Publications by authors named "Jean-Paul Kovalik"

33 Publications

Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure.

Authors:
Johannes Kovarik Norihiko Morisawa Johannes Wild Adriana Marton Kaoru Takase-Minegishi Shintaro Minegishi Steffen Daub Jeff M Sands Janet D Klein James L Bailey Jean-Paul Kovalik Manfred Rauh Susanne Karbach Karl F Hilgers Friedrich Luft Akira Nishiyama Daisuke Nakano Kento Kitada Jens Titze

Acta Physiol (Oxf) 2021 Feb 16:e13629. Epub 2021 Feb 16.

Programme in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, 8 College Road, Singapore, 169856.

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February 2021

The acute transcriptional responses to dietary methionine restriction are triggered by inhibition of ternary complex formation and linked to Erk1/2, mTOR, and ATF4.

Authors:
Kirsten P Stone Sujoy Ghosh Jean Paul Kovalik Manda Orgeron Desiree Wanders Landon C Sims Thomas W Gettys

Sci Rep 2021 Feb 12;11(1):3765. Epub 2021 Feb 12.

Laboratory of Nutrient Sensing and Adipocyte Signaling, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.

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February 2021

Novel metabolomics markers are associated with pre-clinical decline in hand grip strength in community-dwelling older adults.

Authors:
Ted Kheng Siang Ng Jean-Paul Kovalik Jianhong Ching Angelique W Chan David Bruce Matchar

Mech Ageing Dev 2021 Jan 17;193:111405. Epub 2020 Nov 17.

Duke-National University of Singapore Medical School, Center for Aging, Research and Education Singapore; Duke-National University of Singapore Medical School, Program in Health Services and Systems Research, Singapore; Duke University School of Medicine, Department of Medicine (General Internal Medicine), United States. Electronic address:

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January 2021

Coffee, Black Tea, and Green Tea Consumption in Relation to Plasma Metabolites in an Asian Population.

Authors:
Wei Jie Seow Dorrain Yanwen Low Wen-Chi Pan Samuel H Gunther Xueling Sim Federico Torta Deron R Herr Jean-Paul Kovalik Jianhong Ching Chin Meng Khoo Markus R Wenk E Shyong Tai Rob M van Dam

Mol Nutr Food Res 2020 Oct 29:e2000527. Epub 2020 Oct 29.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.

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October 2020

Branched-Chain Amino Acid Oxidation Is Elevated in Adults with Morbid Obesity and Decreases Significantly after Sleeve Gastrectomy.

Authors:
Hong Chang Tan Jean W Hsu Jean-Paul Kovalik Alvin Eng Weng Hoong Chan Chin Meng Khoo E Shyong Tai Shaji Chacko Farook Jahoor

J Nutr 2020 12;150(12):3180-3189

USDA/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

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December 2020

Prdm16 Deficiency Leads to Age-Dependent Cardiac Hypertrophy, Adverse Remodeling, Mitochondrial Dysfunction, and Heart Failure.

Authors:
Dasan Mary Cibi Kathleen Wung Bi-Lin Shamini Guna Shekeran Reddemma Sandireddy Nicole Tee Anamika Singh Yajun Wu Dinesh Kumar Srinivasan Jean-Paul Kovalik Sujoy Ghosh Patrick Seale Manvendra K Singh

Cell Rep 2020 Oct;33(3):108288

Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore 169857; National Heart Research Institute Singapore, National Heart Center Singapore, Singapore 169609. Electronic address:

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October 2020

Organ protection by SGLT2 inhibitors: role of metabolic energy and water conservation.

Authors:
Adriana Marton Tatsuroh Kaneko Jean-Paul Kovalik Atsutaka Yasui Akira Nishiyama Kento Kitada Jens Titze

Nat Rev Nephrol 2021 01 1;17(1):65-77. Epub 2020 Oct 1.

Programme in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.

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January 2021

Serum acylcarnitines and amino acids and risk of type 2 diabetes in a multiethnic Asian population.

Authors:
Samuel H Gunther Chin Meng Khoo E-Shyong Tai Xueling Sim Jean-Paul Kovalik Jianhong Ching Jeannette J Lee Rob M van Dam

BMJ Open Diabetes Res Care 2020 10;8(1)

Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

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October 2020

Resolution of Erosive Esophagitis After Conversion from Vertical Sleeve Gastrectomy to Roux-en-Y Gastric Bypass.

Authors:
Chin Hong Lim Phong Ching Lee Eugene Lim Alvin Eng Weng Hoong Chan Hong Chang Tan Emily Ho Jean-Paul Kovalik Sonali Ganguly Jeremy Tan

Obes Surg 2020 Dec 15;30(12):4751-4759. Epub 2020 Aug 15.

Department of Upper Gastrointestinal & Bariatric Surgery, Division of Surgery, Singapore General Hospital, Academia, 20 College Road, Singapore, 169856, Singapore.

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December 2020

Associations of Bariatric Interventions With Micronutrient and Endocrine Disturbances.

Authors:
Nicholas L Syn Phong Ching Lee Jean-Paul Kovalik Kwang Wei Tham Hock Soo Ong Weng Hoong Chan Chuen Seng Tan Chin Hong Lim

JAMA Netw Open 2020 06 1;3(6):e205123. Epub 2020 Jun 1.

Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore.

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June 2020

Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer's and Parkinson's diseases.

Authors:
Jin-Fang Chai Suryaprakash Raichur Ing Wei Khor Federico Torta Wee Siong Chew Deron Raymond Herr Jianhong Ching Jean-Paul Kovalik Chin Meng Khoo Markus R Wenk E Shyong Tai Xueling Sim

Hum Mol Genet 2020 01;29(2):189-201

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.

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January 2020

Metabolic stress is a primary pathogenic event in transgenic expressing pan-neuronal human amyloid beta.

Authors:
Emelyne Teo Sudharshan Ravi Diogo Barardo Hyung-Seok Kim Sheng Fong Amaury Cazenave-Gassiot Tsze Yin Tan Jianhong Ching Jean-Paul Kovalik Markus R Wenk Rudiyanto Gunawan Philip K Moore Barry Halliwell Nicholas Tolwinski Jan Gruber

Elife 2019 10 15;8. Epub 2019 Oct 15.

Science Division, Yale-NUS College, Singapore, Singapore.

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October 2019

Attitudes and perceptions of the general public on obesity and its treatment options in Singapore.

Authors:
Phong Ching Lee Sonali Ganguly Hong Chang Tan Chin Hong Lim Weng Hoong Chan Jean-Paul Kovalik Alvin Eng Jeremy Tan Eugene Lim Jasmine Chua Kwang Wei Tham

Obes Res Clin Pract 2019 Jul - Aug;13(4):404-407. Epub 2019 Apr 8.

Obesity and Metabolic Unit, Bowyer Block A Level 1, Singapore General Hospital, Outram Road, Singapore 169608, Singapore; Department of Endocrinology, Singapore General Hospital, 20 College Rd., Singapore 169856, Singapore.

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June 2020

Proximal Tubular Cell-Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis.

Authors:
Claudia Kruger Trang-Tiffany Nguyen Chelsea Breaux Alana Guillory Margaret Mangelli Kevin T Fridianto Jean-Paul Kovalik David H Burk Robert C Noland Randall Mynatt Krisztian Stadler

Diabetes 2019 04 6;68(4):819-831. Epub 2019 Feb 6.

Oxidative Stress and Disease Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA

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April 2019

Metabolomic correlates of aerobic capacity among elderly adults.

Authors:
Angela S Koh Fei Gao Ru S Tan Liang Zhong Shuang Leng Xiaodan Zhao Kevin T Fridianto Jianhong Ching Si Y Lee Bryan M H Keng Tee Joo Yeo Shu Y Tan Hong C Tan Chin T Lim Woon-Puay Koh Jean-Paul Kovalik

Clin Cardiol 2018 Oct;41(10):1300-1307

Cardiovascular and Metabolic Diseases Programme, Duke-NUS Medical School, Singapore.

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October 2018

Comprehensive Assessment of the Effects of Sleeve Gastrectomy on Glucose, Lipid, and Amino Acid Metabolism in Asian Individuals with Morbid Obesity.

Authors:
Jie Yao Jean-Paul Kovalik Oi Fah Lai Phong Ching Lee Alvin Eng Weng Hoong Chan Kwang Wei Tham Eugene Lim Yong Mong Bee Hong Chang Tan

Obes Surg 2019 01;29(1):149-158

Department of Endocrinology, The Academia Level 3, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.

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January 2019

Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes.

Authors:
Chrishan J A Ramachandra Ashish Mehta Philip Wong K P Myu Mai Ja Regina Fritsche-Danielson Ratan V Bhat Derek J Hausenloy Jean-Paul Kovalik Winston Shim

Int J Cardiol 2018 Dec 24;272:288-297. Epub 2018 Aug 24.

National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School, Singapore; Health and Social Sciences Cluster, Singapore Institute of Technology, Singapore. Electronic address:

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December 2018

Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction.

Authors:
Leonardo P de Carvalho Sock Hwee Tan Ghim-Siong Ow Zhiqun Tang Jianhong Ching Jean-Paul Kovalik Sock Cheng Poh Chee-Tang Chin A Mark Richards Eliana C Martinez Richard W Troughton Alan Yean-Yip Fong Bryan P Yan Aruni Seneviratna Vitaly Sorokin Scott A Summers Vladimir A Kuznetsov Mark Y Chan

JACC Basic Transl Sci 2018 Apr 30;3(2):163-175. Epub 2018 May 30.

National University Heart Center, Singapore, Singapore.

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April 2018

Urine Tricarboxylic Acid Cycle Metabolites Predict Progressive Chronic Kidney Disease in Type 2 Diabetes.

Authors:
Jian-Jun Liu Sylvia Liu Resham L Gurung Jianhong Ching Jean-Paul Kovalik Tsze Yin Tan Su Chi Lim

J Clin Endocrinol Metab 2018 12;103(12):4357-4364

Diabetes Centre, Khoo Teck Puat Hospital, Singapore.

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December 2018

Dissecting Clinical and Metabolomics Associations of Left Atrial Phasic Function by Cardiac Magnetic Resonance Feature Tracking.

Authors:
Angela S Koh Fei Gao Shuang Leng Jean-Paul Kovalik Xiaodan Zhao Ru San Tan Kevin Timothy Fridianto Jianhong Ching Serene Jm Chua Jian-Min Yuan Woon-Puay Koh Liang Zhong

Sci Rep 2018 05 25;8(1):8138. Epub 2018 May 25.

National Heart Centre Singapore, Singapore, Singapore.

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May 2018

Comprehensive assessment of insulin resistance in non-obese Asian Indian and Chinese men.

Authors:
Hong Chang Tan Tong Wei Yew Shaji Chacko E Shyong Tai Jean-Paul Kovalik Jianhong Ching Sandi Myo Thant Chin Meng Khoo

J Diabetes Investig 2018 Nov 20;9(6):1296-1303. Epub 2018 Apr 20.

Department of Medicine, National University Health System, Singapore.

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November 2018

Profiling of Plasma Metabolites Suggests Altered Mitochondrial Fuel Usage and Remodeling of Sphingolipid Metabolism in Individuals With Type 2 Diabetes and Kidney Disease.

Authors:
Jian-Jun Liu Sujoy Ghosh Jean-Paul Kovalik Jianhong Ching Hyung Won Choi Subramaniam Tavintharan Choon Nam Ong Chee Fang Sum Scott A Summers E Shyong Tai Su Chi Lim

Kidney Int Rep 2017 May 16;2(3):470-480. Epub 2016 Dec 16.

Diabetes Centre, Khoo Teck Puat Hospital, Singapore.

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May 2017

Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation.

Authors:
Kyung Cheul Shin Injae Hwang Sung Sik Choe Jeu Park Yul Ji Jong In Kim Gha Young Lee Sung Hee Choi Jianhong Ching Jean-Paul Kovalik Jae Bum Kim

Nat Commun 2017 10 20;8(1):1087. Epub 2017 Oct 20.

Department of Biological Sciences, National Creative Research Initiatives Center for Adipose Tissue Remodeling, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 08826, Korea.

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October 2017

Metabolomic profile of arterial stiffness in aged adults.

Authors:
Angela S Koh Fei Gao Jin Liu Kevin Timothy Fridianto Jianhong Ching Ru San Tan Jia-Ing Wong Serene Jm Chua Shuang Leng Liang Zhong Bryan Mh Keng Fei Qiong Huang Jian-Min Yuan Woon-Puay Koh Jean-Paul Kovalik

Diab Vasc Dis Res 2018 01 4;15(1):74-80. Epub 2017 Oct 4.

2 Duke-NUS Medical School, Singapore.

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January 2018

Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.

Authors:
Kenji Ohba Rohit Anthony Sinha Brijesh Kumar Singh Liliana Felicia Iannucci Jin Zhou Jean-Paul Kovalik Xiao-Hui Liao Samuel Refetoff Judy Chia Ghee Sng Melvin Khee-Shing Leow Paul Michael Yen

Thyroid 2017 06 24;27(6):852-860. Epub 2017 May 24.

1 Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School , Singapore, Singapore .

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June 2017

BCL6 promotes glioma and serves as a therapeutic target.

Authors:
Liang Xu Ye Chen Marina Dutra-Clarke Anand Mayakonda Masaharu Hazawa Steve E Savinoff Ngan Doan Jonathan W Said William H Yong Ashley Watkins Henry Yang Ling-Wen Ding Yan-Yi Jiang Jeffrey W Tyner Jianhong Ching Jean-Paul Kovalik Vikas Madan Shing-Leng Chan Markus Müschen Joshua J Breunig De-Chen Lin H Phillip Koeffler

Proc Natl Acad Sci U S A 2017 04 29;114(15):3981-3986. Epub 2017 Mar 29.

Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore.

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April 2017

Titin-truncating variants affect heart function in disease cohorts and the general population.

Authors:
Sebastian Schafer Antonio de Marvao Eleonora Adami Lorna R Fiedler Benjamin Ng Ester Khin Owen J L Rackham Sebastiaan van Heesch Chee J Pua Miao Kui Roddy Walsh Upasana Tayal Sanjay K Prasad Timothy J W Dawes Nicole S J Ko David Sim Laura L H Chan Calvin W L Chin Francesco Mazzarotto Paul J Barton Franziska Kreuchwig Dominique P V de Kleijn Teresa Totman Carlo Biffi Nicole Tee Daniel Rueckert Valentin Schneider Allison Faber Vera Regitz-Zagrosek Jonathan G Seidman Christine E Seidman Wolfgang A Linke Jean-Paul Kovalik Declan O'Regan James S Ware Norbert Hubner Stuart A Cook

Nat Genet 2017 01 21;49(1):46-53. Epub 2016 Nov 21.

National Heart Centre Singapore, Singapore.

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January 2017

Physiological and Metabolic Changes During the Transition from Hyperthyroidism to Euthyroidism in Graves' Disease.

Authors:
Chiaw-Ling Chng Adoree Yi Ying Lim Hong Chang Tan Jean-Paul Kovalik Kwang Wei Tham Yong Mong Bee Weiying Lim Sanchalika Acharyya Oi Fah Lai Mary Foong-Fong Chong Paul Michael Yen

Thyroid 2016 10 7;26(10):1422-1430. Epub 2016 Sep 7.

2 Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School , Singapore .

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October 2016

The Effects of Sleeve Gastrectomy and Gastric Bypass on Branched-Chain Amino Acid Metabolism 1 Year After Bariatric Surgery.

Authors:
Hong Chang Tan Chin Meng Khoo Matthew Zhen-Wei Tan Jean-Paul Kovalik Alvin Choong Meng Ng Alvin Kim Hock Eng Oi Fah Lai Jian Hong Ching Kwang Wei Tham Shanker Pasupathy

Obes Surg 2016 08;26(8):1830-5

Advanced Laparoscopic Surgery, Gleneagles Hospital, Singapore, Singapore.

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August 2016

Characterization of a primary brown adipocyte culture system derived from human fetal interscapular fat.

Authors:
Sarah E Seiler Dan Xu Jia-Pei Ho Kinyui Alice Lo Benjamin M Buehrer Y John W Ludlow Jean-Paul Kovalik Lei Sun

Adipocyte 2015 Oct-Dec;4(4):303-10. Epub 2015 Apr 20.

Cardiovascular and Metabolic Disorders Program; Duke-NUS Graduate Medical School ; Singapore ; Institute of Molecular and Cell Biology ; Singapore.

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October 2015