Jean-Paul Soulillou

Jean-Paul Soulillou

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Jean-Paul Soulillou

Jean-Paul Soulillou

Publications by authors named "Jean-Paul Soulillou"

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Gut bacteria elicit a specific IgG response in CSF of patients with MS.

Neurol Neuroimmunol Neuroinflamm 2020 May 2;7(3). Epub 2020 Mar 2.

From the Centre de Recherche en Transplantation et Immunologie UMR1064 (A.V., A.D.S., C.V.M., A.G., J.M., E.D., S.P.S., J.-P.S., J.H., L.M., S.W., A.B.N., D.A.L., L.B.), INSERM, Université de Nantes; Univ Brest (G.H.-A., C.-A.G.), Inserm, EFS, UMR 1078, GGB; Unité de Bactériologie (G.H.-A.), Pôle de Biologie-Pathologie, Centre Hospitalier Régional et Universitaire de Brest, Hôpital de la Cavale Blanche, Boulevard Tanguy Prigent, Brest; Centre de Recherche sur l'Inflammation UMRS1149 (P.J.G., R.C.M.), INSERM, Université Paris Diderot, CNRS ERL8252; Department of biochemistry (J.H., E.B.-C.), CHU Nantes; Department of Neurology (L.M., S.W., D.-A.L.), CHU Nantes; and CIC 1214 (A.G., L.M., S.W., D.-A.L.), CHU Nantes, France.

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http://dx.doi.org/10.1212/NXI.0000000000000688DOI Listing
May 2020

Interleukin-7 receptor blockade by an anti-CD127 monoclonal antibody in nonhuman primate kidney transplantation.

Am J Transplant 2020 Jan 14;20(1):101-111. Epub 2019 Aug 14.

Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, INSERM, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1111/ajt.15543DOI Listing
January 2020

Can we extrapolate from a mouse model a susceptibility for atherosclerosis in humans?

Proc Natl Acad Sci U S A 2020 Jan 21;117(4):1845-1846. Epub 2020 Jan 21.

Cellular and Molecular Immuno-Endocrinology Research Unit, Oniris, Institut National de la Recherche Agronomique, Université Bretagne Loire, 44307 Nantes, France.

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http://dx.doi.org/10.1073/pnas.1915658117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995011PMC
January 2020

Selective Costimulation Blockade With Antagonist Anti-CD28 Therapeutics in Transplantation.

Transplantation 2019 Sep;103(9):1783-1789

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1097/TP.0000000000002740DOI Listing
September 2019

Extracellular hemoglobin combined with an O -generating material overcomes O limitation in the bioartificial pancreas.

Biotechnol Bioeng 2019 05 29;116(5):1176-1189. Epub 2019 Jan 29.

Immuno-Endocrinology Unit (IECM), Oniris, INRA, Université Bretagne Loire, Nantes, France.

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http://dx.doi.org/10.1002/bit.26913DOI Listing
May 2019

Biomimetic Glyconanoparticle Vaccine for Cancer Immunotherapy.

ACS Nano 2019 03 11;13(3):2936-2947. Epub 2019 Mar 11.

Department of Cell Research and Immunology, The George S. Wise Faculty of Life Sciences , Tel Aviv University , Tel Aviv 69978 , Israel.

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http://dx.doi.org/10.1021/acsnano.8b07241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756924PMC
March 2019

No Increase in Colon Cancer Risk Following Induction with Neu5Gc-Bearing Rabbit Anti-T Cell IgG (ATG) in Recipients of Kidney Transplants.

Cancers (Basel) 2018 Sep 12;10(9). Epub 2018 Sep 12.

Institute of Immunology, Heidelberg University, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/cancers10090324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162487PMC
September 2018

Increased degradation of ATP is driven by memory regulatory T cells in kidney transplantation tolerance.

Kidney Int 2018 05 15;93(5):1154-1164. Epub 2018 Feb 15.

Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; LabEx IGO "Immunotherapy, Graft, Oncology," Nantes, France; Centre d'Investigation Clinique (CIC) Biothérapie, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.12.004DOI Listing
May 2018

Are the decrease in circulating anti-α1,3-Gal IgG and the lower content of galactosyl transferase A1 in the microbiota of patients with multiple sclerosis a novel environmental risk factor for the disease?

Mol Immunol 2018 01 28;93:162-165. Epub 2017 Nov 28.

Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2017.09.016DOI Listing
January 2018

Antagonist Anti-CD28 Therapeutics for the Treatment of Autoimmune Disorders.

Antibodies (Basel) 2017 Nov 21;6(4). Epub 2017 Nov 21.

Centre de Recherche en Transplantation et Immunologie (CRTI) UMR1064, INSERM, Université de Nantes, 44035 Nantes, France.

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http://dx.doi.org/10.3390/antib6040019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698823PMC
November 2017

Anti-Gal and Anti-Neu5Gc Responses in Nonimmunosuppressed Patients After Treatment With Rabbit Antithymocyte Polyclonal IgGs.

Transplantation 2017 10;101(10):2501-2507

1 Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France. 2 Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France. 3 Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France. 4 Xenothera, Nantes, France. 5 Biomarker Discovery Research, Immune Tolerance Network, Bethesda, MD, USA. 6 IECM, Immuno-endocrinology, EA4644 Oniris, University of Nantes, USC1383 INRA, Oniris, Nantes, France. 7 Clinical Trials Group, Immune Tolerance Network, San Francisco, CA. 8 Division of Pediatric Endocrinology and Diabetes, University of California San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1097/TP.0000000000001686DOI Listing
October 2017

Blood biomarkers of kidney transplant rejection, an endless search?

Expert Rev Mol Diagn 2017 07 7;17(7):687-697. Epub 2017 Jun 7.

a Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM , Université de Nantes , Nantes , France.

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http://dx.doi.org/10.1080/14737159.2017.1337512DOI Listing
July 2017

A composite score associated with spontaneous operational tolerance in kidney transplant recipients.

Kidney Int 2017 06 24;91(6):1473-1481. Epub 2017 Feb 24.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; CIC Biotherapy, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432017PMC
June 2017

Alloantigen gene transfer to hepatocytes promotes tolerance to pancreatic islet graft by inducing CD8 regulatory T cells.

J Hepatol 2017 04 30;66(4):765-777. Epub 2016 Nov 30.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.11.019DOI Listing
April 2017

The Medawar Prize Acceptance Speech 2016.

Transplantation 2016 12;100(12):2497-2500

University of Nantes, Inserm 1064, France.

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http://dx.doi.org/10.1097/TP.0000000000001527DOI Listing
December 2016

Sialylation of antibodies in kidney recipients with de novo donor specific antibody, with or without antibody mediated rejection.

Hum Immunol 2016 Nov 10;77(11):1076-1083. Epub 2015 Nov 10.

Institut National de la Sante Et de la Recherche Médicale INSERM U1064, and Institut de Transplantation Urologie Néphrologie du Centre Hospitalier Universitaire Hôtel Dieu, LabEx Transplantex, CHU de Nantes, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 01, France; CIC Biothérapie, 5, allée de l'Ile Gloriette, 44093 Nantes Cedex 0144035, Nantes, France; CHU Nantes, CRB, 9 quai Moncousu, 44093 Nantes Cedex 1, Nantes F-44093, France. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2015.10.021DOI Listing
November 2016

Characterization of immunoglobulins through analysis of N-glycopeptides by MALDI-TOF MS.

Methods 2016 07 7;104:170-81. Epub 2016 Jan 7.

Chemistry Department, University of Manitoba, 144 Dysart Road, Winnipeg, MB R2T 2N2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2016.01.005DOI Listing
July 2016

The DESCARTES-Nantes survey of kidney transplant recipients displaying clinical operational tolerance identifies 35 new tolerant patients and 34 almost tolerant patients.

Nephrol Dial Transplant 2016 06 12;31(6):1002-13. Epub 2016 Jan 12.

Nephrology-Renal Transplantation Department, Universitair Ziekenhuis Antwerp, Antwerp, Belgium Université Libre de Bruxelles (ULB), Brussels, Belgium.

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http://dx.doi.org/10.1093/ndt/gfv437DOI Listing
June 2016

Neuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis.

Clin Immunol 2016 05 2;166-167:1-11. Epub 2016 Apr 2.

INSERM, UMR 1064, Nantes F-44093, France; Nantes Hospital, Department of Neurology, Nantes, France; INSERM 015, Centre d'Investigation Clinique, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.03.014DOI Listing
May 2016

Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation.

Xenotransplantation 2015 Mar-Apr;22(2):85-94. Epub 2014 Oct 13.

INSERM UMR1064, Centre for Research in Transplantation and Immunology-ITUN, Université de Nantes, Centre Hospitalier Universitaire Hôtel-Dieu, Nantes, France; Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes Cedex, France.

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http://dx.doi.org/10.1111/xen.12142DOI Listing
April 2016

Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation.

Front Immunol 2016 24;7:89. Epub 2016 Mar 24.

UMR 1064, INSERM, Nantes, France; Faculté de Médecine, Université de Nantes, Nantes, France; LabEx Transplantex, Nantes, France.

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http://dx.doi.org/10.3389/fimmu.2016.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805583PMC
April 2016

Characterization of N-glycosylation and amino acid sequence features of immunoglobulins from swine.

Glycoconj J 2016 Feb 19;33(1):79-91. Epub 2015 Nov 19.

Department of Chemistry, University of Manitoba, 144 Dysart Road, Winnipeg, Manitoba, R3T 2N2, Canada.

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http://dx.doi.org/10.1007/s10719-015-9637-zDOI Listing
February 2016

Tolerant Kidney Transplant Patients Produce B Cells with Regulatory Properties.

J Am Soc Nephrol 2015 Oct 2;26(10):2588-98. Epub 2015 Feb 2.

Joint Research Unit 1064, French Institute of Health and Medical Research, Nantes, France; Faculty of Medicine, Nantes University, Nantes, France; and Institute of Transplantation Urology and Nephrology, Nantes University Hospital, Nantes, France

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http://dx.doi.org/10.1681/ASN.2014040404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587683PMC
October 2015

Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance.

J Am Soc Nephrol 2015 Aug 2;26(8):1795-805. Epub 2015 Jan 2.

French Institute of Health and Medical Research Unit 1064, Research Institute on Urology, Nephrology, and Transplantation, and Biotherapy Clinical Investigation Center, Hôtel Dieu University Hospital, Nantes, France; and

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http://dx.doi.org/10.1681/ASN.2014050480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520169PMC
August 2015

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation.

Xenotransplantation 2014 Sep-Oct;21(5):420-30. Epub 2014 Sep 1.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea; Xenotransplantation Research Center, Seoul National University College Of Medicine and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/xen.12129DOI Listing
June 2015

Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis.

Ann Clin Transl Neurol 2015 Jun 28;2(6):609-22. Epub 2015 Apr 28.

INSERM, UMR 1064 Nantes, F-44093, France ; Neurology Department, Nantes Hospital Nantes, F-44093, France ; INSERM 004, Centre d'Investigation Clinique Nantes, F-44093, France.

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http://dx.doi.org/10.1002/acn3.199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479522PMC
June 2015

A useful scoring system for the prediction and management of delayed graft function following kidney transplantation from cadaveric donors.

Kidney Int 2014 Dec 4;86(6):1130-9. Epub 2014 Jun 4.

1] Institut de Transplantation et de Recherche en Transplantation, ITUN, CHU Nantes, RTRS « Centaure », Nantes and Inserm U1064 (Immunointervention dans les Allo et Xénotransplantation), Nantes University, boulevard Jean Monnet, Nantes, France [2] EA 4275 SPHERE-Biostatistics, Clinical Research and Pharmaco-Epidemiology, Nantes University, Nantes, France.

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http://dx.doi.org/10.1038/ki.2014.188DOI Listing
December 2014

Unaltered regulatory B-cell frequency and function in patients with multiple sclerosis.

Clin Immunol 2014 Dec 28;155(2):198-208. Epub 2014 Sep 28.

INSERM, UMR 1064, Nantes, F-44093, France; Universite de Nantes, Faculte de Medecine, Nantes, F-44035, France; CHU de Nantes, ITUN, Nantes, F-44093, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216616140022
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http://dx.doi.org/10.1016/j.clim.2014.09.011DOI Listing
December 2014

Expansion of highly differentiated cytotoxic terminally differentiated effector memory CD8+ T cells in a subset of clinically stable kidney transplant recipients: a potential marker for late graft dysfunction.

J Am Soc Nephrol 2014 Aug 20;25(8):1856-68. Epub 2014 Mar 20.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1064, Nantes, France; Centre Hospitalier Universitaire de Nantes, Institut de Transplantation Urologie-Néphrologie, Nantes, France; Faculté de Médecine, Université de Nantes, Nantes, France;

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http://dx.doi.org/10.1681/ASN.2013080848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116064PMC
August 2014

MicroRNAs, Major Players in B Cells Homeostasis and Function.

Front Immunol 2014 11;5:98. Epub 2014 Mar 11.

Institut National de la Santé et de la Recherche Médicale, U1064, Institut de Transplantation Urologie Néphrologie , Nantes , France ; Faculté de Médecine, Université de Nantes , Nantes , France ; Centre Hospitalier Universitaire, Hôtel Dieu , Nantes , France.

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http://dx.doi.org/10.3389/fimmu.2014.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949129PMC
June 2014

Biomarkers and possible mechanisms of operational tolerance in kidney transplant patients.

Immunol Rev 2014 Mar;258(1):208-17

INSERM UMR 1064, Nantes, France; Centaure, Nantes, France.

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http://dx.doi.org/10.1111/imr.12156DOI Listing
March 2014

An alternative approach to estimate age-related mortality of kidney transplant recipients compared to the general population: results in favor of old-to-old transplantations.

Transpl Int 2014 Feb 20;27(2):219-25. Epub 2013 Dec 20.

EA 4275 Biostatistics, Clinical Research and Subjective Measures in Health Sciences, Nantes University, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), Nantes Hospital and University, INSERM 1064, CENTAURE, Nantes, France.

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http://dx.doi.org/10.1111/tri.12241DOI Listing
February 2014

Influence of anemia on patient and graft survival after renal transplantation: results from the French DIVAT cohort.

Transplantation 2014 Jan;97(2):168-75

1 Service de Néphrologie, CHU Lapeyronie, Université de Montpellier, Montpellier, France. 2 Institut de Transplantation et de Recherche en Transplantation, CHU Nantes, RTRS « Centaure », et Inserm U1064, Université de Nantes, Nantes, France. 3 Service de Transplantation Rénale et de Soins Intensifs, Hôpital Necker, Paris, France. 4 Universités Paris Descartes et Sorbonne Paris Cité, Paris, France. 5 Service de Néphrologie et Transplantation Rénale, CHU Brabois, Nancy, France. 6 Service de Néphrologie, HTA, Dialyse et Transplantation d'Organes, CHU Rangueil, Toulouse, France. 7 Université Paul Sabatier, Toulouse, France. 8 Service de Néphrologie, Transplantation et Immunologie Clinique, Hôpital Edouard Herriot, Lyon, France. 9 Address correspondence to: Georges Mourad, M.D., Service de Néphrologie, Dialyse et Transplantation, Hôpital Lapeyronie, University of Montpellier, Montpellier 05, France.

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http://dx.doi.org/10.1097/TP.0b013e3182a94a4dDOI Listing
January 2014

Reconsidering the bio-detection of tolerance in renal transplantation.

Chimerism 2013 Jan-Mar;4(1):15-7

Institut National de la Santé et de la Recherche Médicale INSERM U643, Nantes, France.

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http://dx.doi.org/10.4161/chim.23347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654731PMC
December 2013

Missing links in multiple sclerosis etiology. A working connecting hypothesis.

Med Hypotheses 2013 May 5;80(5):509-16. Epub 2013 Mar 5.

INSERM, UMR 1064, Nantes F-44093, France.

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http://dx.doi.org/10.1016/j.mehy.2013.01.036DOI Listing
May 2013

Mechanistic target of rapamycin inhibitors in solid organ transplantation: from benchside to clinical use.

Curr Opin Organ Transplant 2012 Dec;17(6):626-33

Institut de Transplantation Urologie, Néphrologie and Institut National de la Santé Et de la Recherche Médicale UMR1064, Nantes University Hospital, Nantes, France.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MOT.0b013e32835a4be2DOI Listing
December 2012

Gene expression signature in transplantation tolerance.

Clin Chim Acta 2012 Sep 9;413(17-18):1414-8. Epub 2012 May 9.

University of Nantes, Nantes, France.

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http://dx.doi.org/10.1016/j.cca.2012.04.024DOI Listing
September 2012

Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant.

J Am Soc Nephrol 2012 Apr 26;23(4):597-606. Epub 2012 Jan 26.

Institut National de la Santé Et de la Recherche Médicale UMR643 and Institut de Transplantation Urologie, Néphrologie, Nantes, France.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2011060543
Publisher Site
http://dx.doi.org/10.1681/ASN.2011060543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312506PMC
April 2012

Cut-off estimation and medical decision making based on a continuous prognostic factor: the prediction of kidney graft failure.

Int J Biostat 2012 Jan 6;8(1). Epub 2012 Jan 6.

Institut of Transplantation and Research in Transplantation, Department of Biostatistics, Nantes University.

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http://www.degruyter.com/view/j/ijb.2012.8.issue-1/1557-4679
Publisher Site
http://dx.doi.org/10.2202/1557-4679.1215DOI Listing
January 2012

TNF blockade abrogates the induction of T cell-dependent humoral responses in an allotransplantation model.

J Leukoc Biol 2011 Aug 11;90(2):367-75. Epub 2011 May 11.

Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1189/jlb.0710392DOI Listing
August 2011

Xenotransplantation: times are changing.

Curr Opin Organ Transplant 2011 Apr;16(2):188-9

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http://dx.doi.org/10.1097/MOT.0b013e32834494cbDOI Listing
April 2011

More on risk/benefit ratio of anti-IL-2 receptor monoclonal antibodies.

Transpl Int 2010 Dec;23(12):1205-6

Departments of Nephrology and Clinical Immunology, Transplantation, ITUN, Nantes University Hospital, Nantes, France.

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http://dx.doi.org/10.1111/j.1432-2277.2010.01136.xDOI Listing
December 2010

AKT1 leader gene and downstream targets are involved in a rat model of kidney allograft tolerance.

J Cell Biochem 2010 Oct;111(3):709-19

Institut National de la Santé Et de la Recherche Médicale INSERM U643, Institut de Transplantation et de Recherche en Transplantation ITERT, Nantes F-44093, France.

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http://dx.doi.org/10.1002/jcb.22757DOI Listing
October 2010

Six months anti-viral prophylaxis significantly decreased cytomegalovirus disease compared with no anti-viral prophylaxis following renal transplantation.

Transpl Int 2010 Sep 10;23(9):897-906. Epub 2010 Mar 10.

Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes University Hospital, Nantes, France.

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http://dx.doi.org/10.1111/j.1432-2277.2010.01073.xDOI Listing
September 2010

What can we learn from the transcriptional characterization of spontaneously tolerant transplant recipients?

Curr Opin Organ Transplant 2010 Aug;15(4):435-40

INSERM U643, U643-ITERT, 30 Boulevard Jean Monnet, Nantes Cedex 1, France.

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http://dx.doi.org/10.1097/MOT.0b013e32833bfac9DOI Listing
August 2010

Kidney and recipient weight incompatibility reduces long-term graft survival.

J Am Soc Nephrol 2010 Jun 20;21(6):1022-9. Epub 2010 May 20.

Institut de Transplantation et de Recherche en Transplantation, ITERT, CHU Nantes, Réseau Thématique de Recherche et de Soins Centaure, Nantes and INSERM U643 (Immunointervention dans les Allo et Xénotransplantation), Centre d'Investigation Clinique biothérapie, 30 bd Jean Monnet, 44093, Nantes, France.

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http://dx.doi.org/10.1681/ASN.2009121296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900958PMC
June 2010