Publications by authors named "Jean-Paul Kovalik"

33 Publications

The acute transcriptional responses to dietary methionine restriction are triggered by inhibition of ternary complex formation and linked to Erk1/2, mTOR, and ATF4.

Sci Rep 2021 Feb 12;11(1):3765. Epub 2021 Feb 12.

Laboratory of Nutrient Sensing and Adipocyte Signaling, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.

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February 2021

Novel metabolomics markers are associated with pre-clinical decline in hand grip strength in community-dwelling older adults.

Mech Ageing Dev 2021 Jan 17;193:111405. Epub 2020 Nov 17.

Duke-National University of Singapore Medical School, Center for Aging, Research and Education Singapore; Duke-National University of Singapore Medical School, Program in Health Services and Systems Research, Singapore; Duke University School of Medicine, Department of Medicine (General Internal Medicine), United States. Electronic address:

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January 2021

Coffee, Black Tea, and Green Tea Consumption in Relation to Plasma Metabolites in an Asian Population.

Mol Nutr Food Res 2020 Oct 29:e2000527. Epub 2020 Oct 29.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.

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October 2020

Branched-Chain Amino Acid Oxidation Is Elevated in Adults with Morbid Obesity and Decreases Significantly after Sleeve Gastrectomy.

J Nutr 2020 12;150(12):3180-3189

USDA/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

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December 2020

Prdm16 Deficiency Leads to Age-Dependent Cardiac Hypertrophy, Adverse Remodeling, Mitochondrial Dysfunction, and Heart Failure.

Cell Rep 2020 Oct;33(3):108288

Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857; National Heart Research Institute Singapore, National Heart Center Singapore, Singapore 169609. Electronic address:

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October 2020

Organ protection by SGLT2 inhibitors: role of metabolic energy and water conservation.

Nat Rev Nephrol 2021 01 1;17(1):65-77. Epub 2020 Oct 1.

Programme in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.

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January 2021

Resolution of Erosive Esophagitis After Conversion from Vertical Sleeve Gastrectomy to Roux-en-Y Gastric Bypass.

Obes Surg 2020 Dec 15;30(12):4751-4759. Epub 2020 Aug 15.

Department of Upper Gastrointestinal & Bariatric Surgery, Division of Surgery, Singapore General Hospital, Academia, 20 College Road, Singapore, 169856, Singapore.

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December 2020

Associations of Bariatric Interventions With Micronutrient and Endocrine Disturbances.

JAMA Netw Open 2020 06 1;3(6):e205123. Epub 2020 Jun 1.

Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore.

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June 2020

Attitudes and perceptions of the general public on obesity and its treatment options in Singapore.

Obes Res Clin Pract 2019 Jul - Aug;13(4):404-407. Epub 2019 Apr 8.

Obesity and Metabolic Unit, Bowyer Block A Level 1, Singapore General Hospital, Outram Road, Singapore 169608, Singapore; Department of Endocrinology, Singapore General Hospital, 20 College Rd., Singapore 169856, Singapore.

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June 2020

Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes.

Int J Cardiol 2018 Dec 24;272:288-297. Epub 2018 Aug 24.

National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School, Singapore; Health and Social Sciences Cluster, Singapore Institute of Technology, Singapore. Electronic address:

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December 2018

Comprehensive assessment of insulin resistance in non-obese Asian Indian and Chinese men.

J Diabetes Investig 2018 Nov 20;9(6):1296-1303. Epub 2018 Apr 20.

Department of Medicine, National University Health System, Singapore.

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November 2018

Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation.

Nat Commun 2017 10 20;8(1):1087. Epub 2017 Oct 20.

Department of Biological Sciences, National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 08826, Korea.

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October 2017

Characterization of a primary brown adipocyte culture system derived from human fetal interscapular fat.

Adipocyte 2015 Oct-Dec;4(4):303-10. Epub 2015 Apr 20.

Cardiovascular and Metabolic Disorders Program; Duke-NUS Graduate Medical School ; Singapore ; Institute of Molecular and Cell Biology ; Singapore.

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October 2015