Publications by authors named "Jean-Luc Taupin"

93Publications

Urgent desensitization in patients bridged to heart transplantation under extracorporeal membrane oxygenation support: A preliminary experience.

Clin Transplant 2020 Nov 11:e14146. Epub 2020 Nov 11.

Department of Cardiac Surgery, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, University of Paris Saclay School of Medicine, Le Plessis Robinson, France.

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November 2020

Clinical relevance of donor-specific antibodies directed at HLA-C: A long road to acceptance.

HLA 2021 Jan 23;97(1):3-14. Epub 2020 Oct 23.

Laboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, Paris, France.

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January 2021

Reverse transcriptase multiplex ligation-dependent probe amplification in endomyocardial biopsies for the diagnosis of cardiac allograft rejection.

J Heart Lung Transplant 2020 02 26;39(2):115-124. Epub 2019 Nov 26.

Paris Translational Research Centre for Organ Transplantation, INSERM, UMR-S970, Paris, France; Pathology department, Hôpital Necker, Assistance Publique - Hôpitaux de Paris and Paris Descartes University, Paris, France; Pathology department, Nantes University, Nantes, France. Electronic address:

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February 2020

Intragraft donor-specific anti-HLA antibodies in phenotypes of chronic lung allograft dysfunction.

Eur Respir J 2019 11 7;54(5). Epub 2019 Nov 7.

Leuven Lung Transplant Group, Dept of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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November 2019

Abolishing serum interference in detection of HLA antibodies: Who, How, When and Why?

Hum Immunol 2019 Sep 2;80(9):621-628. Epub 2019 Aug 2.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, United States. Electronic address:

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September 2019

HLA-DQ alloantibodies directly activate the endothelium and compromise differentiation of FoxP3 regulatory T lymphocytes.

Kidney Int 2019 09 10;96(3):689-698. Epub 2019 May 10.

Human Immunology and Immunopathology, Inserm UMR 976, Paris, France; Institut de Recherche Saint Louis, Sorbonne Paris Cité, Université Paris Diderot, Sorbonne Paris, Paris, France; LabEx Transplantex, Université de Strasbourg, Strasbourg, France. Electronic address:

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September 2019

Non-HLA agonistic anti-angiotensin II type 1 receptor antibodies induce a distinctive phenotype of antibody-mediated rejection in kidney transplant recipients.

Kidney Int 2019 07 15;96(1):189-201. Epub 2019 Mar 15.

Clinic for Nephrology and Critical Care Medicine, Campus Virchow-Klinikum, Charité Universitätsmedizin Berlin, Germany; Center for Cardiovascular Research, Medical Faculty of the Charité Berlin, Berlin, Germany.

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July 2019

Measuring anti-HLA antibody active concentration and affinity by surface plasmon resonance: Comparison with the luminex single antigen flow beads and T-cell flow cytometry crossmatch results.

Mol Immunol 2019 04 16;108:34-44. Epub 2019 Feb 16.

CHU de Bordeaux, Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, Place Amélie Raba Léon, Bordeaux, France; Immuno ConcEpT, UMR CNRS 5164, 146 rue Léo Saignat, Bordeaux, France; Université de Bordeaux, 146 rue Léo Saignat, Bordeaux, France.

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April 2019

Overcoming non-specific binding to measure the active concentration and kinetics of serum anti-HLA antibodies by surface plasmon resonance.

Biosens Bioelectron 2018 Oct 7;117:191-200. Epub 2018 Jun 7.

CHU de Bordeaux, Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, Place Amélie Raba Léon, Bordeaux, France; Immuno ConcEpT, UMR CNRS 5164, 146 rue Léo Saignat, Bordeaux, France; Université de Bordeaux, 146 rue Léo Saignat, Bordeaux, France. Electronic address:

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October 2018

Complement-binding anti-HLA antibodies are independent predictors of response to treatment in kidney recipients with antibody-mediated rejection.

Kidney Int 2018 10 22;94(4):773-787. Epub 2018 May 22.

Paris Translational Research Center for Organ Transplantation, Institut national de la santé et de la recherche médicale, Unité mixte de recherche-S970, Paris, France; Department of Nephrology and Kidney Transplantation, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address:

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October 2018

Dynamic Prognostic Score to Predict Kidney Allograft Survival in Patients with Antibody-Mediated Rejection.

J Am Soc Nephrol 2018 02 18;29(2):606-619. Epub 2017 Dec 18.

Paris Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche S970, Paris, France;

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February 2018

Comments on "Direct quantitative measurement of the kinetics of HLA-specific antibody interactions with isolated HLA proteins".

Hum Immunol 2018 02 22;79(2):129. Epub 2017 Nov 22.

CHU de Bordeaux, Laboratoire d'Immunologie et Immunogénétique, Place Amélie Raba Léon, F-33000 Bordeaux, France; Université de Bordeaux, Immuno ConcEpT, UMR CNRS 5164, 146 rue Léo Saignat, F-33000 Bordeaux, France. Electronic address:

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February 2018

Predicted indirectly recognizable HLA epitopes (PIRCHE): Only the tip of the iceberg?

Am J Transplant 2018 02 5;18(2):521-522. Epub 2017 Sep 5.

Laboratoire d'Immunologie et Immunogénétique, CHU de Bordeaux, Bordeaux, France.

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February 2018

Circulating donor-specific anti-HLA antibodies are a major factor in premature and accelerated allograft fibrosis.

Kidney Int 2017 09 26;92(3):729-742. Epub 2017 May 26.

Paris Translational Research Center for Organ Transplantation, Institut national de la santé et de la recherche médicale, Unité mixte de recherche-S970, Paris, France; Department of Nephrology and Kidney Transplantation, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

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September 2017

Conformational Variants of HLA-I Antigens on Luminex Single Antigen Beads.

Transplantation 2017 04;101(4):e152-e153

1 Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France. 2 Immuno ConcEpT, Bordeaux, France. 3 Université de Bordeaux, Bordeaux, France. 4 AP-HP, Laboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Paris, France. 5 INSERM U1160, Centre Hayem, Paris, France. 6 Université Paris Diderot, Paris, France.

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April 2017

The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans.

Ageing Res Rev 2017 May 19;35:322-335. Epub 2016 Nov 19.

Department of Experimental, Diagnostic and Specialty Medicine, Interdepartmental Centre "L.Galvani" for Bioinformatics, Biophysics and Biocomplexity, Via San Giacomo, 12, University of Bologna, 40126 Bologna, Italy.

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May 2017

Donor-Specific Anti-HLA Antibodies in Allogeneic Hematopoietic Stem Cell Transplantation.

Front Immunol 2016 12;7:307. Epub 2016 Aug 12.

Laboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), Université Paris Diderot , Paris , France.

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August 2016

Lung intragraft donor-specific antibodies as a risk factor for graft loss.

J Heart Lung Transplant 2016 12 24;35(12):1418-1426. Epub 2016 Jun 24.

Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France; Unité Mixte de Recherche 5164, Centre National de la Recherche Scientifique, Université de Bordeaux, Talence, France. Electronic address:

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December 2016

Reassessment of T Lymphocytes Crossmatches Results Prediction With Luminex Class I Single Antigen Flow Beads Assay.

Transplantation 2017 03;101(3):624-630

1 Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France. 2 UMR 5164 CNRS, Université Bordeaux Segalen, Bordeaux, France. 3 One Lambda, Inc., Canoga Park, CA. 4 Service de Néphrologie, Transplantation, Dialyse, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France.

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March 2017

Donor Specific Antibodies are not only directed against HLA-DR: Minding your Ps and Qs.

Hum Immunol 2016 Nov 6;77(11):1092-1100. Epub 2016 Apr 6.

INSERM UMRs 1160, Institut Universitaire d'Hématologie, Université Paris Diderot, Hôpital Saint Louis, Paris 75010, France; LabEx Transplantex, AP-HP, Hôpital Saint-Louis, Paris 75010, France. Electronic address:

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November 2016

Deciphering IgM interference in IgG anti-HLA antibody detection with flow beads assays.

Hum Immunol 2016 Nov 20;77(11):1048-1054. Epub 2016 Feb 20.

CHU de Bordeaux, Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, Bordeaux, France; Université de Bordeaux, UMR CNRS, 5164 Talence, France. Electronic address:

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November 2016

Are complement-fixing antibodies against denatured HLA antigens clinically relevant?

Exp Mol Pathol 2016 06 19;100(3):532-3. Epub 2016 Jan 19.

AP-HP, Laboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Paris; INSERM U1160, Centre Hayem, Paris, France; Université Paris Diderot, Paris, France. Electronic address:

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June 2016

Anti-HLA donor-specific antibodies are not created equally. Don't forget the flow….

Transpl Int 2016 Apr 17;29(4):508-10. Epub 2016 Feb 17.

Immunology and Immunogenetics Laboratory, Bordeaux University Hospital, Bordeaux, France.

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April 2016

Calibration free concentration analysis by surface plasmon resonance in a capture mode.

Talanta 2016 Feb 10;148:478-85. Epub 2015 Nov 10.

Université de Bordeaux, Laboratoire ARNA, 146 rue Léo Saignat, Bordeaux, France; INSERM, U869, Laboratoire ARNA, IECB, 2 rue Robert Escarpit, Pessac, France. Electronic address:

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February 2016

Use of Single-Antigen Flow Beads Assays to Assess Anti-HLA Donor-Specific Antibody Strength.

Biol Blood Marrow Transplant 2016 Feb 17;22(2):394-395. Epub 2015 Nov 17.

Laboratoire d'immunologie et histocompatibilité, Hôpital Saint-Louis APHP, Paris, France; INSERM U1160 Centre Hayem, Hôpital Saint-Louis APHP and Université Paris Diderot, Paris, France. Electronic address:

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February 2016

Evaluation of the iBeads assay as a tool for identifying class I HLA antibodies.

Hum Immunol 2015 Sep 25;76(9):651-6. Epub 2015 Sep 25.

Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France; UMR CNRS 5164, Université de Bordeaux, Bordeaux, France. Electronic address:

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September 2015

Evolution of serum and intra-graft donor-specific anti-HLA antibodies in a patient with two consecutive liver transplantations.

Transpl Immunol 2015 Oct 28;33(2):58-62. Epub 2015 Aug 28.

Laboratory of Immunology and Immunogenetics, Bordeaux University Hospital, France; CNRS UMR 5164, CIRID, University of Bordeaux, France. Electronic address:

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October 2015

Deleterious Impact of Donor-Specific Anti-HLA Antibodies Toward HLA-Cw and HLA-DP in Kidney Transplantation.

Transplantation 2016 Jan;100(1):159-66

1 Service de Néphrologie, Transplantation, Dialyse, CHU Bordeaux, Bordeaux, France. 2 UMR CNRS 5164, CNRS, Bordeaux, France. 3 Department of Nephrology and Organ Transplantation CHU Rangueil, Toulouse, France. 4 Laboratoire d'Immunologie et Immunogénétique, CHU Bordeaux, France. 5 Laboratoire d'Anatomie Pathologique, CHU Bordeaux, France. 6 Department of Immunology, CHU Rangueil, Toulouse, France. 7 INSERM U1043, IFR-BMT, Toulouse, France.

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January 2016

Non-Complement-Binding De Novo Donor-Specific Anti-HLA Antibodies and Kidney Allograft Survival.

J Am Soc Nephrol 2016 Feb 5;27(2):615-25. Epub 2015 Jun 5.

Bordeaux University, Bordeaux, France; National Center for Scientific Research (CNRS), UMR 5164, Bordeaux, France; Nephrology-Transplantation-Dialysis, and

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February 2016

Deciphering allogeneic antibody response against native and denatured HLA epitopes in organ transplantation.

Eur J Immunol 2015 Jul 28;45(7):2111-21. Epub 2015 Apr 28.

Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France.

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July 2015

Intravenous immunoglobulins and rituximab therapy for severe transplant glomerulopathy in chronic antibody-mediated rejection: a pilot study.

Clin Transplant 2015 May 30;29(5):439-46. Epub 2015 Mar 30.

Unité de Transplantation, Service de Néphrologie, Transplantation, Dialyse, CHU de Bordeaux, Bordeaux, France; UMR 5164, CNRS, Bordeaux, France; Université de Bordeaux, Bordeaux, France.

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May 2015

Clinical impact of preformed donor-specific denatured class I HLA antibodies after kidney transplantation.

Clin Transplant 2015 May 13;29(5):393-402. Epub 2015 Mar 13.

Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France; UMR CNRS 5164, Université de Bordeaux, Bordeaux, France.

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May 2015

Denatured class I human leukocyte antigen antibodies in sensitized kidney recipients: prevalence, relevance, and impact on organ allocation.

Transplantation 2014 Oct;98(7):738-44

1 Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France. 2 UMR CNRS 5164, Université de Bordeaux, Bordeaux, France. 3 Agence de la Biomédecine, Saint-Denis La Plaine, France. 4 One Lambda, Inc., Canoga Park, CA. 5 Laboratoire d'histocompatibilité, Etablissement Français du Sang, Lyon, France. 6 Service de Néphrologie, Transplantation, Dialyse, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France. 7 Address correspondence to: Jean-Luc Taupin, Pharm.D., Ph.D., Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Place Amélie Raba Léon, 33076 Bordeaux Cedex, France.

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October 2014

Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss.

J Am Soc Nephrol 2015 Feb 14;26(2):457-67. Epub 2014 Aug 14.

Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Transplantation, Néphrologie et Immunologie Clinique, Lyon, France; Institut National de la Santé et de la Recherche Médicale U1111, Lyon, France; Unité de Formation et de Recherche Lyon Est, Université de Lyon, Lyon, France;

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February 2015

Deciphering complement interference in anti-human leukocyte antigen antibody detection with flow beads assays.

Transplantation 2014 Sep;98(6):625-31

1 Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France. 2 UMR CNRS 5164, Université de Bordeaux, Talence, France. 3 Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Laboratoire d'immunologie biologique, Paris, France. 4 Service des Maladies Respiratoires, Hôpital Haut-Lévêque, CHU de Bordeaux, Pessac, France. 5 Service de Chirurgie Cardiaque, Hôpital Haut-Lévêque, CHU de Bordeaux, Pessac, France. 6 Service de Transplantation Hépatique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France. 7 Address correspondence to: Jean-Luc Taupin, Pharm. D., Ph.D., Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Place Amélie Raba Léon, 33076 Bordeaux Cedex, France.

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September 2014

Cytomegalovirus-responsive γδ T cells: novel effector cells in antibody-mediated kidney allograft microcirculation lesions.

J Am Soc Nephrol 2014 Nov 17;25(11):2471-82. Epub 2014 Apr 17.

University of Bordeaux, Mixte Research Unit 5164, Bordeaux, France; National Center for Scientific Research (CNRS), Bordeaux, France; and

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November 2014

The complement interference phenomenon as a cause for sharp fluctuations of serum anti-HLA antibody strength in kidney transplant patients.

Transpl Immunol 2013 Dec 20;29(1-4):17-21. Epub 2013 Sep 20.

Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France. Electronic address:

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December 2013

Resistance mutations and CTL epitopes in archived HIV-1 DNA of patients on antiviral treatment: toward a new concept of vaccine.

PLoS One 2013 9;8(7):e69029. Epub 2013 Jul 9.

Laboratoire de Virologie, Hôpital Pellegrin, CHU de Bordeaux et CNRS UMR 5234 (MFP), Université de Bordeaux Segalen, Bordeaux, France.

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February 2014

The LIF cytokine: towards adulthood.

Eur Cytokine Netw 2009 Jun;20(2):51-62

Université de Bordeaux, CNRS-UMR-5164-CIRID, 33076 Bordeaux, France.

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June 2009

Immunological monitoring of calcineurin inhibitors for predicting cytomegalovirus infection in kidney transplant recipients.

Transplantation 2008 Oct;86(8):1060-7

Service de Néphrologie, CHU Bordeaux, Hôpital Pellegrin, CNRS-UMR 5164, 146 rue Léo Saignat, Université Bordeaux 2, INSERM U897, 146, rue Léo Saignat, Bordeaux, France.

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October 2008

Dominant-negative Fas mutation is reversed by down-expression of c-FLIP.

Cancer Res 2007 Jan;67(1):108-15

Laboratoire Composantes Innées de la Réponse Immunitaire et Différenciation, Centre National de la Recherche Scientifique UMR 5164, University of Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, France.

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January 2007

Increased secretion of leukemia inhibitory factor by immature airway smooth muscle cells enhances intracellular signaling and airway contractility.

Am J Physiol Lung Cell Mol Physiol 2006 Aug 17;291(2):L244-51. Epub 2006 Feb 17.

Laboratoire de Physiologie Cellulaire Respiratoire, Université Victor Segalen Bordeaux 2, and Institut National de la Santé et de la Recherche Médicale, France.

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August 2006

Modulation of Fas-mediated apoptosis by lipid rafts in T lymphocytes.

J Immunol 2006 Jan;176(2):716-20

Laboratoire Composantes Innées de la Réponse Immunitaire et Différenciation, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5164, University of Bordeaux, France.

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January 2006

Amplification of Fas-mediated apoptosis in type II cells via microdomain recruitment.

Mol Cell Biol 2005 Aug;25(15):6811-20

Laboratoire CIRID, CNRS UMR 5164, Université de Bordeaux 2, 146 rue Léo Saignat, Bordeaux 33076, France.

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August 2005

Cutting edge: SDS-stable Fas microaggregates: an early event of Fas activation occurring with agonistic anti-Fas antibody but not with Fas ligand.

J Immunol 2003 Dec;171(11):5659-62

Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5540, Université de Bordeaux II, Bordeaux, France.

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December 2003

Gammadelta T lymphocytosis associated with granulomatous disease in a patient with common variable immunodeficiency.

Clin Infect Dis 2002 Dec 2;35(12):e134-7. Epub 2002 Dec 2.

Clinique de Médecine Interne et Maladies Infectieuses, Hôpital Haut-Lévêque, Centre François-Magendie, 33604 Pessac, France.

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December 2002

Detection of oligoclonal immunoglobulins in cerebrospinal fluid by an immunofixation-peroxidase method.

Clin Chem 2002 Jan;48(1):167-73

Laboratory of Immunology, Centre Hospitalier Régional et Universitaire de Bordeaux, 33076 Bordeaux, France.

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January 2002