Je-Wook Yu

Je-Wook Yu

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Je-Wook Yu

Je-Wook Yu

Publications by authors named "Je-Wook Yu"

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ATP-P2X7-Induced Inflammasome Activation Contributes to Melanocyte Death and CD8 T-Cell Trafficking to the Skin in Vitiligo.

J Invest Dermatol 2020 Feb 6. Epub 2020 Feb 6.

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.12.035DOI Listing
February 2020

Non-invasive in vivo imaging of caspase-1 activation enables rapid and spatiotemporal detection of acute and chronic inflammatory disorders.

Biomaterials 2020 Jan 11;226:119543. Epub 2019 Oct 11.

KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea; Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; KIST-DFCI On-Site-Lab, Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2019.119543DOI Listing
January 2020

Zika Virus Impairs Host NLRP3-mediated Inflammasome Activation in an NS3-dependent Manner.

Immune Netw 2019 Dec 23;19(6):e40. Epub 2019 Dec 23.

Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.

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http://dx.doi.org/10.4110/in.2019.19.e40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943171PMC
December 2019

Proteomics-based functional studies reveal that galectin-3 plays a protective role in the pathogenesis of intestinal Behçet's disease.

Sci Rep 2019 08 12;9(1):11716. Epub 2019 Aug 12.

Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1038/s41598-019-48291-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691011PMC
August 2019

Chemotherapeutic Agent Paclitaxel Mediates Priming of NLRP3 Inflammasome Activation.

Front Immunol 2019 16;10:1108. Epub 2019 May 16.

Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.3389/fimmu.2019.01108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532018PMC
May 2019

Brefeldin A-sensitive ER-Golgi vesicle trafficking contributes to NLRP3-dependent caspase-1 activation.

FASEB J 2019 03 28;33(3):4547-4558. Epub 2018 Dec 28.

Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 Program for Leading Universities and Students (PLUS) Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea; and.

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https://www.fasebj.org/doi/10.1096/fj.201801585R
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http://dx.doi.org/10.1096/fj.201801585RDOI Listing
March 2019

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration.

Cell Death Differ 2019 01 21;26(2):213-228. Epub 2018 May 21.

Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.

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http://www.nature.com/articles/s41418-018-0124-5
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http://dx.doi.org/10.1038/s41418-018-0124-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329843PMC
January 2019

Prolonged Exposure to Lipopolysaccharide Induces NLRP3-Independent Maturation and Secretion of Interleukin (IL)-1β in Macrophages.

J Microbiol Biotechnol 2018 Jan;28(1):115-121

Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

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http://dx.doi.org/10.4014/jmb.1709.09017DOI Listing
January 2018

Advanced glycation end products impair NLRP3 inflammasome-mediated innate immune responses in macrophages.

J Biol Chem 2017 12 19;292(50):20437-20448. Epub 2017 Oct 19.

From the Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science,

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http://dx.doi.org/10.1074/jbc.M117.806307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733583PMC
December 2017

NLRP3 Inflammasome Contributes to Lipopolysaccharide-induced Depressive-Like Behaviors via Indoleamine 2,3-dioxygenase Induction.

Int J Neuropsychopharmacol 2017 11;20(11):896-906

Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea; Doping Control Center, Korea Institute of Science and Technology, Seoul, Republic of Korea; Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.

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http://dx.doi.org/10.1093/ijnp/pyx065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737528PMC
November 2017

Bacterial Secretant from Dampens Inflammasome Activation in a Quorum Sensing-Dependent Manner.

Front Immunol 2017 27;8:333. Epub 2017 Mar 27.

Department of Microbiology and Immunology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine , Seoul , South Korea.

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http://dx.doi.org/10.3389/fimmu.2017.00333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366846PMC
March 2017

Immunomodulatory/anti-inflammatory effect of ZOE-based dental materials.

Dent Mater 2017 01 7;33(1):e1-e12. Epub 2016 Oct 7.

Department and Research Institute of Dental Biomaterials and Bioengineering, BK21 PLUS Project, College of Dentistry, Yonsei University, Seoul 03722, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.dental.2016.09.012DOI Listing
January 2017

Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance.

Arch Pharm Res 2016 Nov 7;39(11):1503-1518. Epub 2016 Sep 7.

Severance Biomedical Science Institute and Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.

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http://dx.doi.org/10.1007/s12272-016-0827-4DOI Listing
November 2016

25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome.

Nat Commun 2016 10 25;7:13129. Epub 2016 Oct 25.

Department of Physiology and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.

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http://dx.doi.org/10.1038/ncomms13129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093305PMC
October 2016

Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.

Proc Natl Acad Sci U S A 2016 Feb 25;113(6):E762-71. Epub 2016 Jan 25.

Laboratory of Host Defenses, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea;

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http://dx.doi.org/10.1073/pnas.1518589113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760794PMC
February 2016

Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation.

J Biol Chem 2015 Nov 28;290(45):27425-37. Epub 2015 Sep 28.

From the Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea

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http://dx.doi.org/10.1074/jbc.M115.667063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646374PMC
November 2015

Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation.

Biochem Biophys Res Commun 2015 Nov 21;467(4):973-8. Epub 2015 Oct 21.

Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.10.033DOI Listing
November 2015

Defective mitochondrial fission augments NLRP3 inflammasome activation.

Sci Rep 2015 Oct 22;5:15489. Epub 2015 Oct 22.

Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea.

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http://dx.doi.org/10.1038/srep15489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614538PMC
October 2015

Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4.

Immunol Cell Biol 2015 Jul 20;93(6):591-9. Epub 2015 Jan 20.

Department of Microbiology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1038/icb.2014.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496256PMC
July 2015

The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity.

J Immunol 2013 Oct 18;191(8):4358-66. Epub 2013 Sep 18.

Department of Microbiology, Brain Korea 21 Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 120-752, Korea.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1301170
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http://dx.doi.org/10.4049/jimmunol.1301170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848201PMC
October 2013

Cobalt Chloride-induced Hypoxia Ameliorates NLRP3-Mediated Caspase-1 Activation in Mixed Glial Cultures.

Immune Netw 2013 Aug 26;13(4):141-7. Epub 2013 Aug 26.

Department of Microbiology, BK 21 project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul 120-752, Korea.

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http://dx.doi.org/10.4110/in.2013.13.4.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759711PMC
August 2013

Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome.

J Biol Chem 2013 Apr 11;288(16):11378-83. Epub 2013 Mar 11.

Department of Biochemistry and Molecular Biology and the Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M112.448795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630843PMC
April 2013

Salmonella Promotes ASC Oligomerization-dependent Caspase-1 Activation.

Immune Netw 2012 Dec 31;12(6):284-90. Epub 2012 Dec 31.

Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul 120-752, Korea. ; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, Korea.

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http://dx.doi.org/10.4110/in.2012.12.6.284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566424PMC
December 2012

TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation.

FEBS Lett 2011 Jul 27;585(14):2144-50. Epub 2011 May 27.

Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Republic of Korea.

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http://dx.doi.org/10.1016/j.febslet.2011.05.034DOI Listing
July 2011

CIIA is a novel regulator of detachment-induced cell death.

Cancer Res 2010 Aug;70(15):6352-8

Laboratory of Cell Death and Human Diseases, School of Life Sciences and Biotechnology, Korea University, Seoul, Korea.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-4394DOI Listing
August 2010

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.

Nature 2009 Mar 21;458(7237):509-13. Epub 2009 Jan 21.

Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1038/nature07710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862225PMC
March 2009

Comparison of the clinical outcomes of single- and double-row repairs in rotator cuff tears.

Am J Sports Med 2008 Jul 15;36(7):1310-6. Epub 2008 Apr 15.

Shoulder, Elbow and Sports Service, Department of Orthopaedic Surgery, Konkuk University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1177/0363546508315039DOI Listing
July 2008

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.

Mol Cell 2007 Oct;28(2):214-27

Department of Biochemistry and Molecular Biology, Center for Apoptosis Research, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719761PMC
October 2007

Delayed Post-traumatic Vertebral Collapse: MR Categorization and MR-Pathology Correlation.

Asian Spine J 2007 Jun 30;1(1):32-7. Epub 2007 Jun 30.

Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4184/asj.2007.1.1.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857500PMC
June 2007

Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism.

J Biol Chem 2004 Feb 9;279(9):7584-90. Epub 2003 Dec 9.

National Creative Research Initiative Center for Cell Death and School of Life Science and Biotechnology, Korea University, Seoul, 136-701, Korea.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M304183200
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http://dx.doi.org/10.1074/jbc.M304183200DOI Listing
February 2004