Publications by authors named "Jayaraj Rajagopal"

49Publications

RUVBL1 is an amplified epigenetic factor promoting proliferation and inhibiting differentiation program in head and neck squamous cancers.

Oral Oncol 2020 Jul 31;111:104930. Epub 2020 Jul 31.

Massachusetts Eye and Ear Infirmary, Harvard Medical School, United States; Massachusetts General Hospital Cancer Center, United States; Broad Institute of MIT and Harvard, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2020.104930DOI Listing
July 2020

A Synthesis Concerning Conservation and Divergence of Cell Types across Epithelia.

Cold Spring Harb Perspect Biol 2020 Nov 2;12(11). Epub 2020 Nov 2.

Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1101/cshperspect.a035733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605222PMC
November 2020

Modulating Cell Fate as a Therapeutic Strategy.

Cell Stem Cell 2018 09 14;23(3):329-341. Epub 2018 Jun 14.

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Pathways Program, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Pediatric Pulmonary Medicine, Massachusetts General Hospital for Children, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128730PMC
September 2018

Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity.

Dev Cell 2018 03;44(6):679-693.e5

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Departments of Internal Medicine and Pediatrics, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Ludwig Center at Harvard, Boston, MA 02115, USA; Massachusetts General Hospital for Children, Pediatric Pulmonary Medicine, Boston, MA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15345807183015
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http://dx.doi.org/10.1016/j.devcel.2018.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875457PMC
March 2018

A Conserved Distal Lung Regenerative Pathway in Acute Lung Injury.

Am J Pathol 2018 05 21;188(5):1149-1160. Epub 2018 Feb 21.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440173066
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http://dx.doi.org/10.1016/j.ajpath.2018.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906746PMC
May 2018

The epigenetic basis of cellular plasticity.

Curr Opin Cell Biol 2017 12 4;49:116-122. Epub 2018 Feb 4.

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Departments of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Massachusetts General Hospital for Children, Pediatric Pulmonary Medicine, Boston, MA 02114, USA; Division of Otology and Laryngology, Massachusetts Eye and Ear, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2018.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949887PMC
December 2017

Tips from the embryonic lung.

Elife 2017 08 14;6. Epub 2017 Aug 14.

Massachusetts General Hospital, Harvard University, Boston, United States.

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https://elifesciences.org/articles/30194
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http://dx.doi.org/10.7554/eLife.30194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576478PMC
August 2017

Plasticity in the lung: making and breaking cell identity.

Development 2017 03;144(5):755-766

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA

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http://dx.doi.org/10.1242/dev.143784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374348PMC
March 2017

ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.

Cancer Cell 2017 01 29;31(1):35-49. Epub 2016 Dec 29.

Massachusetts General Hospital Cancer Center, GRJ-904, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108163056
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http://dx.doi.org/10.1016/j.ccell.2016.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225026PMC
January 2017

Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny.

Cell Stem Cell 2016 12;19(6):686-689

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Massachusetts General Hospital for Children, Pediatric Pulmonary Medicine, Boston, MA 02114, USA; Division of Otology and Laryngology, Massachusetts Eye and Ear, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677519PMC
December 2016

Cellular plasticity: 1712 to the present day.

Curr Opin Cell Biol 2016 12 30;43:46-54. Epub 2016 Jul 30.

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA; Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA; Massachusetts General Hospital for Children, Pediatric Pulmonary Medicine, Boston, MA, USA; Division of Otology and Laryngology, Massachusetts Eye and Ear, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2016.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154913PMC
December 2016

Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.

Cell Stem Cell 2016 08 16;19(2):217-231. Epub 2016 Jun 16.

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Division of Pediatric Pulmonary Medicine, Massachusetts General Hospital for Children, Boston, MA 02114, USA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Otology and Laryngology, Massachusetts Eye and Ear, Boston, MA 02114, USA. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30096-0
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http://linkinghub.elsevier.com/retrieve/pii/S193459091630096
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http://dx.doi.org/10.1016/j.stem.2016.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975684PMC
August 2016

Plasticity in the Adult: How Should the Waddington Diagram Be Applied to Regenerating Tissues?

Dev Cell 2016 Jan;36(2):133-7

Departments of Medicine and Cell and Developmental Biology, The Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.12.021DOI Listing
January 2016

Personalized medicine for cystic fibrosis: establishing human model systems.

Pediatr Pulmonol 2015 Oct;50 Suppl 40:S14-23

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ppul.23233DOI Listing
October 2015

Parent stem cells can serve as niches for their daughter cells.

Nature 2015 Jul 6;523(7562):597-601. Epub 2015 Jul 6.

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature14553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521991PMC
July 2015

CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.

J Immunol 2015 Jul 3;195(2):683-94. Epub 2015 Jun 3.

Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114; Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129;

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http://dx.doi.org/10.4049/jimmunol.1402983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489191PMC
July 2015

Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.

J Exp Med 2015 May 27;212(5):759-74. Epub 2015 Apr 27.

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02215 Harvard Stem Cell Institute, Cambridge, MA 02215 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02215

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http://dx.doi.org/10.1084/jem.20141843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419348PMC
May 2015

Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations.

Cell Stem Cell 2015 Feb;16(2):184-97

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Departments of Internal Medicine and Pediatrics, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://www.cell.com/cms/attachment/2027707375/2046058378/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S193459091500003
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http://dx.doi.org/10.1016/j.stem.2015.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334442PMC
February 2015

Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix.

Ann Thorac Surg 2014 Nov 19;98(5):1721-9; discussion 1729. Epub 2014 Aug 19.

Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2014.05.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252658PMC
November 2014

Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells.

Dev Cell 2014 Jul 17;30(2):151-65. Epub 2014 Jul 17.

Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Internal Medicine, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://www.cell.com/cms/attachment/2017253095/2037624123/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S153458071400375
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http://dx.doi.org/10.1016/j.devcel.2014.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130488PMC
July 2014

Dedifferentiation of committed epithelial cells into stem cells in vivo.

Nature 2013 Nov 6;503(7475):218-23. Epub 2013 Nov 6.

1] Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA [2] Departments of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts 02114, USA [3] Department of Internal Medicine, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA [4] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.

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https://ecor.mgh.harvard.edu/content/files/SAC/RajagopalNatu
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http://www.nature.com/doifinder/10.1038/nature12777
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http://dx.doi.org/10.1038/nature12777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035230PMC
November 2013

Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge.

Am J Respir Cell Mol Biol 2013 Mar 13;48(3):364-73. Epub 2012 Dec 13.

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2012-0146OC
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http://dx.doi.org/10.1165/rcmb.2012-0146OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604083PMC
March 2013

Multifocal micronodular pneumocyte hyperplasia: computed tomographic appearance and follow-up in tuberous sclerosis complex.

J Comput Assist Tomogr 2012 Sep-Oct;36(5):518-22

Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1097/RCT.0b013e318264e404DOI Listing
November 2012

In vivo imaging of tracheal epithelial cells in mice during airway regeneration.

Am J Respir Cell Mol Biol 2012 Dec 13;47(6):864-8. Epub 2012 Sep 13.

Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1165/rcmb.2012-0164OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547097PMC
December 2012

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.

Development 2009 May 15;136(10):1751-9. Epub 2009 Apr 15.

Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1242/dev.029249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673763PMC
May 2009

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

Nature 2008 Oct 27;455(7213):627-32. Epub 2008 Aug 27.

Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature07314DOI Listing
October 2008

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme.

Development 2008 May 26;135(9):1625-34. Epub 2008 Mar 26.

Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1242/dev.015495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556060PMC
May 2008

Genetic targeting of the endoderm with claudin-6CreER.

Dev Dyn 2008 Feb;237(2):504-12

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1002/dvdy.21437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665265PMC
February 2008

A multipotent progenitor domain guides pancreatic organogenesis.

Dev Cell 2007 Jul;13(1):103-14

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.devcel.2007.06.001DOI Listing
July 2007

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis.

Genes Dev 2007 Mar;21(6):694-707

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1526207
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http://dx.doi.org/10.1101/gad.1526207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820943PMC
March 2007

Artifactual insulin release from differentiated embryonic stem cells.

Diabetes 2004 Oct;53(10):2603-9

Department of Developmental Biology, Hagedorn Research Institute, Niels Steensens vej 6, DK-2820 Gentofte, Denmark.

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http://dx.doi.org/10.2337/diabetes.53.10.2603DOI Listing
October 2004

Insulin staining of ES cell progeny from insulin uptake.

Science 2003 Jan;299(5605):363

Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/science.1077838DOI Listing
January 2003