Publications by authors named "Jayachandran Kizhakkedathu"

149Publications

Self-Limiting Mussel Inspired Thin Antifouling Coating with Broad-Spectrum Resistance to Biofilm Formation to Prevent Catheter-Associated Infection in Mouse and Porcine Models.

Authors:
Kai Yu Amal Alzahrani Sara Khoddami Demian Ferreira Kymora B Scotland John T J Cheng Hossein Yazdani-Ahmadabadi Yan Mei Arshdeep Gill Lily E Takeuchi Edbert Yeung Dana Grecov Robert E W Hancock Ben H Chew Dirk Lange Jayachandran N Kizhakkedathu

Adv Healthc Mater 2021 Jan 20:e2001573. Epub 2021 Jan 20.

Centre for Blood Research and Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.

View Article and Find Full Text PDF
January 2021

The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis.

Authors:
Eduard Hofsetz Fatih Demir Karolina Szczepanowska Alexandra Kukat Jayachandran N Kizhakkedathu Aleksandra Trifunovic Pitter F Huesgen

Mol Cell Proteomics 2020 Aug 23;19(8):1330-1345. Epub 2020 Nov 23.

Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany, Medical Faculty and University Hospital, University of Cologne, Cologne, Germany; Central Institute for Engineering, Electronics and Analytics, ZEA-3, Forschungszentrum Jülich, Germany; Institute for Biochemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany. Electronic address:

View Article and Find Full Text PDF
August 2020

Mucin-Inspired, High Molecular Weight Virus Binding Inhibitors Show Biphasic Binding Behavior to Influenza A Viruses.

Authors:
Matthias Wallert Chuanxiong Nie Parambath Anilkumar Srinivas Abbina Sumati Bhatia Kai Ludwig Jayachandran N Kizhakkedathu Rainer Haag Stephan Block

Small 2020 Nov 1;16(47):e2004635. Epub 2020 Nov 1.

Institute of Chemistry and Biochemistry, Emmy-Noether Group "Bionanointerfaces", Freie Universität Berlin, Takustr. 3, Berlin, 14195, Germany.

View Article and Find Full Text PDF
November 2020

Evaluation of hyperbranched polyglycerol for cold perfusion and storage of donor kidneys in a pig model of kidney autotransplantation.

Authors:
Shadan Li Zhongli Huang Xiaowei Li Youguang Zhao Xin Jiang Yang Wen Hao Luo Liang Wang Qiunong Guan Irina Cafeeva Donald E Brooks Christopher Y C Nguan Jayachandran N Kizhakkedathu Caigan Du

J Biomed Mater Res B Appl Biomater 2020 Oct 24:e34750. Epub 2020 Oct 24.

Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

View Article and Find Full Text PDF
October 2020

Polyglycerol-Based Macromolecular Iron Chelator Adjuvants for Antibiotics To Treat Drug-Resistant Bacteria.

Authors:
Srinivas Abbina Arshdeep Gill Snehamol Mathew Usama Abbasi Jayachandran N Kizhakkedathu

ACS Appl Mater Interfaces 2020 Aug 13;12(34):37834-37844. Epub 2020 Aug 13.

Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver V6T 1Z4, British Columbia, Canada.

View Article and Find Full Text PDF
August 2020

Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance.

Authors:
Matthew Drayton Jayachandran N Kizhakkedathu Suzana K Straus

Molecules 2020 Jul 3;25(13). Epub 2020 Jul 3.

Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.

View Article and Find Full Text PDF
July 2020

Understanding the Interaction of Polyelectrolyte Architectures with Proteins and Biosystems.

Authors:
Katharina Achazi Rainer Haag Matthias Ballauff Jens Dernedde Jayachandran N Kizhakkedathu Dusica Maysinger Gerd Multhaup

Angew Chem Int Ed Engl 2020 Jun 26. Epub 2020 Jun 26.

Department of Pharmacology and Therapeutics, McGill University, Montreal, H3G 1Y6, Canada.

View Article and Find Full Text PDF
June 2020

Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface.

Authors:
Srinivas Abbina Lily E Takeuchi Parambath Anilkumar Kai Yu Jason C Rogalski Rajesh A Shenoi Iren Constantinescu Jayachandran N Kizhakkedathu

Nat Commun 2020 06 16;11(1):3048. Epub 2020 Jun 16.

Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

View Article and Find Full Text PDF
June 2020

Targeting Biological Polyanions in Blood: Strategies toward the Design of Therapeutics.

Authors:
Chanel C La Lily E Takeuchi Srinivas Abbina Sreeparna Vappala Usama Abbasi Jayachandran N Kizhakkedathu

Biomacromolecules 2020 07 19;21(7):2595-2621. Epub 2020 Jun 19.

View Article and Find Full Text PDF
July 2020

Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death.

Authors:
Natalie C Marshall Maichael Thejoe Theo Klein Antonio Serapio-Palacios Andrew S Santos Niklas von Krosigk Jayachandran N Kizhakkedathu Nikolay Stoynov Leonard J Foster Christopher M Overall B Brett Finlay

mSystems 2020 Jun 2;5(3). Epub 2020 Jun 2.

Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada

View Article and Find Full Text PDF
June 2020

The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis.

Authors:
Eduard Hofsetz Fatih Demir Karolina Szczepanowska Alexandra Kukat Jayachandran N Kizhakkedathu Aleksandra Trifunovic Pitter F Huesgen

Mol Cell Proteomics 2020 08 28;19(8):1330-1345. Epub 2020 May 28.

Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany, Medical Faculty and University Hospital, University of Cologne, Cologne, Germany

View Article and Find Full Text PDF
August 2020

Surface modification approaches for prevention of implant associated infections.

Authors:
Hossein Yazdani Ahmadabadi Kai Yu Jayachandran N Kizhakkedathu

Colloids Surf B Biointerfaces 2020 Sep 12;193:111116. Epub 2020 May 12.

Centre for Blood Research, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada. Electronic address:

View Article and Find Full Text PDF
September 2020

Mega macromolecules as single molecule lubricants for hard and soft surfaces.

Authors:
Parambath Anilkumar Taylor B Lawson Srinivas Abbina Janne T A Mäkelä Robert C Sabatelle Lily E Takeuchi Brian D Snyder Mark W Grinstaff Jayachandran N Kizhakkedathu

Nat Commun 2020 05 1;11(1):2139. Epub 2020 May 1.

Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada.

View Article and Find Full Text PDF
May 2020

Simplified high yield TAILS terminomics using a new HPG-ALD 800K-2000 polymer with precipitation.

Authors:
Nestor Solis Anilkumar Parambath Srinivas Abbina Jayachandran Kizhakkedathu Christopher M Overall

Methods Enzymol 2019 13;626:429-446. Epub 2019 Aug 13.

Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada; Department of Biochemistry & Molecular Biology, University of British Columbia, Vancouver, BC, Canada. Electronic address:

View Article and Find Full Text PDF
June 2020

Proteomic and N-Terminomic TAILS Analyses of Human Alveolar Bone Proteins: Improved Protein Extraction Methodology and LysargiNase Digestion Strategies Increase Proteome Coverage and Missing Protein Identification.

Authors:
Peter A Bell Nestor Solis Jayachandran N Kizhakkedathu Ian Matthew Christopher M Overall

J Proteome Res 2019 12 25;18(12):4167-4179. Epub 2019 Oct 25.

View Article and Find Full Text PDF
December 2019

N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis.

Authors:
Marilyn H Gordon Anthonia Anowai Daniel Young Nabangshu Das Rhiannon I Campden Henna Sekhon Zoe Myers Barbara Mainoli Sameeksha Chopra Peter S Thuy-Boun Jayachandran Kizhakkedathu Gurmeet Bindra Humberto B Jijon Steven Heitman Robin Yates Dennis W Wolan Laura E Edgington-Mitchell Wallace K MacNaughton Antoine Dufour

ACS Chem Biol 2019 11 21;14(11):2471-2483. Epub 2019 Aug 21.

Department of Physiology and Pharmacology , University of Calgary , Calgary , Alberta , Canada T2N 4N1.

View Article and Find Full Text PDF
November 2019

Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Substrates (TAILS) N-Terminomics.

Authors:
André Zelanis Ana K Oliveira Anna Prudova Pitter F Huesgen Alexandre K Tashima Jayachandran Kizhakkedathu Christopher M Overall Solange M T Serrano

J Proteome Res 2019 09 8;18(9):3419-3428. Epub 2019 Aug 8.

Laboratório Especial de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling (CeTICS) , Instituto Butantan , São Paulo , SP 05503-000 , Brazil.

View Article and Find Full Text PDF
September 2019

An enzymatic pathway in the human gut microbiome that converts A to universal O type blood.

Authors:
Peter Rahfeld Lyann Sim Haisle Moon Iren Constantinescu Connor Morgan-Lang Steven J Hallam Jayachandran N Kizhakkedathu Stephen G Withers

Nat Microbiol 2019 09 10;4(9):1475-1485. Epub 2019 Jun 10.

Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.

View Article and Find Full Text PDF
September 2019

Design of Safe Nanotherapeutics for the Excretion of Excess Systemic Toxic Iron.

Authors:
Srinivas Abbina Usama Abbasi Arshdeep Gill Kendrew Wong Manu Thomas Kalathottukaren Jayachandran N Kizhakkedathu

ACS Cent Sci 2019 May 11;5(5):917-926. Epub 2019 Apr 11.

Department of Pathology and Laboratory Medicine, Center for Blood Research and Life Sciences Institute, and Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

View Article and Find Full Text PDF
May 2019

Transcriptome analysis of signaling pathways of human peritoneal mesothelial cells in response to different osmotic agents in a peritoneal dialysis solution.

Authors:
Bin Liu Shijian Feng Ghida Dairi Qiunong Guan Irina Chafeeva Hao Wang Richard Liggins Gerald da Roza Jayachandran N Kizhakkedathu Caigan Du

BMC Nephrol 2019 05 21;20(1):181. Epub 2019 May 21.

Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

View Article and Find Full Text PDF
May 2019