Publications by authors named "Jean D Beggs"

50Publications

Revisiting the window of opportunity for cotranscriptional splicing in budding yeast.

RNA 2020 09 21;26(9):1081-1085. Epub 2020 May 21.

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom.

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September 2020

Blocking late stages of splicing quickly limits pre-spliceosome assembly in vivo.

RNA Biol 2019 12 4;16(12):1775-1784. Epub 2019 Sep 4.

Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

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December 2019

Extremely Rapid and Specific Metabolic Labelling of RNA In Vivo with 4-Thiouracil (Ers4tU).

J Vis Exp 2019 08 22(150). Epub 2019 Aug 22.

Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh.

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August 2019

Tuning Degradation to Achieve Specific and Efficient Protein Depletion.

J Vis Exp 2019 07 20(149). Epub 2019 Jul 20.

Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh.

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July 2019

Spt5 modulates cotranscriptional spliceosome assembly in .

RNA 2019 10 9;25(10):1298-1310. Epub 2019 Jul 9.

Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom.

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October 2019

Mutagenesis of Snu114 domain IV identifies a developmental role in meiotic splicing.

RNA Biol 2019 02 23;16(2):185-195. Epub 2019 Jan 23.

a Wellcome Centre for Cell Biology , University of Edinburgh , Edinburgh , UK.

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February 2019

A fast and tuneable auxin-inducible degron for depletion of target proteins in budding yeast.

Yeast 2019 01 12;36(1):75-81. Epub 2018 Nov 12.

Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

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January 2019

A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA.

Cell Rep 2018 08;24(9):2457-2467.e7

Department of Molecular Biology and Genetics, Aarhus University, C. F. Møllers Allé 3, Building 1130, 8000 Aarhus C, Denmark. Electronic address:

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August 2018

Transcription rate strongly affects splicing fidelity and cotranscriptionality in budding yeast.

Genome Res 2018 02 18;28(2):203-213. Epub 2017 Dec 18.

Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom.

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February 2018

Extremely fast and incredibly close: cotranscriptional splicing in budding yeast.

RNA 2017 05 2;23(5):601-610. Epub 2017 Feb 2.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, EH9 3BF, United Kingdom.

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May 2017

Transcriptome-wide RNA processing kinetics revealed using extremely short 4tU labeling.

Genome Biol 2015 Dec 17;16:282. Epub 2015 Dec 17.

Centre for Synthetic and Systems Biology (SynthSys), University of Edinburgh, Edinburgh, EH9 3BF, UK.

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December 2015

Cwc21p promotes the second step conformation of the spliceosome and modulates 3' splice site selection.

Nucleic Acids Res 2015 Mar 3;43(6):3309-17. Epub 2015 Mar 3.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh, EH9 3BF, UK

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March 2015

Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase.

Nucleic Acids Res 2014 Dec 26;42(22):13897-910. Epub 2014 Nov 26.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh, EH9 3BF, UK

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December 2014

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation.

Mol Cell 2014 Mar 20;53(5):779-90. Epub 2014 Feb 20.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK. Electronic address:

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March 2014

A rule-based kinetic model of RNA polymerase II C-terminal domain phosphorylation.

J R Soc Interface 2013 Sep 26;10(86):20130438. Epub 2013 Jun 26.

MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh EH4 2XU, UK.

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September 2013

Structural basis for dual roles of Aar2p in U5 snRNP assembly.

Genes Dev 2013 Mar 26;27(5):525-40. Epub 2013 Feb 26.

Fachbereich Biologie/Chemie/Pharmazie, Abteilung Strukturbiochemie, Freie Universität Berlin, D-14195 Berlin, Germany.

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March 2013

RNA helicases in splicing.

RNA Biol 2013 Jan 10;10(1):83-95. Epub 2012 Dec 10.

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.

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January 2013

Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning.

Genes Dev 2012 Nov;26(21):2408-21

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom.

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November 2012