Publications by authors named "Jean-Pascal Machiels"

100Publications

HER2 as a Predictive Biomarker and Treatment Target in Colorectal Cancer.

Clin Colorectal Cancer 2020 06 8;19(2):65-72. Epub 2020 Feb 8.

Institut Roi Albert II, Service d'Oncologie Médicale, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (POLE MIRO), Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.clcc.2020.02.007DOI Listing
June 2020

Liquid biopsy for mutational profiling of locoregional recurrent and/or metastatic head and neck squamous cell carcinoma.

Oral Oncol 2020 05 10;104:104631. Epub 2020 Mar 10.

Department of Medical Oncology, Institut Roi Albert II - Cliniques universitaires Saint-Luc, Brussels, Belgium; Institute for Clinical and Experimental Research (MIRO), Université catholique de Louvain, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2020.104631DOI Listing
May 2020

Current applications and challenges of circulating tumor DNA (ctDNA) in squamous cell carcinoma of the head and neck (SCCHN).

Cancer Treat Rev 2020 Apr 14;85:101992. Epub 2020 Feb 14.

Department of Medical Oncology, Institut Roi Albert II - Cliniques universitaires Saint-Luc, Brussels, Belgium; Institute for Clinical and Experimental Research (MIRO), Université catholique de Louvain, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2020.101992DOI Listing
April 2020

Preclinical Activity of Ribociclib in Squamous Cell Carcinoma of the Head and Neck.

Mol Cancer Ther 2020 03 10;19(3):777-789. Epub 2020 Jan 10.

Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain (UCLouvain), Brussels, Belgium.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0695DOI Listing
March 2020

May we rely on induction chemotherapy again as a biological selection of radiosensitive head and neck cancer?

Oral Oncol 2019 07 21;94:121-122. Epub 2019 May 21.

Institut Roi Albert II, Department of Medical Oncology, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.oraloncology.2019.05.011DOI Listing
July 2019

Potential role of cyclin-dependent kinase 4/6 inhibitors in the treatment of squamous cell carcinoma of the head and neck.

Curr Opin Oncol 2019 05;31(3):122-130

Institut de Recherche Clinique et Expérimentale (Laboratory of Medical Oncology, Pole MIRO), UCLouvain.

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http://Insights.ovid.com/crossref?an=00001622-201905000-0000
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http://dx.doi.org/10.1097/CCO.0000000000000513DOI Listing
May 2019

Phase 1 Study Evaluating the Association of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib and Cetuximab in Recurrent/Metastatic p16-Negative Squamous Cell Carcinoma of the Head and Neck.

Front Oncol 2019 19;9:155. Epub 2019 Mar 19.

Departments of Medical Oncology and Head and Neck Surgery, Institut Roi Albert II, Institut de Recherche Clinique et Expérimentale (Pole MIRO), Cliniques Universitaires Saint-Luc, Catholic University of Louvain, Woluwe-Saint-Lambert, Belgium.

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https://www.frontiersin.org/article/10.3389/fonc.2019.00155/
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http://dx.doi.org/10.3389/fonc.2019.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433958PMC
March 2019

Neutropenia management in patients receiving myelosuppressive polychemotherapy for early breast cancer in Belgium: BRONS study results.

Acta Clin Belg 2020 Apr 4;75(2):128-135. Epub 2019 Jan 4.

Department of Medical Oncology, Cliniques universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Institut Roi Albert II, Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1080/17843286.2018.1563735DOI Listing
April 2020

Fibroblast Growth Factor Receptor-2 Polymorphism rs2981582 is Correlated With Progression-free Survival and Overall Survival in Patients With Metastatic Clear-cell Renal Cell Carcinoma Treated With Sunitinib.

Clin Genitourin Cancer 2019 04 16;17(2):e235-e246. Epub 2018 Nov 16.

Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KU Leuven, Leuven, Belgium; Inserm UMR1162 Génomique Fonctionnelle des Tumeurs Solides, Université Paris-5 René Descartes, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2018.11.002DOI Listing
April 2019

Polymorphisms in the Von Hippel-Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors.

Clin Genitourin Cancer 2018 08 5;16(4):266-273. Epub 2018 Feb 5.

Laboratory of Experimental Oncology, Department of Oncology, University of Leuven, Leuven, Belgium; Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2018.01.013DOI Listing
August 2018

Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival.

J Natl Cancer Inst 2018 01;110(1)

Laboratory of Integrative Cancer Immunology, INSERM, UMRS1138, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, UMRS1138, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMRS1138, Centre de Recherche des Cordeliers, Paris, France; Inovarion, Paris, France; Department of Medical Oncology, Cliniques Universitaires St-Luc and Institut de Recherche Clinique et Experimentale (Pole MIRO), Institut Roi Albert II, Université Catholique de Louvain, Brussels, Belgium; Department of Immunology, HEGP, Assistance Publique-Hopitaux de Paris, Paris, France; AstraZeneca, Cambridge, UK; Departments of General and Digestive Surgery, HEGP, AP-HP, Assistance Publique-Hopitaux de Paris, Paris, France; Grand Hopital de Charleroi, Charleroi, Belgium.

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http://dx.doi.org/10.1093/jnci/djx123DOI Listing
January 2018

Expression of SESN1, UHRF1BP1, and miR-377-3p as prognostic markers in mutated TP53 squamous cell carcinoma of the head and neck.

Cancer Biol Ther 2017 Oct 8;18(10):775-782. Epub 2017 Sep 8.

a Department of Medical Oncology, Institut de Recherche Expérimentale et Clinique (IREC)-Pole MIRO , Université Catholique de Louvain , Brussels , Belgium.

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http://dx.doi.org/10.1080/15384047.2017.1373212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678692PMC
October 2017

Safety of drug treatments for head and neck cancer.

Expert Opin Drug Saf 2016 Nov 9;15(11):1527-1539. Epub 2016 Sep 9.

a Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO) , Université catholique de Louvain , Brussels , Belgium.

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http://dx.doi.org/10.1080/14740338.2016.1227789DOI Listing
November 2016

Treatment landscape of metastatic prostate cancer: the role of radium-223.

Acta Clin Belg 2017 Feb 4;72(1):19-23. Epub 2016 Jul 4.

a Department of Medical Oncology, Institut Roi Albert II, Cliniques universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO) , Université catholique de Louvain , Brussels , Belgium.

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http://dx.doi.org/10.1080/17843286.2016.1203545DOI Listing
February 2017

Targeting the Tumor Environment in Squamous Cell Carcinoma of the Head and Neck.

Curr Treat Options Oncol 2016 07;17(7):37

Institut Roi Albert II, Department of Medical Oncology, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (MIRO), Université Catholique de Louvain, Avenue Hippocrate, 1200, Brussels, Belgium.

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http://dx.doi.org/10.1007/s11864-016-0412-6DOI Listing
July 2016

The promise of immunostimulatory antibodies in head and neck cancer.

Lancet Oncol 2016 07 27;17(7):856-857. Epub 2016 May 27.

de Duve Institute, Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1016/S1470-2045(16)30106-1DOI Listing
July 2016

HER2 and HER3 in HPV+ and HPV- HNSCC--Letter.

Clin Cancer Res 2016 Apr;22(7):1825

Institut Roi Albert II, Department of Medical Oncology, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université catholique de Louvain, Brussels, Belgium. Department of Head and Neck Surgery, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2688DOI Listing
April 2016

Posterior Reversible Encephalopathy Syndrome Associated with Sorafenib and Successful Retreatment.

Urol Int 2018 5;100(3):357-360. Epub 2016 Feb 5.

Institut Roi Albert II, Service d'Oncologie Médicale, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1159/000443970DOI Listing
December 2018

Window of opportunity studies: Do they fulfil our expectations?

Cancer Treat Rev 2016 Feb 31;43:50-7. Epub 2015 Dec 31.

Institut Roi Albert II, Department of Medical Oncology, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université catholique de Louvain, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2015.12.005DOI Listing
February 2016

Epidermal Growth Factor Receptor Inhibition in Squamous Cell Carcinoma of the Head and Neck.

Hematol Oncol Clin North Am 2015 Dec;29(6):1011-32

Departments of Medical Oncology and Head and Neck Surgery, King Albert II Institute, Cliniques universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (IREC), Université catholique de Louvain, 10 avenue Hippocrate, Brussels 1200, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S088985881500106
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http://dx.doi.org/10.1016/j.hoc.2015.07.007DOI Listing
December 2015

Cetuximab promotes epithelial to mesenchymal transition and cancer associated fibroblasts in patients with head and neck cancer.

Oncotarget 2015 Oct;6(33):34288-99

Institut Roi Albert II, Department of Medical Oncology, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.18632/oncotarget.5924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741452PMC
October 2015

A phase I study of volasertib combined with afatinib, in advanced solid tumors.

Cancer Chemother Pharmacol 2015 Oct 8;76(4):843-51. Epub 2015 Sep 8.

Department of Medical Oncology Ghent University Hospital, Heymans Institute of Pharmacology, Ghent University, Pintelaan 185, 9000, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00280-015-2860-2DOI Listing
October 2015

Molecular biology and targeted therapies for urothelial carcinoma.

Cancer Treat Rev 2015 Apr 24;41(4):341-53. Epub 2015 Mar 24.

Institut Roi Albert II, Service d'Oncologie Médicale, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2015.03.004DOI Listing
April 2015

Dynamic contrast-enhanced computed tomography to assess early activity of cetuximab in squamous cell carcinoma of the head and neck.

Radiol Oncol 2015 Mar 3;49(1):17-25. Epub 2015 Mar 3.

Department of Medical Oncology and Head and Neck Surgery, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.2478/raon-2014-0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362602PMC
March 2015

Tubulocystic carcinoma of the kidney with fatal outcome in an adolescent male.

Urol Int 2015 16;94(4):485-7. Epub 2014 Dec 16.

Service d'oncologie médicale, Cliniques universitaires Saint Luc, Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1159/000366287DOI Listing
March 2016

Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling.

Cancer Res 2014 Oct 28;74(20):5866-77. Epub 2014 Aug 28.

Department of Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. Oxford Cancer and Haematology Centre, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, Liverpool, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0806DOI Listing
October 2014

Advances in the management of squamous cell carcinoma of the head and neck.

F1000Prime Rep 2014 2;6:44. Epub 2014 Jun 2.

Clinique de cancérologie cervico-maxillo-faciale, Centre du cancer et d'hématologie, Cliniques universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (IREC), Université catholique de Louvain 10 Avenue Hippocrate, 1200 Brussels Belgium.

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http://f1000.com/prime/reports/m/6/44
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http://dx.doi.org/10.12703/P6-44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047945PMC
July 2014

Rationale and design of LUX-Head & Neck 1: a randomised, Phase III trial of afatinib versus methotrexate in patients with recurrent and/or metastatic head and neck squamous cell carcinoma who progressed after platinum-based therapy.

BMC Cancer 2014 Jun 28;14:473. Epub 2014 Jun 28.

Cancer Center, Service d'Oncologie Médicale, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1186/1471-2407-14-473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079914PMC
June 2014

Docetaxel rechallenge after an initial good response in patients with metastatic castration-resistant prostate cancer.

BJU Int 2015 May 29;115(5):744-52. Epub 2014 Dec 29.

Department of Oncology, European Hospital Georges Pompidou and Paris Descartes University, Paris, France.

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http://dx.doi.org/10.1111/bju.12845DOI Listing
May 2015

[Lymph node metastases from squamous cell carcinoma of unknown primary site. Is it time to change of paradigm?].

Bull Cancer 2014 May;101(5):455-60

Institut de recherche expérimentale et clinique, Université catholique de Louvain, Centre du cancer des cliniques universitaires St-Luc, Service de radiothérapie oncologique, 10, avenue Hippocrate, 1200 Bruxelles, Belgique.

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/bd
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http://dx.doi.org/10.1684/bdc.2014.1965DOI Listing
May 2014

A phase I/II, multiple-dose, dose-escalation study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with advanced solid tumors.

Clin Cancer Res 2014 Apr 21;20(8):2192-204. Epub 2014 Feb 21.

Authors' Affiliations: Institut de Cancérologie Gustave Roussy, Villejuif; Centre Francois Baclesse, CHU Côte de Nacre, Caen; Centre Léon Bérard Lyon, Lyon, France; Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona; 12 de Octubre University Hospital, Madrid, Spain; Fox Chase Cancer Center, Philadelphia; Janssen Research & Development, Spring House, Pennsylvania; formerly University of Texas, MD Anderson Cancer Center, Houston, Texas; currently UC San Diego Moores Cancer Center, San Diego, California; Erasme University Hospital; Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Brussels; AZ Sint-Augustinus, Antwerp; Janssen Research & Development, Beerse, Belgium; Southampton University Hospitals NHS Trust, Southampton; Western General Hospital, Edinburgh; University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom; and Janssen Research & Development, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2200DOI Listing
April 2014

One-step TNM staging of high-risk prostate cancer using magnetic resonance imaging (MRI): toward an upfront simplified "all-in-one" imaging approach?

Prostate 2014 May 24;74(5):469-77. Epub 2013 Dec 24.

Department of Radiology, Centre du Cancer et Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1002/pros.22764DOI Listing
May 2014

Castrate-resistant prostate cancer with peritoneal metastases treated with docetaxel-based chemotherapy.

Urol Int 2014 30;93(1):49-54. Epub 2013 Nov 30.

Department of Medical Oncology, Cancer Center, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1159/000354396DOI Listing
April 2015

Targeted therapies for squamous cell carcinoma of the head and neck: current knowledge and future directions.

Cancer Treat Rev 2014 Apr 14;40(3):390-404. Epub 2013 Sep 14.

Cancer Center, Department of Medical Oncology and Head and Neck Surgery, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (Pole MIRO), Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03057372130019
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http://dx.doi.org/10.1016/j.ctrv.2013.09.007DOI Listing
April 2014

Perioperative ketorolac in high risk breast cancer patients. Rationale, feasibility and methodology of a prospective randomized placebo-controlled trial.

Med Hypotheses 2013 Oct 9;81(4):707-12. Epub 2013 Aug 9.

Department of Anesthesiology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mehy.2013.07.033DOI Listing
October 2013

Tamoxifen and ovarian function.

PLoS One 2013 28;8(6):e66616. Epub 2013 Jun 28.

Clinique du sein, Centre du Cancer, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066616PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695994PMC
January 2014

Phase Ib trial of the Toll-like receptor 9 agonist IMO-2055 in combination with 5-fluorouracil, cisplatin, and cetuximab as first-line palliative treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck.

Invest New Drugs 2013 Oct 10;31(5):1207-16. Epub 2013 Feb 10.

Service d'Oncologie Médicale, Centre du Cancer, Cliniques Universitaires Saint-Luc and Institut de Recherche Clinique et Expérimentale (IREC, MIRO), Université Catholique de Louvain, Bruxelles, Belgium,

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http://link.springer.com/content/pdf/10.1007/s10637-013-9933
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http://link.springer.com/10.1007/s10637-013-9933-z
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http://dx.doi.org/10.1007/s10637-013-9933-zDOI Listing
October 2013

An exploratory study of sunitinib in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive metastatic breast cancer.

Breast 2012 Dec 27;21(6):716-23. Epub 2012 Sep 27.

Medical Oncology & Translational Research, Jules Bordet Institute, Boulevard de Waterloo, 125, 1000 Brussels, Belgium.

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http://dx.doi.org/10.1016/j.breast.2012.09.002DOI Listing
December 2012

Phase I study of sorafenib in combination with docetaxel and prednisone in chemo-naïve patients with metastatic castration-resistant prostate cancer.

Cancer Chemother Pharmacol 2012 Aug 1;70(2):293-303. Epub 2012 Jul 1.

Medical Oncology Unit, St-Luc University Hospital, Catholic University of Louvain, 1200 Brussels, Belgium.

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http://dx.doi.org/10.1007/s00280-012-1914-yDOI Listing
August 2012

Evaluation of DCE-MRI postprocessing techniques to assess metastatic bone marrow in patients with prostate cancer.

Clin Imaging 2012 Jul-Aug;36(4):308-15. Epub 2012 Jun 8.

Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.clinimag.2011.10.002DOI Listing
November 2012

Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis.

Oral Oncol 2012 Sep 18;48(9):780-6. Epub 2012 Apr 18.

Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.oraloncology.2012.03.014DOI Listing
September 2012

Distant metastases from head and neck squamous cell carcinoma. Part III. Treatment.

Oral Oncol 2012 Sep 18;48(9):787-93. Epub 2012 Apr 18.

Department of Medicine (Oncology), Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.

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http://dx.doi.org/10.1016/j.oraloncology.2012.03.019DOI Listing
September 2012

Treatment options for patients with recurrent or metastatic squamous cell carcinoma of the head and neck, who progress after platinum-based chemotherapy.

Curr Opin Oncol 2012 May;24(3):211-7

Department of Medical Oncology, Centre du Cancer, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1097/CCO.0b013e3283510773DOI Listing
May 2012