Jean Paul Thiery

Jean Paul Thiery

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Publications by authors named "Jean Paul Thiery"

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EMT signaling: potential contribution of CRISPR/Cas gene editing.

Cell Mol Life Sci 2020 Feb 1. Epub 2020 Feb 1.

Division of Pharmacy, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.

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http://dx.doi.org/10.1007/s00018-020-03449-3DOI Listing
February 2020

AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells.

J Thorac Oncol 2020 Feb 1. Epub 2020 Feb 1.

Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway; Department of Biomedicine, University of Bergen, Bergen, Norway; INSERM UMR 1186, Gustave Roussy, Université Paris-Saclay, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2020.01.015DOI Listing
February 2020

Upregulation of PD-L1 expression in breast cancer cells through the formation of 3D multicellular cancer aggregates under different chemical and mechanical conditions.

Biochim Biophys Acta Mol Cell Res 2019 12 6;1866(12):118526. Epub 2019 Aug 6.

School of Biomedical Engineering, University of Technology Sydney, Sydney, New South Wales 2007, Australia; Institute of Molecular Medicine, Sechenov University, Moscow 119991, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2019.118526DOI Listing
December 2019

Cell free circulating tumor nucleic acids, a revolution in personalized cancer medicine.

Crit Rev Oncol Hematol 2019 Dec 2;144:102827. Epub 2019 Nov 2.

Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore; CNRS UMR 7057 Matter and Complex Systems University Paris Denis Diderot, Paris, France; Inserm Unit 1186 Comprehensive Cancer Center Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1016/j.critrevonc.2019.102827DOI Listing
December 2019

AXL Targeting Overcomes Human Lung Cancer Cell Resistance to NK- and CTL-Mediated Cytotoxicity.

Cancer Immunol Res 2019 Nov 5;7(11):1789-1802. Epub 2019 Sep 5.

INSERM UMR1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Equipe Labellisée par la Ligue Contre le Cancer, EPHE, Faculté de Médecine, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0903DOI Listing
November 2019

Traditional Chinese Medicine and regulatory roles on epithelial-mesenchymal transitions.

Chin Med 2019 23;14:34. Epub 2019 Sep 23.

Guangzhou Regenerative Medicine and Health, Guangdong Laboratory, Guangzhou, China.

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http://dx.doi.org/10.1186/s13020-019-0257-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755703PMC
September 2019

SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition.

Sci Rep 2019 Jun 5;9(1):8295. Epub 2019 Jun 5.

Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, 14 Medical Drive, MD6 #12-01, 117599, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41598-019-44826-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549180PMC
June 2019

Epithelial-to-mesenchymal transition: lessons from development, insights into cancer and the potential of EMT-subtype based therapeutic intervention.

Phys Biol 2019 05 7;16(4):041004. Epub 2019 May 7.

Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, United States of America.

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http://dx.doi.org/10.1088/1478-3975/ab157aDOI Listing
May 2019

Reply to Pontus Eriksson and Gottfrid Sjödahl's Letter to the Editor re: Tuan Zea Tan, Mathieu Rouanne, Kien Thiam Tan, Ruby Yun-Ju Huang, Jean-Paul Thiery. Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors. Eur Urol 2019;75:423-32.

Eur Urol 2019 04 5;75(4):e108-e109. Epub 2018 Dec 5.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou, People's Republic of China; CNRS Emeritus CNRS UMR 7057 Matter and Complex Systems, University Paris Denis Diderot, Paris, France; INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.11.048DOI Listing
April 2019

Integrated use of bioinformatic resources reveals that co-targeting of histone deacetylases, IKBK and SRC inhibits epithelial-mesenchymal transition in cancer.

Brief Bioinform 2019 03;20(2):717-731

Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

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http://dx.doi.org/10.1093/bib/bby030DOI Listing
March 2019

Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors.

Eur Urol 2019 03 10;75(3):423-432. Epub 2018 Sep 10.

Biochemistry Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou, People's Republic of China; CNRS Emeritus CNRS UMR 7057 Matter and Complex Systems, University Paris Denis Diderot, Paris, France; INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, EPHE, PSL, Fac. de Médecine - University Paris-Sud, Université Paris-Saclay, Villejuif, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183061
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http://dx.doi.org/10.1016/j.eururo.2018.08.027DOI Listing
March 2019

Mesenchymal-epithelial transition in development and reprogramming.

Nat Cell Biol 2019 01 2;21(1):44-53. Epub 2019 Jan 2.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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http://dx.doi.org/10.1038/s41556-018-0195-zDOI Listing
January 2019

The prognostic significance of circulating tumor cells in head and neck and non-small-cell lung cancer.

Cancer Med 2018 12 22;7(12):5910-5919. Epub 2018 Nov 22.

The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

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http://dx.doi.org/10.1002/cam4.1832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308060PMC
December 2018

A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells.

Oncotarget 2018 Nov 16;9(90):36110-36125. Epub 2018 Nov 16.

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore.

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http://dx.doi.org/10.18632/oncotarget.26306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281425PMC
November 2018

Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth.

Breast Cancer Res 2018 08 2;20(1):83. Epub 2018 Aug 2.

The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing, 210096, People's Republic of China.

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http://dx.doi.org/10.1186/s13058-018-1018-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090974PMC
August 2018

Probing compression versus stretch activated recruitment of cortical actin and apical junction proteins using mechanical stimulations of suspended doublets.

APL Bioeng 2018 Jun 19;2(2):026111. Epub 2018 Jun 19.

Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.

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http://dx.doi.org/10.1063/1.5025216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481720PMC
June 2018

Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer.

Int J Biol Sci 2017 8;13(4):505-517. Epub 2017 Apr 8.

Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing 210046, P.R. China.

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http://dx.doi.org/10.7150/ijbs.18834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436570PMC
February 2018

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT.

Oncoimmunology 2018 15;7(4):e1345415. Epub 2018 Feb 15.

Laboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, L-1526 Luxembourg City, Luxembourg.

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http://dx.doi.org/10.1080/2162402X.2017.1345415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889210PMC
February 2018

Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention.

Nat Biomed Eng 2018 01 10;2(1):27-37. Epub 2018 Jan 10.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41551-017-0181-yDOI Listing
January 2018

The Emerging Roles of RUNX Transcription Factors in Epithelial-Mesenchymal Transition.

Adv Exp Med Biol 2017 ;962:471-489

Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.

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http://link.springer.com/10.1007/978-981-10-3233-2_28
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http://dx.doi.org/10.1007/978-981-10-3233-2_28DOI Listing
September 2017

New insights into the role of EMT in tumor immune escape.

Mol Oncol 2017 07 27;11(7):824-846. Epub 2017 Jun 27.

INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, EPHE, Fac. de médecine - Univ. Paris-Sud, University Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.1002/1878-0261.12093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496499PMC
July 2017

The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200.

Oncoimmunology 2017 23;6(1):e1263412. Epub 2017 Jan 23.

INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, EPHE, Fac. de médecine - Univ. Paris-Sud, Université Paris-Saclay , Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2016.1263412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283623PMC
January 2017

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity.

Oncoimmunology 2017 17;6(2):e1271858. Epub 2017 Jan 17.

INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, EPHE, Fac. de médecine - Univ. Paris-Sud, University Paris-Saclay , Villejuif, France.

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http://dx.doi.org/10.1080/2162402X.2016.1271858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353930PMC
January 2017

Intraoperative cell salvage in metastatic spine tumour surgery reduces potential for reinfusion of viable cancer cells.

Eur Spine J 2016 12 7;25(12):4008-4015. Epub 2016 Mar 7.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.

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http://dx.doi.org/10.1007/s00586-016-4478-4DOI Listing
December 2016

Corrigendum to "Mach-Zehnder interferometer (MZI) point-of-care system for rapid multiplexed detection of microRNAs in human urine specimens" [Biosens. Bioelectron. 71 (2015) 365-372].

Biosens Bioelectron 2016 11 18;85:996. Epub 2016 May 18.

Institute of Microelectronics, A⁎STAR (Agency for Science, Technology and Research), 11 Science Park Road, Singapore Science Park II, 117685, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2016.05.011DOI Listing
November 2016

Impact of label-free technologies in head and neck cancer circulating tumour cells.

Oncotarget 2016 11;7(44):71223-71234

The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

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http://dx.doi.org/10.18632/oncotarget.12086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342074PMC
November 2016

The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer.

Sci Signal 2016 10 4;9(448):ra97. Epub 2016 Oct 4.

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. Department of Obstetrics and Gynecology, National University Health System, Singapore 119228, Singapore. Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1126/scisignal.aaf8175DOI Listing
October 2016

Microfluidic models for adoptive cell-mediated cancer immunotherapies.

Drug Discov Today 2016 09 13;21(9):1472-1478. Epub 2016 May 13.

Singapore-MIT Alliance for Research and Technology, BioSyM IRG, 1 Create Way, 138602, Singapore; Massachusetts Institute of Technology, Department of Biological Engineering, 77 Massachusetts Avenue, 02139 Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035566PMC
September 2016

Exosome-Mediated Metastasis: From Epithelial-Mesenchymal Transition to Escape from Immunosurveillance.

Trends Pharmacol Sci 2016 07 3;37(7):606-617. Epub 2016 May 3.

Cancer Science Institute of Singapore, Centre for Translational Medicine, National University of Singapore, 14 Medical Drive, #12-01, Singapore 117599, Singapore; Department of Haematology-Oncology, National University Cancer Institute, 1E Kent Ridge Road, NUHS Tower Block, Level 7, Singapore 119228, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.

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http://dx.doi.org/10.1016/j.tips.2016.04.006DOI Listing
July 2016

Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment.

Sci Adv 2016 07 13;2(7):e1600274. Epub 2016 Jul 13.

BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore 138602, Singapore.; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.; Department of Biomedical Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore.; Department of Mechanical Engineering, National University of Singapore, Singapore 117575, Singapore.

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http://advances.sciencemag.org/content/advances/2/7/e1600274
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http://dx.doi.org/10.1126/sciadv.1600274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956185PMC
July 2016

EMT: 2016.

Cell 2016 Jun;166(1):21-45

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore; Institute of Molecular and Cell Biology, A-STAR, Singapore 138673, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.06.028DOI Listing
June 2016

Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse.

Int J Mol Sci 2016 Apr 28;17(5). Epub 2016 Apr 28.

Molecular Pathology Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait 13110, Kuwait.

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http://dx.doi.org/10.3390/ijms17050598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881437PMC
April 2016

Extracellular matrix scaffolding guides lumen elongation by inducing anisotropic intercellular mechanical tension.

Nat Cell Biol 2016 Mar 15;18(3):311-8. Epub 2016 Feb 15.

Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.

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http://dx.doi.org/10.1038/ncb3310DOI Listing
March 2016

GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.

Sci Rep 2016 Feb 18;6:19943. Epub 2016 Feb 18.

Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 14 Medical Drive, #12-01, Singapore 117599.

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http://dx.doi.org/10.1038/srep19943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757891PMC
February 2016

Homophilic interaction and deformation of E-cadherin and cadherin 7 probed by single molecule force spectroscopy.

Arch Biochem Biophys 2015 Dec 24;587:38-47. Epub 2015 Oct 24.

College of Physics, Chongqing University, No.55 Daxuecheng South Rd., Shapingba, Chongqing 401331, China; Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, Singapore; Mechanobiology Institute, National University of Singapore, 5A Engineering Drive 1, Singapore 117411, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00039861153008
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http://dx.doi.org/10.1016/j.abb.2015.10.008DOI Listing
December 2015

CSIOVDB: a microarray gene expression database of epithelial ovarian cancer subtype.

Oncotarget 2015 Dec;6(41):43843-52

Cancer Science Institute of Singapore, National University of Singapore, Center for Translational Medicine, Singapore 117599.

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https://www.csi.nus.edu.sg/ws/wp-content/uploads/12-In-the-s
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http://www.oncotarget.com/abstract/5983
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http://dx.doi.org/10.18632/oncotarget.5983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791271PMC
December 2015

Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment.

Oncotarget 2015 Nov;6(34):36603-14

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, 138602, Singapore.

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http://dx.doi.org/10.18632/oncotarget.5464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742198PMC
November 2015

Mach-Zehnder interferometer (MZI) point-of-care system for rapid multiplexed detection of microRNAs in human urine specimens.

Biosens Bioelectron 2015 09 20;71:365-372. Epub 2015 Apr 20.

Institute of Microelectronics, A⁎STAR (Agency for Science, Technology and Research), 11 Science Park Road, Singapore Science Park II, 117685, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09565663153004
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http://dx.doi.org/10.1016/j.bios.2015.04.052DOI Listing
September 2015

Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions.

Oncotarget 2015 Sep;6(28):25295-307

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, 138602, Singapore.

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http://dx.doi.org/10.18632/oncotarget.4716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694832PMC
September 2015

MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma.

Mol Cancer Ther 2015 Jul 4;14(7):1750-60. Epub 2015 May 4.

Cancer Science Institute of Singapore, National University of Singapore, Singapore. Department of Hematology-Oncology, National University Hospital, Singapore. National University Cancer Institute, Singapore.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0062DOI Listing
July 2015

Pentimento: Neural Crest and the origin of mesectoderm.

Dev Biol 2015 May 15;401(1):37-61. Epub 2015 Jan 15.

Institute of Molecular and Cell Biology, A(⁎)STAR, Proteos, Singapore; Cancer Science Institute, National University of Singapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2014.12.035DOI Listing
May 2015

Tumor plasticity interferes with anti-tumor immunity.

Crit Rev Immunol 2014 ;34(2):91-102

Cancer Science Institute of Singapore, National University of Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore; Department of Biochemistry, National University of Singapore, Singapore.

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http://dx.doi.org/10.1615/critrevimmunol.2014010183DOI Listing
February 2015

Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression.

Oncotarget 2015 Feb;6(5):2951-65

The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing, P.R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413630PMC
http://dx.doi.org/10.18632/oncotarget.3095DOI Listing
February 2015

The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions.

Hum Pathol 2015 Jan 16;46(1):1-8. Epub 2014 Oct 16.

Cancer Science Institute (CSI), Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 117599 Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD6 Centre for Translational Medicine, 117599 Singapore; Institute of Molecular and Cell Biology (IMCB) A*STAR, Proteos 138673, Singapore.

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https://linkinghub.elsevier.com/retrieve/pii/S00468177140041
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http://dx.doi.org/10.1016/j.humpath.2014.10.004DOI Listing
January 2015

A role of autophagy in PTP4A3-driven cancer progression.

Autophagy 2014 Oct 1;10(10):1787-800. Epub 2014 Aug 1.

Institute of Molecular and Cell Biology; A*STAR (Agency for Science, Technology and Research); Singapore; Department of Biochemistry; Yong Loo Lin School of Medicine; National University of Singapore; Singapore.

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http://dx.doi.org/10.4161/auto.29989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198363PMC
October 2014

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients.

EMBO Mol Med 2014 Oct;6(10):1279-93

Cancer Science Institute of Singapore, National University of Singapore, Singapore Institute of Molecular and Cell Biology, A*STAR, Singapore Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

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http://dx.doi.org/10.15252/emmm.201404208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287932PMC
October 2014

Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.

Sci Rep 2014 Oct 30;4:6835. Epub 2014 Oct 30.

1] Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore, Singapore [2] Department of Biochemistry School of Medicine National University of Singapore, Singapore [3] Cancer Science Institute National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/srep06835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213774PMC
October 2014

A central role for TRPS1 in the control of cell cycle and cancer development.

Oncotarget 2014 Sep;5(17):7677-90

The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202153PMC
http://dx.doi.org/10.18632/oncotarget.2291DOI Listing
September 2014

SPHK1 regulates proliferation and survival responses in triple-negative breast cancer.

Oncotarget 2014 Aug;5(15):5920-33

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore; National University Cancer Institute, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171602PMC
http://dx.doi.org/10.18632/oncotarget.1874DOI Listing
August 2014

Rapid prototyping of concave microwells for the formation of 3D multicellular cancer aggregates for drug screening.

Adv Healthc Mater 2014 Apr 27;3(4):609-16. Epub 2013 Aug 27.

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology (SMART) Center, 1 CREATE Way, #04-13/14 Enterprise, Wing, Singapore, 138602, Singapore.

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http://dx.doi.org/10.1002/adhm.201300151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038742PMC
April 2014

α-catenin, vinculin, and F-actin in strengthening E-cadherin cell-cell adhesions and mechanosensing.

Cell Adh Migr 2013 Jul-Aug;7(4):345-50. Epub 2013 Jun 5.

Institut Curie/CNRS UMR144; Paris, France.

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http://dx.doi.org/10.4161/cam.25139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739810PMC
March 2014

Raf kinase inhibitory protein role in the molecular subtyping of breast cancer.

J Cell Biochem 2014 Mar;115(3):488-97

Department of Pathology, Faculty of Medicine, Kuwait University Health Sciences Centre, Safat, 13110, Kuwait.

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http://dx.doi.org/10.1002/jcb.24682DOI Listing
March 2014

Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme.

Development 2013 Dec 6;140(24):4890-902. Epub 2013 Nov 6.

Institute of Molecular Cell Biology, ASTAR, 61 Biopolis Drive, 138673, Singapore.

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http://dx.doi.org/10.1242/dev.094680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074292PMC
December 2013

Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer.

Am J Cancer Res 2013 1;3(5):446-64. Epub 2013 Nov 1.

Department of Pathology, Molecular Pathology Unit, Faculty of Medicine, Kuwait University, Health Sciences Centre Safat, Kuwait.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816965PMC
November 2013

Remarkable disparity in mechanical response among the extracellular domains of type I and II cadherins.

J Biomol Struct Dyn 2013 Oct 4;31(10):1137-49. Epub 2012 Oct 4.

a MechanoBiology Institute, National University of Singapore , 5A Engineering Drive 1 , 117411 , Singapore.

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http://www.tandfonline.com/doi/abs/10.1080/07391102.2012.726
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http://dx.doi.org/10.1080/07391102.2012.726530DOI Listing
October 2013

EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction.

Autophagy 2013 Jul 23;9(7):1104-6. Epub 2013 Apr 23.

Unité INSERM U753; Institut de Cancérologie Gustave Roussy; Villejuif, France.

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http://dx.doi.org/10.4161/auto.24728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722321PMC
July 2013

An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme.

Development 2013 Jul 5;140(14):2923-32. Epub 2013 Jun 5.

Institute of Molecular and Cell Biology-IMCB, A*STAR-Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673, Singapore.

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http://dx.doi.org/10.1242/dev.093534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699280PMC
July 2013

Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1.

J Cell Sci 2013 Jun 16;126(Pt 12):2740-6. Epub 2013 Apr 16.

Institute of Molecular and Cell Biology, A STAR, Singapore 138673.

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http://dx.doi.org/10.1242/jcs.126367DOI Listing
June 2013

Translating metastasis-related biomarkers to the clinic--progress and pitfalls.

Nat Rev Clin Oncol 2013 Mar 5;10(3):169-79. Epub 2013 Feb 5.

Department of Medical Oncology, Institut Curie & Université Paris Descartes, 26 rue d'Ulm, 75005 Paris, France.

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http://dx.doi.org/10.1038/nrclinonc.2013.4DOI Listing
March 2013

Tumor dissemination: an EMT affair.

Cancer Cell 2013 Mar;23(3):272-3

Department of Biochemistry, National University of Singapore, Singapore 117599.

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http://dx.doi.org/10.1016/j.ccr.2013.03.004DOI Listing
March 2013

Microfluidic cell trap array for controlled positioning of single cells on adhesive micropatterns.

Lab Chip 2013 Feb;13(4):714-21

NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 119077, Singapore.

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http://dx.doi.org/10.1039/c2lc41070bDOI Listing
February 2013

Targeting pathways contributing to epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer.

Curr Drug Targets 2012 Dec;13(13):1649-53

Department of Obstetrics & Gynaecology, National University Hospital, Singapore.

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http://dx.doi.org/10.2174/138945012803530044DOI Listing
December 2012

Histotype-specific copy-number alterations in ovarian cancer.

BMC Med Genomics 2012 Oct 18;5:47. Epub 2012 Oct 18.

Department of Obstetrics & Gynaecology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.

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http://bmcmedgenomics.biomedcentral.com/articles/10.1186/175
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http://dx.doi.org/10.1186/1755-8794-5-47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567940PMC
October 2012

Early events in cell adhesion and polarity during epithelial-mesenchymal transition.

J Cell Sci 2012 Oct;125(Pt 19):4417-22

Department of Obstetrics and Gynaecology, National University Hospital, 119074, Singapore.

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http://dx.doi.org/10.1242/jcs.099697DOI Listing
October 2012