Jean-Philippe Stephan

Jean-Philippe Stephan

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Jean-Philippe Stephan

Jean-Philippe Stephan

Publications by authors named "Jean-Philippe Stephan"

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39Publications

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Filling the drug discovery gap: is high-content screening the missing link?

Curr Opin Pharmacol 2018 Jul 19;42:40-45. Epub 2018 Jul 19.

Center of Excellence Pharmacological Screening, Compound Management & Biobanking, Institut de Recherches SERVIER, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France. Electronic address:

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July 2018

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis.

Cell Metab 2016 Nov 8;24(5):753-761. Epub 2016 Sep 8.

Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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November 2016

Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs.

Nat Commun 2016 08 3;7:12351. Epub 2016 Aug 3.

Department of Discovery Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.

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August 2016

High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes.

Am J Physiol Heart Circ Physiol 2016 07 3;311(1):H44-53. Epub 2016 May 3.

Pôle d'Expertise Biotechnologie, Chimie & Biologie, Institut de Recherches SERVIER, Croissy-sur-Seine, France.

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July 2016

Membrane display and functional analysis of juxtacrine ligand-receptor signaling.

Biotechniques 2015 Oct 1;59(4):231-8, 240. Epub 2015 Oct 1.

Cancer Immunology, Genentech, Inc, South San Francisco, CA.

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October 2015

Using RNAi screening technologies to interrogate the extrinsic apoptosis pathway.

Methods Enzymol 2014 ;544:129-60

Protein Chemistry Department/Discovery Oncology Department, Genentech Inc., South San Francisco, California, USA.

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February 2015

Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor.

PLoS One 2014 6;9(1):e84823. Epub 2014 Jan 6.

Department of Protein Chemistry, Genentech, South San Francisco, California, United States of America.

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September 2014

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition.

Oncotarget 2014 Sep;5(17):7328-41

Department of Discovery Oncology, Genentech, 1 DNA Way, South San Francisco, CA.

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September 2014

Application of a new wall-less plate technology to complex multistep cell-based investigations using suspension cells.

Blood 2013 Feb 19;121(7):e25-33. Epub 2012 Dec 19.

Protein Chemistry Department, Genentech Inc, South San Francisco, CA 94080, USA.

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February 2013

TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.

Mol Cell 2012 Dec 8;48(6):888-99. Epub 2012 Nov 8.

Department of Molecular Oncology, Genentech Inc., South San Francisco, CA 94080, USA.

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December 2012

Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans.

MAbs 2012 Jul-Aug;4(4):475-87. Epub 2012 Jul 1.

Oceanside Pharma Technical Development, Genentech, Inc., Oceanside, CA USA.

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November 2012

Preclinical pharmacokinetics of MFGR1877A, a human monoclonal antibody to FGFR3, and prediction of its efficacious clinical dose for the treatment of t(4;14)-positive multiple myeloma.

Cancer Chemother Pharmacol 2012 Apr 28;69(4):1071-8. Epub 2011 Dec 28.

Department of Pharmacokinetics and Pharmacodynamics, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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April 2012

Challenges in developing bioanalytical assays for characterization of antibody-drug conjugates.

Bioanalysis 2011 Mar;3(6):677-700

Protein Chemistry Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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March 2011

High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate.

Br J Haematol 2008 Jan 7;140(1):46-58. Epub 2007 Nov 7.

Department of Molecular Biology, Genentech, Inc., South San Francisco, CA 94080, USA.

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January 2008

Albumin stimulates the accumulation of extracellular matrix in renal tubular epithelial cells.

Am J Nephrol 2004 Jan-Feb;24(1):14-9. Epub 2003 Dec 3.

Assay & Automation Technology Department, Genentech, Inc., South San Francisco, Calif. 94080-4990, USA.

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June 2004

Nucleic acid capture assay, a new method for direct quantitation of nucleic acids.

Nucleic Acids Res 2003 Mar;31(6):e25

Assay and Automation Technology Department, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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March 2003

Development of a frozen cell array as a high-throughput approach for cell-based analysis.

Am J Pathol 2002 Sep;161(3):787-97

Department of Assay and Automation Technology, South San Francisco, California 94080, USA.

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September 2002