Jean-Francois Emile

Jean-Francois Emile

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Jean-Francois Emile

Publications by authors named "Jean-Francois Emile"

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Autoimmunity associated with Erdheim-Chester disease improves with BRAF/MEK inhibitors.

Haematologica 2019 Nov 28;104(11):e502-e505. Epub 2019 Mar 28.

Sorbonne Université, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Service de Médecine Interne 2, Centre National de Référence Maladies Systémiques Rares et Histiocytoses, Paris-75013.

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http://dx.doi.org/10.3324/haematol.2018.214007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821627PMC
November 2019

Lung Involvement in Destombes-Rosai-Dorfman Disease: Clinical and Radiological Features and Response to the MEK Inhibitor Cobimetinib.

Chest 2019 Oct 24. Epub 2019 Oct 24.

Service de Médecine Interne 2, Centre National de Référence Maladies Systémiques Rares et Histiocytoses, Sorbonne Université, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2019.09.036DOI Listing
October 2019

Response to trametinib of histiocytosis with an activating mutation.

Leuk Lymphoma 2019 Aug 8:1-4. Epub 2019 Aug 8.

b Pathology Department, Ambroise Paré Hospital, APHP , Boulogne , France.

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http://dx.doi.org/10.1080/10428194.2019.1650175DOI Listing
August 2019

Plasma Biomarkers and Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: New Tools for Better Patient Selection?

Cancers (Basel) 2019 Aug 29;11(9). Epub 2019 Aug 29.

Department of Respiratory Diseases and Thoracic Oncology, APHP-Hôpital Ambroise Paré, 92100 Boulogne-Billancourt, France.

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http://dx.doi.org/10.3390/cancers11091269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769436PMC
August 2019

Tubercular splenic abscesses: A rare entity sometimes hard to sterilize.

Int J Infect Dis 2019 05 5;82:18-20. Epub 2019 Mar 5.

Service de Maladies Infectieuses, Hôpital Raymond Poincaré, Garches, France. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2019.02.048DOI Listing
May 2019

Systemic Histiocytosis (Langerhans Cell Histiocytosis, Erdheim-Chester Disease, Destombes-Rosai-Dorfman Disease): from Oncogenic Mutations to Inflammatory Disorders.

Curr Oncol Rep 2019 May 21;21(7):62. Epub 2019 May 21.

Assistance Publique-Hôpitaux de Paris, Service de Médecine Interne 2, Centre National de Références des Histiocytoses, Hôpital Pitié-Salpêtrière, Sorbonne Université, 47-83, Boulevard de l'Hôpital, 75651, Paris Cedex 13, France.

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http://link.springer.com/10.1007/s11912-019-0810-6
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http://dx.doi.org/10.1007/s11912-019-0810-6DOI Listing
May 2019

CDKN2A Depletion Causes Aneuploidy and Enhances Cell Proliferation in Non-Immortalized Normal Human Cells.

Cancer Invest 2018 23;36(6):338-348. Epub 2018 Aug 23.

a EA4340, UVSQ , Boulogne-Billancourt , France.

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http://dx.doi.org/10.1080/07357907.2018.1491588DOI Listing
October 2018

Efficacy of infliximab in the treatment of Erdheim-Chester disease.

Ann Rheum Dis 2018 09 23;77(9):1387-1390. Epub 2018 Jan 23.

Internal Medicine Department 2, AP-HP, French National Reference Centre for Rare Systemic Diseases, Pitié-Salpêtrière Hospital, Paris, France.

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http://dx.doi.org/10.1136/annrheumdis-2017-212678DOI Listing
September 2018

Hypoalphalipoproteinemia and BRAF Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease.

Arterioscler Thromb Vasc Biol 2018 08;38(8):1913-1925

Inserm, Institute of Cardiometabolism and Nutrition (ICAN), UMR_S1166, Hôpital de la Pitié, Sorbonne Université, Paris, France (M.G., F.S.-C., Y.A., E.F., P.L., W.L.G.).

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http://dx.doi.org/10.1161/ATVBAHA.118.310803DOI Listing
August 2018

Phenotypes and survival in Erdheim-Chester disease: Results from a 165-patient cohort.

Am J Hematol 2018 May 10;93(5):E114-E117. Epub 2018 Feb 10.

Internal Medicine Department 2, Pitié-Salpêtrière Hospital, French National Centre for Rare Systemic Diseases, AP-HP, Paris, 75013, France.

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http://doi.wiley.com/10.1002/ajh.25055
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http://dx.doi.org/10.1002/ajh.25055DOI Listing
May 2018

Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Gastroenterology 2018 03 20;154(4):1061-1065. Epub 2017 Nov 20.

INSERM, UMR S 938 - Centre de Recherche Saint-Antoine, Equipe Instabilité des Microsatellites et Cancers, Equipe labellisée par la Ligue Nationale contre le Cancer, F-75012, Paris, France; Sorbonne Université, Université Pierre et Marie Curie - Paris 6, Paris, France; AP-HP, Hôpitaux Universitaires Est Parisien, Hôpital Saint-Antoine, Service d'Anatomie et Cytologie Pathologiques, Paris, France. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.11.009DOI Listing
March 2018

Efficacy of the MEK inhibitor cobimetinib for wild-type BRAF Erdheim-Chester disease.

Br J Haematol 2018 01 6;180(1):150-153. Epub 2016 Oct 6.

Internal Medicine Department, French National Center for Rare Systemic Diseases, Pitié-Salpêtrière Hospital, AP-HP, Paris, France.

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http://doi.wiley.com/10.1111/bjh.14284
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http://dx.doi.org/10.1111/bjh.14284DOI Listing
January 2018

Neurodegeneration in histiocytoses might start in utero.

Lancet Neurol 2017 12 27;16(12):953-954. Epub 2017 Oct 27.

Service de Médecine Interne 2, Centre de Référence des Histiocytoses, Institut E3M, AP-HP, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/S1474-4422(17)30373-3DOI Listing
December 2017

Molecular characterization of circulating tumor cells in lung cancer: moving beyond enumeration.

Oncotarget 2017 12 23;8(65):109818-109835. Epub 2017 Nov 23.

Department of Respiratory Diseases and Thoracic Oncology, APHP - Ambroise Pare Hospital, Boulogne-Billancourt, France.

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http://dx.doi.org/10.18632/oncotarget.22651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752564PMC
December 2017

Targeted therapies in 54 patients with Erdheim-Chester disease, including follow-up after interruption (the LOVE study).

Blood 2017 09 30;130(11):1377-1380. Epub 2017 Jun 30.

Department of Internal Medicine 2, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière Hospital, French National Centre for Rare Systemic Diseases, Paris, France.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-03
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http://dx.doi.org/10.1182/blood-2017-03-771873DOI Listing
September 2017

High prevalence of myeloid neoplasms in adults with non-Langerhans cell histiocytosis.

Blood 2017 08 5;130(8):1007-1013. Epub 2017 Jul 5.

Service de Médecine Interne 2, Institut E3M, Centre de Références des Maladies Auto-Immunes et Systémiques Rares, Centre de Référence des Histiocytoses, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.1182/blood-2017-01-761718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570678PMC
August 2017

Variation of mutant allele frequency in NRAS Q61 mutated melanomas.

BMC Dermatol 2017 07 1;17(1). Epub 2017 Jul 1.

Research Unit EA4340 Biomarkers in Cancerology and Hemato Oncology, Versailles SQY University, Paris-Saclay University, 9, Avenue Charles de Gaulle, 92104, Boulogne-Billancourt, France.

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http://dx.doi.org/10.1186/s12895-017-0061-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494128PMC
July 2017

Prognostic Value of BRAF and KRAS Mutations in MSI and MSS Stage III Colon Cancer.

J Natl Cancer Inst 2017 05 31;109(5). Epub 2016 Dec 31.

Affiliations of authors: Department of Gastroenterology and GI Oncology, Université Paris Descartes, Hopital Européen Georges Pompidou, Paris, France (JTai); Fédération Francophone de Cancérologie Digestive (FFCD), Dijon, France (KLM); Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN (QS, DJS); Department of Pathology, Centre Jean Perrin, EA ERTICa, Université d'Auvergne, Clermont-Ferrand, France (FPL); Centre Hospitalier Universitaire Robert Debré, Reims, France (OB); Medical Oncology Department, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain (JTab); Spanish Gastrointestinal Tumors TTD Group, Universitat Autònoma de Barcelona, Barcelona, Spain (JTab); Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy (EM); Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, Columbus, OH (RMG); First Medical Department, University Hospital Carl Gustav Carus, Dresden, Germany (GF); Department of Gastroenterology, Hôpital Universitaire Erasme, Brussels, Belgium (JLVL); Department of Oncology, Mayo Clinic and Mayo Cancer Center, Rochester, MN (SRA, FAS); Pathology Department, Ambroise Paré Hospital, Boulogne, France (JFE); Université Paris Descartes, Sorbonne Paris Cité, France (PLP); Assistance Publique Hôpitaux de Paris, Department of Biology, Hôpital Européen Georges Pompidou, Paris, France (PLP); INSERM UMR-S1147, Paris, France (PLP).

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http://dx.doi.org/10.1093/jnci/djw272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075212PMC
May 2017

Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas.

J Pathol 2017 05 29;242(1):10-15. Epub 2017 Mar 29.

INSERM UMR-S1147, Personalized Medicine, Pharmacogenomics, Therapeutic Optimization, Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1002/path.4880DOI Listing
May 2017

Histiocytoses: emerging neoplasia behind inflammation.

Lancet Oncol 2017 02;18(2):e113-e125

Service de Médecine Interne 2, Centre National de Référence Maladies Auto Immunes Systémiques Rares, Institut E3M, Hôpital Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/S1470-2045(17)30031-1DOI Listing
February 2017

[Histiocytoses: General classification and molecular criteria].

Presse Med 2017 Jan 4;46(1):46-54. Epub 2016 Mar 4.

Hôpital Ambroise-Paré, service de pathologie, 44000 Nantes, France.

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http://dx.doi.org/10.1016/j.lpm.2016.01.016DOI Listing
January 2017

[Erdheim-Chester disease (ECD), an inflammatory myeloid neoplasia].

Presse Med 2017 Jan 24;46(1):96-106. Epub 2016 May 24.

Assistance publique-Hôpitaux de Paris, hôpital Pitié-Salpêtrière, université Pierre-et-Marie-Curie Paris 6, institut E3M, centre de référence des maladies rares auto-immunes et systémiques, service de médecine interne 2, Paris, France.

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http://dx.doi.org/10.1016/j.lpm.2016.02.025DOI Listing
January 2017

BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy.

J Clin Oncol 2016 09 5;34(25):3023-30. Epub 2016 Jul 5.

Sébastien Héritier, Mohamed-Aziz Barkaoui, Jean Miron, and Jean Donadieu, French Reference Center for Langerhans Cell Histiocytosis, Trousseau Hospital; Sébastien Héritier, Sabah Boudjemaa, Guy Leverger, and Jean Donadieu, Trousseau Hospital, Assistance Publique-Hôpitaux de Paris; Sylvie Fraitag, Despina Moshous, and Christine Bodemer, Necker Hospital, Assistance Publique-Hôpitaux de Paris; Michel Peuchmaur and Brigitte Lescoeur, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris; Michel Peuchmaur, Université Paris Diderot, Sorbonne Paris Cité; Hélène Pacquement, Institut Curie Medical Center; Guy Leverger, Université Pierre et Marie Curie; Fleur Cohen-Aubart and Julien Haroche, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris; Roger Lacave, Tenon Hospital, Assistance Publique-Hôpitaux de Paris; Valérie Taly, Institut National de la Santé et de la Recherche Médicale, Unités Mixte de Recherche S1147, Centre National de la Recherche Scientifique SNC 5014, Université Paris Sorbonne Cité, Paris; Sébastien Héritier, Jean-François Emile, Zofia Hélias-Rodzewicz, and Jean Donadieu, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay; Jean-François Emile, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt; Caroline Thomas and Anne Moreau, Centre Hospitalo-Universitaire de Nantes, Nantes; Florence Renaud, Centre Hospitalier Régional Universitaire, Université de Lille; Anne Lambilliotte and Françoise Mazingue, Centre Hospitalo-Universitaire de Lille, Lille; Catherine Chassagne-Clément, Centre Léon Bérard; Frédérique Dijoud, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon; Kamila Kebaili, Institut d'Hémato-Oncologie Pediatrique, Lyon; Valérie Rigau, Gui de Chauliac Hospital; Eric Jeziorski, Hôpital Arnaud de Villeneuve, Montpellier; Geneviève Plat, Centre Hospitalo-Universitaire de Toulouse, Toulouse; Nathalie Aladjidi, Centre Hospitalo-Universit

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http://ascopubs.org/doi/10.1200/JCO.2015.65.9508
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http://dx.doi.org/10.1200/JCO.2015.65.9508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321082PMC
September 2016

Superior efficacy and tolerance of reduced doses of vemurafenib plus anakinra in Erdheim-Chester disease: Towards the paradigm of combined targeting and immune therapies.

Acta Oncol 2016 Jul 31;55(7):930-2. Epub 2016 Mar 31.

a Department of Internal Medicine and Clinical Immunology , CHU Côte De Nacre, Université Basse Normandie , Caen , France.

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http://dx.doi.org/10.3109/0284186X.2015.1120885DOI Listing
July 2016

Increase in NRAS mutant allele percentage during metastatic melanoma progression.

Exp Dermatol 2016 06 18;25(6):472-4. Epub 2016 May 18.

Research Unit EA 4340 'Biomarkers in cancerology and in hemato-oncology', Université de Versailles-Saint-Quentin-en-Yvelines, Université Paris-Saclay, Boulogne-Billancourt, France.

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http://dx.doi.org/10.1111/exd.13001DOI Listing
June 2016

The histiocytosis Erdheim-Chester disease is an inflammatory myeloid neoplasm.

Expert Rev Clin Immunol 2015 21;11(9):1033-42. Epub 2015 Jul 21.

Department of Internal Medicine and French Reference Center for Rare Autoimmune and Systemic Diseases, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.

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http://dx.doi.org/10.1586/1744666X.2015.1060857DOI Listing
May 2016

Prognostic Effect of BRAF and KRAS Mutations in Patients With Stage III Colon Cancer Treated With Leucovorin, Fluorouracil, and Oxaliplatin With or Without Cetuximab: A Post Hoc Analysis of the PETACC-8 Trial.

JAMA Oncol 2016 May;2(5):643-653

Centre de Recherché UMR-S 1147, Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique, Institut National de la Santé et de la Recherche Médicale, Paris, France6Paris Descartes University, Department of Biology, European Georges Pompidou Ho.

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http://dx.doi.org/10.1001/jamaoncol.2015.5225DOI Listing
May 2016

Cutaneous manifestations of Erdheim-Chester disease (ECD): Clinical, pathological, and molecular features in a monocentric series of 40 patients.

J Am Acad Dermatol 2016 Mar 16;74(3):513-20. Epub 2016 Jan 16.

E3M Institute, Service de Medecine Interne 2, French National Reference Center for Rare Systemic and Autoimmune Diseases, Assistance Publique Hôpitaux de Paris (AP-HP), Groupement Hospitalier Pitié-Salpêtrière, Paris, France; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Université Paris VI, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622150247
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http://dx.doi.org/10.1016/j.jaad.2015.11.007DOI Listing
March 2016

Asparagine Synthetase Expression and Phase I Study With L-Asparaginase Encapsulated in Red Blood Cells in Patients With Pancreatic Adenocarcinoma.

Pancreas 2015 Oct;44(7):1141-7

From the *Department of Hepato-Gastroenterology, Pitié Salpêtrière Hospital, Paris; and †Erytech Pharma, Lyon, France; ‡Department of Gastroenterology, Erasme University Hospital, Brussels, Belgium; §Department of Oncology, Centre François Baclesse, Caen; ∥Department of Oncology, Centre Oscar Lambret, Lille; and ¶Pathology Department, Beaujon Hospital, Paris, France; #Department of Pathology, Erasme Hospital, Brussels, Belgium; **Department of Pathology, Saint Antoine Hospital; and ††Department of Pathology, Pitié Salpêtrière Hospital, Paris; ‡‡Department of Pathology, Ambroise Paré Hospital, Boulogne-Billancourt; and §§Department of Gastroenterology, Beaujon Hospital; and Departments of ∥∥Medical Oncology and ¶¶Oncology, Saint-Antoine Hospital, Paris, France.

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http://dx.doi.org/10.1097/MPA.0000000000000394DOI Listing
October 2015

Vemurafenib Use in an Infant for High-Risk Langerhans Cell Histiocytosis.

JAMA Oncol 2015 Sep;1(6):836-8

Department of Pediatric Hematology and Oncology, Trousseau Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France Trousseau Hospital, Paris, France.

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http://dx.doi.org/10.1001/jamaoncol.2015.0736DOI Listing
September 2015

Vemurafenib as first line therapy in BRAF-mutated Langerhans cell histiocytosis.

J Am Acad Dermatol 2015 Jul;73(1):e29-30

Department of Internal Medicine and French Reference Center for Rare Auto-immune and Systemic Diseases, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière Hospital, Paris, France; Université Pierre et Marie Curie, UPMC University Paris 6, Paris, France.

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http://dx.doi.org/10.1016/j.jaad.2014.10.045DOI Listing
July 2015

Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis.

J Immunol 2015 Apr 20;194(7):3259-66. Epub 2015 Feb 20.

INSERM, U1016, Institut Cochin, 75014 Paris, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France;

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http://dx.doi.org/10.4049/jimmunol.1401260DOI Listing
April 2015

Complete remission of critical neurohistiocytosis by vemurafenib.

Neurol Neuroimmunol Neuroinflamm 2015 Apr 26;2(2):e78. Epub 2015 Feb 26.

Departments of Neurology (P.E., A.M.), Nuclear Medicine (R.B.), and Dermatology (S.V.), Charité Universitätsmedizin Berlin, Germany; Service de Médecine Interne (J.H.), Hôpital Pitié-Salpêtrière, Paris, France; and Service de Pathologie (J.-F.E.), Hôpital universitaire Ambroise Paré, Paris, France.

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http://dx.doi.org/10.1212/NXI.0000000000000078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345630PMC
April 2015

Common cancer-associated PIK3CA activating mutations rarely occur in Langerhans cell histiocytosis.

Blood 2015 Apr;125(15):2448-9

EA4340, Versailles University, Boulogne-Billancourt, France Pathology Department, Ambroise Paré Hospital, Assistance Publique Hôpitaux de Paris, Boulogne-Billancourt, France.

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http://dx.doi.org/10.1182/blood-2015-01-625491DOI Listing
April 2015

Reproducible and sustained efficacy of targeted therapy with vemurafenib in patients with BRAF(V600E)-mutated Erdheim-Chester disease.

J Clin Oncol 2015 Feb 24;33(5):411-8. Epub 2014 Nov 24.

Julien Haroche, Fleur Cohen-Aubart, Philippe Maksud, Aurélie Drier, Dan Tolédano, Stéphane Barete, Frédéric Charlotte, Philippe Cluzel, Neïla Benameur, Philippe A. Grenier, Ahmed Idbaih, Baptiste Hervier, Laurent Arnaud, and Zahir Amoura, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpêtrière; Philippe Maksud, Stéphane Barete, Frédéric Charlotte, Philippe Cluzel, Philippe A. Grenier, Ahmed Idbaih, Julien Haroche, Fleur Cohen-Aubart, Baptiste Hervier, Laurent Arnaud, and Zahir Amoura, Paris VI University Pierre et Marie Curie; Jean Donadieu, AP-HP, Hôpital Trousseau, French National Center for Histiocytosis, Paris; Jean-François Emile, EA4340-BCOH, Versailles University, and AP-HP, Hôpital Ambroise Paré, Boulogne; Sophie Besnard, Centre Hospitalier Universitaire de Rennes, Pontchaillou University Hospital, Rennes Cedex; Jean-Paul Ory, Centre Hospitalier Régional de Vesoul, Vesoul; François Lifermann, Hôpital de Dax-Côte d'Argent, Dax; Brigitte Granel, Assistance Publique-Hôpitaux de Marseille, Hôpital Nord, Marseille; and Bruno Graffin, Hôpital d'Instruction des Armées Legouest, Metz, France.

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http://dx.doi.org/10.1200/JCO.2014.57.1950DOI Listing
February 2015

KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence.

J Clin Oncol 2015 Feb 20;33(6):634-42. Epub 2015 Jan 20.

Heikki Joensuu, Helsinki University Central Hospital, Helsinki, Finland; Piotr Rutkowski, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland; Toshirou Nishida, National Cancer Center Hospital East, Kashiwa, Japan; Sonja E. Steigen, University Hospital of North Norway and Tumor Biology Research Group, UiT The Arctic University of Norway, Tromsø, Norway; Peter Brabec, Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic; Lukas Plank, Jessenius Medical Faculty of Comenius University and University Hospital, Martin; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovak Republic; Bengt Nilsson, Sahlgrenska University Hospital, Gothenburg, Sweden; Chiara Braconi, Centro Regionale di Genetica Oncologica, Oncologia Medica, Ancona; Massimo Federico, University of Modena and Reggio Emilia, Modena, Italy; Chiara Braconi, The Institute of Cancer Research, Belmont, United Kingdom; Andrea Bordoni, Ticino Cancer Registry, Insitute of Pathology South of Switzerland, Locarno, Switzerland; Magnus K. Magnusson, University of Iceland; Jon G. Jonasson, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland; Isabelle Hostein, Bergonié Institute, Bordeaux; Pierre-Paul Bringier, E. Herriot Hospital, Lyon; Jean-Francois Emile, Versailles University and Assistance Publique-Hôpitaux de Paris, Ambroise Paré Hospital, Boulogne, France.

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http://dx.doi.org/10.1200/JCO.2014.57.4970DOI Listing
February 2015

BRAF(V600E) mutation in a histiocytic sarcoma arising from hairy cell leukemia.

J Clin Oncol 2014 Dec 24;32(35):e117-21. Epub 2014 Feb 24.

Hôpital Necker, Assistance Publique-Hôpitaux de Paris; and Université Paris Descartes, Sorbonne Paris Cite, Institut Hospitalo-Universitaire Imagine, Paris, France.

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http://dx.doi.org/10.1200/JCO.2013.49.0078DOI Listing
December 2014

Recurrent RAS and PIK3CA mutations in Erdheim-Chester disease.

Blood 2014 Nov 22;124(19):3016-9. Epub 2014 Aug 22.

Department of Internal Medicine & French Reference Center for Rare Auto-immune & Systemic Diseases, Hôpital Pitié-Salpêtrière Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Pierre and Marie Curie University, Paris, France;

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http://dx.doi.org/10.1182/blood-2014-04-570937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224196PMC
November 2014

Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib.

Neurology 2014 Oct 10;83(16):1478-80. Epub 2014 Sep 10.

From the Université Pierre et Marie Curie-Paris 6 (A.I., K.M., C.C., J.-Y.D., K.H.-X.), Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière (CRICM), UMRS 975; Inserm U 975 (A.I., K.M., C.C., J.-Y.D., K.H.-X.); CNRS (A.I., K.M., C.C., J.-Y.D., K.H.-X.), UMR 7225; AP-HP (A.I., K.M., D.G., H.B., N.B., V.-C.B., D.P., N.M.-D., J.H., L.F., N.Z., J.-Y.D., K.H.-X.), Groupe Hospitalier Pitié-Salpêtrière, Paris; Versailles University & Ambroise Paré Hospital (J.-F.E.), AP-HP, Boulogne; AltraBio (S.d.B.), Lyon; and AP-HP (J.D.), Hôpital Trousseau, Paris, France.

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http://dx.doi.org/10.1212/WNL.0000000000000880DOI Listing
October 2014

Marked efficacy of vemurafenib in suprasellar Erdheim-Chester disease.

Neurology 2014 Sep 29;83(14):1294-6. Epub 2014 Aug 29.

From AP-HP (F.C.-A., P.M., D.G., A.I., D.C., N.B., Z.A., J.H.), Groupe Hospitalier Pitié-Salpêtrière, Paris; Université Paris VI Pierre et Marie Curie (F.C.-A., P.M., Z.A., D.G., A.I., D.C., J.H.); AP-HP (J.-F.E.), Hôpital Ambroise-Paré, Boulogne; Université de Versailles (J.-F.E.); and AP-HP (Y.A.), Hôpital Cochin, Paris, France.

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http://dx.doi.org/10.1212/WNL.0000000000000832DOI Listing
September 2014

Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to the BRAFV600E mutation.

Blood 2014 Aug 3;124(7):1119-26. Epub 2014 Jun 3.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpêtrière, Service de Médecine Interne 2, Centre National de Référence des Maladies Auto-Immune et Systémiques Rares, Paris, France; Université Pierre & Marie Curie Université Paris 06, Paris, France; INSERM, Unité Mixte de Recherche-S 945, Paris, France;

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http://dx.doi.org/10.1182/blood-2013-12-543793DOI Listing
August 2014

BRAFV600E mutation analysis by immunohistochemistry in patients with thoracic metastases from colorectal cancer.

Pathology 2014 Jun;46(4):311-5

1INSERM U1081/CNRS UMR7284, Team 3, University of Nice Sophia Antipolis, Antoine Lacassagne Cancer Center, Institute for Research on Cancer and Aging in Nice (IRCAN), Nice 2Human Biobank, Pasteur Hospital, Nice 3Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, Nice 4Cancer Research Association (ARC) Labelled Team, Villejuif 5Department of Thoracic Surgery, Pasteur Hospital, Nice 6Laboratory of Pathology, University Hospital of Nancy-Brabois, Nancy 7Laboratory of Pathology, Haut Lévêque Hospital, Bordeaux 8Department of Pathology, Ambroise Paré Hospital, Paris 9EA 4340, Université de Versailles SQY, Boulogne 10Department of Gastroenterology, Archet Hospital, Nice, France.

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http://dx.doi.org/10.1097/PAT.0000000000000113DOI Listing
June 2014

Erdheim-Chester disease.

Curr Rheumatol Rep 2014 Apr;16(4):412

Department of Internal Medicine and French Reference Center for Rare Autoimmune and Systemic Diseases, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France,

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http://dx.doi.org/10.1007/s11926-014-0412-0DOI Listing
April 2014