Jean-Luc Boucher

Jean-Luc Boucher

UNVERIFIED PROFILE

Are you Jean-Luc Boucher?   Register this Author

Register author
Jean-Luc Boucher

Jean-Luc Boucher

Publications by authors named "Jean-Luc Boucher"

Are you Jean-Luc Boucher?   Register this Author

77Publications

1371Reads

29Profile Views

Solid Phase Synthesis and Evaluation of Substrate-based Dipeptides and Heterocyclic Pseudo-dipeptides as Potential NO Synthases Inhibitors.

ChemMedChem 2020 Feb 6. Epub 2020 Feb 6.

CNRS, Université Montpellier, Institut des Biomolécules Max Mousseron UMR5247, 15 avenue Charles Flahault, Faculté de Pharmacie, 34093, Montpellier, FRANCE.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201900659DOI Listing
February 2020

Mechanism of HS Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes.

Drug Metab Dispos 2019 10 18;47(10):1061-1065. Epub 2019 Jun 18.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS UMR 8601, University Paris Descartes, Paris, France

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.119.087205DOI Listing
October 2019

Light-induced formation of NO in endothelial cells by photoactivatable NADPH analogues targeting nitric-oxide synthase.

Biochim Biophys Acta Gen Subj 2019 06 13;1863(6):1127-1137. Epub 2019 Apr 13.

LBPA, CNRS UMR8113, IDA FR3242, ENS Paris-Saclay, Université Paris-Saclay, F-94235 Cachan, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagen.2019.04.004DOI Listing
June 2019

Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its -Demethylation and -Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways.

Drug Metab Dispos 2018 10 17;46(10):1390-1395. Epub 2018 Jul 17.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS UMR 8601, University Paris Descartes, Paris, France (M.D., A.S., C.N., P.D., D.M., J.-L.B.) and Marie-Odile Christen Behavior, Paris, France (M.-O.C.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.118.082545DOI Listing
October 2018

Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase.

FEBS Open Bio 2018 Sep 20;8(9):1553-1566. Epub 2018 Aug 20.

Department of Biosciences Section for Biochemistry and Molecular Biology University of Oslo Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/2211-5463.12503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120233PMC
September 2018

Membrane-bound human orphan cytochrome P450 2U1: Sequence singularities, construction of a full 3D model, and substrate docking.

Biochimie 2017 Sep 23;140:166-175. Epub 2017 Jul 23.

University Paris Saclay, I2BC/CNRS UMR 9198, CEA Saclay, 91191, Gif sur Yvette, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biochi.2017.07.007DOI Listing
September 2017

Spectral and 3D model studies of the interaction of orphan human cytochrome P450 2U1 with substrates and ligands.

Biochim Biophys Acta Gen Subj 2017 Jan 25;1861(1 Pt A):3144-3153. Epub 2016 Jul 25.

UMR 8601 CNRS, University Paris Descartes, Paris Sorbonne Cité, 75270 Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagen.2016.07.018DOI Listing
January 2017

Mechanism of melanoma cells selective apoptosis induced by a photoactive NADPH analogue.

Oncotarget 2016 Dec;7(50):82804-82819

INSERM U1065 Team 1, Université de Nice Sophia Antipolis et Centre Méditerranéen de Médecine Moléculaire, Nice, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.12651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347734PMC
December 2016

Oxygen activation in NO synthases: evidence for a direct role of the substrate.

FEBS Open Bio 2016 May 18;6(5):386-97. Epub 2016 Mar 18.

Laboratoire Stress Oxydant et Détoxication Institute for Integrative Biology of the Cell (I2BC) CEA, CNRS, Université Paris-Saclay Gif-sur-Yvette Cedex France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/2211-5463.12036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856417PMC
May 2016

TLR4/IFNγ pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models.

Oncoimmunology 2016 May 29;5(5):e1123369. Epub 2015 Dec 29.

EPHE, PSL Research University, Laboratoire d'Immunologie et Immunothérapie des Cancers, F-75014, Paris, France; Univ. Bourgogne Franche-Comté, LIIC EA7269, Dijon, France; INSERM U 866, Burgundy University, Dijon, France.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/2162402X.2015.1
Publisher Site
http://dx.doi.org/10.1080/2162402X.2015.1123369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910700PMC
May 2016

Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation.

Eur J Immunol 2014 Nov 25;44(11):3353-67. Epub 2014 Sep 25.

Division of Gastroenterology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Child & Family Research Institute, BC Children's Hospital, Vancouver, British Columbia, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201343981DOI Listing
November 2014

Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.

Science 2014 Aug 17;345(6196):578-82. Epub 2014 Jul 17.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1256942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548887PMC
August 2014

Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model.

Cancer Lett 2014 Jul 19;349(2):120-7. Epub 2014 Apr 19.

UMR 8601 CNRS, Université Paris Descartes, Sorbonne Paris Cité, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UFR Biomédicale des Saints Pères, 45 rue des Saints Pères, 75270 Paris cedex 06, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2014.04.004DOI Listing
July 2014

Reactions of amino acids, peptides, and proteins with oxidized metabolites of tris(p-carboxyltetrathiaaryl)methyl radical EPR probes.

Chem Res Toxicol 2014 Apr 11;27(4):627-36. Epub 2014 Mar 11.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris Descartes , Sorbonne Paris Cité, 45 rue des Saints-Pères, 75270 Paris, France.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/tx400467p
Publisher Site
http://dx.doi.org/10.1021/tx400467pDOI Listing
April 2014

Metabolic stability of superoxide adducts derived from newly developed cyclic nitrone spin traps.

Free Radic Biol Med 2014 Feb 24;67:150-8. Epub 2013 Oct 24.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (UMR CNRS 8601), Université Paris Descartes, 75006 Paris, France; IUFM de Paris, Université Paris Sorbonne, 75016 Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.812DOI Listing
February 2014

Single-electron reduction of quinone and nitroaromatic xenobiotics by recombinant rat neuronal nitric oxide synthase.

Acta Biochim Pol 2013 7;60(2):217-22. Epub 2013 Jun 7.

Institute of Biochemistry of Vilnius University, Vilnius, Lithuania.

View Article

Download full-text PDF

Source
October 2013

Toward stable electron paramagnetic resonance oximetry probes: synthesis, characterization, and metabolic evaluation of new ester derivatives of a tris-(para-carboxyltetrathiaaryl)methyl (TAM) radical.

Chem Res Toxicol 2013 Oct 26;26(10):1561-9. Epub 2013 Sep 26.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris Descartes, Sorbonne Paris Cité, 45 rue des Saints-Pères, 75270 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx400250aDOI Listing
October 2013

Rational design of a fluorescent NADPH derivative imaging constitutive nitric-oxide synthases upon two-photon excitation.

Proc Natl Acad Sci U S A 2012 Jul 16;109(31):12526-31. Epub 2012 Jul 16.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Centre National de la Recherche Scientifique UMR8601, Université Paris Descartes, 75270 Paris, France.

View Article

Download full-text PDF

Source
http://www.pnas.org/content/109/31/12526.full.pdf
Web Search
http://www.pnas.org/cgi/doi/10.1073/pnas.1205645109
Publisher Site
http://dx.doi.org/10.1073/pnas.1205645109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411954PMC
July 2012

L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution.

Am J Physiol Gastrointest Liver Physiol 2012 May 23;302(9):G1061-73. Epub 2012 Feb 23.

Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpgi.00544.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362080PMC
May 2012

Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.

J Inorg Biochem 2012 Jan 8;106(1):164-71. Epub 2011 Oct 8.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, UMR 8601 CNRS, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2011.10.003DOI Listing
January 2012

Aminoboronic acids and esters: from synthetic challenges to the discovery of unique classes of enzyme inhibitors.

Chem Soc Rev 2011 Jul 22;40(7):3895-914. Epub 2011 Mar 22.

UMR CNRS 6226 Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, Avenue du Général Leclerc, 35042 Rennes Cedex, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c0cs00154fDOI Listing
July 2011

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).

J Mol Biol 2011 Jul 13;410(2):268-79. Epub 2011 May 13.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2011.04.075DOI Listing
July 2011

SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis.

Am J Pathol 2011 Jul 7;179(1):180-8. Epub 2011 May 7.

Division of Gastroeneterology, Department of Pediatrics, BC Children's Hospital, Vancouver, British Columbia, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2011.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123870PMC
July 2011

Helicobacter pylori arginase mutant colonizes arginase II knockout mice.

World J Gastroenterol 2011 Jul;17(28):3300-9

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71130, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v17.i28.3300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160534PMC
July 2011

L-arginine binding to human inducible nitric oxide synthase: an antisymmetric funnel route toward isoform-specific inhibitors?

J Chem Inf Model 2011 Jun 16;51(6):1325-35. Epub 2011 May 16.

Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 Université Montpellier 1, Université Montpellier 2, CNRS, Faculté de Pharmacie, Montpellier, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci100422vDOI Listing
June 2011

Unprecedented ipso aromatic nucleophilic substitution upon oxidative decarboxylation of tris(p-carboxyltetrathiaaryl)methyl (TAM) radicals: a new access to diversely substituted TAM radicals.

Chem Commun (Camb) 2011 Apr 16;47(16):4805-7. Epub 2011 Mar 16.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, UMR 8601 CNRS, 45 Rue des Saints Pères, 75270 Paris cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c1cc10426hDOI Listing
April 2011

Oxidative decarboxylation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes by peroxidases and related hemeproteins: intermediate formation and characterization of the corresponding cations.

Arch Biochem Biophys 2010 Oct 6;502(1):74-80. Epub 2010 Jul 6.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris Descartes, 45 rue des Saints Pères, 75270 Paris Cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2010.07.002DOI Listing
October 2010

Comparison of wild type neuronal nitric oxide synthase and its Tyr588Phe mutant towards various L-arginine analogues.

J Inorg Biochem 2010 Oct 18;104(10):1043-50. Epub 2010 Jun 18.

UMR 8601 CNRS-University Paris Descartes, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2010.06.001DOI Listing
October 2010

TLR agonists that induce IFN-beta abrogate resident macrophage suppression of T cells.

J Immunol 2010 Oct 15;185(8):4545-53. Epub 2010 Sep 15.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1002045DOI Listing
October 2010

Metabolic stability of superoxide and hydroxyl radical adducts of a cyclic nitrone toward rat liver microsomes and cytosol: A stopped-flow ESR spectroscopy study.

Free Radic Biol Med 2010 Aug 7;49(3):437-46. Epub 2010 May 7.

CNRS UMR 8601, Université Paris Descartes, 45 rue des Saints-Pères, 75270 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2010.04.035DOI Listing
August 2010

Role of arginine guanidinium moiety in nitric-oxide synthase mechanism of oxygen activation.

J Biol Chem 2010 Mar 30;285(10):7233-45. Epub 2009 Nov 30.

Laboratoire Stress Oxydants et Detoxication, Commissariat à l'Energie Atomique Saclay, Institut de Biologie et de Technologies de Saclay, 91191 Gif-sur-Yvette Cedex, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.038240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844172PMC
March 2010

Arginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophages.

J Immunol 2010 Mar 22;184(5):2572-82. Epub 2010 Jan 22.

Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0902436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841360PMC
March 2010

Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.

Eur J Med Chem 2009 Jul 16;44(7):2877-87. Epub 2008 Dec 16.

Department of Pharmaceutical Chemistry, Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Kiel, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02235234080059
Publisher Site
http://dx.doi.org/10.1016/j.ejmech.2008.12.007DOI Listing
July 2009

Oxidative and reductive metabolism of tris(p-carboxyltetrathiaaryl)methyl radicals by liver microsomes.

Chem Res Toxicol 2009 Jul;22(7):1342-50

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Universite Paris Descartes, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx9001379DOI Listing
July 2009

N-Hydroxyguanidines oxidation by a N3S copper-complex mimicking the reactivity of Dopamine beta-Hydroxylase.

J Inorg Biochem 2009 Mar 27;103(3):455-62. Epub 2008 Dec 27.

Institut des Sciences Moléculaires de Marseille/BiosCiences UMR-CNRS 6263, Campus Scientifique de Saint Jérôme, Université Paul Cézanne, 13397 Marseille, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2008.12.012DOI Listing
March 2009

Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-.

Chem Commun (Camb) 2009 Mar 22(11):1416-8. Epub 2009 Jan 22.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, CNRS UMR 8601, 45 rue des Saints Pères, 75006 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b819259fDOI Listing
March 2009

Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.

Am J Respir Crit Care Med 2008 Sep 26;178(6):565-73. Epub 2008 Jun 26.

Department of Molecular Pharmacology, University Center for Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.200710-1588OCDOI Listing
September 2008

Diastereoselective functionalizations of enecarbamates derived from pipecolic acid towards 5-guanidinopipecolates as arginine mimetics.

Org Biomol Chem 2008 Sep 23;6(18):3388-98. Epub 2008 Jul 23.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, (UMR-8601 CNRS) Université Paris Descartes, UFR Biomédicale, 45, rue des Saints-Pères, 75270, Paris 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b805811cDOI Listing
September 2008

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.

Bioorg Med Chem 2008 Jun 26;16(11):5962-73. Epub 2008 Apr 26.

Institut Lavoisier, CNRS UMR 8180, Université de Versailles, 45 Avenue des Etats Unis, 78035 Versailles cedex, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2008.04.056DOI Listing
June 2008

Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases.

Chem Res Toxicol 2008 Apr 28;21(4):836-43. Epub 2008 Mar 28.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université R. Descartes, UMR 8601 CNRS, 45 rue des Saints-Pères, 75270 Paris cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/tx7004234DOI Listing
April 2008

The endogenous neurotransmitter, serotonin, modifies neuronal nitric oxide synthase activities.

Free Radic Res 2007 Apr;41(4):413-23

Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Avenue de la terrasse, Gif sur Yvette 91190, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10715760601105681DOI Listing
April 2007

Analogies and surprising differences between recombinant nitric oxide synthase-like proteins from Staphylococcus aureus and Bacillus anthracis in their interactions with l-arginine analogs and iron ligands.

J Inorg Biochem 2006 Dec 28;100(12):2024-33. Epub 2006 Sep 28.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université R. Descartes Paris 5, UMR 8601 CNRS, 45 rue des Saints Pères, 75270 Paris cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2006.09.017DOI Listing
December 2006

Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites.

Nat Med 2006 Aug 30;12(8):955-60. Epub 2006 Jul 30.

Department of Medicine, New Jersey Medical School, 185 S. Orange Avenue, Newark, New Jersey 07103, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm1451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955764PMC
August 2006

Differential effects of alkyl- and arylguanidines on the stability and reactivity of inducible NOS heme-dioxygen complexes.

Biochemistry 2006 Mar;45(12):3988-99

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris V R. Descartes, 45 Rue des Saints-Pères, 75270 Paris Cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi051488pDOI Listing
March 2006

Metabolism of nilutamide in rat lung.

Biochem Pharmacol 2006 Jan 28;71(3):377-85. Epub 2005 Nov 28.

Laboratory of Pulmonary Pharmacology and Toxicology, UMR INRA/Université de Bourgogne 1234, Faculté de Médecine et de Pharmacie, Dijon, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2005.10.034DOI Listing
January 2006

Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.

FEBS J 2006 Jan;273(1):180-91

Department of Immunology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1742-4658.2005.05056.xDOI Listing
January 2006

Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.

J Biol Chem 2005 Aug 22;280(34):30046-54. Epub 2005 Jun 22.

Unité 486 INSERM, Université Paris 11, Faculté de Pharmacie, 5, rue J. B. Clément, 92296 Châtenay-Malabry Cedex, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M500516200DOI Listing
August 2005

Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents.

Eur J Pharmacol 2005 Jun;516(3):260-7

Pharmacology and Physico-Chemistry, Centre National de la Recherche Scientifique and University Louis Pasteur of Strasbourg, Unité Mixte de Recherche 7034, Illkirch, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2005.04.021DOI Listing
June 2005

Spectroscopic investigation of isonitrile complexes of ferric and ferrous microperoxidase 8.

J Inorg Biochem 2005 May;99(5):1165-73

Laboratoire de Chimie Bioorganique et Bioinorganique, UMR 8124, CNRS, Institut de Chimie Moléculaire et des Matériaux d'Orsay, Bâtiment 420, Université Paris-Sud XI, F-91405 Orsay, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2005.02.012DOI Listing
May 2005

Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors.

Bioorg Med Chem 2005 Apr;13(7):2373-9

Laboratoire de Synthèse et Electrosynthèse Organiques, Institut de Chimie, Université de Rennes 1, Campus de Beaulieu, 35042 Rennes Cedex, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2005.01.053DOI Listing
April 2005

New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties.

Bioorg Med Chem Lett 2005 Jan;15(1):135-8

Laboratoire de Chimie Biomoléculaire, Unité INSERM U-623-IBDM, Département de Chimie, Faculté des Sciences Luminy, Université de La Méditerranée, 13288 Marseille cedex 9, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2004.10.018DOI Listing
January 2005

Alternative nitric oxide-producing substrates for NO synthases.

Free Radic Biol Med 2004 Oct;37(8):1105-21

UMR 8601-Université Paris 5, 75270 Paris Cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2004.06.031DOI Listing
October 2004

Protective role of arginase in a mouse model of colitis.

J Immunol 2004 Aug;173(3):2109-17

Department of Medicine, Division of Gastroenterology, School of Medicine, University of Maryland, and Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.173.3.2109DOI Listing
August 2004

Importance of valine 567 in substrate recognition and oxidation by neuronal nitric oxide synthase.

J Inorg Biochem 2004 Jul;98(7):1200-9

UMR 8601 CNRS, Université Paris V R. Descartes, 45 Rue des Saints-Pères, 75270 Paris Cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2004.03.015DOI Listing
July 2004

Inhibitor coordination interactions in the binuclear manganese cluster of arginase.

Biochemistry 2004 Jul;43(28):8987-99

Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi0491705DOI Listing
July 2004

Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin.

Free Radic Biol Med 2004 Jun;36(12):1532-41

Département de Signalisation cellulaire et athérosclérose précoce, UMR CNRS 7131- Université Paris 6, Hôpital Broussais, 102 rue Didot, 75014 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2004.03.019DOI Listing
June 2004

Aromatic N-hydroxyguanidines as new reduction cosubstrates for dopamine beta-hydroxylase.

Biochem Biophys Res Commun 2004 Apr;316(4):1081-7

Chimie, Biologie et Radicaux libres, UMR-CNRS 6517, Faculté des Sciences et Techniques de Saint-Jérome, case 432, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2004.02.163DOI Listing
April 2004

Effects of gamma-butyrobetaine and mildronate on nitric oxide production in lipopolysaccharide-treated rats.

Basic Clin Pharmacol Toxicol 2004 Jan;94(1):46-50

Faculty of Medicine, University of Latvia, and Latvian Institute of Organic Synthesis, Riga.

View Article

Download full-text PDF

Source
January 2004

Very general formation of tetrahydropterin cation radicals during reaction of iron porphyrins with tetrahydropterins: model for the corresponding NO-synthase reaction.

Chem Commun (Camb) 2004 Jan 2(1):54-5. Epub 2003 Dec 2.

UMR 8601, Université Paris V, 45 rue des Saints-Pères, 75270 PARIS Cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b312441jDOI Listing
January 2004

Inhibitory effects and spectral interactions of isomeric methoxyindazoles on recombinant nitric oxide synthases.

Nitric Oxide 2003 Sep;9(2):86-94

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR CNRS 8601, Université R. Descartes, 45 rue des Saints Pères, 75270 Paris Cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.niox.2003.09.004DOI Listing
September 2003

Microperoxidase 8 catalysed nitrogen oxides formation from oxidation of N-hydroxyguanidines by hydrogen peroxide.

Eur J Biochem 2003 Jan;270(1):47-55

Laboratoire de Chimie Bioorganique et Bioinorganique, Institut de Chimie Moléculaire d'Orsay, Université Paris-Sud XI, Orsay, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1432-1033.2003.03358.xDOI Listing
January 2003

Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta.

J Pharmacol Exp Ther 2002 Nov;303(2):823-30

Pharmacology and Physico-Chemistry, Centre National de la Recherche Scientifique (Unité Mixte Recherche 7034) and University Louis Pasteur, Strasbourg, France.

View Article

Download full-text PDF

Source
http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.102.03861
Publisher Site
http://dx.doi.org/10.1124/jpet.102.038612DOI Listing
November 2002

Oxidation of N-hydroxyguanidines by cytochromes P450 and NO-synthases and formation of nitric oxide.

Drug Metab Rev 2002 Aug;34(3):593-606

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université René Descartes (Paris V), UMR 8601 CNRS, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1081/dmr-120005661DOI Listing
August 2002

Helicobacter pylori induces macrophage apoptosis by activation of arginase II.

J Immunol 2002 May;168(9):4692-700

Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, and Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.168.9.4692DOI Listing
May 2002

N-Aryl N'-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: structure-activity relationship.

J Med Chem 2002 Feb;45(4):944-54

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris V, 45 Rue des Saints Pères, 75270 Paris Cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm011006hDOI Listing
February 2002

Interaction of anions with rat liver arginase: specific inhibitory effects of fluoride.

J Inorg Biochem 2002 Feb;88(3-4):397-402

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601, Université René Descartes, 45 Rue des Saints-Pères, 75270 Paris Cedex 06, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0162-0134(01)00417-2DOI Listing
February 2002