Publications by authors named "Jean-Leon Thomas"

59Publications

[Meningeal lymphatics, a potential target for the treatment of brain tumors].

Med Sci (Paris) 2020 Aug-Sep;36(8-9):709-713. Epub 2020 Aug 21.

Department of immunobiology, Yale university school of medicine, New Haven, CT, États-Unis - Howard Hughes medical institute, Chevy Chase, MD, États-Unis.

View Article and Find Full Text PDF
November 2020

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy.

J Vis Exp 2020 05 22(159). Epub 2020 May 22.

Université Pierre et Marie Curie Paris, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière; Department of Neurology, Yale University School of Medicine;

View Article and Find Full Text PDF
May 2020

Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex.

Cell Rep 2020 04;31(1):107489

Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Comparative Medicine, Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, New Haven, CT 06510, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair and Yale Child Study Center, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

View Article and Find Full Text PDF
April 2020

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours.

Nature 2020 01 15;577(7792):689-694. Epub 2020 Jan 15.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

View Article and Find Full Text PDF
January 2020

Author Correction: Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone.

Sci Rep 2020 Jan 14;10(1):621. Epub 2020 Jan 14.

Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT, 06511, United States.

View Article and Find Full Text PDF
January 2020

Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone.

Sci Rep 2019 11 28;9(1):17798. Epub 2019 Nov 28.

Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT, 06511, United States.

View Article and Find Full Text PDF
November 2019

Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis.

Nat Commun 2019 05 28;10(1):2350. Epub 2019 May 28.

Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA.

View Article and Find Full Text PDF
May 2019

RNA Profiling of the Human and Mouse Spinal Cord Stem Cell Niches Reveals an Embryonic-like Regionalization with MSX1 Roof-Plate-Derived Cells.

Stem Cell Reports 2019 05 25;12(5):1159-1177. Epub 2019 Apr 25.

INSERM U1051, INM, Hopital Saint Eloi, 80 Avenue Augustin Fliche, 34091 Montpellier, France; University of Montpellier, Faculté des Sciences, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France. Electronic address:

View Article and Find Full Text PDF
May 2019

[Lymphatic system in central nervous system].

Med Sci (Paris) 2019 Jan 23;35(1):55-61. Epub 2019 Jan 23.

Department of neurology, Yale University School of Medicine, New Haven, CT, 06511, États-Unis.

View Article and Find Full Text PDF
January 2019

To BBB or Not to BBB?

Dev Cell 2018 12;47(6):689-691

INSERM U970, Paris Cardiovascular Research Center, 56 Rue Leblanc, 75015 Paris, France; Cardiovascular Research Center and the Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510-3221, USA. Electronic address:

View Article and Find Full Text PDF
December 2018

Orchestrating cortical brain development.

Authors:
Jean-Leon Thomas

Science 2018 08;361(6404):754-755

Department of Neurology, Yale University School of Medicine, New Haven, CT 06511, USA.

View Article and Find Full Text PDF
August 2018

Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.

Proc Natl Acad Sci U S A 2018 08 14;115(35):E8246-E8255. Epub 2018 Aug 14.

Institut du Cerveau et de la Moelle Épinière, INSERM U1127, CNRS UMR 7225, GH Pitié-Salpêtrière, Sorbonne Université, 75013 Paris, France;

View Article and Find Full Text PDF
August 2018

The phenotypic and functional properties of mouse yolk-sac-derived embryonic macrophages.

Dev Biol 2018 10 30;442(1):138-154. Epub 2018 Jul 30.

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA; Department of Bioengineering, Rice University, Houston, TX, USA. Electronic address:

View Article and Find Full Text PDF
October 2018

Adult Human Hippocampus: No New Neurons in Sight.

Cereb Cortex 2018 07;28(7):2479-2481

Department of Neurology, Yale University, New Haven, CT, USA.

View Article and Find Full Text PDF
July 2018

Development and plasticity of meningeal lymphatic vessels.

J Exp Med 2017 Dec 15;214(12):3645-3667. Epub 2017 Nov 15.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland

View Article and Find Full Text PDF
December 2017

The Xenopus tadpole: An in vivo model to screen drugs favoring remyelination.

Mult Scler 2018 10 28;24(11):1421-1432. Epub 2017 Jul 28.

Sorbonne Universités UPMC Univ Paris 06, Inserm, CNRS, APHP, Institut du Cerveau et de la Moelle épinière (ICM), GH Pitié-Salpêtrière, Paris, France.

View Article and Find Full Text PDF
October 2018

Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension.

Circulation 2017 Jun 29;135(23):2288-2298. Epub 2017 Mar 29.

From Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (C.H., H.-W.L., H.K., H.J., I.P., J.H., J.-D.K., W.P.D., X.H., S.L., O.E.-H., A.S., H.J.C., S.-W.J.); Department of Biology, University of North Carolina, Chapel Hill (D.S.W., V.L.B.); School of Life Sciences and Cell Logistics Research Center, Gwangju Institute of Science and Technology, Korea (B.P., S.-W.J.); Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, OH (L.P., S.C., S.C.E.); Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul (E.M.H., J.-Y.P.); School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul (J.-Y.P.); Department of Neurology, Yale University School of Medicine, New Haven, CT (J.-L.T.); and Université Pierre and Marie Curie-Paris 6, CRICM, Groupe Hospitalier Pitié-Salpètrière, France; INSERM, UMRS 975, Groupe Hospitalier Pitié-Salpètrière, Paris, France; APHP, Groupe Hospitalier Pitié-Salpètrière, Paris, France (J.-L.T.).

View Article and Find Full Text PDF
June 2017

Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres.

J Vis Exp 2016 Feb 29(108):53617. Epub 2016 Feb 29.

Yale Cardiovascular Research Center, Internal Medicine, Yale University;

View Article and Find Full Text PDF
February 2016

Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging.

ACS Nano 2016 04 16;10(4):4209-18. Epub 2016 Mar 16.

Department of Neurosurgery, #Department of Biomedical Engineering, ‡PET Center, Department of Diagnostic Radiology, §Department of Neurology, and ⊥Department of Pathology, Yale University , New Haven, Connecticut 06511, United States.

View Article and Find Full Text PDF
April 2016

Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.

Circulation 2016 Jan 9;133(4):409-21. Epub 2015 Dec 9.

From Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (A.D., G.G., R.O., F.Z., J.H., J.Z., J.-L.T., A.E.); INSERM U1050, Collège de France, Center for Interdisciplinary Research in Biology (CIRB), Paris (L.P.-F., A.E.); Department of Neurology, Yale University School of Medicine, New Haven, CT (J.-L.T.); Institut du Cerveau et de la Moelle, Inserm, Université Pierre et Marie Curie, Paris, France (J.-L.T.); Sorbonne Universités, UPMC Universités Paris 06, INSERM, UMR-S968, CNRS, UMR-7210, Institut de la Vision, France (A.C.); Departments of Cell Biology and Biomedical Engineering, Yale University, New Haven, CT (M.A.S.); and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT (A.E.).

View Article and Find Full Text PDF
January 2016

Cell autonomous Vegf-C/Vegfr3 signaling in adult neural stem cells.

Oncotarget 2015 Nov;6(37):39387-8

Université Pierre and Marie Curie-Paris 6, INSERM/CNRS U-1127/UMR-7225, 4APHP, Groupe Hospitalier Pitié-Salpètrière, Paris, France.

View Article and Find Full Text PDF
November 2015

Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis.

Stem Cell Reports 2015 Nov 1;5(5):881-894. Epub 2015 Oct 1.

Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA; Department of Surgery, Weill Cornell Medical College, New York, NY, 10065 USA; Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

View Article and Find Full Text PDF
November 2015

Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress.

Stem Cell Reports 2015 Aug 16;5(2):185-94. Epub 2015 Jul 16.

Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA; SIAIS and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address:

View Article and Find Full Text PDF
August 2015

Remyelination by Resident Oligodendrocyte Precursor Cells in a Xenopus laevis Inducible Model of Demyelination.

Dev Neurosci 2015 15;37(3):232-42. Epub 2015 Apr 15.

Sorbonne Universités UPMC Université Paris-6, UM-75, ICM-GHU Pitié-Salpêtrière, Paris, France.

View Article and Find Full Text PDF
March 2016

Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans.

Cell Rep 2015 Feb 19;10(7):1158-72. Epub 2015 Feb 19.

Université Pierre and Marie Curie-Paris 6, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France; INSERM/CNRS U-1127/UMR-7225, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France; APHP, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France; Department of Neurology, Yale University School of Medicine, New Haven, CT 06510-3221, USA. Electronic address:

View Article and Find Full Text PDF
February 2015

A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis.

Dev Cell 2015 Mar 5;32(5):546-60. Epub 2015 Feb 5.

Yale Cardiovascular Research Center, Internal Medicine, Yale University, New Haven, CT 06511, USA. Electronic address:

View Article and Find Full Text PDF
March 2015

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point.

Elife 2015 Feb 2;4. Epub 2015 Feb 2.

Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, United States.

View Article and Find Full Text PDF
February 2015

Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.

PLoS One 2014 22;9(12):e115789. Epub 2014 Dec 22.

Department of Environmental Health Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America.

View Article and Find Full Text PDF
December 2015

Tumor and endothelial cell hybrids participate in glioblastoma vasculature.

Biomed Res Int 2014 24;2014:827327. Epub 2014 Apr 24.

Sorbonne Universités, UPMC, Université Paris 06, Inserm, CNRS, UM 75, U 1127, UMR 7225, ICM, 75013 Paris, France ; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie Mazarin, 75013 Paris, France.

View Article and Find Full Text PDF
November 2015

Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells.

Cell Mol Life Sci 2013 May 12;70(10):1779-92. Epub 2013 Mar 12.

Department of Neurology, Yale University School of Medicine, New Haven, CT 06510-3221, USA.

View Article and Find Full Text PDF
May 2013

The power of VEGF (vascular endothelial growth factor) family molecules.

Cell Mol Life Sci 2013 May 12;70(10):1673-4. Epub 2013 Mar 12.

Department of Neurology, Yale University School of Medicine, New-Haven, CT 06510-3221, USA.

View Article and Find Full Text PDF
May 2013

Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning.

J Neurosci 2012 Nov;32(48):17172-85

Université Pierre and Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, 75013 Paris, France.

View Article and Find Full Text PDF
November 2012

Molecular parallels between neural and vascular development.

Cold Spring Harb Perspect Med 2013 Jan 1;3(1):a006551. Epub 2013 Jan 1.

Center for Interdisciplinary Research in Biology, CNRS/UMR 7241-INSERM U1050, Collège de France, 75005 Paris, France.

View Article and Find Full Text PDF
January 2013

Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube.

Development 2011 Nov;138(22):4991-5001

Collège de France, Center for Interdisciplinary Research in Biology, 11 place Marcelin Berthelot, Paris F-75005, France.

View Article and Find Full Text PDF
November 2011

A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells.

Proc Natl Acad Sci U S A 2011 Oct 3;108(42):17498-503. Epub 2011 Oct 3.

Départment de Neuroscience, Institut Pasteur de Paris, 75624 Paris, France.

View Article and Find Full Text PDF
October 2011

A novel role for anosmin-1 in the adhesion and migration of oligodendrocyte precursors.

Dev Neurobiol 2008 Nov;68(13):1503-16

Grupo de Neurobiología del Desarrollo-GNDe, Hospital Nacional de Parapléjicos, Finca La Peraleda s/n, Toledo E-45071, Spain.

View Article and Find Full Text PDF
November 2008

Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve.

J Neurosci 2008 Jul;28(30):7624-36

Institut National de la Santé et de la Recherche Médicale, Unité 711, Université Pierre et Marie Curie, Faculté de Médecine, Hôpital de la Salpêtrière, Institut Fédératif de Recherche 70, F-75013 Paris, France.

View Article and Find Full Text PDF
July 2008

Control of axonophilic migration of oligodendrocyte precursor cells by Eph-ephrin interaction.

Neuron Glia Biol 2004 Feb;1(1):73-83

Biologie des Interactions Neurones/Glie, INSERM U-495, IFR Neurosciences Pitié-Salpêtrière, UPMC, Hôpital de la Salpetrière, 75651 Paris.

View Article and Find Full Text PDF
February 2004

Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?

Brain 2007 Oct 11;130(Pt 10):2554-65. Epub 2007 Sep 11.

Inserm, U711, Paris, F-75013 and Université Pierre & Marie Curie, Faculté de médecine, IFR 70, Paris, France.

View Article and Find Full Text PDF
October 2007

Evaluation of hematopoietic potential generated by transplantation of muscle-derived stem cells in mice.

Stem Cells Dev 2004 Feb;13(1):83-92

Translational Research-Cell Therapy Laboratory, Department of Clinical Biology, Institut Gustave Roussy, Villejuif, France.

View Article and Find Full Text PDF
February 2004

Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1.

J Neurosci 2002 Jul;22(14):5992-6004

Biologie des Interactions Neurones, Glie Institut National de la Santé et de la Recherche Médicale U-495, Hôpital de la Salpêtrière, 75651 Paris, France.

View Article and Find Full Text PDF
July 2002