Jean-Pierre Changeux

Jean-Pierre Changeux

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Jean-Pierre Changeux

Publications by authors named "Jean-Pierre Changeux"

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Drug Addiction: From Neuroscience to Ethics.

Front Psychiatry 2018 19;9:595. Epub 2018 Nov 19.

Collège de France and Institut Pasteur CNRS, Paris, France.

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https://www.frontiersin.org/article/10.3389/fpsyt.2018.00595
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http://dx.doi.org/10.3389/fpsyt.2018.00595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262362PMC
November 2018

The nicotinic acetylcholine receptor: a typical 'allosteric machine'.

Philos Trans R Soc Lond B Biol Sci 2018 06;373(1749)

CNRS UMR 3571, Institut Pasteur, Paris 75724, France

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http://dx.doi.org/10.1098/rstb.2017.0174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941169PMC
June 2018

Structural Identification of the Nicotinic Receptor Ion Channel.

Trends Neurosci 2018 02;41(2):67-70

CNRS UMR 3571, Institut Pasteur, Paris F-75724 Cedex 15, France; Chaire de Communications Cellulaires, Collège de France, Paris F-75005, France. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2017.11.003DOI Listing
February 2018

Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics.

PLoS Comput Biol 2017 Oct 25;13(10):e1005784. Epub 2017 Oct 25.

Laboratoire d'Ingénierie des Fonctions Moléculaire, ISIS, UMR 7006 CNRS, Université de Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1371/journal.pcbi.1005784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673239PMC
October 2017

Allosteric modulation as a unifying mechanism for receptor function and regulation.

Diabetes Obes Metab 2017 09;19 Suppl 1:4-21

Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, VIC 3052 Parkville, Australia.

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http://dx.doi.org/10.1111/dom.12959DOI Listing
September 2017

Response by the authors.

EMBO Rep 2017 Jul 25. Epub 2017 Jul 25.

Institut Pasteur and Collège de France, Paris, France.

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http://dx.doi.org/10.15252/embr.201744696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538420PMC
July 2017

Climbing Brain Levels of Organisation from Genes to Consciousness.

Trends Cogn Sci 2017 03 1;21(3):168-181. Epub 2017 Feb 1.

Collège de France and CNRS UMR 3571, Institut Pasteur, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.tics.2017.01.004DOI Listing
March 2017

Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing.

Proc Natl Acad Sci U S A 2016 12 2;113(51):14823-14828. Epub 2016 Dec 2.

Neurobiologie Intégrative des Systèmes Cholinergiques, Institut Pasteur, Paris F-75724 cedex 15, France;

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http://dx.doi.org/10.1073/pnas.1614417113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187677PMC
December 2016

Proactive epigenesis and ethical innovation: A neuronal hypothesis for the genesis of ethical rules.

EMBO Rep 2016 10 9;17(10):1361-1364. Epub 2016 Sep 9.

Collège de France & Institut Pasteur UMR 3571 CNRS, Paris, France.

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http://dx.doi.org/10.15252/embr.201642783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048375PMC
October 2016

Biased Allostery.

Biophys J 2016 Sep;111(5):902-8

CNRS, URA 2182, Institut Pasteur & College de France, Paris, France; Kavli Institute for Brain & Mind, University of California, San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.07.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018148PMC
September 2016

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation.

Cell 2016 Aug;166(5):1084-1102

Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, VIC 3052 Parkville, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.08.015DOI Listing
August 2016

Bradykinin Induces TRPV1 Exocytotic Recruitment in Peptidergic Nociceptors.

Front Pharmacol 2016 23;7:178. Epub 2016 Jun 23.

Instituto de Biología Molecular y Celular, Universitas Miguel Hernández Elche, Spain.

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http://dx.doi.org/10.3389/fphar.2016.00178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917537PMC
July 2016

Historical perspective: An INTERVIEW WITH JEAN-PIERRE CHANGEUX by Ernesto Carafoli.

Biochem Biophys Res Commun 2015 Nov 24;467(4):612-6. Epub 2015 Oct 24.

Venetian Institute of Molecular Medicine, Via G.Orus, 2, 35129, Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.10.046DOI Listing
November 2015

The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation.

Neuropharmacology 2015 Sep 18;96(Pt B):137-49. Epub 2014 Dec 18.

CNRS, URA 2182, F-75015 Paris, France; Collège de France, F-75005 Paris, France; Kavli Institute for Brain & Mind University of California, San Diego La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2014.12.006DOI Listing
September 2015

The nicotinic acetylcholine receptor: From molecular biology to cognition.

Neuropharmacology 2015 Sep 1;96(Pt B):135-6. Epub 2015 Apr 1.

Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1016/j.neuropharm.2015.03.024DOI Listing
September 2015

αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors.

Proc Natl Acad Sci U S A 2014 Dec 8;111(51):18345-50. Epub 2014 Dec 8.

Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, 03202 Elche, Spain; Unidad de Biofísica, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Consejo Superior de Investigaciones Científicas, 48940 Leioa, Spain

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http://dx.doi.org/10.1073/pnas.1420252111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280602PMC
December 2014

Protein dynamics and the allosteric transitions of pentameric receptor channels.

Biophys Rev 2014;6(3-4):311-321. Epub 2014 Nov 29.

UMR 3571 CNRS, Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France ; Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France ; Kavli Brain-Mind Institute University of California, San Diego, CA USA.

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http://dx.doi.org/10.1007/s12551-014-0149-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256460PMC
November 2014

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

Pharmacol Rev 2014 Oct;66(4):918-47

Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (A.C., P.M.S., C.J.L.); Collège de France and CNRS URA 2182, Institut Pasteur, Paris, France (J.-P.C.); Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington (W.A.C.); PIQUR Therapeutics AG, Basel, Switzerland (D.F.); Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, St. Louis, Louisiana (T.P.B.); Signal Transduction Laboratory, Molecular Endocrinology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (J.A.C.); Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California (R.W.O.); Division of Neuroscience, School of Medicine, University of Dundee, Scotland, United Kingdom (J.A.P.); Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (R.R.N.); Institut de Genomique Fonctionelle, CNRS, Montpellier, France (J.-P.P.); Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina (T.P.K.); Department of Pharmacology, University of California, Irvine, California (F.J.E.); and Research Solutions SARL, Paris, France (M.S.).

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http://dx.doi.org/10.1124/pr.114.008862DOI Listing
October 2014

Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein.

Proc Natl Acad Sci U S A 2014 Jul 8;111(29):10749-54. Epub 2014 Jul 8.

Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093;

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http://dx.doi.org/10.1073/pnas.1410992111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115551PMC
July 2014

The concept of allosteric modulation: an overview.

Drug Discov Today Technol 2013 ;10(2):e223-8

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http://dx.doi.org/10.1016/j.ddtec.2012.07.007DOI Listing
April 2014

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.

Proc Natl Acad Sci U S A 2014 Jan 23;111(3):966-71. Epub 2013 Dec 23.

Unité de Dynamique Structurale des Macromolécules, Unité Mixte de Recherche (UMR) 3528 du Centre National de la Recherche Scientifique (CNRS), Institut Pasteur, 75015 Paris, France.

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http://dx.doi.org/10.1073/pnas.1314997111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903189PMC
January 2014

50 years of allosteric interactions: the twists and turns of the models.

Nat Rev Mol Cell Biol 2013 12 23;14(12):819-29. Epub 2013 Oct 23.

Collège de France and CNRS URA 2182, Institut Pasteur, 47 rue du Four Paris 7506, Paris, France.

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http://dx.doi.org/10.1038/nrm3695DOI Listing
December 2013

A gating mechanism of pentameric ligand-gated ion channels.

Proc Natl Acad Sci U S A 2013 Oct 16;110(42):E3987-96. Epub 2013 Sep 16.

Institut de Science et d'Ingénierie Supramoléculaires, Unité Mixte de Recherche 7006, Centre National de la Recherche Scientifique, Université de Strasbourg, F-67083 Strasbourg Cedex, France.

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http://www.pnas.org/content/110/42/E3987.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1313785110
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http://dx.doi.org/10.1073/pnas.1313785110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801054PMC
October 2013

The concept of allosteric interaction and its consequences for the chemistry of the brain.

J Biol Chem 2013 Sep 22;288(38):26969-86. Epub 2013 Jul 22.

From the Collège de France, 75005 Paris and the Institut Pasteur, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1074/jbc.X113.503375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779700PMC
September 2013

The origins of allostery: from personal memories to material for the future.

J Mol Biol 2013 May 20;425(9):1396-406. Epub 2013 Mar 20.

Collège de France and Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1016/j.jmb.2013.02.033DOI Listing
May 2013

Allostery and the Monod-Wyman-Changeux model after 50 years.

Annu Rev Biophys 2012 6;41:103-33. Epub 2012 Jan 6.

Collège de France & Institut Pasteur, URA CNRS 2182, Paris Cedex 15 75724, France.

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http://dx.doi.org/10.1146/annurev-biophys-050511-102222DOI Listing
March 2013

Altered paralimbic interaction in behavioral addiction.

Proc Natl Acad Sci U S A 2013 Mar 4;110(12):4744-9. Epub 2013 Mar 4.

Center of Functionally Integrative Neuroscience, Aarhus University, 8000 Aarhus, Denmark.

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http://dx.doi.org/10.1073/pnas.1302374110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606979PMC
March 2013

The nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamily.

J Biol Chem 2012 Nov 4;287(48):40207-15. Epub 2012 Oct 4.

Collège de France, 75005 Paris, France.

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http://dx.doi.org/10.1074/jbc.R112.407668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504736PMC
November 2012

Conscious processing: implications for general anesthesia.

Curr Opin Anaesthesiol 2012 Aug;25(4):397-404

Collège de France and Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1097/ACO.0b013e32835561deDOI Listing
August 2012

Structure and pharmacology of pentameric receptor channels: from bacteria to brain.

Structure 2012 Jun;20(6):941-56

Institut Pasteur, Groupe Récepteurs-Canaux, F-75015 Paris, France.

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http://dx.doi.org/10.1016/j.str.2012.05.003DOI Listing
June 2012

Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment.

Cereb Cortex 2012 May 1;22(5):1007-15. Epub 2011 Aug 1.

Unité de Génétique Humaine et Fonctions Cognitives, Département des Neurosciences, Institut Pasteur, 75015 Paris, France.

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http://dx.doi.org/10.1093/cercor/bhr159DOI Listing
May 2012

Deciding between conflicting motivations: what mice make of their prefrontal cortex.

Behav Brain Res 2012 Apr 18;229(2):419-26. Epub 2011 Nov 18.

Centre de Neuroscience Paris Sud, Université Paris Sud 11, CNRS 8195, Orsay, France.

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http://dx.doi.org/10.1016/j.bbr.2011.11.011DOI Listing
April 2012

Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice.

Psychopharmacology (Berl) 2012 Mar 8;220(1):1-14. Epub 2011 Sep 8.

Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Unité de Recherche Associée 2182, Centre National de la recherche Scientifique, Institut Pasteur, 75015 Paris, France.

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http://dx.doi.org/10.1007/s00213-011-2422-1DOI Listing
March 2012

A neuronal model of predictive coding accounting for the mismatch negativity.

J Neurosci 2012 Mar;32(11):3665-78

Commissariat à l'Energie Atomique, DSV/I2BM, NeuroSpin Center, F-91191 Gif/Yvette, France, University Paris 11, F-91405 Orsay, France.

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http://dx.doi.org/10.1523/JNEUROSCI.5003-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703454PMC
March 2012

Prefrontal nicotinic receptors control novel social interaction between mice.

FASEB J 2011 Jul 14;25(7):2145-55. Epub 2011 Mar 14.

Unité Neurobiologie Intégrative des Systèmes Cholinergiques, CNRS URA 2182, Institut Pasteur, Paris, France.

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http://www.fasebj.org/doi/10.1096/fj.10-178558
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http://dx.doi.org/10.1096/fj.10-178558DOI Listing
July 2011

50th anniversary of the word "allosteric".

Protein Sci 2011 Jul 10;20(7):1119-24. Epub 2011 Jun 10.

Collège de France and Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1002/pro.658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149185PMC
July 2011

Emergent pharmacology of conscious experience: new perspectives in substance addiction.

FASEB J 2011 Jul;25(7):2098-108

Collège de France, Paris, France.

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http://dx.doi.org/10.1096/fj.11-0702ufmDOI Listing
July 2011

Experimental and theoretical approaches to conscious processing.

Neuron 2011 Apr;70(2):200-27

INSERM, Cognitive Neuroimaging Unit, Gif sur Yvette, 91191 France.

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http://dx.doi.org/10.1016/j.neuron.2011.03.018DOI Listing
April 2011

Nicotine addiction and nicotinic receptors: lessons from genetically modified mice.

Nat Rev Neurosci 2010 Jun;11(6):389-401

Collge de France and the Institut Pasteur CNRS URA 2182, 25 rue du Dr Roux, 75015 Paris, France.

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http://www.nature.com/articles/nrn2849
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http://dx.doi.org/10.1038/nrn2849DOI Listing
June 2010

Basic consciousness of the newborn.

Semin Perinatol 2010 Jun;34(3):201-6

Neonatal Research Unit, Karolinska Institute, Astrid Lindgren Children's Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1053/j.semperi.2010.02.004DOI Listing
June 2010

Relationships between structural dynamics and functional kinetics in oligomeric membrane receptors.

Biophys J 2010 May;98(10):2045-52

European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1016/j.bpj.2010.01.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872211PMC
May 2010

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue.

Proc Natl Acad Sci U S A 2010 Apr 22;107(14):6275-80. Epub 2010 Mar 22.

Institut Pasteur, Unit of Structural Dynamics of Macromolecules, Centre National de la Recherche Scientifique Unité de Recherche Associée 2185, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1073/pnas.1001832107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852019PMC
April 2010

A versatile system for the neuronal subtype specific expression of lentiviral vectors.

FASEB J 2010 Mar 26;24(3):723-30. Epub 2009 Oct 26.

Unité Neurobiologie Intégrative des Systèmes Cholinergiques, CNRS URA 2182, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.

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http://www.fasebj.org/content/24/3/723.full.pdf
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http://www.fasebj.org/cgi/doi/10.1096/fj.09-139790
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http://dx.doi.org/10.1096/fj.09-139790DOI Listing
March 2010

Allosteric receptors: from electric organ to cognition.

Annu Rev Pharmacol Toxicol 2010 ;50:1-38

Institut Pasteur and Collège de France, Paris, France.

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http://dx.doi.org/10.1146/annurev.pharmtox.010909.105741DOI Listing
March 2010

Object memory in young and aged mice after sevoflurane anaesthesia.

Neuroreport 2009 Oct;20(16):1419-23

Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1097/WNR.0b013e328330cd2bDOI Listing
October 2009

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.

Nat Rev Drug Discov 2009 Sep;8(9):733-50

Laboratoire de Chimie Biophysique, Institut de Science et d'Ingénierie Supramoléculaires, UMR 7006 (CNRS-Université de Strasbourg), 8 Allée Gaspard Monge, 67000 Strasbourg, France.

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http://dx.doi.org/10.1038/nrd2927DOI Listing
September 2009

Nicotinic receptors and nicotine addiction.

C R Biol 2009 May 20;332(5):421-5. Epub 2009 Mar 20.

Département neurosciences, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1016/j.crvi.2009.02.005DOI Listing
May 2009

Jean-Pierre Changeux: allostery as neuro-enlightenment.

Mol Interv 2009 Apr;9(2):61-7

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http://dx.doi.org/10.1124/mi.9.2.2DOI Listing
April 2009

The emergence of human consciousness: from fetal to neonatal life.

Pediatr Res 2009 Mar;65(3):255-60

Karolinska Institute, Neonatal Research Unit, Astrid Lindgren Children's Hospital, 171 76 Stockholm, Sweden.

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http://www.nature.com/doifinder/10.1203/PDR.0b013e3181973b0d
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http://dx.doi.org/10.1203/PDR.0b013e3181973b0dDOI Listing
March 2009

Regional changes in the cholinergic system in mice lacking monoamine oxidase A.

Brain Res Bull 2009 Mar 25;78(6):283-9. Epub 2008 Dec 25.

Institut Pasteur URA CNRS D 2182, 28 rue du Docteur Roux, 75015 Paris, France.

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http://linkinghub.elsevier.com/retrieve/pii/S036192300800416
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http://dx.doi.org/10.1016/j.brainresbull.2008.12.004DOI Listing
March 2009

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation.

Nature 2009 Jan 5;457(7225):111-4. Epub 2008 Nov 5.

Pasteur Institute, G5 Group of Channel-Receptor, CNRS URA 2182.

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http://dx.doi.org/10.1038/nature07462DOI Listing
January 2009

Sevoflurane anesthesia alters exploratory and anxiety-like behavior in mice lacking the beta2 nicotinic acetylcholine receptor subunit.

Anesthesiology 2008 Nov;109(5):790-8

Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://anesthesiology.pubs.asahq.org/Article.aspx?doi=10.109
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http://dx.doi.org/10.1097/ALN.0b013e31818a379aDOI Listing
November 2008

Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.

PLoS Comput Biol 2008 Nov 21;4(11):e1000229. Epub 2008 Nov 21.

Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1371/journal.pcbi.1000229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581917PMC
November 2008

Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion.

Proc Natl Acad Sci U S A 2008 Oct 2;105(41):15991-6. Epub 2008 Oct 2.

Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Unité de Recherche Associée 2182, Centre National de la Recherche Scientifique, Institut Pasteur, F75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1073/pnas.0807635105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559801PMC
October 2008

Functional organization and conformational dynamics of the nicotinic receptor: a plausible structural interpretation of myasthenic mutations.

Ann N Y Acad Sci 2008 ;1132:42-52

Laboratoire de Chimie Biophysique, ISIS, Université Louis Pasteur, Strasbourg, France.

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http://dx.doi.org/10.1196/annals.1405.008DOI Listing
September 2008

Chronic nicotine exposure has dissociable behavioural effects on control and beta2-/- mice.

Behav Genet 2008 Sep 8;38(5):503-14. Epub 2008 Jul 8.

Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Department of Neuroscience and CNRS URA2182, Institut Pasteur, 25 rue du Dr. Roux, Paris 75015, France.

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http://dx.doi.org/10.1007/s10519-008-9216-1DOI Listing
September 2008

Abnormal response of dopaminergic neurons to nicotine without perturbation of nicotinic receptors in alphaCGRP knock-out mice.

Brain Res 2008 Sep 27;1228:89-96. Epub 2008 Jun 27.

CNRS URA 2182 Integrative Neurobiology of Cholinergic Systems, Institut Pasteur, 75724 Paris CEDEX 15, France.

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http://dx.doi.org/10.1016/j.brainres.2008.06.072DOI Listing
September 2008

A non-radioactive ligand-binding assay for detection of cyanobacterial anatoxins using Torpedo electrocyte membranes.

Toxicon 2008 Jul 29;52(1):163-74. Epub 2008 May 29.

CNRS, Institut de Neurobiologie Alfred Fessard - FRC2118, Laboratoire de Neurobiologie Cellulaire et Moléculaire - UPR9040, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, France.

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http://dx.doi.org/10.1016/j.toxicon.2008.05.001DOI Listing
July 2008

Nicotinic receptors, allosteric proteins and medicine.

Trends Mol Med 2008 Mar 11;14(3):93-102. Epub 2008 Feb 11.

Research unit, National Center of Scientific Research 2182, Department of Neuroscience, Pasteur Institute, Paris, France.

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http://dx.doi.org/10.1016/j.molmed.2008.01.001DOI Listing
March 2008

Loss of high-affinity nicotinic receptors increases the vulnerability to excitotoxic lesion and decreases the positive effects of an enriched environment.

FASEB J 2007 Dec 10;21(14):4028-37. Epub 2007 Jul 10.

Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, via Campi 287, 41100 Modena, Italy.

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http://www.fasebj.org/doi/10.1096/fj.07-8260com
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http://dx.doi.org/10.1096/fj.07-8260comDOI Listing
December 2007

Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics.

Proc Natl Acad Sci U S A 2007 Dec 10;104(51):20570-5. Epub 2007 Dec 10.

Récepteurs et Cognition, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182, Institut Pasteur, 75724 Paris, France.

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http://dx.doi.org/10.1073/pnas.0710314104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154472PMC
December 2007

Docking of alpha-cobratoxin suggests a basal conformation of the nicotinic receptor.

Biochem Biophys Res Commun 2007 Aug 4;359(3):413-8. Epub 2007 Jun 4.

Recepteurs et Cognition, Unité de Recherche Associée, Centre National de la Recherche Scientifique 2182, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1016/j.bbrc.2007.05.126DOI Listing
August 2007

Long-term effects of chronic nicotine exposure on brain nicotinic receptors.

Proc Natl Acad Sci U S A 2007 May 30;104(19):8155-60. Epub 2007 Apr 30.

Récepteurs et Cognition, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182, Unité de Neurobiologie Intégrative des Systémes Cholinergiques, Institut Pasteur, 75724 Paris, France.

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http://dx.doi.org/10.1073/pnas.0702698104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1859991PMC
May 2007

Nicotine and serotonin in immune regulation and inflammatory processes: a perspective.

J Leukoc Biol 2007 Mar 15;81(3):599-606. Epub 2006 Nov 15.

Unité de Recherche Associée, Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1189/jlb.0906544DOI Listing
March 2007

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family.

Nature 2007 Jan 10;445(7123):116-9. Epub 2006 Dec 10.

Unit of Receptor and Cognition, CNRS URA D2182, Pasteur Institute, 75015 Paris, France.

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http://www.nature.com/articles/nature05371
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January 2007

The Ferrier Lecture 1998. The molecular biology of consciousness investigated with genetically modified mice.

Philos Trans R Soc Lond B Biol Sci 2006 Dec;361(1476):2239-59

Institut Pasteur & Collège de France, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France.

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http://dx.doi.org/10.1098/rstb.2006.1832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764850PMC
December 2006

Live imaging of neural structure and function by fibred fluorescence microscopy.

EMBO Rep 2006 Nov 29;7(11):1154-61. Epub 2006 Sep 29.

Université Pierre et Marie Curie-Paris, ERT 1059, Boîte Courrier number 16, 9 Quai St Bernard, 75005 Paris, France.

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http://dx.doi.org/10.1038/sj.embor.7400801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1679781PMC
November 2006

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors.

Proc Natl Acad Sci U S A 2006 Nov 31;103(45):16965-70. Epub 2006 Oct 31.

Recepteurs et Cognition, Unité de Recherche Associée Centre National de la Recherche Scientifique 2182, Institut Pasteur, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1073/pnas.0607477103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1629088PMC
November 2006

Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice.

J Physiol 2006 Oct 10;576(Pt 2):533-46. Epub 2006 Aug 10.

Neurobiology Department, International School for Advanced Studies, Via Beirut 2-4, 34014 Trieste, Italy.

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http://dx.doi.org/10.1113/jphysiol.2006.117572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890366PMC
October 2006

Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine.

Neuropsychopharmacology 2006 Aug 14;31(8):1704-13. Epub 2005 Dec 14.

Inserm U.114, Collège de France.

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http://dx.doi.org/10.1038/sj.npp.1300987DOI Listing
August 2006

Inhibition of both alpha7* and beta2* nicotinic acetylcholine receptors is necessary to prevent development of sensitization to cocaine-elicited increases in extracellular dopamine levels in the ventral striatum.

Psychopharmacology (Berl) 2006 Aug 1;187(2):181-8. Epub 2006 Jun 1.

Department of Biomedical Sciences, Section of Physiology University of Modena and Reggio Emilia, via Campi 287, 41100 Modena, Italy.

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http://link.springer.com/10.1007/s00213-006-0419-y
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August 2006

Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity?

J Physiol Paris 2006 Mar-May;99(2-3):162-71. Epub 2006 Feb 3.

Unit of receptor and Cognition, Pasteur Institute, 25 rue du docteur Roux, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1016/j.jphysparis.2005.12.012DOI Listing
June 2006

Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors.

Neuropharmacology 2006 Jun 31;50(8):1030-40. Epub 2006 Mar 31.

Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Université de Bordeaux I, Talence, France.

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http://dx.doi.org/10.1016/j.neuropharm.2006.02.003DOI Listing
June 2006

Attention-deficit/hyperactivity disorder: a plausible mouse model?

Acta Paediatr 2006 Jun;95(6):645-9

URA CNRS Récepteur et Cognition, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1080/08035250600719747DOI Listing
June 2006

Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors.

Neuron 2006 Jun;50(6):911-21

CNRS URA 2182 Unité Récepteurs et Cognition, Institut Pasteur, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1016/j.neuron.2006.05.007DOI Listing
June 2006

Mechanism of Cl- selection by a glutamate-gated chloride (GluCl) receptor revealed through mutations in the selectivity filter.

J Biol Chem 2006 May 9;281(21):14875-81. Epub 2006 Mar 9.

Unit of Receptors and Cognition, URA 2182 CNRS, Pasteur Institute, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1074/jbc.M511657200DOI Listing
May 2006

Conscious, preconscious, and subliminal processing: a testable taxonomy.

Trends Cogn Sci 2006 May 17;10(5):204-11. Epub 2006 Apr 17.

INSERM-CEA Cognitive Neuroimaging Unit, Service Hospitalier Frédéric Joliot, Orsay, France.

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http://dx.doi.org/10.1016/j.tics.2006.03.007DOI Listing
May 2006

The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice.

Psychopharmacology (Berl) 2006 Mar 14;184(3-4):339-44. Epub 2006 Jan 14.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1007/s00213-005-0295-xDOI Listing
March 2006

The role of nicotinic acetylcholine receptors in lymphocyte development.

J Neuroimmunol 2006 Feb 25;171(1-2):86-98. Epub 2005 Oct 25.

Department of Molecular Immunology, Palladin Institute of Biochemistry, 01601 Kiev, Ukraine.

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http://dx.doi.org/10.1016/j.jneuroim.2005.09.011DOI Listing
February 2006

A neurocomputational hypothesis for nicotine addiction.

Proc Natl Acad Sci U S A 2006 Jan 13;103(4):1106-11. Epub 2006 Jan 13.

Récepteurs et Cognition, Unité de Recherche Associée, Centre National de la Recherche Scientifique 2184, Institut Pasteur, 75015 Paris, France.

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http://dx.doi.org/10.1073/pnas.0510220103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1348008PMC
January 2006

Pore conformations and gating mechanism of a Cys-loop receptor.

Proc Natl Acad Sci U S A 2005 Nov 24;102(44):15877-82. Epub 2005 Oct 24.

Récepteurs et Cognition, Unité de Recherche Associée 2182 Centre National de la Recherche Scientifique, Institut Pasteur, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1073/pnas.0507599102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276086PMC
November 2005