Publications by authors named "Jean-Francois Peyrat"

21Publications

Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency.

Eur J Med Chem 2020 Aug 5;199:112355. Epub 2020 May 5.

BioCIS, Equipe Labellisée Ligue Contre le Cancer, Univ. Paris-Sud, CNRS, University Paris-Saclay, F-92290, Châtenay Malabry, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2020.112355DOI Listing
August 2020

Synthesis and preliminary biological evaluation of new antiproliferative aromatic analogues of 1α,25-dihydroxyvitamin D3.

Eur J Med Chem 2014 Oct 15;86:381-93. Epub 2014 Jul 15.

Laboratoire de Chimie Thérapeutique, BioCIS-CNRS (UMR 8076), Université Paris-Sud, Faculté de Pharmacie, Rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.07.037DOI Listing
October 2014

Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization.

Anticancer Agents Med Chem 2013 Dec;13(10):1614-35

Univ. Paris-Sud 11, CNRS, BioCIS-UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.2174/187152061310131206162302DOI Listing
December 2013

An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity.

Org Biomol Chem 2013 Jun;11(22):3664-73

Université Paris-Sud, CNRS, BioCIS UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J-B Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1039/c3ob40263kDOI Listing
June 2013

A palladium-catalyzed coupling of 3-chloroquinoxalinones with various nitrogen-containing nucleophiles.

Org Biomol Chem 2013 Jun;11(23):3808-16

Université Paris-Sud, CNRS, BioCIS UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1039/c3ob40338fDOI Listing
June 2013

Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors.

Org Biomol Chem 2013 Jan 9;11(3):430-42. Epub 2012 Oct 9.

Université Paris-Sud, CNRS, BioCIS UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J-B Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1039/c2ob26253cDOI Listing
January 2013

Synthetic 2-methoxyestradiol derivatives: structure-activity relationships.

Curr Med Chem 2012 ;19(24):4142-56

Univ Paris-Sud, CNRS, BioCIS - UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clement, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.2174/092986712802430072DOI Listing
February 2013

Synthesis and antikinetoplastid activities of 3-substituted quinolinones derivatives.

Eur J Med Chem 2012 Jun 16;52:44-50. Epub 2012 Mar 16.

Univ Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, LabEx LERMIT, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1016/j.ejmech.2012.03.003DOI Listing
June 2012

Heat-shock protein 90 inhibitors as antitumor agents: a survey of the literature from 2005 to 2010.

Expert Opin Ther Pat 2011 Oct 21;21(10):1501-42. Epub 2011 Jun 21.

Univ Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1517/13543776.2011.594041DOI Listing
October 2011

A general copper powder-catalyzed Ullmann-type reaction of 3-halo-4(1H)-quinolones with various nitrogen-containing nucleophiles.

J Org Chem 2011 Jun 13;76(12):4995-5005. Epub 2011 May 13.

1Univ Paris-Sud, 2CNRS, BioCIS UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.

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http://dx.doi.org/10.1021/jo200680jDOI Listing
June 2011

Discovery and biological activity of 6BrCaQ as an inhibitor of the Hsp90 protein folding machinery.

ChemMedChem 2011 May 4;6(5):804-15. Epub 2011 Mar 4.

Université Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Châtenay-Malabry, France.

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http://dx.doi.org/10.1002/cmdc.201000489DOI Listing
May 2011

Pd-catalyzed reaction of sterically hindered hydrazones with aryl halides: synthesis of tetra-substituted olefins related to iso-combretastatin A4.

Org Lett 2010 Sep;12(18):4042-5

University Paris-Sud 11, CNRS, BioCIS UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France.

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http://dx.doi.org/10.1021/ol101639gDOI Listing
September 2010

Assessing the chemical diversity of an hsp90 database.

Eur J Med Chem 2010 May 28;45(5):2000-9. Epub 2010 Jan 28.

University Paris-Sud, CNRS, BioCIS UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France.

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http://dx.doi.org/10.1016/j.ejmech.2010.01.048DOI Listing
May 2010

Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23.

Biochem Biophys Res Commun 2009 Feb 30;379(2):514-8. Epub 2008 Dec 30.

Université Paris Sud, CNRS, UMR 8612, Laboratoire de Pharmacologie Cellulaire et Moléculaire des Anticancéreux, Faculté de Pharmacie, IFR 141, 5 rue J.-B. Clément, F-92296 Châtenay-Malabry, France.

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http://dx.doi.org/10.1016/j.bbrc.2008.12.102DOI Listing
February 2009

Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.

Cancer Lett 2009 Feb 7;274(1):88-94. Epub 2008 Oct 7.

Université Paris Sud, CNRS, UMR 8612, Laboratoire de Pharmacologie Cellulaire et Moléculaire des Anticancéreux, Faculté de Pharmacie, IFR 141, 5 rue Jean Baptiste Clément, F-92296 Châtenay-Malabry, France.

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http://dx.doi.org/10.1016/j.canlet.2008.09.001DOI Listing
February 2009

Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90).

Bioorg Med Chem Lett 2008 Apr 14;18(7):2495-8. Epub 2008 Feb 14.

Univ Paris-Sud, CNRS, UMR 8612, Laboratoire de Pharmacologie Cellulaire et Moléculaire des Anticancéreux, Faculté de Pharmacie, IFR 141, 5 rue J.-B. Clément, Châtenay-Malabry F-92296, France.

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http://dx.doi.org/10.1016/j.bmcl.2008.01.128DOI Listing
April 2008

New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.

J Med Chem 2007 Nov 3;50(24):6189-200. Epub 2007 Nov 3.

University of Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, and University of Paris-Sud, 5 rue J.-B. Clément, Châtenay-Malabry, France.

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http://dx.doi.org/10.1021/jm0707774DOI Listing
November 2007

Ortho substituents direct regioselective addition of tributyltin hydride to unsymmetrical diaryl (or heteroaryl) alkynes: an efficient route to stannylated stilbene derivatives.

Angew Chem Int Ed Engl 2002 May;41(9):1578-80

BioCIS, Laboratoire de Chimie Therapeutique CNRS UPRES-A 8076, Université Paris XI, Faculté de Pharmacie, rue J.B. C1ément, 92296 Châtenay Malabry Cedex, France.

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http://dx.doi.org/10.1002/1521-3773(20020503)41:9<1578::aid-anie1578>3.0.co;2-cDOI Listing
May 2002