Publications by authors named "Jean Quancard"

22Publications

Discovery of Potent, Highly Selective, and Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.

Authors:
Carole Pissot Soldermann Oliver Simic Martin Renatus Paulus Erbel Samu Melkko Markus Wartmann Marc Bigaud Andreas Weiss Paul McSheehy Ralf Endres Paulo Santos Jutta Blank Ansgar Schuffenhauer Guido Bold Nicole Buschmann Thomas Zoller Eva Altmann Paul W Manley Ina Dix Elisabeth Buchdunger Julien Scesa Jean Quancard Achim Schlapbach Frédéric Bornancin Thomas Radimerski Catherine H Régnier

J Med Chem 2020 12 30;63(23):14576-14593. Epub 2020 Nov 30.

Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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December 2020

Optimization of the Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.

Authors:
Jean Quancard Oliver Simic Carole Pissot Soldermann Reiner Aichholz Markus Blatter Martin Renatus Paulus Erbel Samu Melkko Ralf Endres Mickael Sorge Laurence Kieffer Trixie Wagner Karen Beltz Paul Mcsheehy Markus Wartmann Catherine H Régnier Thomas Calzascia Thomas Radimerski Marc Bigaud Andreas Weiss Frédéric Bornancin Achim Schlapbach

J Med Chem 2020 12 20;63(23):14594-14608. Epub 2020 Nov 20.

Novartis Pharma AG, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.

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December 2020

The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes.

Authors:
Jean Quancard Brian Cox Dirk Finsinger Stéphanie M Guéret Ingo V Hartung Hannes F Koolman Josef Messinger Gianluca Sbardella Stefan Laufer

ChemMedChem 2020 Dec 3;15(24):2388-2390. Epub 2020 Sep 3.

Pharmaceutical&Medicinal Chemistry, Institute of Pharmacy&Biochemistry, Tübingen Center for Academic Drug Discovery, Auf der Morgenstelle 8 D, 72070 Tuebingen, Germany.

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December 2020

Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology.

Authors:
Kea Martin Ursula Junker Elaine Tritto Esther Sutter Tina Rubic-Schneider Hannah Morgan Satoru Niwa Jianping Li Achim Schlapbach Dana Walker Marc Bigaud Christian Beerli Amanda Littlewood-Evans Bettina Rudolph Marc Laisney David Ledieu Karen Beltz Jean Quancard Frédéric Bornancin Natasa Zamurovic Ribrioux Thomas Calzascia

Front Immunol 2020 30;11:745. Epub 2020 Apr 30.

Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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April 2020

Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice.

Authors:
Kea Martin Ratiba Touil Grozdan Cvijetic Laura Israel Yeter Kolb Sophie Sarret Stéphanie Valeaux Elena Degl'Innocenti Thomas Le Meur Nadja Caesar Maureen Bardet Christian Beerli Hans-Guenter Zerwes Jiri Kovarik Karen Beltz Achim Schlapbach Jean Quancard Catherine H Régnier Marc Bigaud Tobias Junt Grazyna Wieczorek Isabelle Isnardi Amanda Littlewood-Evans Frédéric Bornancin Thomas Calzascia

Arthritis Rheumatol 2020 06 26;72(6):919-930. Epub 2020 Apr 26.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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June 2020

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.

Authors:
Jean Quancard Theo Klein Shan-Yu Fung Martin Renatus Nicola Hughes Laura Israël John J Priatel Sohyeong Kang Michael A Blank Rosa I Viner Jutta Blank Achim Schlapbach Paul Erbel Jayachandran Kizhakkedathu Frédéric Villard René Hersperger Stuart E Turvey Joerg Eder Frédéric Bornancin Christopher M Overall

Nat Chem Biol 2019 03 28;15(3):304-313. Epub 2019 Jan 28.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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March 2019

N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.

Authors:
Achim Schlapbach Laszlo Revesz Carole Pissot Soldermann Thomas Zoller Catherine H Régnier Frédéric Bornancin Thomas Radimerski Jutta Blank Ansgar Schuffenhauer Martin Renatus Paulus Erbel Samu Melkko Richard Heng Oliver Simic Ralf Endres Markus Wartmann Jean Quancard

Bioorg Med Chem Lett 2018 07 9;28(12):2153-2158. Epub 2018 May 9.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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July 2018

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.

Authors:
Maureen Bardet Adeline Unterreiner Claire Malinverni Frédérique Lafossas Corinne Vedrine Danielle Boesch Yeter Kolb Daniel Kaiser Anton Glück Martin A Schneider Andreas Katopodis Martin Renatus Oliver Simic Achim Schlapbach Jean Quancard Catherine H Régnier Guido Bold Carole Pissot-Soldermann José M Carballido Jiri Kovarik Thomas Calzascia Frédéric Bornancin

Immunol Cell Biol 2018 01 21;96(1):81-99. Epub 2017 Dec 21.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland.

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January 2018

Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism.

Authors:
Marc Bigaud Zuhal Dincer Birgit Bollbuck Janet Dawson Nicolau Beckmann Christian Beerli Gina Fishli-Cavelti Michaela Nahler Daniela Angst Philipp Janser Heike Otto Elisabeth Rosner Rene Hersperger Christian Bruns Jean Quancard

PLoS One 2016 22;11(12):e0168252. Epub 2016 Dec 22.

Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland.

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July 2017

Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.

Authors:
Eva Altmann Paul Erbel Martin Renatus Michael Schaefer Anita Schlierf Adelaide Druet Laurence Kieffer Mickael Sorge Keith Pfister Ulrich Hassiepen Matthew Jones Simon Ruedisser Daniela Ostermeier Bruno Martoglio Anne B Jefferson Jean Quancard

Angew Chem Int Ed Engl 2017 01 16;56(5):1294-1297. Epub 2016 Dec 16.

Novartis Institutes for BioMedical Research, Novartis Campus, 4002, Basel, Switzerland.

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January 2017

Targeted inhibition of the COP9 signalosome for treatment of cancer.

Authors:
Anita Schlierf Eva Altmann Jean Quancard Anne B Jefferson René Assenberg Martin Renatus Matthew Jones Ulrich Hassiepen Michael Schaefer Michael Kiffe Andreas Weiss Christian Wiesmann Richard Sedrani Jörg Eder Bruno Martoglio

Nat Commun 2016 10 24;7:13166. Epub 2016 Oct 24.

Novartis Institutes for Biomedical Research, Novartis Pharma AG, 4002 Basel, Switzerland.

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October 2016

An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.

Authors:
Daniela Angst Philipp Janser Jean Quancard Peter Buehlmayer Frederic Berst Lukas Oberer Christian Beerli Markus Streiff Charles Pally Rene Hersperger Christian Bruns Frederic Bassilana Birgit Bollbuck

J Med Chem 2012 Nov 26;55(22):9722-34. Epub 2012 Oct 26.

Novartis Pharma AG, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.

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November 2012

A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.

Authors:
Jean Quancard Birgit Bollbuck Philipp Janser Daniela Angst Frédéric Berst Peter Buehlmayer Markus Streiff Christian Beerli Volker Brinkmann Danilo Guerini Paul A Smith Timothy J Seabrook Martin Traebert Klaus Seuwen René Hersperger Christian Bruns Frédéric Bassilana Marc Bigaud

Chem Biol 2012 Sep;19(9):1142-51

Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.

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September 2012

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.

Authors:
Sai Chetan K Sukuru Florian Nigsch Jean Quancard Martin Renatus Rajiv Chopra Natasja Brooijmans Dmitri Mikhailov Zhan Deng Allen Cornett Jeremy L Jenkins Ulrich Hommel John W Davies Meir Glick

Protein Sci 2010 Nov;19(11):2096-109

Lead Discovery Informatics, Lead Finding Platform, Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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November 2010

Prolinoamino acids as tools to build bifunctionalized, stable beta-turns in water.

Authors:
Céline Mothes Maud Larregola Jean Quancard Nicole Goasdoué Solange Lavielle Gérard Chassaing Olivier Lequin Philippe Karoyan

Chembiochem 2010 Jan;11(1):55-8

UPMC Université de Paris 06, UMR 7203 CNRS-UPMC-ENS, Laboratoire des Biomolécules, UPMC, 4 Place Jussieu, Paris Cedex 05, France.

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January 2010

Palladium-catalyzed enantioselective C-3 allylation of 3-substituted-1H-indoles using trialkylboranes.

Authors:
Barry M Trost Jean Quancard

J Am Chem Soc 2006 May;128(19):6314-5

Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.

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May 2006

Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance P bound to the NK-1 receptor.

Authors:
Sandrine Sagan Jean Quancard Olivier Lequin Philippe Karoyan Gérard Chassaing Solange Lavielle

Chem Biol 2005 May;12(5):555-65

Synthèse, Structure et Fonction de Molécules Bioactives, Unite Mixte de Recherche 7613, Centre National de la Recherche Scientifique-Université Paris 6, Paris, France.

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May 2005

Asymmetric synthesis of 3-substituted proline chimeras bearing polar side chains of proteinogenic amino acids.

Authors:
Jean Quancard Aurélie Labonne Yves Jacquot Gérard Chassaing Solange Lavielle Philippe Karoyan

J Org Chem 2004 Nov;69(23):7940-8

Synthèse, Structure et Fonction de Molécules Bioactives, CNRS/UMR 7613, Université Pierre et Marie Curie, 4 Place Jussieu, 75252 Paris Cedex 05, France.

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November 2004

Development of potent inhibitors of botulinum neurotoxin type B.

Authors:
Christine Anne Serge Turcaud Jean Quancard Franck Teffo Hervé Meudal Marie-Claude Fournié-Zaluski Bernard P Roques

J Med Chem 2003 Oct;46(22):4648-56

Département de Pharmacochimie Moléculaire et Structurale, INSERM U266--CNRS FRE2463, UFR des Sciences Pharmaceutiques et Biologiques 4, Avenue de l'Observatoire--75270 Paris Cedex 06, France.

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October 2003

Characterization of the bioactive conformation of the C-terminal tripeptide Gly-Leu-Met-NH2 of substance P using [3-prolinoleucine10]SP analogues.

Authors:
Jean Quancard Philippe Karoyan Sandrine Sagan Odile Convert Solange Lavielle Gérard Chassaing Olivier Lequin

Eur J Biochem 2003 Jul;270(13):2869-78

UMR 7613 Paris 6-CNRS, Université Pierre et Marie Curie, Paris, France.

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July 2003

Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver.

Authors:
Dhirendra Nandi Eric S Lightcap Yumee Kim Koo Xingliang Lu Jean Quancard Richard B Silverman

Int J Biochem Cell Biol 2003 Jul;35(7):1085-97

Department of Chemistry, Northwestern University, Evanston IL 60208-3113, USA.

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July 2003

Amino-zinc-enolate carbometalation reactions: application to ring closure of terminally substituted olefin for the asymmetric synthesis of cis- and trans-3-prolinoleucine.

Authors:
Philippe Karoyan Jean Quancard Jacqueline Vaissermann Gérard Chassaing

J Org Chem 2003 Mar;68(6):2256-65

UMR CNRS 7613, Structure et Fonction de Molécules Bioactives, Université Paris VI, France.

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March 2003