Publications by authors named "Jean J Zhao"

91Publications

The role of the PIK3CA gene in the development and aging of the brain.

Sci Rep 2021 Jan 11;11(1):291. Epub 2021 Jan 11.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

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January 2021

Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas.

Cell Rep 2020 Sep;32(13):108196

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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September 2020

PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition.

Proc Natl Acad Sci U S A 2020 09 14;117(39):24427-24433. Epub 2020 Sep 14.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

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September 2020

Integrating Immunotherapy and Targeted Therapy in Cancer Treatment: Mechanistic Insights and Clinical Implications.

Clin Cancer Res 2020 Nov 23;26(21):5557-5566. Epub 2020 Jun 23.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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November 2020

Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers.

Oncogene 2020 01 28;39(1):50-63. Epub 2019 Aug 28.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.

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January 2020

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer.

Cell Rep 2018 12;25(11):2972-2980.e5

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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December 2018

A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells.

iScience 2018 Nov 18;9:149-160. Epub 2018 Oct 18.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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November 2018

Targeted Profiling of RNA Translation.

Curr Protoc Mol Biol 2019 01 22;125(1):e71. Epub 2018 Oct 22.

Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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January 2019

Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins.

Proc Natl Acad Sci U S A 2018 10 17;115(40):E9325-E9332. Epub 2018 Sep 17.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;

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October 2018

CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest.

Trends Cell Biol 2018 11 27;28(11):911-925. Epub 2018 Jul 27.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address:

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November 2018

Oridonin inhibits aberrant AKT activation in breast cancer.

Oncotarget 2018 May 1;9(35):23878-23889. Epub 2018 Feb 1.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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May 2018

Isoform-Selective Phosphatidylinositol 3-Kinase Inhibition in Cancer.

J Clin Oncol 2018 05 8;36(13):1339-1342. Epub 2018 Mar 8.

Johann S. Bergholz, Thomas M. Roberts, and Jean J. Zhao, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA.

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May 2018

Oncogenic Kinase-Induced PKM2 Tyrosine 105 Phosphorylation Converts Nononcogenic PKM2 to a Tumor Promoter and Induces Cancer Stem-like Cells.

Cancer Res 2018 05 12;78(9):2248-2261. Epub 2018 Feb 12.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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May 2018

Drug Resistance in HER2-Positive Breast Cancer Brain Metastases: Blame the Barrier or the Brain?

Clin Cancer Res 2018 04 6;24(8):1795-1804. Epub 2018 Feb 6.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts.

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April 2018

Pik3ca is required for mouse uterine gland development and pregnancy.

PLoS One 2018 18;13(1):e0191433. Epub 2018 Jan 18.

Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI, United States of America.

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March 2018

CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.

Cell Rep 2017 07;20(3):549-557

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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July 2017

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.

Proc Natl Acad Sci U S A 2017 07 19;114(27):7095-7100. Epub 2017 Jun 19.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115;

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July 2017

The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.

Biochim Biophys Acta Rev Cancer 2017 Aug 14;1868(1):123-131. Epub 2017 Mar 14.

Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA. Electronic address:

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August 2017

Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.

Proc Natl Acad Sci U S A 2016 11 31;113(46):13156-13161. Epub 2016 Oct 31.

Department of Ophthalmology, Columbia University, New York, NY 10032;

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November 2016

Discovery of a Series of 5,11-Dihydro-6-benzo[]pyrimido[5,4-][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors.

ACS Med Chem Lett 2016 Oct 2;7(10):908-912. Epub 2016 Aug 2.

Department of Cancer Biology, Dana-Farber Cancer Institute , Boston, Massachusetts 02215, United States.

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October 2016

Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss.

Elife 2016 10 4;5. Epub 2016 Oct 4.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, United States.

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October 2016

NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways.

Cell Discov 2016 20;2:16030. Epub 2016 Sep 20.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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September 2016

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.

Proc Natl Acad Sci U S A 2016 08 15;113(35):9810-5. Epub 2016 Aug 15.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

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August 2016

Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes.

Gynecol Oncol 2016 09 15;142(3):548-56. Epub 2016 Jul 15.

Cancer Institute, The Second Hospital of Dalian Medical University, Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, China. Electronic address:

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September 2016

Tyrosine receptor kinase B is a drug target in astrocytomas.

Neuro Oncol 2017 01 10;19(1):22-30. Epub 2016 Jul 10.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (J.N., S.X., V.L., Y.S., P.B., R.B., T.M.R., C.D.S., R.A.S., J.J.Z.); Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts (J.N., S.X., V.L., T.M.R., J.J.Z.); Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts (S.H.R., R.B., K.L.L., W.C.H.); Broad Institute, Boston, Massachusetts (P.B., R.B., W.C.H.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.H.R., K.L.L.); Department of Pathology, Boston Children's Hospital, Boston, Massachusetts (K.L.L.)

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January 2017

CDK4/6 inhibition: the late harvest cycle begins.

Oncotarget 2016 08;7(31):48854-48856

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.

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August 2016

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.

Cell Rep 2016 06 9;15(12):2692-704. Epub 2016 Jun 9.

Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA. Electronic address:

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June 2016

Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors.

Cancer Cell 2016 Mar;29(3):255-269

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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March 2016

Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.

Oncotarget 2016 Mar;7(11):13153-66

Cancer Institute, The Second Hospital of Dalian Medical University, Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, China.

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March 2016

Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.

Elife 2015 Dec 3;4. Epub 2015 Dec 3.

Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, United States.

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December 2015

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

Cell 2015 Sep;163(1):174-86

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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September 2015

Bioprinting for cancer research.

Trends Biotechnol 2015 Sep 24;33(9):504-13. Epub 2015 Jul 24.

Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Road, Storrs, CT 06269, USA; Department of Mechanical Engineering, University of Connecticut, 191 Auditorium Road, Storrs, CT 06269, USA. Electronic address:

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September 2015

Light-triggered, self-immolative nucleic Acid-drug nanostructures.

J Am Chem Soc 2015 May 7;137(19):6112-5. Epub 2015 May 7.

†Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.

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May 2015

Class IA Phosphatidylinositol 3-Kinase Isoform p110α Mediates Vascular Remodeling.

Arterioscler Thromb Vasc Biol 2015 Jun 23;35(6):1434-44. Epub 2015 Apr 23.

From the Klinik III für Innere Medizin, Universität zu Köln, Germany (M.V., J.J., E.M.B., L.M., X.C., T.K., M.Z., M.G., H.t.F., S.B., S.R.); Center for Molecular Medicine Cologne (CMMC), Universität zu Köln, Germany (M.V., J.J., E.M.B., L.M., X.C., T.K., M.Z., M.G., H.t.F., S.B., S.R.); Center for R&D, Uppsala University/County Council of Gävleborg, Gävle, Sweden (O.L.); Klinik für Herz- und Thoraxchirurgie, Universität zu Köln, Germany (M.S.); Cologne Cardiovascular Research Center (CCRC), Universität zu Köln, Germany (H.t.F., S.B., S.R.); Klinik für Kardiologie, Charité Universitätsmedizin, Berlin, Germany (F.B.); Institut für Experimentelle Medizin, Universität zu Köln, Germany (A.S.-K.); and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA (J.J.Z.).

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June 2015

Chemopreventive effects of aspirin at a glance.

Biochim Biophys Acta 2015 Apr 2;1855(2):254-63. Epub 2015 Apr 2.

Cancer Institute, Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, China; Department of Cancer Biology, Dana-Farber Cancer Institute Harvard Medical School, Boston, MA, USA. Electronic address:

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April 2015

Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis.

Mol Cell Biol 2015 Apr 20;35(7):1182-96. Epub 2015 Jan 20.

Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

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April 2015

PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.

Nat Rev Cancer 2015 Jan;15(1):7-24

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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January 2015

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.

Elife 2014 May 20;3:e01763. Epub 2014 May 20.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, United States Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States

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May 2014

PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.

Proc Natl Acad Sci U S A 2014 Apr 15;111(17):6395-400. Epub 2014 Apr 15.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.

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April 2014

A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.

Cancer Res 2014 Jan 9;74(1):15-23. Epub 2013 Dec 9.

Authors' Affiliations: Department of Cancer Biology; Division of Women's Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of Biological Chemistry and Molecular Pharmacology and Systems Biology; Rodent Histopathology Core, DF/HCC, Harvard Medical School; Department of Surgery, Brigham and Women's Hospital; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston; Novartis Institutes for Biomedical Research, Cambridge, Massacheusetts; Department of System Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and Novartis Institutes for Biomedical Research, Oncology Disease Area, Novartis Pharma AG, Basel, Switzerland.

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January 2014

The gene dosage of class Ia PI3K dictates the development of PTEN hamartoma tumor syndrome.

Cell Cycle 2013 Dec 15;12(23):3589-93. Epub 2013 Oct 15.

Department of Cancer Biology; Dana-Farber Cancer Institute; Boston, MA USA; Department of Biological Chemistry and Molecular Pharmacology; Harvard Medical School; Boston, MA USA.

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December 2013

Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons.

Cell Metab 2013 Jul;18(1):86-98

USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

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July 2013

Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention.

Cancer Discov 2013 Jan 20;3(1):44-51. Epub 2012 Dec 20.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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January 2013

Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells.

Cancer Res 2011 Dec 28;71(24):7481-9. Epub 2011 Oct 28.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

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December 2011

The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus.

J Neurosci 2011 Sep;31(37):13147-56

Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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September 2011

Therapeutic implications of GIPC1 silencing in cancer.

PLoS One 2010 Dec 30;5(12):e15581. Epub 2010 Dec 30.

Functional Genomics and Computational Biology Group, Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States America.

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December 2010

PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.

Cell Metab 2010 Jul;12(1):88-95

Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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July 2010

Estrogen receptor-negative breast cancer: new insights into subclassification and targeting.

Clin Cancer Res 2009 Oct 13;15(20):6309-10. Epub 2009 Oct 13.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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October 2009

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

Endocrinology 2009 Nov 9;150(11):4874-82. Epub 2009 Oct 9.

Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9077, USA.

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November 2009

Targeting the phosphoinositide 3-kinase pathway in cancer.

Nat Rev Drug Discov 2009 Aug;8(8):627-44

Department of Cancer Biology, Dana-Farber Cancer Institute, Pathology, Harvard Medical School, Boston, MA 02115, USA.

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August 2009

Should individual PI3 kinase isoforms be targeted in cancer?

Curr Opin Cell Biol 2009 Apr 4;21(2):199-208. Epub 2009 Feb 4.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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April 2009

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.

Nature 2008 Aug 25;454(7205):776-9. Epub 2008 Jun 25.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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August 2008

The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation.

J Virol 2007 Jul 18;81(13):7069-76. Epub 2007 Apr 18.

Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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July 2007

PI3 kinases in cancer: from oncogene artifact to leading cancer target.

Sci STKE 2006 Dec 12;2006(365):pe52. Epub 2006 Dec 12.

Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Harvard Medical School, Boston, MA 02115, USA.

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December 2006

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation.

Proc Natl Acad Sci U S A 2006 Oct 23;103(44):16296-300. Epub 2006 Oct 23.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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October 2006

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.

Proc Natl Acad Sci U S A 2005 Dec 8;102(51):18443-8. Epub 2005 Dec 8.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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December 2005

A genetic screen for candidate tumor suppressors identifies REST.

Cell 2005 Jun;121(6):837-48

Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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June 2005

Functional genetics and experimental models of human cancer.

Trends Mol Med 2004 Jul;10(7):344-50

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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July 2004