10.

Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX 77030, United States.

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http://dx.doi.org/10.1016/j.febslet.2010.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378045PMC
July 2011

Detection of bladder cancer using novel DNA methylation biomarkers in urine sediments.

Cancer Epidemiol Biomarkers Prev 2011 Jul 17;20(7):1483-91. Epub 2011 May 17.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-11-0067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132294PMC
July 2011

DNA methylation predicts recurrence from resected stage III proximal colon cancer.

Cancer 2011 May 18;117(9):1847-54. Epub 2010 Nov 18.

Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/cncr.25737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117123PMC
May 2011

Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.

EMBO Rep 2011 Mar 18;12(3):238-43. Epub 2011 Feb 18.

Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Park Road 1C, Smithville, Texas 78957, USA.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2011.9
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http://dx.doi.org/10.1038/embor.2011.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059907PMC
March 2011

Epigenetics in cancer: what's the future?

Oncology (Williston Park) 2011 Mar;25(3):220-6, 228

Hematology/Oncology Fellowship Program, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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March 2011

Time to think outside the (genetic) box.

Cancer Prev Res (Phila) 2011 Jan;4(1):6-8

Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 428, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0348DOI Listing
January 2011

Cancer epigenetics.

CA Cancer J Clin 2010 Nov-Dec;60(6):376-92. Epub 2010 Oct 19.

Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.3322/caac.20085DOI Listing
December 2010

Epigenetic mechanisms in AML - a target for therapy.

Cancer Treat Res 2010 ;145:19-40

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1007/978-0-387-69259-3_2DOI Listing
October 2010

Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation.

Cancer Res 2010 Sep 16;70(17):6968-77. Epub 2010 Aug 16.

Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, TX, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932851PMC
September 2010

DNA methylation profiling in cancer.

Expert Rev Mol Med 2010 Jul 28;12:e23. Epub 2010 Jul 28.

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.

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http://dx.doi.org/10.1017/S1462399410001559DOI Listing
July 2010

Widespread and tissue specific age-related DNA methylation changes in mice.

Genome Res 2010 Mar 27;20(3):332-40. Epub 2010 Jan 27.

Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/gr.096826.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840983PMC
March 2010

DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes.

J Clin Oncol 2010 Feb 28;28(4):605-13. Epub 2009 Dec 28.

Department of Leukemia and Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1200/JCO.2009.23.4781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815995PMC
February 2010

Tackling the methylome: recent methodological advances in genome-wide methylation profiling.

Genome Med 2009 Nov 16;1(11):106. Epub 2009 Nov 16.

Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://genomemedicine.biomedcentral.com/articles/10.1186/gm1
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http://dx.doi.org/10.1186/gm106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808741PMC
November 2009

Concordant DNA methylation in synchronous colorectal carcinomas.

Cancer Prev Res (Phila) 2009 Sep 8;2(9):814-22. Epub 2009 Sep 8.

Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544187PMC
September 2009

Histone deacetylase inhibitors as anti-neoplastic agents.

Cancer Lett 2009 Aug 3;280(2):192-200. Epub 2009 Apr 3.

Department of Leukemia, MD Anderson Cancer Center, Unit 428, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.canlet.2009.03.013DOI Listing
August 2009

CpG island methylation profiling in human melanoma cell lines.

Melanoma Res 2009 Jun;19(3):146-55

Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1097/cmr.0b013e32832b274eDOI Listing
June 2009

Targeting DNA methylation.

Clin Cancer Res 2009 Jun 9;15(12):3938-46. Epub 2009 Jun 9.

Department of Leukemia and Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732562PMC
June 2009

Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.

Cancer Epidemiol Biomarkers Prev 2009 Apr 31;18(4):1041-9. Epub 2009 Mar 31.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-08-0926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712652PMC
April 2009

Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas.

Mod Pathol 2009 Mar 9;22(3):442-9. Epub 2009 Jan 9.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/modpathol.2008.203DOI Listing
March 2009

An Sp1/Sp3 binding polymorphism confers methylation protection.

PLoS Genet 2008 Aug 22;4(8):e1000162. Epub 2008 Aug 22.

Department of Leukemia, MD Anderson Cancer Center, University of Texas, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515197PMC
August 2008

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.

Nat Genet 2008 Jun 18;40(6):741-50. Epub 2008 May 18.

Department of Leukemia, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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http://www.nature.com/articles/ng.159
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http://dx.doi.org/10.1038/ng.159DOI Listing
June 2008

Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation.

Cancer 2008 Apr;112(7):1489-502

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA.

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http://dx.doi.org/10.1002/cncr.23323DOI Listing
April 2008

Methylated CpG Island Amplification and Microarray (MCAM) for High-Throughput Analysis of DNA Methylation.

CSH Protoc 2008 Mar 1;2008:pdb.prot4974. Epub 2008 Mar 1.

Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1101/pdb.prot4974DOI Listing
March 2008

Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel.

Cancer Res 2007 Dec;67(23):11335-43

Department of Leukemia, the University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1502DOI Listing
December 2007

PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.

Cancer Biol Ther 2007 Dec 4;6(12):1967-77. Epub 2007 Sep 4.

Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.4161/cbt.6.12.4982DOI Listing
December 2007

Review: recent clinical trials in epigenetic therapy.

Rev Recent Clin Trials 2006 May;1(2):169-82

Department of Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 428, Houston, TX, 77030, USA.

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http://dx.doi.org/10.2174/157488706776876490DOI Listing
May 2006