Publications by authors named "Jayantha Gunaratne"

66Publications

An Optimized Protocol for Proximity Biotinylation in Confluent Epithelial Cell Cultures Using the Peroxidase APEX2.

STAR Protoc 2020 Sep 31;1(2):100074. Epub 2020 Jul 31.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.

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http://dx.doi.org/10.1016/j.xpro.2020.100074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580243PMC
September 2020

The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions.

Curr Biol 2020 Jul 11;30(14):2791-2804.e6. Epub 2020 Jun 11.

School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551 Singapore; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, 636921 Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2020.05.032DOI Listing
July 2020

Comprehensive Proteomic Characterization Reveals Subclass-Specific Molecular Aberrations within Triple-negative Breast Cancer.

iScience 2020 Feb 28;23(2):100868. Epub 2020 Jan 28.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673, Singapore; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015993PMC
February 2020

Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction.

JACC Basic Transl Sci 2019 Dec 20;4(8):924-937. Epub 2019 Nov 20.

State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1016/j.jacbts.2019.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939002PMC
December 2019

Tracking genome-editing and associated molecular perturbations by SWATH mass spectrometry.

Sci Rep 2019 10 23;9(1):15240. Epub 2019 Oct 23.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, 138673, Singapore.

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http://dx.doi.org/10.1038/s41598-019-51612-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811567PMC
October 2019

Genome-Wide Transcriptome Analysis Reveals Intermittent Fasting-Induced Metabolic Rewiring in the Liver.

Dose Response 2019 Jul-Sep;17(3):1559325819876780. Epub 2019 Sep 25.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1177/1559325819876780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764061PMC
September 2019

Mapping the Interactions of HBV cccDNA with Host Factors.

Int J Mol Sci 2019 Sep 1;20(17). Epub 2019 Sep 1.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, Singapore 117545, Singapore.

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http://dx.doi.org/10.3390/ijms20174276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747236PMC
September 2019

Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics.

Cells 2019 08 26;8(9). Epub 2019 Aug 26.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.

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http://dx.doi.org/10.3390/cells8090975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769472PMC
August 2019

Silencing Y-box binding protein-1 inhibits triple-negative breast cancer cell invasiveness via regulation of MMP1 and beta-catenin expression.

Cancer Lett 2019 06 21;452:119-131. Epub 2019 Mar 21.

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 117594, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.03.014DOI Listing
June 2019

Multiplex targeted mass spectrometry assay for one-shot flavivirus diagnosis.

Proc Natl Acad Sci U S A 2019 04 18;116(14):6754-6759. Epub 2019 Mar 18.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Proteos, 138673 Singapore;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1817867116
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http://dx.doi.org/10.1073/pnas.1817867116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452653PMC
April 2019

Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia.

Oncogene 2019 02 10;38(9):1508-1519. Epub 2018 Oct 10.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://www.nature.com/articles/s41388-018-0526-3
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http://dx.doi.org/10.1038/s41388-018-0526-3DOI Listing
February 2019

CDK1-mediated BCL9 phosphorylation inhibits clathrin to promote mitotic Wnt signalling.

EMBO J 2018 10 14;37(20). Epub 2018 Sep 14.

Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, School of Medicine, Holistic Integrative Pharmacy Institutes (HIPI), Hangzhou Normal University, Hangzhou, China

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http://dx.doi.org/10.15252/embj.201899395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187222PMC
October 2018

Phosphoproteomics reveals network rewiring to a pro-adhesion state in annexin-1-deficient mammary epithelial cells.

Breast Cancer Res 2017 Dec 12;19(1):132. Epub 2017 Dec 12.

Translational Biomedical Proteomics, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore, 138673, Singapore.

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http://dx.doi.org/10.1186/s13058-017-0924-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727667PMC
December 2017

Phosphorylation of Mig6 negatively regulates the ubiquitination and degradation of EGFR mutants in lung adenocarcinoma cell lines.

Cell Signal 2018 03 2;43:21-31. Epub 2017 Dec 2.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, 138673, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.11.006DOI Listing
March 2018

In vitro cytotoxicity of L-amino acid oxidase from the venom of Crotalus mitchellii pyrrhus.

Toxicon 2017 Dec 22;139:20-30. Epub 2017 Sep 22.

Department of Anatomy, National University of Singapore, Singapore; Health and Social Science Cluster, Singapore Institute of Technology, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2017.09.012DOI Listing
December 2017

Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.

Cancer Res 2017 09 18;77(18):4921-4933. Epub 2017 Jul 18.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047736PMC
September 2017

YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro.

BMC Cancer 2017 03 16;17(1):201. Epub 2017 Mar 16.

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, Blk MD10, Singapore, 117594, Singapore.

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http://dx.doi.org/10.1186/s12885-017-3187-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356414PMC
March 2017

Mechanisms of Yersinia YopO kinase substrate specificity.

Sci Rep 2017 01 4;7:39998. Epub 2017 Jan 4.

Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore.

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http://dx.doi.org/10.1038/srep39998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209680PMC
January 2017

The Golgi associated ERI3 is a Flavivirus host factor.

Sci Rep 2016 Sep 29;6:34379. Epub 2016 Sep 29.

Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041148PMC
http://dx.doi.org/10.1038/srep34379DOI Listing
September 2016

Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint.

PLoS Genet 2016 09 15;12(9):e1006310. Epub 2016 Sep 15.

Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore, Republic of Singapore.

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http://dx.doi.org/10.1371/journal.pgen.1006310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025047PMC
September 2016

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale.

Sci Signal 2016 06 14;9(432):rs4. Epub 2016 Jun 14.

sGSK Group, Institute of Molecular and Cell Biology, Agency for Science Technology and Research, Proteos Building, 61 Biopolis Drive, Singapore 138673, Singapore. Institute of Medical Biology, 8A Biomedical Grove, #06-06 Immunos Building, Singapore 138648, Singapore. Department of Pharmacology, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1126/scisignal.aaf3572DOI Listing
June 2016

Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.

Sci Rep 2016 05 16;6:25844. Epub 2016 May 16.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673, Singapore.

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http://dx.doi.org/10.1038/srep25844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867603PMC
May 2016

ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

Cell Stem Cell 2015 Oct 17;17(4):435-47. Epub 2015 Sep 17.

Institute of Medical Biology, Human Genetics and Embryology Laboratory, A(∗)STAR, Singapore 138648; Institute of Molecular and Cell Biology, A(∗)STAR, Singapore 138673. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.08.010DOI Listing
October 2015

Systematic identification of factors for provirus silencing in embryonic stem cells.

Cell 2015 Sep 10;163(1):230-45. Epub 2015 Sep 10.

Epigenetics and Cell Fates Laboratory, A(∗)STAR Institute of Molecular and Cell Biology, 61 Biopolis Drive Proteos, Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)01089-2.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741501089
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http://dx.doi.org/10.1016/j.cell.2015.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686136PMC
September 2015

Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signaling.

Glycobiology 2015 Dec 24;25(12):1491-504. Epub 2015 Aug 24.

Glycotherapeutics Group, Institute of Medical Biology, Agency for Science, Technology and Research, Singapore, Singapore 138648 Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 119228

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https://academic.oup.com/glycob/article-lookup/doi/10.1093/g
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http://dx.doi.org/10.1093/glycob/cwv064DOI Listing
December 2015

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness.

Science 2015 Oct 2;350(6257):217-21. Epub 2015 Jul 2.

Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Singapore-Massachusetts Institute of Technology Alliance in Research and Technology Infectious Disease Interdisciplinary Research Group, Singapore.

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http://www.nus.edu.sg/dpr/files/research_highlights/2016_01D
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http://www.sciencemag.org/cgi/doi/10.1126/science.aab3369
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http://dx.doi.org/10.1126/science.aab3369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824004PMC
October 2015

EBprot: Statistical analysis of labeling-based quantitative proteomics data.

Proteomics 2015 Aug 28;15(15):2580-91. Epub 2015 May 28.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.

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http://dx.doi.org/10.1002/pmic.201400620DOI Listing
August 2015

Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy.

Cell Cycle 2015 ;14(9):1459-70

a Cell Cycle Control in Skin Epidermis; Institute of Medical Biology; A*Star, Biopolis ; Immunos , Singapore.

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http://dx.doi.org/10.1080/15384101.2015.1021519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614697PMC
February 2016

An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma.

Nat Commun 2015 Jan 29;6:6184. Epub 2015 Jan 29.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61, Biopolis Drive, Proteos, Singapore 138673, Singapore.

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http://dx.doi.org/10.1038/ncomms7184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317502PMC
January 2015

Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex.

Cell Signal 2015 Mar 19;27(3):436-42. Epub 2014 Dec 19.

Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore; Department of Biological Sciences, National University of Singapore, 117543, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.12.010DOI Listing
March 2015

Altered protein expression profile associated with phenotypic changes in lung fibroblasts co-cultured with gold nanoparticle-treated small airway epithelial cells.

Biomaterials 2015 Jan 13;39:31-8. Epub 2014 Nov 13.

Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, Block MD10, S117594, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2014.10.063DOI Listing
January 2015

Functional mapping of the zebrafish early embryo proteome and transcriptome.

J Proteome Res 2014 Dec 26;13(12):5536-50. Epub 2014 Sep 26.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research , 61 Biopolis Drive, 138673, Singapore.

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http://dx.doi.org/10.1021/pr5005136DOI Listing
December 2014

Mass spectrometry based quantitative proteomics and integrative network analysis accentuates modulating roles of annexin-1 in mammary tumorigenesis.

Proteomics 2015 Jan 30;15(2-3):408-18. Epub 2014 Sep 30.

Quantitative Proteomics Group, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.

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http://dx.doi.org/10.1002/pmic.201400175DOI Listing
January 2015

NUCKS is a positive transcriptional regulator of insulin signaling.

Cell Rep 2014 Jun 12;7(6):1876-86. Epub 2014 Jun 12.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138673, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.030DOI Listing
June 2014

Isg15 controls p53 stability and functions.

Cell Cycle 2014 20;13(14):2200-10. Epub 2014 May 20.

Institute of Molecular and Cell Biology; A*STAR; Singapore; Institute for Research on Cancer and Ageing of Nice (IRCAN); INSERM; U1081-UMR CNRS 7284; University of Nice - Sophia Antipolis; Centre Antoine Lacassagne; Nice, France.

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http://dx.doi.org/10.4161/cc.29209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111675PMC
December 2015

Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism.

PLoS One 2013 24;8(9):e75625. Epub 2013 Sep 24.

Papillomavirus Regulation and Cancer, Institute of Medical Biology, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075625PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782431PMC
July 2014

"Reductional anaphase" in replication-defective cells is caused by ubiquitin-conjugating enzyme Cdc34-mediated deregulation of the spindle.

Cell Cycle 2012 Aug 1;11(15):2896-910. Epub 2012 Aug 1.

Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research), Singapore.

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http://dx.doi.org/10.4161/cc.21303DOI Listing
August 2012

Expanding the zebrafish embryo proteome using multiple fractionation approaches and tandem mass spectrometry.

Proteomics 2012 Jun;12(11):1879-82

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.

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http://dx.doi.org/10.1002/pmic.201100576DOI Listing
June 2012

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.

EMBO Rep 2012 Jun 29;13(7):638-44. Epub 2012 Jun 29.

Quantitative Proteomics Group, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.

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http://dx.doi.org/10.1038/embor.2012.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388785PMC
June 2012

RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors.

Cell Cycle 2012 May 15;11(10):1938-47. Epub 2012 May 15.

Cancer Science Institute of Singapore; National University of Singapore; Singapore.

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http://dx.doi.org/10.4161/cc.20278DOI Listing
May 2012

HPV-18 E2^E4 chimera: 2 new spliced transcripts and proteins induced by keratinocyte differentiation.

Virology 2012 Jul 27;429(1):47-56. Epub 2012 Apr 27.

Papillomavirus Regulation and Cancer, Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.virol.2012.03.023DOI Listing
July 2012

Quantitative proteomics profiling of murine mammary gland cells unravels impact of annexin-1 on DNA damage response, cell adhesion, and migration.

Mol Cell Proteomics 2012 Aug 16;11(8):381-93. Epub 2012 Apr 16.

Quantitative Proteomics Group, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.

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http://dx.doi.org/10.1074/mcp.M111.011205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412969PMC
August 2012

Enhanced performance of pulsed Q collision induced dissociation-based peptide identification on a dual-pressure linear ion trap.

J Am Soc Mass Spectrom 2012 Jan 27;23(1):186-9. Epub 2011 Oct 27.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore, Singapore 138673.

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http://dx.doi.org/10.1007/s13361-011-0256-zDOI Listing
January 2012

The 10 sea urchin receptor for egg jelly proteins (SpREJ) are members of the polycystic kidney disease-1 (PKD1) family.

BMC Genomics 2007 Jul 13;8:235. Epub 2007 Jul 13.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093-0202, USA.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2164-8-235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934368PMC
July 2007

Sequence, annotation and developmental expression of the sea urchin Ca(2+) -ATPase family.

Gene 2007 Aug 14;397(1-2):67-75. Epub 2007 Apr 14.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093-0202, USA.

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http://dx.doi.org/10.1016/j.gene.2007.04.007DOI Listing
August 2007