Publications by authors named "Jean-Paul Desaulniers"

28Publications

Controlling Gene-Silencing with Azobenzene-Containing siRNAs (siRNAzos).

Curr Protoc Nucleic Acid Chem 2020 12;83(1):e119

University of Ontario Institute of Technology, Faculty of Science, Oshawa, Ontario, Canada.

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December 2020

To Conjugate or to Package? A Look at Targeted siRNA Delivery Through Folate Receptors.

Nucleic Acid Ther 2020 Oct 29. Epub 2020 Oct 29.

Faculty of Science, University of Ontario Institute of Technology, Oshawa, Canada.

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October 2020

Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs.

ACS Med Chem Lett 2020 Jul 9;11(7):1457-1462. Epub 2020 Jun 9.

Faculty of Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario L1G 0C5, Canada.

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July 2020

Synthesis of Azobenzene Derivative Phosphoramidites for Incorporation into Oligonucleotides.

Curr Protoc Nucleic Acid Chem 2020 06;81(1):e107

Faculty of Science, University of Ontario Institute of Technology, Oshawa, Ontario, Canada.

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June 2020

Synthesis, Derivatization and Photochemical Control of ortho-Functionalized Tetrachlorinated Azobenzene-Modified siRNAs.

Chembiochem 2020 Aug 22;21(16):2367-2372. Epub 2020 Apr 22.

Faculty of Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario L1G 0C5, Canada.

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August 2020

Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells.

Nucleic Acid Ther 2020 08 12;30(4):229-236. Epub 2020 Mar 12.

Faculty of Science, University of Ontario Institute of Technology, Oshawa, Canada.

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August 2020

Reversible control of RNA interference by siRNAzos.

Org Biomol Chem 2019 12;18(1):41-46

University of Ontario Institute of Technology, Faculty of Science, 2000 Simcoe Street North, Oshawa, Ontario L1G 0C5, Canada.

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December 2019

Targeted delivery and enhanced gene-silencing activity of centrally modified folic acid-siRNA conjugates.

Nucleic Acids Res 2020 01;48(1):75-85

Faculty of Science, University of Ontario Institute of Technology, Oshawa, Ontario L1G 0C5, Canada.

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January 2020

Stability and evaluation of siRNAs labeled at the sense strand with a 3'-azobenzene unit.

Bioorg Med Chem Lett 2018 12 26;28(23-24):3613-3616. Epub 2018 Oct 26.

Faculty of Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario L1H 7K4, Canada. Electronic address:

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December 2018

Efficient synthesis of the GABA receptor agonist trans-4-aminocrotonic acid (TACA).

Bioorg Med Chem Lett 2017 09 20;27(18):4512-4513. Epub 2017 Jul 20.

Faculty of Science, University of Ontario Institute of Technology, Oshawa, ON L1H 7K4, Canada. Electronic address:

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September 2017

A molecular characterization of the agonist binding site of a nematode cys-loop GABA receptor.

Br J Pharmacol 2015 Aug 19;172(15):3737-47. Epub 2015 May 19.

Faculty of Science, University of Ontario Institute of Technology, Oshawa, ON, Canada.

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August 2015

Conjugation and Evaluation of Small Hydrophobic Molecules to Triazole-Linked siRNAs.

ACS Med Chem Lett 2015 Feb 4;6(2):117-22. Epub 2014 Dec 4.

University of Ontario Institute of Technology , Faculty of Science, 2000 Simcoe Street North, Oshawa, Ontario L1H 7K4, Canada.

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February 2015

Synthesis of triazole-nucleoside phosphoramidites and their use in solid-phase oligonucleotide synthesis.

Curr Protoc Nucleic Acid Chem 2014 Dec 19;55:4.57.1-38. Epub 2014 Dec 19.

Faculty of Science, University of Ontario Institute of Technology, Oshawa, Ontario, Canada.

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December 2014

Inter-year repeatability study of volatile organic compounds from surface decomposition of human analogues.

Int J Legal Med 2015 May 28;129(3):641-50. Epub 2014 May 28.

Faculty of Science, University of Ontario Institute of Technology, 2000 Simcoe St N., Oshawa, Ontario, Canada, L1H 7K4.

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May 2015

Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry.

Molecules 2012 Oct 26;17(11):12665-703. Epub 2012 Oct 26.

Faculty of Science, University of Ontario Institute of Technology, 2000 Simcoe St N, Oshawa, ON L1H 7K4, Canada.

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October 2012

Gene-silencing properties of siRNAs that contain internal amide-bond linkages.

Bioorg Med Chem Lett 2012 Nov 20;22(22):6934-7. Epub 2012 Sep 20.

Faculty of Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario, Canada L1H 7K4.

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November 2012

Evaluation of siRNAs that contain internal variable-length spacer linkages.

Bioorg Med Chem Lett 2012 Sep 16;22(17):5590-4. Epub 2012 Jul 16.

Faculty of Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario, Canada L1H 7K4.

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September 2012

Synthesis and properties of RNAs that contain a PNA-RNA dimer.

Nucleosides Nucleotides Nucleic Acids 2012 May;31(5):389-400

Faculty of Science, University of Ontario Institute of Technology, Oshawa, Ontario, Canada.

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May 2012

Efficient synthesis and cell-based silencing activity of siRNAS that contain triazole backbone linkages.

Bioorg Med Chem Lett 2012 Feb 30;22(4):1722-6. Epub 2011 Dec 30.

Faculty of Science, University of Ontario Institute of Technology, Oshawa, Ontario, Canada.

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February 2012

Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.

Bioorg Med Chem Lett 2009 Nov 1;19(21):6233-6. Epub 2009 Sep 1.

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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November 2009

Pseudouridines in rRNA helix 69 play a role in loop stacking interactions.

Org Biomol Chem 2008 Nov 19;6(21):3892-5. Epub 2008 Sep 19.

Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.

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November 2008

Expanding the repertoire of small molecule transcriptional activation domains.

Bioorg Med Chem 2009 Feb 16;17(3):1034-43. Epub 2008 Feb 16.

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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February 2009

Solution conformations of two naturally occurring RNA nucleosides: 3-methyluridine and 3-methylpseudouridine.

Bioorg Med Chem 2005 Dec 24;13(24):6777-81. Epub 2005 Aug 24.

Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.

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December 2005

Sheep red blood cells armed with anti-CD20 single-chain variable fragments (scFvs) fused to a glycosylphosphatidylinositol (GPI) anchor: a strategy to target CD20-positive tumor cells.

J Immunol Methods 2005 Feb 11;297(1-2):109-24. Epub 2005 Jan 11.

Lymphoma Research Laboratory, Department of Internal Medicine, School of Medicine, Wayne State University Detroit, MI 48201, USA.

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February 2005

NMR conformational analysis of p-tolyl furanopyrimidine 2'-deoxyribonucleoside and crystal structure of its 3',5'-di-O-acetyl derivative.

Bioorg Med Chem 2005 Feb;13(4):1231-8

Department of Chemistry and Center for Biomedical Research, Oakland University, 2200 N. Squirrel Rd, Rochester, MI 48309-4477, USA.

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February 2005

Synthesis of 15N-enriched pseudouridine derivatives.

Org Lett 2003 Oct;5(22):4093-6

Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.

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October 2003