Jayandra J Himali

Jayandra J Himali

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Jayandra J Himali

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Association of CD14 with incident dementia and markers of brain aging and injury.

Neurology 2019 Dec 9. Epub 2019 Dec 9.

From the Harvard T.H. Chan School of Public Health (M.P.P.), Boston; Department of Neurology (J.J.H., A.S.B., C.L.S., H.J.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.D., E.R.M., C.L.S., H.J.A., D.L., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology; Melbourne Dementia Research Centre (M.P.P.), The Florey Institute for Neuroscience and Mental Health & The University of Melbourne, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health, MA; Department of Neurology (C.D.), School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento; Departments of Epidemiology (H.H.H.A.) and Radiology and Nuclear Medicine (H.H.H.A.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (A.P.R., W.T.L., B.M.P.), Fred Hutchinson Cancer Research Center (A.P.R.), Department of Neurology (W.T.L.), Cardiovascular Health Research Unit, Department of Medicine (B.M.P., J.C.B.), and Department of Health Services (B.M.P.), University of Washington, Seattle; Human Genetics Center, Department of Epidemiology (M.F.), Human Genetics & Environmental Sciences, School of Public Health (M.F.), and The Brown Foundation Institute of Molecular Medicine, Research Center for Human Genetics (M.F.), University of Texas Health Science Center, Houston; Departments of Pathology and Laboratory Medicine (R.P.T.) and Biochemistry (R.P.T.), Larner College of Medicine, University of Vermont, Burlington; Department of Neurology (O.L.), School of Medicine, University of Pittsburgh, PA; Kaiser Permanente Washington Health Research Institute (B.M.P.), Seattle; The Population Sciences Branch of the National Heart, Lung and Blood Institute (D.L.), NIH, Bethesda, MD; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio; Department of Neurology (E.R.M.), Brigham & Women's Hospital; and Harvard Medical School (E.R.M.), Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000008682DOI Listing
December 2019

Genetic architecture of subcortical brain structures in 38,851 individuals.

Authors:
Claudia L Satizabal Hieab H H Adams Derrek P Hibar Charles C White Maria J Knol Jason L Stein Markus Scholz Muralidharan Sargurupremraj Neda Jahanshad Gennady V Roshchupkin Albert V Smith Joshua C Bis Xueqiu Jian Michelle Luciano Edith Hofer Alexander Teumer Sven J van der Lee Jingyun Yang Lisa R Yanek Tom V Lee Shuo Li Yanhui Hu Jia Yu Koh John D Eicher Sylvane Desrivières Alejandro Arias-Vasquez Ganesh Chauhan Lavinia Athanasiu Miguel E Rentería Sungeun Kim David Hoehn Nicola J Armstrong Qiang Chen Avram J Holmes Anouk den Braber Iwona Kloszewska Micael Andersson Thomas Espeseth Oliver Grimm Lucija Abramovic Saud Alhusaini Yuri Milaneschi Martina Papmeyer Tomas Axelsson Stefan Ehrlich Roberto Roiz-Santiañez Bernd Kraemer Asta K Håberg Hannah J Jones G Bruce Pike Dan J Stein Allison Stevens Janita Bralten Meike W Vernooij Tamara B Harris Irina Filippi A Veronica Witte Tulio Guadalupe Katharina Wittfeld Thomas H Mosley James T Becker Nhat Trung Doan Saskia P Hagenaars Yasaman Saba Gabriel Cuellar-Partida Najaf Amin Saima Hilal Kwangsik Nho Nazanin Mirza-Schreiber Konstantinos Arfanakis Diane M Becker David Ames Aaron L Goldman Phil H Lee Dorret I Boomsma Simon Lovestone Sudheer Giddaluru Stephanie Le Hellard Manuel Mattheisen Marc M Bohlken Dalia Kasperaviciute Lianne Schmaal Stephen M Lawrie Ingrid Agartz Esther Walton Diana Tordesillas-Gutierrez Gareth E Davies Jean Shin Jonathan C Ipser Louis N Vinke Martine Hoogman Tianye Jia Ralph Burkhardt Marieke Klein Fabrice Crivello Deborah Janowitz Owen Carmichael Unn K Haukvik Benjamin S Aribisala Helena Schmidt Lachlan T Strike Ching-Yu Cheng Shannon L Risacher Benno Pütz Debra A Fleischman Amelia A Assareh Venkata S Mattay Randy L Buckner Patrizia Mecocci Anders M Dale Sven Cichon Marco P Boks Mar Matarin Brenda W J H Penninx Vince D Calhoun M Mallar Chakravarty Andre F Marquand Christine Macare Shahrzad Kharabian Masouleh Jaap Oosterlaan Philippe Amouyel Katrin Hegenscheid Jerome I Rotter Andrew J Schork David C M Liewald Greig I de Zubicaray Tien Yin Wong Li Shen Philipp G Sämann Henry Brodaty Joshua L Roffman Eco J C de Geus Magda Tsolaki Susanne Erk Kristel R van Eijk Gianpiero L Cavalleri Nic J A van der Wee Andrew M McIntosh Randy L Gollub Kazima B Bulayeva Manon Bernard Jennifer S Richards Jayandra J Himali Markus Loeffler Nanda Rommelse Wolfgang Hoffmann Lars T Westlye Maria C Valdés Hernández Narelle K Hansell Theo G M van Erp Christiane Wolf John B J Kwok Bruno Vellas Andreas Heinz Loes M Olde Loohuis Norman Delanty Beng-Choon Ho Christopher R K Ching Elena Shumskaya Baljeet Singh Albert Hofman Dennis van der Meer Georg Homuth Bruce M Psaty Mark E Bastin Grant W Montgomery Tatiana M Foroud Simone Reppermund Jouke-Jan Hottenga Andrew Simmons Andreas Meyer-Lindenberg Wiepke Cahn Christopher D Whelan Marjolein M J van Donkelaar Qiong Yang Norbert Hosten Robert C Green Anbupalam Thalamuthu Sebastian Mohnke Hilleke E Hulshoff Pol Honghuang Lin Clifford R Jack Peter R Schofield Thomas W Mühleisen Pauline Maillard Steven G Potkin Wei Wen Evan Fletcher Arthur W Toga Oliver Gruber Matthew Huentelman George Davey Smith Lenore J Launer Lars Nyberg Erik G Jönsson Benedicto Crespo-Facorro Nastassja Koen Douglas N Greve André G Uitterlinden Daniel R Weinberger Vidar M Steen Iryna O Fedko Nynke A Groenewold Wiro J Niessen Roberto Toro Christophe Tzourio William T Longstreth M Kamran Ikram Jordan W Smoller Marie-Jose van Tol Jessika E Sussmann Tomas Paus Hervé Lemaître Matthias L Schroeter Bernard Mazoyer Ole A Andreassen Florian Holsboer Chantal Depondt Dick J Veltman Jessica A Turner Zdenka Pausova Gunter Schumann Daan van Rooij Srdjan Djurovic Ian J Deary Katie L McMahon Bertram Müller-Myhsok Rachel M Brouwer Hilkka Soininen Massimo Pandolfo Thomas H Wassink Joshua W Cheung Thomas Wolfers Jean-Luc Martinot Marcel P Zwiers Matthias Nauck Ingrid Melle Nicholas G Martin Ryota Kanai Eric Westman René S Kahn Sanjay M Sisodiya Tonya White Arvin Saremi Hans van Bokhoven Han G Brunner Henry Völzke Margaret J Wright Dennis van 't Ent Markus M Nöthen Roel A Ophoff Jan K Buitelaar Guillén Fernández Perminder S Sachdev Marcella Rietschel Neeltje E M van Haren Simon E Fisher Alexa S Beiser Clyde Francks Andrew J Saykin Karen A Mather Nina Romanczuk-Seiferth Catharina A Hartman Anita L DeStefano Dirk J Heslenfeld Michael W Weiner Henrik Walter Pieter J Hoekstra Paul A Nyquist Barbara Franke David A Bennett Hans J Grabe Andrew D Johnson Christopher Chen Cornelia M van Duijn Oscar L Lopez Myriam Fornage Joanna M Wardlaw Reinhold Schmidt Charles DeCarli Philip L De Jager Arno Villringer Stéphanie Debette Vilmundur Gudnason Sarah E Medland Joshua M Shulman Paul M Thompson Sudha Seshadri M Arfan Ikram

Nat Genet 2019 Nov 21;51(11):1624-1636. Epub 2019 Oct 21.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1038/s41588-019-0511-yDOI Listing
November 2019

Plasma total-tau as a biomarker of stroke risk in the community.

Ann Neurol 2019 Sep 29;86(3):463-467. Epub 2019 Jul 29.

Framingham Heart Study, Framingham, MA.

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http://dx.doi.org/10.1002/ana.25542DOI Listing
September 2019

Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study.

Stroke 2019 Jun 14;50(6):1558-1560. Epub 2019 May 14.

From the Boston University School of Medicine, MA (H.J.A., J.J.H., C.L.S., J.R.R., C.S.K., A.S.B., S.S.).

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http://dx.doi.org/10.1161/STROKEAHA.119.025171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538454PMC
June 2019

Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition.

Neurobiol Aging 2018 12 9;72:14-22. Epub 2018 Aug 9.

Department of Neurology, Center for Neurosciences, University of California at Davis, Davis, CA, USA; Imaging of Dementia and Aging (IDeA) Laboratory, University of California at Davis, Davis, CA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242702PMC
December 2018

Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study.

Neurology 2018 11 24;91(21):e1961-e1970. Epub 2018 Oct 24.

From the Division of Endocrinology, Diabetes and Hypertension (J.B.E.-T.), Brigham and Women's Hospital/Harvard Medical School, Boston; National Heart, Lung, and Blood Institute (J.B.E.-T., S.C.C., J.J.H., A.S.B., R.S.V., S.S.), Framingham Heart Study, MA; Department of Neurology (S.C.C., J.J.H., A.S.B., S.S.) and Sections of Preventive Medicine and Epidemiology (R.S.V.) and Cardiology (R.S.V.), Department of Medicine, Boston University School of Medicine; Departments of Biostatistics (J.J.H., A.S.B.) and Epidemiology (R.S.V.), Boston University School of Public Health, MA; Department of Neurology (P.M., C.S.D.), University of California, Davis, Sacramento; and Glenn Biggs Institute of Alzheimer's and Neurodegenerative Diseases (S.S.), University of Texas Health Sciences Center, San Antonio.

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http://dx.doi.org/10.1212/WNL.0000000000006549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260201PMC
November 2018

Vascular risk at younger ages most strongly associates with current and future brain volume.

Neurology 2018 10 19;91(16):e1479-e1486. Epub 2018 Sep 19.

From the Melbourne Dementia Research Centre (M.P.P.), the Florey Institute for Neuroscience and Mental Health, the University of Melbourne, Australia; Department of Neurology (M.P.P., J.J.H., C.L.S., H.A., S.S., A.S.B), Boston University School of Medicine; Framingham Heart Study (M.P.P., K.D-.P., J.J.H., H.A., S.S., A.S.B., C.D.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology, Australia; Department of Biostatistics (K.D.-P., J.J.H., A.S.B.), Boston University School of Public Health, MA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (C.L.S., S.S., C.D.), University of Texas Health Sciences Center, San Antonio; and Department of Neurology, School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento.

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http://dx.doi.org/10.1212/WNL.0000000000006360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202941PMC
October 2018

Vascular risk factor burden and new-onset depression in the community.

Prev Med 2018 06 29;111:348-350. Epub 2017 Nov 29.

Department of Neurology, Boston University School of Medicine, 72 East Concord St., Boston, MA 02118, USA; Framingham Heart Study, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA 01702-5827, USA; Centre for Human Psychopharmacology, Swinburne University of Technology, Burwood Rd, Hawthorn 3122, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ypmed.2017.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930122PMC
June 2018

Atrial fibrillation and cognitive decline in the Framingham Heart Study.

Heart Rhythm 2018 02 22;15(2):166-172. Epub 2017 Sep 22.

Department of Neurology, Boston University School of Medicine, Boston, Massachusetts; The Framingham Heart Study, Framingham, Massachusetts; Department of Anatomy & Neurobiology, Boston University School of Public Health, Boston, Massachusetts; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2017.09.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881912PMC
February 2018

Sugary beverage intake and preclinical Alzheimer's disease in the community.

Alzheimers Dement 2017 Sep 6;13(9):955-964. Epub 2017 Mar 6.

Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Framingham Heart Study, Framingham, MA, USA.

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http://dx.doi.org/10.1016/j.jalz.2017.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820519PMC
September 2017

Response by Pase et al to Letter Regarding Article, "Sweetened Beverages and the Risks of Incident Stroke and Dementia".

Stroke 2017 09 7;48(9):e269. Epub 2017 Aug 7.

Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA.

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http://dx.doi.org/10.1161/STROKEAHA.117.018603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575961PMC
September 2017

Sleep architecture and the risk of incident dementia in the community.

Neurology 2017 Sep 23;89(12):1244-1250. Epub 2017 Aug 23.

From the Department of Neurology (M.P.P., J.J.H., A.S.B., C.L.S., H.J.A., S.H.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.L.S., H.J.A., S.H.A., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health; Cognitive Neurology Unit (N.A.G.) and Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine (R.J.T.), Beth Israel Deaconess Medical Center; Harvard Medical School (N.A.G., D.J.G.); Division of Sleep and Circadian Disorders (D.J.G.), Brigham & Women's Hospital, Boston; and Medical Service (D.J.G.), VA Boston Healthcare System, MA.

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http://dx.doi.org/10.1212/WNL.0000000000004373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606917PMC
September 2017

Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study.

Stroke 2017 07 8;48(7):1760-1765. Epub 2017 Jun 8.

From the Framingham Heart Study, MA (H.S., J.J.H., A.S.B., J.R.R., C.S.K., R.S.V., S.S.); Boston University School of Public Health, MA (J.J.H., A.S.B.); McMaster University/Population Health Research Institute, Hamilton, Ontario, Canada (A.S.); Department of Neurology, University of Toronto, Ontario, Canada (A.P.); Department of Medicine, Tufts University School of Medicine, Boston, MA (R.R.); Department of Neurology, Boston University School of Medicine, MA (J.J.H., A.S.B., J.R.R., C.S.K., R.S.V., S.S.); and Department of Neurology, Wayne State University School of Medicine, Detroit, MI (H.S.).

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.116.016563
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.116.016563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505338PMC
July 2017

Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study.

Neurobiol Aging 2017 06 6;54:94-99. Epub 2017 Mar 6.

Department of Neurology, School of Public Health at Boston University, Boston, MA, USA; NHLBI's Framingham Heart Study, Framingham, MA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401784PMC
June 2017

Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury.

Stroke 2017 06 4;48(6):1567-1573. Epub 2017 May 4.

From the Imaging of Dementia and Aging (IDeA) Laboratory, Davis, CA (P.M., E.F., C.D.); Department of Neurology and Center for Neurosciences, University of California, Davis (P.M., E.F., C.D.); Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.); The Framingham Heart Study, MA (J.J.H., A.B., M.P.P., C.L.S., S.S.); Department of Neurology (J.J.H., A.B., M.P.P., C.L.S., S.S.) and Department of Medicine (R.S.V.), Boston University School of Medicine, MA; Department of Biostatistics, Boston University School of Public Health, MA (J.J.H., A.B.); Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (C.W.T.); and Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia (M.P.P.).

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http://dx.doi.org/10.1161/STROKEAHA.116.016321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502744PMC
June 2017

Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study.

Stroke 2017 05;48(5):1139-1146

From the Department of Neurology (M.P.P., J.J.H., A.S.B., H.J.A., C.L.S., S.S.) and Sections of Preventive Medicine and Epidemiology, Department of Medicine (R.S.V), Boston University School of Medicine, MA; Framingham Heart Study, MA (M.P.P., J.J.H., A.S.B., H.J.A., C.L.S., R.S.V., S.S., P.F.J.); Centre for Human Psychopharmacology, Swinburne University of Technology, Australia (M.P.P.); Department of Biostatistics (J.J.H., A.S.B.) and Department of Epidemiology (R.S.V.), Boston University School of Public Health, MA; and Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA (P.F.J.).

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http://dx.doi.org/10.1161/STROKEAHA.116.016027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405737PMC
May 2017

Cerebral Microbleeds as Predictors of Mortality: The Framingham Heart Study.

Stroke 2017 03 31;48(3):781-783. Epub 2017 Jan 31.

From the Department of Neurology (J.R.R., A.B., P.A.W., C.S.K., S.S.), Section of Preventive Medicine (V.S.R.), and Department of Cardiology (V.S.R.), School of Medicine and Department of Biostatistics (S.R.P., A.B., J.J.H.), School of Public Health at Boston University, MA; Department of Medicine-Neurology, McMaster University and Population Health Research Institute, Hamilton, Ontario, Canada (A.S.); Department of Neurology, University of California-Davis (C.D.); and the NHLBI's Framingham Heart Study, Framingham, MA (J.R.R., S.R.P., A.B., J.J.H., P.A.W., C.S.K., V.S.R., S.S.).

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http://dx.doi.org/10.1161/STROKEAHA.116.015354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330856PMC
March 2017

Revised Framingham Stroke Risk Profile to Reflect Temporal Trends.

Circulation 2017 Mar 3;135(12):1145-1159. Epub 2017 Feb 3.

From Inserm, Bordeaux Population Health Research Center, UMR 1219, Univ. Bordeaux, France (C.D., C.T., C.S., G.C.); ISPED, Univ. Bordeaux, France (C.D., C.S., G.C.); CHU de Bordeaux, Pole de sante publique, France (C.D., C.T., G.C.); Department of Neurology, School of Medicine (A.B., P.A.W., J.J.H., H.J.A., M.K.-H., C.S.K., A.P., J.R.R., S.S.), Department of Biostatistics, School of Public Health (A.B., L.S.), and Department of Mathematics (R.B.D.), Boston University, MA; National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (A.B., P.A.W., A.J.W., J.J.H., H.J.A., M.K.-H., C.S.K., A.P., J.R.R., R.B.D., R.S.V., S.S.); Department of Biostatistics, Drexel University School of Public Health, Philadelphia, PA (L.A.M.); Departments of Epidemiology (V.J.H.) and Biostatistics (G.H.), School of Public Health, University of Alabama at Birmingham; and INSERM Unit 1061, Montpellier University, France (K.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.021275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504355PMC
March 2017

Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia.

Neurology 2017 Mar 22;88(12):1172-1179. Epub 2017 Feb 22.

From the Department of Neurology (A.J.W., A.B., J.J.H., S.H.A., M.P.P., S.S.), Boston University School of Medicine; Department of Biostatistics (A.B., J.J.H.), Boston University School of Public Health; Framingham Heart Study (A.B., J.J.H., S.H.A., M.P.P., S.S.); Department of Neuroscience (N.J.), Boston University, MA; University of California at Davis (C.D.), Sacramento; and Center for Human Psychopharmacology (M.P.P.), Swinburne University of Technology, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000003732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373785PMC
March 2017

Effects of white matter integrity and brain volumes on late life depression in the Framingham Heart Study.

Int J Geriatr Psychiatry 2017 02 5;32(2):214-221. Epub 2016 Apr 5.

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052093PMC
http://dx.doi.org/10.1002/gps.4469DOI Listing
February 2017

Serum brain-derived neurotrophic factor and risk of atrial fibrillation.

Am Heart J 2017 Jan 17;183:69-73. Epub 2016 Oct 17.

National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.

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http://dx.doi.org/10.1016/j.ahj.2016.07.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166602PMC
January 2017

Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia.

Stroke 2016 09 4;47(9):2256-61. Epub 2016 Aug 4.

From the Department of Neurology, Boston University School of Medicine, MA (M.P.P., A.B., J.J.H., C.L.S., S.S.); Framingham Heart Study, MA (M.P.P., A.B., J.J.H., C.L.S., R.S.V., S.S., G.F.M.); Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia (M.P.P.); Department of Biostatistics, Boston University School of Public Health, MA (A.B.); Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Centre, Boston, MA (C.T.); and Cardiovascular Engineering Inc, Norwood, MA (G.F.M.).

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http://dx.doi.org/10.1161/STROKEAHA.116.013508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995162PMC
September 2016

Midlife Hypertension Risk and Cognition in the Non-Demented Oldest Old: Framingham Heart Study.

J Alzheimers Dis 2015 ;47(1):197-204

Framingham Heart Study, Department of Neurology, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.3233/JAD-141881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827717PMC
June 2016

Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia.

Stroke 2016 05 12;47(5):1201-6. Epub 2016 Apr 12.

From the Department of Neurology (M.P.P., A.B., H.A., C.L.S., J.J.H., S.S.), and Section of Preventive Medicine, Department of Medicine (D.E., V.X., R.S.V.), Boston University School of Medicine and Framingham Heart Study (M.P.P., A.B., D.E., V.X., H.A., C.L.S., J.J.H., R.S.V., S.S.), Boston, MA; Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Victoria, Australia (M.P.P.); Department of Biostatistics, Boston University School of Public Health, MA (A.B.); Department of Neurology, Boston Medical Centre, MA (H.A., C.S.K.); and Department of Neurology, School of Medicine and Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento (C.D.).

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http://stroke.ahajournals.org/content/early/2016/04/12/STROK
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http://stroke.ahajournals.org/lookup/doi/10.1161/STROKEAHA.1
Publisher Site
http://dx.doi.org/10.1161/STROKEAHA.115.012608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006676PMC
May 2016

Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later.

Neurology 2016 Apr 10;86(14):1313-1319. Epub 2016 Feb 10.

From the Section of Preventive Medicine and Epidemiology (N.L.S., R.S.V.), The Whitaker Cardiovascular Institute (N.L.S.), and Department of Neurology (J.J.H., A.S.B., S.S.), Boston University School of Medicine; the Framingham Heart Study (N.L.S., J.J.H., A.S.B., R.S.V., S.S.); Departments of Biostatistics (A.S.B.) and Epidemiology (R.S.V.), Boston University School of Public Health; Cardiology Division (G.D.L.) and the Pulmonary and Critical Care Unit (G.D.L.), Massachusetts General Hospital, Harvard Medical School; Broad Institute of MIT & Harvard (G.D.L.), Cambridge, MA; and Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis.

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http://dx.doi.org/10.1212/WNL.0000000000002415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826343PMC
April 2016

Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study.

Stroke 2016 Apr 10;47(4):1030-6. Epub 2016 Mar 10.

From the Imaging of Dementia and Aging (IDeA) Laboratory, Davis, CA (P.M.); Department of Neurology and Center for Neurosciences, University of California, Davis, CA (P.M., C.D.); Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.); The Framingham Heart Study, MA (J.J.H., A.B., M.P.P., C.L.S., S.S.); Boston University School of Medicine, MA (J.J.H., A.B., M.P.P., C.L.S., R.S.V., S.S.); Department of Biostatistics, Boston University School of Public Health, MA (A.B.); Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA (C.W.T.); and Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia (M.P.P.).

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http://dx.doi.org/10.1161/STROKEAHA.116.012949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811686PMC
April 2016

Factors Associated With New-Onset Depression After Stroke.

J Neuropsychiatry Clin Neurosci 2016 8;28(4):286-291. Epub 2016 Apr 8.

From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (JS, JR); The Framingham Heart Study, Boston (AB, JJH, SS); the Department of Biostatistics, Boston University School of Medicine, Boston (AB); the Department of Neurology, Boston University School of Medicine, Boston (AB, SS); and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston (ECD).

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http://dx.doi.org/10.1176/appi.neuropsych.15110388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474200PMC
April 2016

Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study.

Hypertension 2016 Mar 11;67(3):513-9. Epub 2016 Jan 11.

From the Department of Neurology, Boston University School of Medicine, MA (M.P.P., J.J.H., A.B., S.S.); Framingham Heart Study, MA (M.P.P., J.J.H., G.F.M., A.B., M.G.L., R.S.V., S.S.); Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Victoria, Australia (M.P.P.); Cardiovascular Engineering Inc, Norwood, MA (G.F.M.); Department of Biostatistics, Boston University School of Public Health, MA (A.B.); Department of Neurology, School of Medicine and Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento (P.M., C.D.); and Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Centre, Boston, MA (C.T.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752398PMC
March 2016

Association of arterial stiffness with progression of subclinical brain and cognitive disease.

Neurology 2016 Feb 20;86(7):619-26. Epub 2016 Jan 20.

From the Department of Medicine (C.W.T.), Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA; Departments of Neurology (J.J.H., A.S.B., S.S.) and Medicine (R.S.V.), School of Medicine, Departments of Biostatistics (J.J.H., A.S.B.) and Epidemiology (R.S.V.), School of Public Health, and the Department of Mathematics and Statistics (M.G.L.), Boston University, Boston, MA; Department of Neurology and Center for Neuroscience and Division of Biostatistics (C.D.), Department of Public Health Sciences, School of Medicine, University of California, Davis, CA; The Framingham Heart Study (C.W.T., J.J.H., A.S.B., M.G.L., R.S.V., S.S.), Framingham, MA; and Cardiovascular Engineering Inc. (G.F.M.), Norwood, MA.

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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000236
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http://dx.doi.org/10.1212/WNL.0000000000002368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762417PMC
February 2016

Serum Leptin Levels and the Risk of Stroke: The Framingham Study.

Stroke 2015 Oct 3;46(10):2881-5. Epub 2015 Sep 3.

From the Framingham Heart Study, MA (H.S., A.B., J.R.R., C.S.K., R.S.V., S.S.); Department of Biostatistics, Boston University School of Public Health, MA (A.B.); Division of Neurology, Department of Medicine, McMaster University/Population Health Research Institute, Hamilton, ON, Canada (A.S.); Department of Neurology, University of Toronto, Toronto, ON, Canada (A.P.); Geriatric Epidemiology section, National Institute on Aging, National Institute of Health, Bethesda, MD (T.B.H.); Friedman School of Nutrition Science and Policy, Tufts University School of Medicine, Boston, MA (R.R.); and Department of Neurology, Boston University School of Medicine, MA (H.S., J.J.H., A.B., J.R.R., C.S.K., R.S.V., S.S.).

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http://dx.doi.org/10.1161/STROKEAHA.115.009463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589501PMC
October 2015

Glucose indices are associated with cognitive and structural brain measures in young adults.

Neurology 2015 Jun 6;84(23):2329-37. Epub 2015 May 6.

From the Department of Neurology (G.W., J.J.H., A.S.B., R.A., P.A.W., S.S.), Boston University School of Medicine, MA; The Framingham Heart Study (G.W., J.J.H., A.S.B., R.A., P.A.W., S.S.), MA; the Department of Neurology (P.M., C.D.), The University of California at Davis, Sacramento; and the Department of Biostatistics (A.S.B.), Boston University School of Public Health, MA.

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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000165
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http://dx.doi.org/10.1212/WNL.0000000000001655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464744PMC
June 2015

Association between neuropathology and brain volume in the Framingham Heart Study.

Alzheimer Dis Assoc Disord 2014 Jul-Sep;28(3):219-25

*Department of Neurology, University of California, Davis, Sacramento, CA †Department of Neurology, Boston University School of Medicine, Framingham Heart Study ‡Department of Biostatistics, Boston University School of Public Health, Boston, MA.

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https://insights.ovid.com/crossref?an=00002093-201407000-000
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http://dx.doi.org/10.1097/WAD.0000000000000032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139422PMC
April 2015

Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study.

Circulation 2015 Apr 19;131(15):1333-9. Epub 2015 Feb 19.

From Vanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN (A.L.J.); Departments of Neurology (A.S.B., J.J.H., S.S., P.A.W., R.A.) and Medicine (E.J.B.), Boston University School of Medicine, Boston, MA; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (A.S.B., J.J.H., S.S., C.J.O., P.A.W., R.A., E.J.B.); Departments of Epidemiology (E.J.B.) and Biostatistics (A.S.B.), Boston University School of Public Health, Boston, MA; and Departments of Medicine (Cardiovascular Division) (W.J.M.) and Radiology (W.J.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.114.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.012438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398627PMC
April 2015

Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study.

Neurology 2015 Feb 7;84(5):472-9. Epub 2015 Jan 7.

From the Boston University Schools of Medicine and Public Health (A.P., A.S.B., J.W., J.J.H., M.K.-H., C.S.K., Q.Y., S.S., P.A.W.), Boston; and Framingham Heart Study (A.P., A.S.B., M.K.-H., C.S.K., Q.Y., S.S., P.A.W.), Framingham, MA.

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http://dx.doi.org/10.1212/WNL.0000000000001202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336066PMC
February 2015

Lexical retrieval in discourse: an early indicator of Alzheimer's dementia.

Clin Linguist Phon 2013 Dec 28;27(12):905-21. Epub 2013 Aug 28.

Institute of Behavioural Sciences, University of Helsinki , Helsinki , Finland .

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http://dx.doi.org/10.3109/02699206.2013.815278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095845PMC
December 2013

Relations of arterial stiffness and endothelial function to brain aging in the community.

Neurology 2013 Sep 9;81(11):984-91. Epub 2013 Aug 9.

From the Department of Medicine (C.W.T.), Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston; Departments of Neurology (S.S., A.S.B., A.J.W., R.A., J.J.H., P.A.W.), Medicine (N.M.H., J.A.V., D.L., E.J.B., R.S.V.), and Biostatistics (A.S.B., J.J.H., M.G.L.), School of Public Health, School of Medicine and the Department of Mathematics (M.G.L.), Boston University, MA; Department of Neurology (C.D.), Center for Neuroscience and Division of Biostatistics, Department of Public Health Sciences, School of Medicine, University of California, Davis; National Heart Lung and Blood Institute (D.L.), NHLBI's Framingham Heart Study (C.W.T., S.S., A.S.B., R.A., D.L., M.G.L., E.J.B., P.A.W., R.S.V.), Framingham; and Cardiovascular Engineering Inc. (G.F.M.), Norwood, MA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888200PMC
September 2013

The Framingham Brain Donation Program: neuropathology along the cognitive continuum.

Curr Alzheimer Res 2012 Jul;9(6):673-86

Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622706PMC
http://dx.doi.org/10.2174/156720512801322609DOI Listing
July 2012

Cardiac index is associated with brain aging: the Framingham Heart Study.

Circulation 2010 Aug 2;122(7):690-7. Epub 2010 Aug 2.

Department of Neurology, Alzheimer's Disease Center, Boston University School of Medicine, 72 E Concord St, B-7800, Boston, MA 02118, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.905091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929763PMC
August 2010

Apolipoprotein e, alcohol consumption, and risk of ischemic stroke: the Framingham Heart Study revisited.

J Stroke Cerebrovasc Dis 2009 Sep-Oct;18(5):384-8

Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10523057090002
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2009.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743951PMC
December 2009