Jayne A Franklyn

Jayne A Franklyn

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Jayne A Franklyn

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Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis.

J Clin Endocrinol Metab 2016 11 7;101(11):4270-4282. Epub 2016 Sep 7.

Departments of Internal Medicine (R.P.P., L.C., M.M.) and Epidemiology (R.P.P., O.H.F., A.D., A.H., A.I., L.C., M.L.P.P.), Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands; Rotterdam Thyroid Center (R.P.P., L.C., M.M.) and Department of Radiology and Neurology (M.A.I.), Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (N.R., C.B., M.R.B.), Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Departments of Clinical Chemistry and Laboratory Medicine (W.P.J.d.E.), Public Health and Primary Care (J.G.), and Cardiology (W.J.), Leiden University Medical Center, 2300 RC Leiden, The Netherlands; Departments of Medicine and Epidemiology and Biostatistics (D.C.B.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology, Diabetes, and Metabolism (A.R.C.), Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104; Department of Epidemiology (A.H.), Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115; Department of Endocrinology (S.R.), Gateshead Health Foundation National Health Service Trust, Gateshead, SE18 4QH, United Kingdom; Department of Endocrinology and Diabetes (J.P.W.), Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia; Schools of Medicine and Pharmacology (J.P.W.) and Population Health (A.B.), University of Western Australia, Crawley, Western Australia 6009, Australia; National Council Research Institute of Clinical Physiology (G.I.), 56124 Pisa, Italy; Robertson Centre for Biostatistics (I.F.) and Institute of Cardiovascular and Medical Sciences (D.J.S.), Faculty of Medicine, University of Glasgow, Glasgow G12 8TA, United Kingdom; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Department of Internal Medicine (S.J.L.B., R.P.D.), University Medical Center, University of Groningen, 9700 AB Groningen, The Netherlands; Department of Medicine (C.W., C.D.), Division of Nephrology, University Hospital of Würzburg, and Comprehensive Heart Failure Centre (C.W., C.D.), 97070 Würzburg, Germany; Department of Clinical Studies (M.I.), Radiation Effects Research Foundation, Nagasaki 850-8555, Japan; Department of Clinical and Experimental Medicine (G.C.), University of Parma, 143100 Parma, Italy; National Institute on Aging (L.F.), Baltimore, Maryland 21225; Institute for Community Medicine (H.V.), Clinical-Epidemiological Research/Study of Health in Pomerania, University Medicine, German Centre of Cardiovascular Research, Partner Site, Department of Internal Medicine (M.D.), and University Medicine (M.D.), German Centre of Cardiovascular Research, Partner Site, 17487 Greifswald, Germany; Departments of Neurology and Epidemiology (W.T.L.), and Cardiovascular Health Research Unit (W.T.L.), Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington 98108; Group Health Research Institute (B.M.P.), Group Health Cooperative, Seattle, Washington 98101; Division of Endocrinology (R.M.B.M., J.A.S.), Department of Medicine, Federal University of Sao Paulo, 05508-900 São Paulo, Brazil; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Brazil; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; Interuniversity Cardiology Institute of The Netherlands (W.J.), 3508 GA Utrecht, The Netherlands; School of Clinical and Experimental Medicine (J.A.F.), College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom; and Department of Public Health and Center for Healthy Ageing (R.G.W.), Faculty of Health and Medical Sciences, University of Copenhagen, DK-2400 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2016-2255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095234PMC
November 2016

Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis.

J Clin Endocrinol Metab 2015 Jun 9;100(6):2181-91. Epub 2015 Apr 9.

Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di

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http://dx.doi.org/10.1210/jc.2015-1438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454799PMC
June 2015

Differences in the recurrence and mortality outcomes rates of incidental and nonincidental papillary thyroid microcarcinoma: a systematic review and meta-analysis of 21 329 person-years of follow-up.

J Clin Endocrinol Metab 2014 Aug 14;99(8):2834-43. Epub 2014 May 14.

Institute of Head and Neck Studies and Education, School of Cancer Sciences (H.M., T.A., N.C.), University of Birmingham, Birmingham B15 2TT, United Kingdom; Cancer Research Clinical Trials Unit, School of Cancer Sciences (B.C., E.M.), University of Birmingham, Birmingham B15 2TT, United Kingdom; University Hospitals Birmingham NHS Foundation Trust (J.W.), University of Birmingham, Birmingham B15 2TT, United Kingdom; and School of Clinical and Experimental Medicine (C.M., K.B., J.A.F.), University of Birmingham, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1210/jc.2013-2118DOI Listing
August 2014

Impact of month of birth on the development of autoimmune thyroid disease in the United Kingdom and Europe.

J Clin Endocrinol Metab 2014 Aug 19;99(8):E1459-65. Epub 2014 May 19.

Oxford Centre for Diabetes, Endocrinology, and Metabolism (A.H., J.A.H.W., S.C.L.G., M.J.S.), Department of Physiology, Anatomy, and Genetics (G.D., S.V.R.), and Oxford National Institute for Health Research Biomedical Research Centre (J.C.T.), Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7LE, United Kingdom; Centre for Endocrinology, Diabetes, and Metabolism (P.R.N., J.D.C.-S., J.A.F.), School of Clinical and Experimental Medicine, College of Medical and Dental Science, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom; Northern General Hospital (A.A.), Sheffield S5 7AU, United Kingdom; Royal Bournemouth Hospital (M.A.), Bournemouth BH7 7DW, United Kingdom; Department of Endocrinology and Metabolism (T.H.B., L.H.), Odense University Hospital, DK-5000 Odense, Denmark; Department of Medicine (K.C.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; School of Medicine (J.M.C.), University of Dundee, Dundee DD1 9SY, United Kingdom; Department of Medicine (P.J.H.), University of Otago, Dunedein 9016, New Zealand; Centre for Endocrine and Diabetes Sciences (J.H.L.), Cardiff University, Cardiff C14 4XN, United Kingdom; Institute of Genetic Medicine (S.H.P.), Newcastle University, Newcastle-upon-Tyne NE1 3BZ, Newcastle, United Kingdom; Kolling Institute (B.G.R.), Royal North Shore Hospital and The University of Sydney, Sydney NSW 2006, Australia; Royal Devon and Exeter Hospital (B.V.), Exeter EX2 5DW, United Kingdom; Department of Endocrinology and Metabolism (W.M.W.), University of Amsterdam, 1100 DE Amsterdam, The Netherlands; Department of Human Metabolism (A.P.W.), University of Sheffield, Sheffield S10 2RX, United Kingdom; and Oxford National Institute for Health Research Biomedical Research Centre (S.C.L.G.), Churchill Hospital, Oxford OX3 7LE, United Kingdom.

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http://dx.doi.org/10.1210/jc.2014-1270DOI Listing
August 2014

The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells.

Endocrinology 2014 Apr 7;155(4):1222-34. Epub 2014 Feb 7.

School of Clinical and Experimental Medicine (M.L.R., R.I.S., J.C.W.F., B.M., G.A.R., R.J.W., V.E.S., P.K.K., N.S., O.M.D., K.B., J.A.F., C.J.M.) and School of Cancer Sciences (A.S.T.), University of Birmingham, Birmingham, United Kingdom; Department of Medical Sciences (T.G.), University of Ferrara, Ferrara, Italy; Department of Pediatrics (A.L.S.), University of British Columbia, Vancouver, British Columbia, Canada; and University Hospitals Birmingham National Health Service Foundation Trust (J.C.W.), Birmingham, United Kingdom.

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http://dx.doi.org/10.1210/en.2013-1646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759943PMC
April 2014

MCT8 expression in human fetal cerebral cortex is reduced in severe intrauterine growth restriction.

J Endocrinol 2014 Feb 8;220(2):85-95. Epub 2014 Jan 8.

School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK Department of Pathology Fetal Medicine Centre, Birmingham Women's NHS Foundation Trust, Edgbaston, Birmingham B15 2TG, UK.

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http://dx.doi.org/10.1530/JOE-13-0400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921694PMC
February 2014

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.

Authors:
Marco Medici Eleonora Porcu Giorgio Pistis Alexander Teumer Suzanne J Brown Richard A Jensen Rajesh Rawal Greet L Roef Theo S Plantinga Sita H Vermeulen Jari Lahti Matthew J Simmonds Lise Lotte N Husemoen Rachel M Freathy Beverley M Shields Diana Pietzner Rebecca Nagy Linda Broer Layal Chaker Tim I M Korevaar Maria Grazia Plia Cinzia Sala Uwe Völker J Brent Richards Fred C Sweep Christian Gieger Tanguy Corre Eero Kajantie Betina Thuesen Youri E Taes W Edward Visser Andrew T Hattersley Jürgen Kratzsch Alexander Hamilton Wei Li Georg Homuth Monia Lobina Stefano Mariotti Nicole Soranzo Massimiliano Cocca Matthias Nauck Christin Spielhagen Alec Ross Alice Arnold Martijn van de Bunt Sandya Liyanarachchi Margit Heier Hans Jörgen Grabe Corrado Masciullo Tessel E Galesloot Ee M Lim Eva Reischl Peter J Leedman Sandra Lai Alessandro Delitala Alexandra P Bremner David I W Philips John P Beilby Antonella Mulas Matteo Vocale Goncalo Abecasis Tom Forsen Alan James Elisabeth Widen Jennie Hui Holger Prokisch Ernst E Rietzschel Aarno Palotie Peter Feddema Stephen J Fletcher Katharina Schramm Jerome I Rotter Alexander Kluttig Dörte Radke Michela Traglia Gabriela L Surdulescu Huiling He Jayne A Franklyn Daniel Tiller Bijay Vaidya Tim de Meyer Torben Jørgensen Johan G Eriksson Peter C O'Leary Eric Wichmann Ad R Hermus Bruce M Psaty Till Ittermann Albert Hofman Emanuele Bosi David Schlessinger Henri Wallaschofski Nicola Pirastu Yurii S Aulchenko Albert de la Chapelle Romana T Netea-Maier Stephen C L Gough Henriette Meyer Zu Schwabedissen Timothy M Frayling Jean-Marc Kaufman Allan Linneberg Katri Räikkönen Johannes W A Smit Lambertus A Kiemeney Fernando Rivadeneira André G Uitterlinden John P Walsh Christa Meisinger Martin den Heijer Theo J Visser Timothy D Spector Scott G Wilson Henry Völzke Anne Cappola Daniela Toniolo Serena Sanna Silvia Naitza Robin P Peeters

PLoS Genet 2014 Feb 27;10(2):e1004123. Epub 2014 Feb 27.

Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://repub.eur.nl/pub/65428/REPUB_65428_OA.pdf
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http://dx.plos.org/10.1371/journal.pgen.1004123
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http://dx.doi.org/10.1371/journal.pgen.1004123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937134PMC
February 2014

Patient information in Graves' disease and thyroid-associated ophthalmopathy: readability assessment of online resources.

Thyroid 2014 Jan 29;24(1):67-72. Epub 2013 Oct 29.

1 Academic Unit of Ophthalmology, College of Medical and Dental Sciences, University of Birmingham , Birmingham, United Kingdom .

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http://dx.doi.org/10.1089/thy.2013.0252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887410PMC
January 2014

Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis.

J Clin Endocrinol Metab 2014 Jan 20;99(1):E127-31. Epub 2013 Dec 20.

Oxford Centre for Diabetes, Endocrinology, and Metabolism (M.J.S., F.K.K., O.J.B., S.C.L.G.) and Oxford National Institute for Health Research Biomedical Research Centre (F.K.K., S.C.L.G.), Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom; and Centre for Endocrinology, Diabetes, and Metabolism (P.R.N., L.E.J., C.E.H., J.A.F.), School of Clinical and Experimental Medicine, College of Medical and Dental Science, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1210/jc.2013-2667DOI Listing
January 2014

Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells.

Endocrinology 2013 Nov 18;154(11):4408-22. Epub 2013 Jul 18.

FRCP, PhD, Senior Clinical Lecturer and Honorary Consultant Physician, Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TH, United Kingdom.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2012-2156DOI Listing
November 2013

Subclinical thyroid disease: where is the evidence?

Lancet Diabetes Endocrinol 2013 Nov 23;1(3):172-3. Epub 2013 May 23.

Centre for Diabetes, Endocrinology and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1016/S2213-8587(13)70030-5DOI Listing
November 2013

Comparison of mortality in hyperthyroidism during periods of treatment with thionamides and after radioiodine.

J Clin Endocrinol Metab 2013 May 29;98(5):1869-82. Epub 2013 Mar 29.

Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-3459DOI Listing
May 2013

Childhood weight gain and thyroid autoimmunity at age 60-64 years: the 1946 British birth cohort study.

J Clin Endocrinol Metab 2013 Apr 22;98(4):1435-42. Epub 2013 Feb 22.

Medical Research Council Unit for Lifelong Health and Ageing, London, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-3761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651609PMC
April 2013

A comparative quality assessment of evidence-based clinical guidelines in endocrinology.

Clin Endocrinol (Oxf) 2013 Feb;78(2):183-90

The Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.

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http://doi.wiley.com/10.1111/j.1365-2265.2012.04441.x
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http://dx.doi.org/10.1111/j.1365-2265.2012.04441.xDOI Listing
February 2013

The thyroid--too much and too little across the ages. The consequences of subclinical thyroid dysfunction.

Authors:
Jayne A Franklyn

Clin Endocrinol (Oxf) 2013 Jan;78(1):1-8

School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1111/cen.12011DOI Listing
January 2013

Seven newly identified loci for autoimmune thyroid disease.

Hum Mol Genet 2012 Dec 24;21(23):5202-8. Epub 2012 Aug 24.

Department of Medical Genetics, Cambridge Institute for Medical Research, Juvenile Diabetes Research Foundation/ Wellcome Trust Diabetes and Inflammation Laboratory, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK.

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http://dx.doi.org/10.1093/hmg/dds357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490518PMC
December 2012

The relationship between serum TSH and free T4 in older people.

J Clin Pathol 2012 May 28;65(5):463-5. Epub 2012 Jan 28.

The Regional Endocrine Laboratories, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

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http://jcp.bmj.com/content/early/2012/01/27/jclinpath-2011-2
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http://www.thyroid.org/wp-content/uploads/publications/clint
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http://jcp.bmj.com/cgi/doi/10.1136/jclinpath-2011-200433
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http://dx.doi.org/10.1136/jclinpath-2011-200433DOI Listing
May 2012

Thyrotoxicosis.

Lancet 2012 Mar 5;379(9821):1155-66. Epub 2012 Mar 5.

Centre for Diabetes, Endocrinology and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1016/S0140-6736(11)60782-4DOI Listing
March 2012

Expression and function of the novel proto-oncogene PBF in thyroid cancer: a new target for augmenting radioiodine uptake.

J Endocrinol 2011 Aug 30;210(2):157-63. Epub 2011 Mar 30.

School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK.

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http://dx.doi.org/10.1530/JOE-11-0064DOI Listing
August 2011

Iodine status of UK schoolgirls: a cross-sectional survey.

Lancet 2011 Jun 2;377(9782):2007-12. Epub 2011 Jun 2.

Department of Endocrinology, Royal Free Hampstead NHS Trust, London, UK.

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http://dx.doi.org/10.1016/S0140-6736(11)60693-4DOI Listing
June 2011

Pituitary tumor-transforming gene and its binding factor in endocrine cancer.

Expert Rev Mol Med 2010 Dec 3;12:e38. Epub 2010 Dec 3.

School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, UK.

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http://dx.doi.org/10.1017/S1462399410001699DOI Listing
December 2010

Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3.

Clin Endocrinol (Oxf) 2010 Nov;73(5):654-60

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2265.2010.03843.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299549PMC
November 2010

Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study.

Eur J Hum Genet 2010 Sep 5;18(9):1021-6. Epub 2010 May 5.

Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, West Midlands, UK.

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http://dx.doi.org/10.1038/ejhg.2010.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987410PMC
September 2010

Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression.

Clin Endocrinol (Oxf) 2010 Jul 10;73(1):119-25. Epub 2010 Feb 10.

Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.1111/j.1365-2265.2010.03780.xDOI Listing
July 2010

Pituitary tumor transforming gene binding factor: a new gene in breast cancer.

Cancer Res 2010 May 20;70(9):3739-49. Epub 2010 Apr 20.

School of Clinical and Experimental Medicine, Centre for Liver Research, Institute of Biomedical Research, and Cancer Research UK Clinical Trials Unit, School of Cancer Sciences, University of Birmingham, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875163PMC
May 2010

Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease.

Thyroid 2010 Apr;20(4):413-7

Institute of Biomedical Research, University of Birmingham , Edgbaston, Birmingham, UK .

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http://dx.doi.org/10.1089/thy.2009.0375DOI Listing
April 2010

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

Authors:
Nick Craddock Matthew E Hurles Niall Cardin Richard D Pearson Vincent Plagnol Samuel Robson Damjan Vukcevic Chris Barnes Donald F Conrad Eleni Giannoulatou Chris Holmes Jonathan L Marchini Kathy Stirrups Martin D Tobin Louise V Wain Chris Yau Jan Aerts Tariq Ahmad T Daniel Andrews Hazel Arbury Anthony Attwood Adam Auton Stephen G Ball Anthony J Balmforth Jeffrey C Barrett Inês Barroso Anne Barton Amanda J Bennett Sanjeev Bhaskar Katarzyna Blaszczyk John Bowes Oliver J Brand Peter S Braund Francesca Bredin Gerome Breen Morris J Brown Ian N Bruce Jaswinder Bull Oliver S Burren John Burton Jake Byrnes Sian Caesar Chris M Clee Alison J Coffey John M C Connell Jason D Cooper Anna F Dominiczak Kate Downes Hazel E Drummond Darshna Dudakia Andrew Dunham Bernadette Ebbs Diana Eccles Sarah Edkins Cathryn Edwards Anna Elliot Paul Emery David M Evans Gareth Evans Steve Eyre Anne Farmer I Nicol Ferrier Lars Feuk Tomas Fitzgerald Edward Flynn Alistair Forbes Liz Forty Jayne A Franklyn Rachel M Freathy Polly Gibbs Paul Gilbert Omer Gokumen Katherine Gordon-Smith Emma Gray Elaine Green Chris J Groves Detelina Grozeva Rhian Gwilliam Anita Hall Naomi Hammond Matt Hardy Pile Harrison Neelam Hassanali Husam Hebaishi Sarah Hines Anne Hinks Graham A Hitman Lynne Hocking Eleanor Howard Philip Howard Joanna M M Howson Debbie Hughes Sarah Hunt John D Isaacs Mahim Jain Derek P Jewell Toby Johnson Jennifer D Jolley Ian R Jones Lisa A Jones George Kirov Cordelia F Langford Hana Lango-Allen G Mark Lathrop James Lee Kate L Lee Charlie Lees Kevin Lewis Cecilia M Lindgren Meeta Maisuria-Armer Julian Maller John Mansfield Paul Martin Dunecan C O Massey Wendy L McArdle Peter McGuffin Kirsten E McLay Alex Mentzer Michael L Mimmack Ann E Morgan Andrew P Morris Craig Mowat Simon Myers William Newman Elaine R Nimmo Michael C O'Donovan Abiodun Onipinla Ifejinelo Onyiah Nigel R Ovington Michael J Owen Kimmo Palin Kirstie Parnell David Pernet John R B Perry Anne Phillips Dalila Pinto Natalie J Prescott Inga Prokopenko Michael A Quail Suzanne Rafelt Nigel W Rayner Richard Redon David M Reid Renwick Susan M Ring Neil Robertson Ellie Russell David St Clair Jennifer G Sambrook Jeremy D Sanderson Helen Schuilenburg Carol E Scott Richard Scott Sheila Seal Sue Shaw-Hawkins Beverley M Shields Matthew J Simmonds Debbie J Smyth Elilan Somaskantharajah Katarina Spanova Sophia Steer Jonathan Stephens Helen E Stevens Millicent A Stone Zhan Su Deborah P M Symmons John R Thompson Wendy Thomson Mary E Travers Clare Turnbull Armand Valsesia Mark Walker Neil M Walker Chris Wallace Margaret Warren-Perry Nicholas A Watkins John Webster Michael N Weedon Anthony G Wilson Matthew Woodburn B Paul Wordsworth Allan H Young Eleftheria Zeggini Nigel P Carter Timothy M Frayling Charles Lee Gil McVean Patricia B Munroe Aarno Palotie Stephen J Sawcer Stephen W Scherer David P Strachan Chris Tyler-Smith Matthew A Brown Paul R Burton Mark J Caulfield Alastair Compston Martin Farrall Stephen C L Gough Alistair S Hall Andrew T Hattersley Adrian V S Hill Christopher G Mathew Marcus Pembrey Jack Satsangi Michael R Stratton Jane Worthington Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem Ouwehand Miles Parkes Nazneen Rahman John A Todd Nilesh J Samani Peter Donnelly

Nature 2010 Apr;464(7289):713-20

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http://dx.doi.org/10.1038/nature08979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892339PMC
April 2010

The effects of acute triiodothyronine therapy on myocardial gene expression in brain stem dead cardiac donors.

J Clin Endocrinol Metab 2010 Mar 15;95(3):1338-43. Epub 2010 Jan 15.

Department of Cardiothoracic Surgery, University Hospitals Birmingham, National Health Service Foundation Trust, Edgbaston, Birmingham B15 2TH, United Kingdom.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2009-1659DOI Listing
March 2010

Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease.

Am J Med 2010 Feb;123(2):183.e1-9

School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1016/j.amjmed.2009.06.030DOI Listing
February 2010

What is the role of radioiodine uptake measurement and thyroid scintigraphy in the diagnosis and management of hyperthyroidism?

Authors:
Jayne A Franklyn

Clin Endocrinol (Oxf) 2010 Jan 16;72(1):11-2. Epub 2009 May 16.

School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1111/j.1365-2265.2009.03633.xDOI Listing
January 2010

Thyroid gland: Antithyroid therapy--best choice of drug and dose.

Authors:
Jayne A Franklyn

Nat Rev Endocrinol 2009 Nov;5(11):592-4

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http://dx.doi.org/10.1038/nrendo.2009.201DOI Listing
November 2009

A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer.

J Cell Sci 2009 Sep 25;122(Pt 18):3393-402. Epub 2009 Aug 25.

School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham B15 2TH, UK.

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http://dx.doi.org/10.1242/jcs.045427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736868PMC
September 2009

Should we treat subclinical hyperthyroidism?

Authors:
Jayne A Franklyn

Nat Clin Pract Endocrinol Metab 2008 Oct 29;4(10):550-1. Epub 2008 Jul 29.

Institute ofBiomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.1038/ncpendmet0917DOI Listing
October 2008

Is radioiodine good for hyperthyroidism?

Authors:
Jayne A Franklyn

Nat Clin Pract Endocrinol Metab 2008 Feb;4(2):59

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http://dx.doi.org/10.1038/ncpendmet0728DOI Listing
February 2008

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Authors:
Paul R Burton David G Clayton Lon R Cardon Nick Craddock Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem H Ouwehand Nilesh J Samani John A Todd Peter Donnelly Jeffrey C Barrett Dan Davison Doug Easton David M Evans Hin-Tak Leung Jonathan L Marchini Andrew P Morris Chris C A Spencer Martin D Tobin Antony P Attwood James P Boorman Barbara Cant Ursula Everson Judith M Hussey Jennifer D Jolley Alexandra S Knight Kerstin Koch Elizabeth Meech Sarah Nutland Christopher V Prowse Helen E Stevens Niall C Taylor Graham R Walters Neil M Walker Nicholas A Watkins Thilo Winzer Richard W Jones Wendy L McArdle Susan M Ring David P Strachan Marcus Pembrey Gerome Breen David St Clair Sian Caesar Katharine Gordon-Smith Lisa Jones Christine Fraser Elaine K Green Detelina Grozeva Marian L Hamshere Peter A Holmans Ian R Jones George Kirov Valentina Moskivina Ivan Nikolov Michael C O'Donovan Michael J Owen David A Collier Amanda Elkin Anne Farmer Richard Williamson Peter McGuffin Allan H Young I Nicol Ferrier Stephen G Ball Anthony J Balmforth Jennifer H Barrett Timothy D Bishop Mark M Iles Azhar Maqbool Nadira Yuldasheva Alistair S Hall Peter S Braund Richard J Dixon Massimo Mangino Suzanne Stevens John R Thompson Francesca Bredin Mark Tremelling Miles Parkes Hazel Drummond Charles W Lees Elaine R Nimmo Jack Satsangi Sheila A Fisher Alastair Forbes Cathryn M Lewis Clive M Onnie Natalie J Prescott Jeremy Sanderson Christopher G Matthew Jamie Barbour M Khalid Mohiuddin Catherine E Todhunter John C Mansfield Tariq Ahmad Fraser R Cummings Derek P Jewell John Webster Morris J Brown Mark G Lathrop John Connell Anna Dominiczak Carolina A Braga Marcano Beverley Burke Richard Dobson Johannie Gungadoo Kate L Lee Patricia B Munroe Stephen J Newhouse Abiodun Onipinla Chris Wallace Mingzhan Xue Mark Caulfield Martin Farrall Anne Barton Ian N Bruce Hannah Donovan Steve Eyre Paul D Gilbert Samantha L Hilder Anne M Hinks Sally L John Catherine Potter Alan J Silman Deborah P M Symmons Wendy Thomson Jane Worthington David B Dunger Barry Widmer Timothy M Frayling Rachel M Freathy Hana Lango John R B Perry Beverley M Shields Michael N Weedon Andrew T Hattersley Graham A Hitman Mark Walker Kate S Elliott Christopher J Groves Cecilia M Lindgren Nigel W Rayner Nicolas J Timpson Eleftheria Zeggini Melanie Newport Giorgio Sirugo Emily Lyons Fredrik Vannberg Adrian V S Hill Linda A Bradbury Claire Farrar Jennifer J Pointon Paul Wordsworth Matthew A Brown Jayne A Franklyn Joanne M Heward Matthew J Simmonds Stephen C L Gough Sheila Seal Michael R Stratton Nazneen Rahman Maria Ban An Goris Stephen J Sawcer Alastair Compston David Conway Muminatou Jallow Melanie Newport Giorgio Sirugo Kirk A Rockett Suzannah J Bumpstead Amy Chaney Kate Downes Mohammed J R Ghori Rhian Gwilliam Sarah E Hunt Michael Inouye Andrew Keniry Emma King Ralph McGinnis Simon Potter Rathi Ravindrarajah Pamela Whittaker Claire Widden David Withers Niall J Cardin Dan Davison Teresa Ferreira Joanne Pereira-Gale Ingeleif B Hallgrimsdo'ttir Bryan N Howie Zhan Su Yik Ying Teo Damjan Vukcevic David Bentley Matthew A Brown Alastair Compston Martin Farrall Alistair S Hall Andrew T Hattersley Adrian V S Hill Miles Parkes Marcus Pembrey Michael R Stratton Sarah L Mitchell Paul R Newby Oliver J Brand Jackie Carr-Smith Simon H S Pearce R McGinnis A Keniry P Deloukas John D Reveille Xiaodong Zhou Anne-Marie Sims Alison Dowling Jacqueline Taylor Tracy Doan John C Davis Laurie Savage Michael M Ward Thomas L Learch Michael H Weisman Mathew Brown

Nat Genet 2007 Nov 21;39(11):1329-37. Epub 2007 Oct 21.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/ng.2007.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680141PMC
November 2007

A novel and major association of HLA-C in Graves' disease that eclipses the classical HLA-DRB1 effect.

Hum Mol Genet 2007 Sep 27;16(18):2149-53. Epub 2007 Jun 27.

Division of Medical Sciences, University of Birmingham, UK.

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http://dx.doi.org/10.1093/hmg/ddm165DOI Listing
September 2007

Treatment of amiodarone-associated thyrotoxicosis.

Nat Clin Pract Endocrinol Metab 2007 Sep;3(9):662-6

Institute of Biomedical Research, The Medical School, University of Birmingham, UK.

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http://dx.doi.org/10.1038/ncpendmet0592DOI Listing
September 2007

Placental transport of thyroid hormone.

Best Pract Res Clin Endocrinol Metab 2007 Jun;21(2):253-64

Division of Reproductive and Child Health, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1016/j.beem.2007.03.001DOI Listing
June 2007

Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.

Clin Endocrinol (Oxf) 2007 Apr;66(4):508-12

Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1111/j.1365-2265.2007.02762.xDOI Listing
April 2007

Association of PTPN22 haplotypes with Graves' disease.

J Clin Endocrinol Metab 2007 Feb 5;92(2):685-90. Epub 2006 Dec 5.

Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

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http://dx.doi.org/10.1210/jc.2006-2064DOI Listing
February 2007

131I activity for remnant ablation in patients with differentiated thyroid cancer: A systematic review.

J Clin Endocrinol Metab 2007 Jan 10;92(1):28-38. Epub 2006 Oct 10.

Cancer Research UK & UCL Cancer Trials Centre, University College London, Stephenson House, 158-160 North Gower Street, London NW1 2ND, United Kingdom.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2006-1345DOI Listing
January 2007

Cardiovascular manifestations of hyperthyroidism before and after antithyroid therapy: a matched case-control study.

J Am Coll Cardiol 2007 Jan 13;49(1):71-81. Epub 2006 Dec 13.

Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham, England.

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http://dx.doi.org/10.1016/j.jacc.2006.08.042DOI Listing
January 2007

Prevalence of subclinical thyroid dysfunction and its relation to socioeconomic deprivation in the elderly: a community-based cross-sectional survey.

J Clin Endocrinol Metab 2006 Dec 26;91(12):4809-16. Epub 2006 Sep 26.

Department of Primary Care and General Practice, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.

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http://dx.doi.org/10.1210/jc.2006-1557DOI Listing
December 2006

Does impaired secretion of gastric acid reduce absorption of levothyroxine?

Authors:
Jayne A Franklyn

Nat Clin Pract Endocrinol Metab 2006 Oct;2(10):542-3

Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.

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http://dx.doi.org/10.1038/ncpendmet0297DOI Listing
October 2006

Detection and surgical treatment of cervical lymph nodes in differentiated thyroid cancer.

Thyroid 2006 Feb;16(2):187-94

Department of Otolaryngology-Head & Neck Surgery, Queen Elizabeth Hospital, University of Birmingham NHS Trust, UK.

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http://dx.doi.org/10.1089/thy.2006.16.187DOI Listing
February 2006

Maternal nutrient deprivation induces sex-specific changes in thyroid hormone receptor and deiodinase expression in the fetal guinea pig brain.

J Physiol 2005 Jul 5;566(Pt 2):467-80. Epub 2005 May 5.

Division of Reproductive and Child Health, University of Birmingham, Birmingham Women's Hospital, Edgbaston, Birmingham B15 2TG, UK.

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http://doi.wiley.com/10.1113/jphysiol.2005.084673
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464754PMC
July 2005

Pituitary tumor transforming gene binding factor: a novel transforming gene in thyroid tumorigenesis.

J Clin Endocrinol Metab 2005 Jul 10;90(7):4341-9. Epub 2005 May 10.

Division of Medical Sciences, University of Birmingham, Birmingham, B15 2TH, United Kingdom.

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http://dx.doi.org/10.1210/jc.2005-0523DOI Listing
July 2005

Pituitary tumour transforming gene (PTTG) induces genetic instability in thyroid cells.

Oncogene 2005 Jul;24(30):4861-6

Division of Medical Sciences, 2nd Floor IBR, University of Birmingham, Edgbaston, Birmingham B12 5TT, UK.

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http://dx.doi.org/10.1038/sj.onc.1208659DOI Listing
July 2005

Thyroid function and mortality in patients treated for hyperthyroidism.

JAMA 2005 Jul;294(1):71-80

Division of Medical Sciences, University of Birmingham, England.

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http://dx.doi.org/10.1001/jama.294.1.71DOI Listing
July 2005

Regression mapping of association between the human leukocyte antigen region and Graves disease.

Am J Hum Genet 2005 Jan 22;76(1):157-63. Epub 2004 Nov 22.

Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, and Birmingham Heartlands Hospital, Birmingham B9 5SS, United Kingdom.

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http://dx.doi.org/10.1086/426947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196419PMC
January 2005

A single nucleotide polymorphism in the CD40 gene on chromosome 20q (GD-2) provides no evidence for susceptibility to Graves' disease in UK Caucasians.

Clin Endocrinol (Oxf) 2004 Aug;61(2):269-72

Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Edgbaston, Birmingham, UK, B15 2TT.

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http://dx.doi.org/10.1111/j.1365-2265.2004.02099.xDOI Listing
August 2004

Heart rate variability and turbulence in hyperthyroidism before, during, and after treatment.

Am J Cardiol 2004 Aug;94(4):465-9

Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom.

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http://dx.doi.org/10.1016/j.amjcard.2004.04.061DOI Listing
August 2004

Polymorphisms of interleukin 4 receptor gene and interleukin 10 gene are not associated with Graves' disease in the UK.

Autoimmunity 2004 May;37(3):189-94

Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK.

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May 2004

Subclinical thyroid disease: scientific review and guidelines for diagnosis and management.

JAMA 2004 Jan;291(2):228-38

Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467-2490, USA.

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http://dx.doi.org/10.1001/jama.291.2.228DOI Listing
January 2004

Radioiodine treatment of Graves' hyperthyroidism.

J Clin Endocrinol Metab 2003 Dec;88(12):6113

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http://dx.doi.org/10.1210/jc.2003-031172DOI Listing
December 2003

Role and regulation of the fibroblast growth factor axis in human thyroid follicular cells.

Am J Physiol Endocrinol Metab 2003 Sep 13;285(3):E460-9. Epub 2003 May 13.

University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1152/ajpendo.00519.2002DOI Listing
September 2003

Early expression of thyroid hormone deiodinases and receptors in human fetal cerebral cortex.

Brain Res Dev Brain Res 2002 Oct;138(2):109-16

Department of Fetal Medicine, University of Birmingham, B15 2TG, Birmingham, UK.

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October 2002

Hyperthyroidism and cardiovascular morbidity and mortality.

Thyroid 2002 Jun;12(6):483-7

Department of Cardiovascular Medicine, Queen Elizabeth Hospital, University of Birmingham, Edgbaston, Birmingham, England.

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http://dx.doi.org/10.1089/105072502760143854DOI Listing
June 2002

Clinical review 142: cardiac dysrhythmias and thyroid dysfunction: the hidden menace?

J Clin Endocrinol Metab 2002 Mar;87(3):963-7

Division of Medical Sciences, Queen Elizabeth Hospital, University of Birmingham, Birmingham, United Kingdom B15 2TH.

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http://dx.doi.org/10.1210/jcem.87.3.8217DOI Listing
March 2002

Successful treatment of amiodarone-induced thyrotoxicosis.

Circulation 2002 Mar;105(11):1275-7

Division of Medical Sciences, University of Birmingham, Birmingham, UK.

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March 2002

Parameters for reliable results in genetic association studies in common disease.

Nat Genet 2002 Feb 22;30(2):149-50. Epub 2002 Jan 22.

JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK.

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http://dx.doi.org/10.1038/ng825DOI Listing
February 2002

Levothyroxine treatment and occurrence of fracture of the hip.

Arch Intern Med 2002 Feb;162(3):338-43

Department of Medicine, The University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, United Kingdom.

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http://dx.doi.org/10.1001/archinte.162.3.338DOI Listing
February 2002

Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom.

Thyroid 2002 Jan;12(1):3-6

Division of Medical Sciences, University of Birmingham, Birmingham Heartlands Hospital, United Kingdom.

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http://dx.doi.org/10.1089/105072502753451896DOI Listing
January 2002