Publications by authors named "Jean J Noubiap"

4 Publications

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Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016.

Authors:
Valery L Feigin Grant Nguyen Kelly Cercy Catherine O Johnson Tahiya Alam Priyakumari G Parmar Amanuel A Abajobir Kalkidan H Abate Foad Abd-Allah Ayenew N Abejie Gebre Y Abyu Zanfina Ademi Gina Agarwal Muktar B Ahmed Rufus O Akinyemi Rajaa Al-Raddadi Leopold N Aminde Catherine Amlie-Lefond Hossein Ansari Hamid Asayesh Solomon W Asgedom Tesfay M Atey Henok T Ayele Maciej Banach Amitava Banerjee Aleksandra Barac Suzanne L Barker-Collo Till Bärnighausen Lars Barregard Sanjay Basu Neeraj Bedi Masoud Behzadifar Yannick Béjot Derrick A Bennett Isabela M Bensenor Derbew F Berhe Dube J Boneya Michael Brainin Ismael R Campos-Nonato Valeria Caso Carlos A Castañeda-Orjuela Jacquelin C Rivas Ferrán Catalá-López Hanne Christensen Michael H Criqui Albertino Damasceno Lalit Dandona Rakhi Dandona Kairat Davletov Barbora de Courten Gabrielle deVeber Klara Dokova Dumessa Edessa Matthias Endres Emerito J A Faraon Maryam S Farvid Florian Fischer Kyle Foreman Mohammad H Forouzanfar Seana L Gall Tsegaye T Gebrehiwot Johanna M Geleijnse Richard F Gillum Maurice Giroud Alessandra C Goulart Rahul Gupta Rajeev Gupta Vladimir Hachinski Randah R Hamadeh Graeme J Hankey Habtamu A Hareri Rasmus Havmoeller Simon I Hay Mohamed I Hegazy Desalegn T Hibstu Spencer L James Panniyammakal Jeemon Denny John Jost B Jonas Jacek Jóźwiak Rizwan Kalani Amit Kandel Amir Kasaeian Andre P Kengne Yousef S Khader Abdur R Khan Young-Ho Khang Jagdish Khubchandani Daniel Kim Yun J Kim Mika Kivimaki Yoshihiro Kokubo Dhaval Kolte Jacek A Kopec Soewarta Kosen Michael Kravchenko Rita Krishnamurthi G Anil Kumar Alessandra Lafranconi Pablo M Lavados Yirga Legesse Yongmei Li Xiaofeng Liang Warren D Lo Stefan Lorkowski Paulo A Lotufo Clement T Loy Mark T Mackay Hassan Magdy Abd El Razek Mahdi Mahdavi Azeem Majeed Reza Malekzadeh Deborah C Malta Abdullah A Mamun Lorenzo G Mantovani Sheila C O Martins Kedar K Mate Mohsen Mazidi Suresh Mehata Toni Meier Yohannes A Melaku Walter Mendoza George A Mensah Atte Meretoja Haftay B Mezgebe Tomasz Miazgowski Ted R Miller Norlinah M Ibrahim Shafiu Mohammed Ali H Mokdad Mahmood Moosazadeh Andrew E Moran Kamarul I Musa Ruxandra I Negoi Minh Nguyen Quyen L Nguyen Trang H Nguyen Tung T Tran Thanh T Nguyen Dina Nur Anggraini Ningrum Bo Norrving Jean J Noubiap Martin J O’Donnell Andrew T Olagunju Oyere K Onuma Mayowa O Owolabi Mahboubeh Parsaeian George C Patton Michael Piradov Martin A Pletcher Farshad Pourmalek V Prakash Mostafa Qorbani Mahfuzar Rahman Muhammad A Rahman Rajesh K Rai Annemarei Ranta David Rawaf Salman Rawaf Andre MN Renzaho Stephen R Robinson Ramesh Sahathevan Amirhossein Sahebkar Joshua A Salomon Paola Santalucia Itamar S Santos Benn Sartorius Aletta E Schutte Sadaf G Sepanlou Azadeh Shafieesabet Masood A Shaikh Morteza Shamsizadeh Kevin N Sheth Mekonnen Sisay Min-Jeong Shin Ivy Shiue Diego A S Silva Eugene Sobngwi Michael Soljak Reed J D Sorensen Luciano A Sposato Saverio Stranges Rizwan A Suliankatchi Rafael Tabarés-Seisdedos David Tanne Cuong Tat Nguyen J S Thakur Amanda G Thrift David L Tirschwell Roman Topor-Madry Bach X Tran Luong T Nguyen Thomas Truelsen Nikolaos Tsilimparis Stefanos Tyrovolas Kingsley N Ukwaja Olalekan A Uthman Yuri Varakin Tommi Vasankari Narayanaswamy Venketasubramanian Vasiliy V Vlassov Wenzhi Wang Andrea Werdecker Charles D A Wolfe Gelin Xu Yuichiro Yano Naohiro Yonemoto Chuanhua Yu Zoubida Zaidi Maysaa El Sayed Zaki Maigeng Zhou Boback Ziaeian Ben Zipkin Theo Vos Mohsen Naghavi Christopher J L Murray Gregory A Roth

N Engl J Med 2018 12;379(25):2429-2437

Background: The lifetime risk of stroke has been calculated in a limited number of selected populations. We sought to estimate the lifetime risk of stroke at the regional, country, and global level using data from a comprehensive study of the prevalence of major diseases.

Methods: We used the Global Burden of Disease (GBD) Study 2016 estimates of stroke incidence and the competing risks of death from any cause other than stroke to calculate the cumulative lifetime risks of first stroke, ischemic stroke, or hemorrhagic stroke among adults 25 years of age or older. Estimates of the lifetime risks in the years 1990 and 2016 were compared. Countries were categorized into quintiles of the sociodemographic index (SDI) used in the GBD Study, and the risks were compared across quintiles. Comparisons were made with the use of point estimates and uncertainty intervals representing the 2.5th and 97.5th percentiles around the estimate.

Results: The estimated global lifetime risk of stroke from the age of 25 years onward was 24.9% (95% uncertainty interval, 23.5 to 26.2); the risk among men was 24.7% (95% uncertainty interval, 23.3 to 26.0), and the risk among women was 25.1% (95% uncertainty interval, 23.7 to 26.5). The risk of ischemic stroke was 18.3%, and the risk of hemorrhagic stroke was 8.2%. In high-SDI, high-middle-SDI, and low-SDI countries, the estimated lifetime risk of stroke was 23.5%, 31.1% (highest risk), and 13.2% (lowest risk), respectively; the 95% uncertainty intervals did not overlap between these categories. The highest estimated lifetime risks of stroke according to GBD region were in East Asia (38.8%), Central Europe (31.7%), and Eastern Europe (31.6%), and the lowest risk was in eastern sub-Saharan Africa (11.8%). The mean global lifetime risk of stroke increased from 22.8% in 1990 to 24.9% in 2016, a relative increase of 8.9% (95% uncertainty interval, 6.2 to 11.5); the competing risk of death from any cause other than stroke was considered in this calculation.

Conclusions: In 2016, the global lifetime risk of stroke from the age of 25 years onward was approximately 25% among both men and women. There was geographic variation in the lifetime risk of stroke, with the highest risks in East Asia, Central Europe, and Eastern Europe. (Funded by the Bill and Melinda Gates Foundation.).
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http://dx.doi.org/10.1056/NEJMoa1804492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247346PMC
December 2018

Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case-control study in a sub-Saharan African population with diabetes.

J Diabetes 2018 Nov 28;10(11):866-873. Epub 2018 May 28.

Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon.

Background: Viruses have been considered potential triggers for the development of diabetes. This study assessed insulin secretion and insulin sensitivity in human herpesvirus 8 (HHV8)-infected and uninfected sub-Saharan African people with diabetes.

Methods: In all, 173 people with non-autoimmune diabetes were enrolled consecutively: 124 with type 2 diabetes mellitus (T2DM) and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycemic crisis. Those with KPD were further subdivided into those with new-onset ketotic-phase KPD (n = 34) or non-ketotic phase KPD (n = 15). All participants were screened for HHV8-specific antibodies and genomic DNA. Blood samples were collected for analysis of fasting glucose, HbA1c, lipid profile, and C-peptide, with insulin resistance and secretion estimated by homeostasis model assessment.

Results: Among the 173 diabetic participants, 88 (50.9%) were positive for HHV8 antibodies (Ac-HHV8+), including 15 (8.7%) positive for HHV8 DNA (DNA-HHV8+). The seroprevalence of HHV8 was similar between T2DM (55.6%) and KPD (61.2%) subjects. Of those with and without ketotic-phase KPD, 35.3% and 46.7% were Ac-HHV8+, respectively. Body mass index was significantly in lower DNA-HHV8+ than DNA-HHV8- subjects. Low-density lipoprotein and total cholesterol were significantly higher, but C-peptide and homeostatic model assessment of β-cell function (HOMA-β) were significantly lower in DNA-HHV8+ than DNA-HHV8- participants. After excluding DNA-HHV8+ participants, triglyceride concentrations were significantly higher in Ac-HHV8+ (n = 73) than Ac-HHV8- (n = 85) subjects. In contrast, HOMA-β was significantly higher among Ac-HHV8+ than Ac-HHV8- participants.

Conclusions: In the present study, HHV8 DNA positivity was associated with low insulin secretion in this sub-Saharan African diabetes population.
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http://dx.doi.org/10.1111/1753-0407.12777DOI Listing
November 2018

Health Effects of Overweight and Obesity in 195 Countries over 25 Years.

Authors:
Ashkan Afshin Mohammad H Forouzanfar Marissa B Reitsma Patrick Sur Kara Estep Alex Lee Laurie Marczak Ali H Mokdad Maziar Moradi-Lakeh Mohsen Naghavi Joseph S Salama Theo Vos Kalkidan H Abate Cristiana Abbafati Muktar B Ahmed Ziyad Al-Aly Ala’a Alkerwi Rajaa Al-Raddadi Azmeraw T Amare Alemayehu Amberbir Adeladza K Amegah Erfan Amini Stephen M Amrock Ranjit M Anjana Johan Ärnlöv Hamid Asayesh Amitava Banerjee Aleksandra Barac Estifanos Baye Derrick A Bennett Addisu S Beyene Sibhatu Biadgilign Stan Biryukov Espen Bjertness Dube J Boneya Ismael Campos-Nonato Juan J Carrero Pedro Cecilio Kelly Cercy Liliana G Ciobanu Leslie Cornaby Solomon A Damtew Lalit Dandona Rakhi Dandona Samath D Dharmaratne Bruce B Duncan Babak Eshrati Alireza Esteghamati Valery L Feigin João C Fernandes Thomas Fürst Tsegaye T Gebrehiwot Audra Gold Philimon N Gona Atsushi Goto Tesfa D Habtewold Kokeb T Hadush Nima Hafezi-Nejad Simon I Hay Masako Horino Farhad Islami Ritul Kamal Amir Kasaeian Srinivasa V Katikireddi Andre P Kengne Chandrasekharan N Kesavachandran Yousef S Khader Young-Ho Khang Jagdish Khubchandani Daniel Kim Yun J Kim Yohannes Kinfu Soewarta Kosen Tiffany Ku Barthelemy Kuate Defo G Anil Kumar Heidi J Larson Mall Leinsalu Xiaofeng Liang Stephen S Lim Patrick Liu Alan D Lopez Rafael Lozano Azeem Majeed Reza Malekzadeh Deborah C Malta Mohsen Mazidi Colm McAlinden Stephen T McGarvey Desalegn T Mengistu George A Mensah Gert B M Mensink Haftay B Mezgebe Erkin M Mirrakhimov Ulrich O Mueller Jean J Noubiap Carla M Obermeyer Felix A Ogbo Mayowa O Owolabi George C Patton Farshad Pourmalek Mostafa Qorbani Anwar Rafay Rajesh K Rai Chhabi L Ranabhat Nikolas Reinig Saeid Safiri Joshua A Salomon Juan R Sanabria Itamar S Santos Benn Sartorius Monika Sawhney Josef Schmidhuber Aletta E Schutte Maria I Schmidt Sadaf G Sepanlou Moretza Shamsizadeh Sara Sheikhbahaei Min-Jeong Shin Rahman Shiri Ivy Shiue Hirbo S Roba Diego A S Silva Jonathan I Silverberg Jasvinder A Singh Saverio Stranges Soumya Swaminathan Rafael Tabarés-Seisdedos Fentaw Tadese Bemnet A Tedla Balewgizie S Tegegne Abdullah S Terkawi J S Thakur Marcello Tonelli Roman Topor-Madry Stefanos Tyrovolas Kingsley N Ukwaja Olalekan A Uthman Masoud Vaezghasemi Tommi Vasankari Vasiliy V Vlassov Stein E Vollset Elisabete Weiderpass Andrea Werdecker Joshua Wesana Ronny Westerman Yuichiro Yano Naohiro Yonemoto Gerald Yonga Zoubida Zaidi Zerihun M Zenebe Ben Zipkin Christopher J L Murray

N Engl J Med 2017 07 12;377(1):13-27. Epub 2017 Jun 12.

Background: Although the rising pandemic of obesity has received major attention in many countries, the effects of this attention on trends and the disease burden of obesity remain uncertain.

Methods: We analyzed data from 68.5 million persons to assess the trends in the prevalence of overweight and obesity among children and adults between 1980 and 2015. Using the Global Burden of Disease study data and methods, we also quantified the burden of disease related to high body-mass index (BMI), according to age, sex, cause, and BMI in 195 countries between 1990 and 2015.

Results: In 2015, a total of 107.7 million children and 603.7 million adults were obese. Since 1980, the prevalence of obesity has doubled in more than 70 countries and has continuously increased in most other countries. Although the prevalence of obesity among children has been lower than that among adults, the rate of increase in childhood obesity in many countries has been greater than the rate of increase in adult obesity. High BMI accounted for 4.0 million deaths globally, nearly 40% of which occurred in persons who were not obese. More than two thirds of deaths related to high BMI were due to cardiovascular disease. The disease burden related to high BMI has increased since 1990; however, the rate of this increase has been attenuated owing to decreases in underlying rates of death from cardiovascular disease.

Conclusions: The rapid increase in the prevalence and disease burden of elevated BMI highlights the need for continued focus on surveillance of BMI and identification, implementation, and evaluation of evidence-based interventions to address this problem. (Funded by the Bill and Melinda Gates Foundation.).
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http://dx.doi.org/10.1056/NEJMoa1614362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477817PMC
July 2017

Barriers to the implementation of mobile phone reminders in pediatric HIV care: a pre-trial analysis of the Cameroonian MORE CARE study.

BMC Health Serv Res 2014 Oct 26;14:523. Epub 2014 Oct 26.

Background: Mobile health (mhealth) has emerged as a powerful resource in the medical armamentarium against human immunodeficiency virus (HIV) infection. We sought to determine among adult caregivers of HIV-exposed/infected children; the extent of mobile phone ownership, the ability to communicate in Cameroon's national official languages (NOL), and the refusal to receive such reminders.

Methods: We conducted a pre-trial analysis of potentials participants of the MORE CARE trial. MORE CARE took place from January through March 2013 in three geographic locations in Cameroon. We included caregivers aged 18 years or older. Written communication was assessed by the ability to read and understand information presented in the consent form. Verbal communication was assessed during a two-way conversation and in a discussion about HIV infection. A question about mobile phone ownership and another about refusal to receive reminders via mobile phone were phrased to allow "Yes" or "No" as the only possible reply. A p <0.05 was considered statistically significant.

Results: We enrolled 301 caregivers of HIV-exposed/infected children from rural (n = 119), semi-urban (n = 142) and urban (n = 40) areas of Cameroon. The mean caregiver age was 42.9 years (SD 13.4) and 85% were women. A fifth of our study population overall had at least one of the three obstacles to mobile phone reminders. By region, 39.5% in rural, 6.3% in semi-urban, and 7.5% in urban setting had at least one obstacle, with significant differences between the rural and urban settings (p<0.001) and the rural and semi-urban settings (p<0.001). The acceptability of SMS was 96.3% and of mobile phone calls 96% (p = 0.054). The ability to communicate in NOL orally was 89.7% and 84.4% in writing (p = 0.052). Mobile phone ownership (p<0.001; p = 0.03) and the ability to communicate in an NOL orally (p<0.001; p = 0.002) or in writing (both p<0.001), were significantly lower in rural compared to semi-urban and urban settings respectively.

Conclusions: The use of mHealth was limited in about one fifth of our population. The greatest obstacle was the inability to use oral or written NOL, followed by non-ownership of a mobile phone. These impediments were higher in a rural setting as compared to urban or semi-urban areas.
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http://dx.doi.org/10.1186/s12913-014-0523-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220055PMC
October 2014