Jay S Skyler

Jay S Skyler

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Jay S Skyler

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Imagining a better future for all people with type 1 diabetes mellitus.

Nat Rev Endocrinol 2019 Nov;15(11):623-624

Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1038/s41574-019-0257-8DOI Listing
November 2019

Exploring Patient Preferences for Adjunct-to-Insulin Therapy in Type 1 Diabetes.

Diabetes Care 2019 Sep 8;42(9):1716-1723. Epub 2019 Jun 8.

Boehringer Ingelheim (Canada) Ltd./Ltée, Burlington, Canada

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http://dx.doi.org/10.2337/dc19-0548DOI Listing
September 2019

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.

N Engl J Med 2019 08 9;381(7):603-613. Epub 2019 Jun 9.

From the Departments of Immunobiology and Internal Medicine, Yale University, New Haven, CT (K.C.H.); the Departments of Epidemiology and Pediatrics, University of South Florida, Tampa (B.N.B., J.P.K., H.R.), the Department of Medicine, University of Miami, Miami (J.B.M., J.S.S.), and the Department of Pediatrics, University of Florida, Gainesville (D.S.) - all in Florida; Benaroya Research Institute, Seattle (S.A.L., M.J.D., P.S.L., C.J.G.); the Diabetes Center, University of California at San Francisco, San Francisco (J.A.B., S.E.G.); the Department of Pediatrics, Indiana University, Indianapolis (L.A.D.); the Barbara Davis Diabetes Center, University of Colorado, Anschultz (P.A.G.); Children's Mercy Hospital, Kansas City, MO (W.M.); the Department of Pediatrics, University of Minnesota, Minneapolis (A.M.); the Department of Pediatrics and Cell and Developmental Biology, Vanderbilt University, Nashville (W.E.R.); the Department of Pediatrics, University of Iowa, Iowa City (E.T.); the Hospital for Sick Children, University of Toronto, Toronto (D.K.W.); and Forschergruppe Diabetes, Technical University Munich, at Klinikum rechts der Isar, Munich, Germany (A.-G.Z.).

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http://dx.doi.org/10.1056/NEJMoa1902226DOI Listing
August 2019

Empagliflozin as Adjunctive to Insulin Therapy in Type 1 Diabetes: The EASE Trials.

Diabetes Care 2018 12 4;41(12):2560-2569. Epub 2018 Oct 4.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and Division of Endocrinology and Metabolism, University of Toronto, Toronto, Canada

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-174
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http://dx.doi.org/10.2337/dc18-1749DOI Listing
December 2018

Brief Commentary: Confusing Treatment Guidelines for Patients With Type 2 Diabetes.

Ann Intern Med 2018 08 26;169(4):253. Epub 2018 Jun 26.

University of Miami School of Medicine, Miami, Florida (J.S.S.).

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http://dx.doi.org/10.7326/M18-1473DOI Listing
August 2018

Sleeping oxygen saturation, rapid eye movement sleep, and the adaptation of postprandial metabolic function in insulin sensitive and resistant individuals without diabetes.

Physiol Behav 2018 07 12;191:123-130. Epub 2018 Apr 12.

Behavioral Medicine Research Center, University of Miami, Miami, FL, USA; Department of Psychology, University of Miami, Coral Gables, FL, USA; Division of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.physbeh.2018.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975635PMC
July 2018

The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1.

Pediatr Diabetes 2018 05 24;19(3):403-409. Epub 2017 Nov 24.

VA Puget Sound Health Care System; Division of Endocrinology, Metabolism and Nutrition, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1111/pedi.12609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918232PMC
May 2018

Hope vs hype: where are we in type 1 diabetes?

Authors:
Jay S Skyler

Diabetologia 2018 03 23;61(3):509-516. Epub 2017 Dec 23.

Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10th Avenue - Suite 3054, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/s00125-017-4530-xDOI Listing
March 2018

The shape of the glucose concentration curve during an oral glucose tolerance test predicts risk for type 1 diabetes.

Diabetologia 2018 01 27;61(1):84-92. Epub 2017 Sep 27.

Division of Endocrinology, Diabetes and Metabolism, Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1007/s00125-017-4453-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850999PMC
January 2018

Diabetes Research and Care Through the Ages.

Diabetes Care 2017 10;40(10):1302-1313

CNR Institute of Clinical Physiology, and the Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.2337/dci17-0042DOI Listing
October 2017

Harold E. Lebovitz, MD: Legendary Diabetologist.

Authors:
Jay S Skyler

Diabetes Care 2016 12;39(12):2118-2121

Diabetes Research Institute, University of Miami, Miami, FL

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http://dx.doi.org/10.2337/dci16-0039DOI Listing
December 2016

Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus.

Cell Chem Biol 2016 05 12;23(5):618-628. Epub 2016 May 12.

Departments of Chemistry and Cancer Biology, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890052PMC
May 2016

Struggles with clinical translation of immune intervention trials.

Authors:
Jay S Skyler

Diabetes Care 2014 ;37(5):1173-5

Corresponding author: Jay S. Skyler,

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http://dx.doi.org/10.2337/dc13-2878DOI Listing
August 2015

The development, validation, and utility of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS).

Curr Diab Rep 2015 Aug;15(8):49

Division of Endocrinology, University of Miami, PO Box 016960 (D110), Miami, FL, 33101, USA,

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http://dx.doi.org/10.1007/s11892-015-0626-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795007PMC
August 2015

Adaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance.

Diabetes 2015 Jul 9;64(7):2550-9. Epub 2015 Mar 9.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy National Research Council Institute of Clinical Physiology, Pisa, Italy

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http://dx.doi.org/10.2337/db15-0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477346PMC
July 2015

Effect of Ranolazine Monotherapy on Glycemic Control in Subjects With Type 2 Diabetes.

Diabetes Care 2015 Jul 6;38(7):1189-96. Epub 2015 Jun 6.

Divisions of Endocrinology, Diabetes, and Metabolism, Pediatrics, and Psychology, University of Miami Miller School of Medicine, Miami, FL.

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http://dx.doi.org/10.2337/dc14-2629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477340PMC
July 2015

Prevention and reversal of type 1 diabetes--past challenges and future opportunities.

Authors:
Jay S Skyler

Diabetes Care 2015 Jun;38(6):997-1007

Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL

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http://dx.doi.org/10.2337/dc15-0349DOI Listing
June 2015

The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months.

Diabetes Care 2015 May 10;38(5):940-2. Epub 2015 Mar 10.

VA Puget Sound Health Care System; Division of Endocrinology, Metabolism, and Nutrition, University of Washington, Seattle, WA.

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http://dx.doi.org/10.2337/dc14-2787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407750PMC
May 2015

Toward primary prevention of type 1 diabetes.

Authors:
Jay S Skyler

JAMA 2015 Apr;313(15):1520-1

Division of Endocrinology, Diabetes, & Metabolism, Pediatrics, and Psychology, University of Miami Miller School of Medicine, Miami, Florida2Clinical Research and Academic Programs, Diabetes Research Institute, University of Miami Miller School of Medicin.

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http://dx.doi.org/10.1001/jama.2015.2054DOI Listing
April 2015

A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history.

Diabetes Care 2015 Feb 17;38(2):271-6. Epub 2014 Dec 17.

VA Puget Sound Health Care System, Division of Endocrinology, Metabolism, and Nutrition, University of Washington, Seattle, WA.

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http://dx.doi.org/10.2337/dc14-1813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302258PMC
February 2015

T1DM in 2014: Progress towards a bionic pancreas.

Authors:
Jay S Skyler

Nat Rev Endocrinol 2015 Feb 23;11(2):75-6. Epub 2014 Dec 23.

Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10th Avenue, Suite 3054, Miami, FL 33136, USA.

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http://dx.doi.org/10.1038/nrendo.2014.228DOI Listing
February 2015

Immune intervention for type 1 diabetes, 2013-2014.

Authors:
Jay S Skyler

Diabetes Technol Ther 2015 Feb;17 Suppl 1:S80-7

Division of Endocrinology, Diabetes, & Metabolism, and Diabetes Research Institute, University of Miami Miller School of Medicine , Miami, FL.

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http://dx.doi.org/10.1089/dia.2015.1510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333515PMC
February 2015

Immune therapy for treating type 1 diabetes: challenging existing paradigms.

Authors:
Jay S Skyler

J Clin Invest 2015 Jan 15;125(1):94-6. Epub 2014 Dec 15.

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http://dx.doi.org/10.1172/JCI79190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382231PMC
January 2015

Characterizing subgroups of type 1 diabetes.

Authors:
Jay S Skyler

Diabetes 2014 Nov;63(11):3578-80

Diabetes Research Institute, University of Miami, Miami, FL

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http://dx.doi.org/10.2337/db14-1160DOI Listing
November 2014

The artificial pancreas: current status and future prospects in the management of diabetes.

Ann N Y Acad Sci 2014 Apr;1311:102-23

Dexcom, Inc, San Diego, California.

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http://dx.doi.org/10.1111/nyas.12431DOI Listing
April 2014

Immune intervention for type 1 diabetes, 2012-2013.

Authors:
Jay S Skyler

Diabetes Technol Ther 2014 Feb;16 Suppl 1:S85-91

Division of Endocrinology, Diabetes, & Metabolism, and Diabetes Research Institute, University of Miami Miller School of Medicine , Miami, FL.

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http://dx.doi.org/10.1089/dia.2014.1510DOI Listing
February 2014

ATG in type 1 diabetes: an unanswered question.

Authors:
Jay S Skyler

Lancet Diabetes Endocrinol 2013 Dec 28;1(4):265-6. Epub 2013 Aug 28.

Diabetes Research Institute, University of Miami Miller School of Medicine, Miami 33136, Florida, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(13)70087-1DOI Listing
December 2013

The compelling case for anti-CD3 in type 1 diabetes.

Authors:
Jay S Skyler

Diabetes 2013 Nov;62(11):3656-7

Diabetes Research Institute, University of Miami, Miami, Florida.

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http://dx.doi.org/10.2337/db13-1157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806623PMC
November 2013

Decision-making in diabetes mellitus type 1.

J Neuropsychiatry Clin Neurosci 2013 ;25(1):40-50

Dept. of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1176/appi.neuropsych.12010016DOI Listing
September 2013

An analysis of characteristics of subjects examined for incretin effects on pancreatic pathology.

Diabetes Technol Ther 2013 Aug 8;15(8):609-18. Epub 2013 Aug 8.

Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1089/dia.2013.0177DOI Listing
August 2013

George S. Eisenbarth: insulin and type 1 diabetes.

Diabetes Care 2013 Jun;36(6):1437-42

Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.

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http://dx.doi.org/10.2337/dc13-0753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661806PMC
June 2013

The evolution of type 1 diabetes.

JAMA 2013 Jun;309(23):2491-2

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http://dx.doi.org/10.1001/jama.2013.6286DOI Listing
June 2013

Immunotherapy trials for type 1 diabetes: the contribution of George Eisenbarth.

Diabetes Technol Ther 2013 Jun;15 Suppl 2:S2-13-S2-20

Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1089/dia.2013.0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676656PMC
June 2013

The year in immune intervention for type 1 diabetes.

Authors:
Jay S Skyler

Diabetes Technol Ther 2013 Feb;15 Suppl 1:S88-95

Division of Endocrinology, Diabetes & Metabolism, and Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1089/dia.2013.1510DOI Listing
February 2013

The metabolic progression to type 1 diabetes as indicated by serial oral glucose tolerance testing in the Diabetes Prevention Trial-type 1.

Diabetes 2012 Jun;61(6):1331-7

Division of Endocrinology, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.2337/db11-1660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357303PMC
June 2012

Meta-analysis of safety for low event-rate binomial trials.

Res Synth Methods 2012 Mar;3(1):30-50

Diabetes Research Institute and Division of Endocrinology Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, FL, 33136, U.S.A.

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http://dx.doi.org/10.1002/jrsm.1039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856441PMC
March 2012

Type 1 diabetes mellitus: immune intervention.

Authors:
Jay S Skyler

Int J Clin Pract Suppl 2012 Feb(175):56-61

Division of Endocrinology, Diabetes, and Metabolism, and Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1111/j.1742-1241.2011.02855.xDOI Listing
February 2012

New medications for the treatment of diabetes.

Int J Clin Pract Suppl 2012 Feb(175):85-93

University of Colorado Health Sciences Center, Aurora, CO, USA.

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http://dx.doi.org/10.1111/j.1742-1241.2011.02859.xDOI Listing
February 2012

Comparison of two insulin assays for first-phase insulin release in type 1 diabetes prediction and prevention studies.

Clin Chim Acta 2011 Nov 6;412(23-24):2128-31. Epub 2011 Aug 6.

Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cca.2011.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839139PMC
November 2011

Development of autoantibodies in the TrialNet Natural History Study.

Diabetes Care 2011 Sep 12;34(9):1897-901. Epub 2011 Jul 12.

University of South Florida, Pediatrics Epidemiology Center, Tampa, FL, USA.

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http://dx.doi.org/10.2337/dc11-0560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161292PMC
September 2011

Stopping type 1 diabetes: attempts to prevent or cure type 1 diabetes in man.

Diabetes 2011 Jan;60(1):1-8

Diabetes Research Institute, University of Miami Miller School of Medicine, Florida, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db10-11
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http://dx.doi.org/10.2337/db10-1114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012160PMC
January 2011

Prognostic performance of metabolic indexes in predicting onset of type 1 diabetes.

Diabetes Care 2010 Dec 31;33(12):2508-13. Epub 2010 Aug 31.

Department of Pediatrics, College of Medicine, University of South Florida, Tampa, Florida, USA.

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http://dx.doi.org/10.2337/dc10-0802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992179PMC
December 2010

Continuous subcutaneous insulin infusion--an historical perspective.

Authors:
Jay S Skyler

Diabetes Technol Ther 2010 Jun;12 Suppl 1:S5-9

Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10 Avenue, Miami, FL 33136, USA.

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http://dx.doi.org/10.1089/dia.2010.0068DOI Listing
June 2010

Progression to diabetes in relatives of type 1 diabetic patients: mechanisms and mode of onset.

Diabetes 2010 Mar 22;59(3):679-85. Epub 2009 Dec 22.

Department of Medicine, University of Pisa School of Medicine, Pisa, Italy.

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http://dx.doi.org/10.2337/db09-1378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828663PMC
March 2010

Challenges in developing endpoints for type 1 diabetes intervention studies.

Diabetes Metab Res Rev 2009 Nov;25(8):694-704

Department of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1002/dmrr.1002DOI Listing
November 2009

Insulin glargine and cancer--an unsubstantiated allegation.

Diabetes Technol Ther 2009 Aug;11(8):473-6

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http://dx.doi.org/10.1089/dia.2009.1705DOI Listing
August 2009

Continuous glucose monitoring: an overview of its development.

Authors:
Jay S Skyler

Diabetes Technol Ther 2009 Jun;11 Suppl 1:S5-10

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http://dx.doi.org/10.1089/dia.2009.0045DOI Listing
June 2009

High-dose insulin therapy: is it time for U-500 insulin?

Endocr Pract 2009 Jan-Feb;15(1):71-9

Mountain Diabetes and Endocrine Center, Asheville, North Carolina 2880, USA.

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http://dx.doi.org/10.4158/EP.15.1.71DOI Listing
May 2009

CGM--a technology in evolution.

Authors:
Jay S Skyler

Diabetes Technol Ther 2009 Feb;11(2):63-4

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http://dx.doi.org/10.1089/dia.2008.0140DOI Listing
February 2009

Update on worldwide efforts to prevent type 1 diabetes.

Authors:
Jay S Skyler

Ann N Y Acad Sci 2008 Dec;1150:190-6

Diabetes Research Institute, Miami, Florida 33101-6960, USA.

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http://dx.doi.org/10.1196/annals.1447.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928677PMC
December 2008

Latent autoimmune diabetes in adults: the search for interventions continues.

Authors:
Jay S Skyler

Nat Clin Pract Endocrinol Metab 2008 Nov 2;4(11):600-1. Epub 2008 Sep 2.

Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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http://dx.doi.org/10.1038/ncpendmet0949DOI Listing
November 2008

Safety and efficacy of inhaled human insulin (Exubera) during discontinuation and readministration of therapy in adults with type 1 diabetes: A 3-year randomized controlled trial.

Diabetes Res Clin Pract 2008 Nov 27;82(2):238-46. Epub 2008 Sep 27.

Division of Endocrinology, Diabetes, and Metabolism, University of Miami, 1450 NW 10th Avenue, Suite 3054, Miami, FL 33136, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S016882270800385
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http://dx.doi.org/10.1016/j.diabres.2008.08.008DOI Listing
November 2008

Prevention of type 1 diabetes: the time has come.

Nat Clin Pract Endocrinol Metab 2008 Jun 29;4(6):334-43. Epub 2008 Apr 29.

Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/ncpendmet0832DOI Listing
June 2008