Jean-Pierre Issa

Jean-Pierre Issa

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Jean-Pierre Issa

Jean-Pierre Issa

Publications by authors named "Jean-Pierre Issa"

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Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology.

Mol Psychiatry 2019 Aug 27. Epub 2019 Aug 27.

Alzheimer's Center at Temple, Lewis Katz School of Medicine Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41380-019-0489-yDOI Listing
August 2019

Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia.

Clin Epigenetics 2019 Jul 22;11(1):106. Epub 2019 Jul 22.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/s13148-019-0704-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647096PMC
July 2019

Introduction: Cancer as an Epigenetic Disease.

Cancer J 2017 Sep/Oct;23(5):255-256

From the Fels Institute, Temple University School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1097/PPO.0000000000000285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708861PMC
March 2019

Demethylator phenotypes in acute myeloid leukemia.

Leukemia 2018 10 7;32(10):2178-2188. Epub 2018 Mar 7.

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1038/s41375-018-0084-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128790PMC
October 2018

TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer.

Cancer Res 2018 08 11;78(15):4126-4137. Epub 2018 Jun 11.

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-2082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072603PMC
August 2018

Digital Restriction Enzyme Analysis of Methylation (DREAM).

Methods Mol Biol 2018 ;1708:247-265

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/978-1-4939-7481-8_13DOI Listing
July 2018

Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion.

J Neurosci 2018 07 6;38(27):6090-6101. Epub 2018 Jun 6.

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140 and

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http://dx.doi.org/10.1523/JNEUROSCI.2616-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031579PMC
July 2018

Epigenetics and Precision Oncology.

Cancer J 2017 Sep/Oct;23(5):262-269

From the *Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

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http://dx.doi.org/10.1097/PPO.0000000000000281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708865PMC
May 2018

Caloric restriction delays age-related methylation drift.

Nat Commun 2017 09 14;8(1):539. Epub 2017 Sep 14.

Fels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, 19140, USA.

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http://dx.doi.org/10.1038/s41467-017-00607-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599616PMC
September 2017

A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer.

Nucleic Acids Res 2017 Aug;45(14):8269-8281

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1093/nar/gkx435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737541PMC
August 2017

DNA Hypomethylating Drugs in Cancer Therapy.

Cold Spring Harb Perspect Med 2017 May 1;7(5). Epub 2017 May 1.

Fox Chase Cancer Center, Temple Health, Philadelphia, Pennsylvania 19111.

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http://dx.doi.org/10.1101/cshperspect.a026948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411681PMC
May 2017

Repositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome.

Mol Cancer Ther 2017 02 15;16(2):397-407. Epub 2016 Dec 15.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292054PMC
February 2017

The promise of epigenetic therapy: reprogramming the cancer epigenome.

Curr Opin Genet Dev 2017 Feb 14;42:68-77. Epub 2017 Apr 14.

Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X173003
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http://dx.doi.org/10.1016/j.gde.2017.03.015DOI Listing
February 2017

Transcriptional Selectivity of Epigenetic Therapy in Cancer.

Cancer Res 2017 01 22;77(2):470-481. Epub 2016 Nov 22.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243171PMC
January 2017

Healthcare utilization and costs associated with tyrosine kinase inhibitor switching in patients with chronic myeloid leukemia.

Leuk Lymphoma 2016 20;57(4):935-41. Epub 2015 Nov 20.

c Fels Institute for Cancer Research , Temple University School of Medicine , Philadelphia , PA , USA.

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http://dx.doi.org/10.3109/10428194.2015.1088654DOI Listing
December 2016

Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells.

Epigenetics 2015 ;10(11):1006-13

a Fels Institute for Cancer Research and Molecular Biology; Temple University ; Philadelphia , PA USA.

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http://dx.doi.org/10.1080/15592294.2015.1091145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844212PMC
October 2016

Targeting the cancer epigenome for therapy.

Nat Rev Genet 2016 09;17(10):630-41

Van Andel Research Institute, Grand Rapids, Michigan 49503, USA.

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http://dx.doi.org/10.1038/nrg.2016.93DOI Listing
September 2016

Diet, Nutrition, and Cancer Epigenetics.

Annu Rev Nutr 2016 07 23;36:665-81. Epub 2016 Mar 23.

Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140; email:

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http://dx.doi.org/10.1146/annurev-nutr-121415-112634DOI Listing
July 2016

Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas.

Epigenetics 2016 03 18;11(3):184-93. Epub 2016 Feb 18.

f Department of Genitourinary Medical Oncology , Unit 1374, The University of Texas MD Anderson Cancer Center , 1515 Holcombe Blvd., Houston , Texas.

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http://dx.doi.org/10.1080/15592294.2016.1146851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854553PMC
March 2016

Zebrafish embryos as a screen for DNA methylation modifications after compound exposure.

Toxicol Appl Pharmacol 2016 Jan 19;291:84-96. Epub 2015 Dec 19.

Center for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2015.12.012DOI Listing
January 2016

Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.

J Clin Oncol 2015 Dec 12;33(34):4032-8. Epub 2015 Oct 12.

Scott Kopetz, Dipen Maru, Van Morris, Filip Janku, and Arvind Dasari, The University of Texas MD Anderson Cancer Center, Houston, TX; Emily Chan, Vanderbilt-Ingram Cancer Center, Nashville, TN; Joel Randolph Hecht, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles; Brian James and Garth Powis, Sanford Burnham Institute, La Jolla; Keith B. Nolop, Plexxikon, Berkeley; Suman Bhattacharya, Genentech, South San Francisco, CA; Peter J. O'Dwyer, Abramson Cancer Center at University of Pennsylvania, Philadelphia, PA; Woonbook Chung and Jean-Pierre J. Issa, Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA; Leonard Saltz, Memorial Sloan-Kettering Cancer Center, New York, NY; and Jayesh Desai and Peter Gibbs, Royal Melbourne Hospital, Parkville, Victoria, Australia.

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http://jco.ascopubs.org/content/early/2015/10/12/JCO.2015.63
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http://jco.ascopubs.org/content/suppl/2015/11/23/33.34.4032.
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.63.2497
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http://dx.doi.org/10.1200/JCO.2015.63.2497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669589PMC
December 2015

G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition.

Nat Neurosci 2015 Dec 9;18(12):1746-55. Epub 2015 Nov 9.

Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1038/nn.4165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661086PMC
December 2015

New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development.

Cancer Prev Res (Phila) 2015 Nov 4;8(11):1027-35. Epub 2015 Sep 4.

Cancer Research Center of Lyon, UMR INSERM 1052-CNRS 5286, Lyon, France. Department of Translational Research and Innovation, Centre Léon Bérard, Lyon, France. Department of Medicine, Centre Léon Bérard, Lyon, France. Université de Lyon, Lyon, France.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777304PMC
November 2015

Hypomethylation of TET2 Target Genes Identifies a Curable Subset of Acute Myeloid Leukemia.

J Natl Cancer Inst 2015 Nov 13;108(2). Epub 2015 Nov 13.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA (JY, JJ, NJMR, MC, JPJI); Department of Leukemia (JY, RT, JJ, NJMR, SAP, SMK, FR, HMK, JPJI) and Department of Hematopathology (CEBR), The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1093/jnci/djv323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862435PMC
November 2015

Will next-generation agents deliver on the promise of epigenetic hypomethylation therapy?

Epigenomics 2015 Oct 6;7(7):1083-8. Epub 2015 Nov 6.

Fels Institute, Temple University School of Medicine & Cancer Epigenetics Program, Fox Chase Cancer Center, Temple Health, 3307 North Broad Street, Room 154, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.2217/epi.15.66DOI Listing
October 2015

Regulation of AURKC expression by CpG island methylation in human cancer cells.

Tumour Biol 2015 Sep 20;36(10):8147-58. Epub 2015 May 20.

Department of Translational Molecular Pathology, UT MD Anderson Cancer Center, Unit 2951, Life Science Plaza Building, 2130 W. Holcombe Blvd., Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s13277-015-3553-5DOI Listing
September 2015

Epigenetic synergy between decitabine and platinum derivatives.

Clin Epigenetics 2015 11;7:97. Epub 2015 Sep 11.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA.

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http://dx.doi.org/10.1186/s13148-015-0131-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567801PMC
September 2015

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs.

Authors:
Ayalew Tefferi Hagop Kantarjian S Vincent Rajkumar Lawrence H Baker Jan L Abkowitz John W Adamson Ranjana Hira Advani James Allison Karen H Antman Robert C Bast John M Bennett Edward J Benz Nancy Berliner Joseph Bertino Ravi Bhatia Smita Bhatia Deepa Bhojwani Charles D Blanke Clara D Bloomfield Linda Bosserman Hal E Broxmeyer John C Byrd Fernando Cabanillas George Peter Canellos Bruce A Chabner Asher Chanan-Khan Bruce Cheson Bayard Clarkson Susan L Cohn Gerardo Colon-Otero Jorge Cortes Steven Coutre Massimo Cristofanilli Walter J Curran George Q Daley Daniel J DeAngelo H Joachim Deeg Lawrence H Einhorn Harry P Erba Francisco J Esteva Elihu Estey Isaiah J Fidler James Foran Stephen Forman Emil Freireich Charles Fuchs James N George Morie A Gertz Sergio Giralt Harvey Golomb Peter Greenberg Jordan Gutterman Robert I Handin Samuel Hellman Paulo Marcelo Hoff Ronald Hoffman Waun Ki Hong Mary Horowitz Gabriel N Hortobagyi Clifford Hudis Jean Pierre Issa Bruce Evan Johnson Philip W Kantoff Kenneth Kaushansky David Khayat Fadlo R Khuri Thomas J Kipps Margaret Kripke Robert A Kyle Richard A Larson Theodore S Lawrence Ross Levine Michael P Link Scott M Lippman Sagar Lonial Gary H Lyman Maurie Markman John Mendelsohn Neal J Meropol Yoav Messinger Therese M Mulvey Susan O'Brien Roman Perez-Soler Raphael Pollock Josef Prchal Oliver Press Jerald Radich Kanti Rai Saul A Rosenberg Jacob M Rowe Hope Rugo Carolyn D Runowicz Brenda M Sandmaier Alan Saven Andrew I Schafer Charles Schiffer Mikkael A Sekeres Richard T Silver Lillian L Siu David P Steensma F Marc Stewart Wendy Stock Richard Stone Rainer Storb Louise C Strong Martin S Tallman Michael Thompson Naoto T Ueno Richard A Van Etten Julie M Vose Peter H Wiernik Eric P Winer Anas Younes Andrew D Zelenetz Charles A LeMaistre

Mayo Clin Proc 2015 Aug 23;90(8):996-1000. Epub 2015 Jul 23.

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http://dx.doi.org/10.1016/j.mayocp.2015.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365030PMC
August 2015

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.

Cancer Res 2015 Jul 13;75(14):2833-43. Epub 2015 May 13.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506197PMC
July 2015

A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gene.

Cancer Res 2014 Jul 29;74(14):3834-43. Epub 2014 May 29.

Authors' Affiliations: Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103012PMC
July 2014

Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties.

Sci Rep 2013 ;3:2687

1] Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA [2] Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA [3] Center for Stem Cells & Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1038/srep02687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776231PMC
June 2014

TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells.

Nucleic Acids Res 2014 Jun 29;42(11):6956-71. Epub 2014 May 29.

Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140, USA

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http://dx.doi.org/10.1093/nar/gku372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066785PMC
June 2014

Age-related epigenetic drift in the pathogenesis of MDS and AML.

Genome Res 2014 Apr 10;24(4):580-91. Epub 2014 Jan 10.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, Pennsylvania 19140, USA;

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http://dx.doi.org/10.1101/gr.157529.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975058PMC
April 2014

Fusobacterium in colonic flora and molecular features of colorectal carcinoma.

Cancer Res 2014 Mar 2;74(5):1311-8. Epub 2014 Jan 2.

Authors' Affiliations: Fels Institute for Cancer Research & Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania; Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake; First Departments of Internal Medicine and Molecular Biology, Sapporo Medical University, Sapporo; Department of Gastroenterology, Akita Red Cross Hospital, Akita; Department of Pathology, Iwate Medical University, Morioka; Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan; Division of OVP, Department of Clinical Cancer Prevention, Cancer Prevention and Population Sciences; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston; and Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396185PMC
March 2014

Hepatitis virus infection affects DNA methylation in mice with humanized livers.

Gastroenterology 2014 Feb 30;146(2):562-72. Epub 2013 Oct 30.

Division of Epigenomics, Aichi Cancer Center, Nagoya, Japan; Division of Molecular Oncology, Aichi Cancer Center, Nagoya, Japan; Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, Japan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2013.10.056DOI Listing
February 2014

Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.

Gastroenterology 2014 Feb 6;146(2):530-38.e5. Epub 2013 Nov 6.

Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085130157
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http://dx.doi.org/10.1053/j.gastro.2013.10.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918446PMC
February 2014

Aging and epigenetic drift: a vicious cycle.

Authors:
Jean-Pierre Issa

J Clin Invest 2014 Jan 2;124(1):24-9. Epub 2014 Jan 2.

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http://dx.doi.org/10.1172/JCI69735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871228PMC
January 2014

β-Thalassemia due to intronic LINE-1 insertion in the β-globin gene (HBB): molecular mechanisms underlying reduced transcript levels of the β-globin(L1) allele.

Hum Mutat 2013 Oct 13;34(10):1361-5. Epub 2013 Aug 13.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic; Departments of Medicine, Pathology and Genetics, University of Utah and Medical Service, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1002/humu.22383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993193PMC
October 2013

Examination of whole blood DNA methylation as a potential risk marker for gastric cancer.

Cancer Prev Res (Phila) 2013 Oct 13;6(10):1093-100. Epub 2013 Aug 13.

Temple University School of Medicine, 3307 N. Broad Street, Room 154 PAHB, Philadelphia, PA 19140.

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http://dx.doi.org/10.1158/1940-6207.CAPR-13-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337829PMC
October 2013

Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma.

Cancer Res 2013 Jul 29;73(14):4559-70. Epub 2013 May 29.

Department of Neurosurgery, Nagoya University School of Medicine, Divisions of Epigenomics and Molecular Oncology, Aichi Cancer Center Research Institute.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0109DOI Listing
July 2013

The myelodysplastic syndrome as a prototypical epigenetic disease.

Blood 2013 May;121(19):3811-7

Fels Institute, Temple University School of Medicine, Philadelphia, PA 19140,

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http://dx.doi.org/10.1182/blood-2013-02-451757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650703PMC
May 2013

Epigenetic aspects of MDS and its molecular targeted therapy.

Int J Hematol 2013 Feb 10;97(2):175-82. Epub 2012 Oct 10.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1007/s12185-012-1197-4DOI Listing
February 2013

The epigenome of AML stem and progenitor cells.

Epigenetics 2013 Jan 18;8(1):92-104. Epub 2012 Dec 18.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.4161/epi.23243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549884PMC
January 2013

Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique.

Epigenetics 2012 Dec 17;7(12):1368-78. Epub 2012 Oct 17.

Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/epi.22552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528692PMC
December 2012

A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force.

Cancer Res 2012 Dec 27;72(24):6319-24. Epub 2012 Nov 27.

Research Department of Cancer Biology, University College London Cancer Institute, University College London, London, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-3658DOI Listing
December 2012

A Bayesian Model for SNP Discovery Based on Next-Generation Sequencing Data.

IEEE Int Workshop Genomic Signal Process Stat 2012 Dec;2012:42-45

Department of Bioinformatics and Computational Biology, The University of Texas, MD Anderson Cancer Center Houston, TX.

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http://dx.doi.org/10.1109/GENSIPS.2012.6507722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697941PMC
December 2012

SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters.

Mol Cancer Res 2012 Oct 4;10(10):1332-42. Epub 2012 Sep 4.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-12-0351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475755PMC
October 2012

Metabolic, hormonal and immunological associations with global DNA methylation among postmenopausal women.

Epigenetics 2012 Sep 7;7(9):1020-8. Epub 2012 Aug 7.

Division of Preventive Oncology, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.4161/epi.21464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515011PMC
September 2012

Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island.

Nucleic Acids Res 2012 Aug 17;40(15):7257-68. Epub 2012 May 17.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gks429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424568PMC
August 2012

DNA methylation as a clinical marker in oncology.

Authors:
Jean-Pierre Issa

J Clin Oncol 2012 Jul 7;30(20):2566-8. Epub 2012 May 7.

Fels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1200/JCO.2012.42.1016DOI Listing
July 2012

Dissecting DNA hypermethylation in cancer.

FEBS Lett 2011 Jul 10;585(13):2078-86. Epub 2010 Dec 10.

Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX 77030, United States.

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http://dx.doi.org/10.1016/j.febslet.2010.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378045PMC
July 2011

Detection of bladder cancer using novel DNA methylation biomarkers in urine sediments.

Cancer Epidemiol Biomarkers Prev 2011 Jul 17;20(7):1483-91. Epub 2011 May 17.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-11-0067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132294PMC
July 2011

Epigenetics.

FEBS Lett 2011 Jul 17;585(13):1993. Epub 2011 Jun 17.

Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.febslet.2011.06.007DOI Listing
July 2011

Epigenetic variation and cellular Darwinism.

Authors:
Jean-Pierre Issa

Nat Genet 2011 Jul 27;43(8):724-6. Epub 2011 Jul 27.

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http://dx.doi.org/10.1038/ng.897DOI Listing
July 2011

DNA methylation predicts recurrence from resected stage III proximal colon cancer.

Cancer 2011 May 18;117(9):1847-54. Epub 2010 Nov 18.

Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1002/cncr.25737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117123PMC
May 2011

Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.

EMBO Rep 2011 Mar 18;12(3):238-43. Epub 2011 Feb 18.

Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Park Road 1C, Smithville, Texas 78957, USA.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2011.9
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http://dx.doi.org/10.1038/embor.2011.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059907PMC
March 2011

Epigenetics in cancer: what's the future?

Oncology (Williston Park) 2011 Mar;25(3):220-6, 228

Hematology/Oncology Fellowship Program, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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March 2011

Time to think outside the (genetic) box.

Cancer Prev Res (Phila) 2011 Jan;4(1):6-8

Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 428, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0348DOI Listing
January 2011

Cancer epigenetics.

CA Cancer J Clin 2010 Nov-Dec;60(6):376-92. Epub 2010 Oct 19.

Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.3322/caac.20085DOI Listing
December 2010

Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation.

Cancer Res 2010 Sep 16;70(17):6968-77. Epub 2010 Aug 16.

Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, TX, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932851PMC
September 2010

Introductory editorial.

Clin Epigenetics 2010 Sep 11;1(1-2). Epub 2010 Sep 11.

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http://dx.doi.org/10.1007/s13148-010-0009-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365367PMC
September 2010