Jay D Humphrey

Jay D Humphrey

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Jay D Humphrey

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Co-localization of microstructural damage and excessive mechanical strain at aortic branches in angiotensin-II-infused mice.

Biomech Model Mechanobiol 2020 Feb 4;19(1):81-97. Epub 2019 Jul 4.

Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://link.springer.com/10.1007/s10237-019-01197-3
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http://dx.doi.org/10.1007/s10237-019-01197-3DOI Listing
February 2020

Venous Mechanical Properties After Arteriovenous Fistulae in Mice.

J Surg Res 2019 Dec 31;248:129-136. Epub 2019 Dec 31.

Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut; Department of Surgery, Yale University School of Medicine, New Haven, Connecticut; Department of Surgery, VA Connecticut Healthcare Systems, West Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2019.12.007DOI Listing
December 2019

Optimization of Tissue-Engineered Vascular Graft Design Using Computational Modeling.

Tissue Eng Part C Methods 2019 10 3;25(10):561-570. Epub 2019 Sep 3.

Department of Biomedical Engineering, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1089/ten.TEC.2019.0086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791486PMC
October 2019

Differential outcomes of venous and arterial tissue engineered vascular grafts highlight the importance of coupling long-term implantation studies with computational modeling.

Acta Biomater 2019 08 12;94:183-194. Epub 2019 Jun 12.

Center for Regenerative Medicine, Tissue Engineering Program, The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States; Department of Surgery, Nationwide Children's Hospital, Columbus, OH, United States.

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http://dx.doi.org/10.1016/j.actbio.2019.05.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819998PMC
August 2019

Growth and remodelling of living tissues: perspectives, challenges and opportunities.

J R Soc Interface 2019 Aug 21;16(157):20190233. Epub 2019 Aug 21.

Department of Mechanical Engineering, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1098/rsif.2019.0233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731508PMC
August 2019

Regional Heterogeneity in the Regulation of Vasoconstriction in Arteries and Its Role in Vascular Mechanics.

Adv Exp Med Biol 2018;1097:105-128

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

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http://link.springer.com/10.1007/978-3-319-96445-4_6
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http://dx.doi.org/10.1007/978-3-319-96445-4_6DOI Listing
July 2019

Mechanobiological Stability of Biological Soft Tissues.

J Mech Phys Solids 2019 Apr 21;125:298-325. Epub 2018 Dec 21.

Department of Biomedical Engineering Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1016/j.jmps.2018.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754118PMC
April 2019

Fundamental Roles of Axial Stretch in Isometric and Isobaric Evaluations of Vascular Contractility.

J Biomech Eng 2019 03;141(3)

Department of Biomedical Engineering, Yale University, 55 Prospect Street, New Haven, CT 06520 e-mail: .

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http://dx.doi.org/10.1115/1.4042171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379827PMC
March 2019

Combining in vivo and in vitro biomechanical data reveals key roles of perivascular tethering in central artery function.

PLoS One 2018 7;13(9):e0201379. Epub 2018 Sep 7.

Department of Biomedical Engineering, Yale University, New Haven, CT, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201379PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128471PMC
February 2019

Local variations in material and structural properties characterize murine thoracic aortic aneurysm mechanics.

Biomech Model Mechanobiol 2019 Feb 24;18(1):203-218. Epub 2018 Sep 24.

INSERM U1059, SAINBIOSE, CIS-EMSE, Mines Saint-Etienne, University of Lyon, 42023, Saint Etienne, France.

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http://dx.doi.org/10.1007/s10237-018-1077-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367054PMC
February 2019

Maladaptive aortic remodeling in hypertension associates with dysfunctional smooth muscle contractility.

Am J Physiol Heart Circ Physiol 2019 02 9;316(2):H265-H278. Epub 2018 Nov 9.

Department of Biomedical Engineering, Yale University , New Haven, Connecticut.

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http://dx.doi.org/10.1152/ajpheart.00503.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397387PMC
February 2019

Biomechanical characterization of murine pulmonary arteries.

J Biomech 2019 02 12;84:18-26. Epub 2018 Dec 12.

Department of Biomedical Engineering, Yale University, New Haven, CT, United States; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jbiomech.2018.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361676PMC
February 2019

Sex-dependent differences in central artery haemodynamics in normal and fibulin-5 deficient mice: implications for ageing.

Proc Math Phys Eng Sci 2019 Jan 9;475(2221):20180076. Epub 2019 Jan 9.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1098/rspa.2018.0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364598PMC
January 2019

A Mechanobiologically Equilibrated Constrained Mixture Model for Growth and Remodeling of Soft Tissues.

Z Angew Math Mech 2018 Dec 23;98(12):2048-2071. Epub 2018 Mar 23.

Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1002/zamm.201700302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319907PMC
December 2018

Modeling mechano-driven and immuno-mediated aortic maladaptation in hypertension.

Biomech Model Mechanobiol 2018 Oct 7;17(5):1497-1511. Epub 2018 Jun 7.

Department of Biomedical Engineering, Yale University, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1007/s10237-018-1041-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286240PMC
October 2018

Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation.

Tissue Eng Part A 2018 08 10;24(15-16):1251-1261. Epub 2018 May 10.

3 Department of Surgery, Division of Cardiac Surgery, Johns Hopkins Hospital , Baltimore, Maryland.

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http://dx.doi.org/10.1089/ten.TEA.2017.0483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079650PMC
August 2018

Potential biomechanical roles of risk factors in the evolution of thrombus-laden abdominal aortic aneurysms.

Int J Numer Method Biomed Eng 2017 12 2;33(12). Epub 2017 Jun 2.

Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, Zagreb, Croatia.

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http://doi.wiley.com/10.1002/cnm.2893
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http://dx.doi.org/10.1002/cnm.2893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658277PMC
December 2017

Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts.

J Biomech Eng 2017 Dec;139(12)

Fellow ASME Department of Biomedical Engineering, Yale University, New Haven, CT 06520 e-mail: .

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http://dx.doi.org/10.1115/1.4037856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676664PMC
December 2017

mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice.

Arterioscler Thromb Vasc Biol 2017 09 27;37(9):1657-1666. Epub 2017 Jul 27.

From the Department of Surgery (Y.J., G.L., Q.L., R.A., L.Q., W.L., A.G., G.T.), Department of Internal Medicine (Y.Q., D.M.G.), and Vascular Biology and Therapeutics Program (Y.Q., D.M.G., A.G., J.D.H., G.T.), Yale University School of Medicine, New Haven, CT; Department of Vascular Surgery, Peking University People's Hospital, Beijing, P. R. China (Y.J., Q.L., W.L.); Department of Biomedical Engineering, Yale University, New Haven, CT (J.D.H.); and Veterans Affairs Connecticut Healthcare System, West Haven (G.T.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574180PMC
September 2017

Multiscale and Multiaxial Mechanics of Vascular Smooth Muscle.

Biophys J 2017 Aug;113(3):714-727

Institute of Biomechanics, Graz University of Technology, Graz, Austria; Faculty of Engineering Science and Technology, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2017.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549653PMC
August 2017

Correlation of Wall Microstructure and Heterogeneous Distributions of Strain in Evolving Murine Abdominal Aortic Aneurysms.

Cardiovasc Eng Technol 2017 06 4;8(2):193-204. Epub 2017 Apr 4.

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1007/s13239-017-0301-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481725PMC
June 2017

An augmented iterative method for identifying a stress-free reference configuration in image-based biomechanical modeling.

J Biomech 2017 06 5;58:227-231. Epub 2017 May 5.

Department of Biomedical Engineering, Yale University, United States.

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http://dx.doi.org/10.1016/j.jbiomech.2017.04.021DOI Listing
June 2017

Aging, Smooth Muscle Vitality, and Aortic Integrity.

Circ Res 2017 06;120(12):1849-1851

From the Department of Biomedical Engineering and Vascular Biology and Therapeutics Program, Yale University, New Haven, CT (J.D.H.); and Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (D.M.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508728PMC
June 2017

Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency.

Arterioscler Thromb Vasc Biol 2017 05 2;37(5):930-941. Epub 2017 Mar 2.

From the Department of Surgery, Yale University School of Medicine, New Haven, CT (Y.J., G.L., L.Q., Q.L., W.L., G.T.); Department of Vascular Surgery, Peking University People's Hospital, Beijing, People's Republic of China (Y.J., Q.L., W.L.); Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, People's Republic of China (G.L.); Department of Biomedical Engineering, Yale University, New Haven, CT (A.K., A.W.C., M.R.B., J.D.H.); Department of Cell Biology, Washington University School of Medicine, St Louis, MO (R.P.M.); Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine (J.D.H., G.T.); and Veterans Affairs Connecticut Healthcare System, West Haven (G.T.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501334PMC
May 2017

Gradual loading ameliorates maladaptation in computational simulations of vein graft growth and remodelling.

J R Soc Interface 2017 05;14(130)

Department of Pediatrics, Institute for Computational and Mathematical Engineering, Stanford, CA, USA

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http://dx.doi.org/10.1098/rsif.2016.0995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454282PMC
May 2017

A General Shear-Dependent Model for Thrombus Formation.

PLoS Comput Biol 2017 01 17;13(1):e1005291. Epub 2017 Jan 17.

Division of Applied Mathematics, Brown University, Providence, Rhode Island, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240924PMC
January 2017

Long-Term Functional Efficacy of a Novel Electrospun Poly(Glycerol Sebacate)-Based Arterial Graft in Mice.

Ann Biomed Eng 2016 08 21;44(8):2402-2416. Epub 2016 Jan 21.

Tissue Engineering Program and Surgical Research, Nationwide Children's Hospital, 575 Children's Crossroads, Research III - WB4151, Columbus, OH, 43215, USA.

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http://dx.doi.org/10.1007/s10439-015-1545-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938761PMC
August 2016

Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties.

Arterioscler Thromb Vasc Biol 2016 05 17;36(5):919-27. Epub 2016 Mar 17.

From the Department of Biomedical Engineering, Yale University, New Haven, CT (J.F., S.-I.M., S.U., M.Y.L.T., J.D.H.); and Department of Surgery (G.L., Y.J., G.T.) and Vascular Biology & Therapeutics Program (G.T., J.D.H.), Yale School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/ATVBAHA.116.307436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850095PMC
May 2016

Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension.

Hypertension 2016 Feb 22;67(2):461-8. Epub 2015 Dec 22.

From the Division of Clinical Pharmacology, Department of Medicine (J.W., K.R.C.M., M.A.S., L.X., W.C., M.S.M., D.G.H.), Department of Molecular Physiology and Biophysics (K.R.C.M., M.S.M., D.G.H.), Division of Cardiovascular Medicine, Department of Medicine (D.T.P., A.K.H.), and Department of Cell and Developmental Biology (D.T.P., A.K.H.), School of Medicine, Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt (M.A.S.); Robert M. Berne Cardiovascular Research Center, Department of Physiology, University of Virginia, Charlottesville (G.K.O.); Department of Biomedical Engineering, Yale University, New Haven, CT (J.D.H.); Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT (J.D.H.); Seattle Children's Research Institute, WA (M.W.M.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713264PMC
February 2016

Central Artery Stiffness in Hypertension and Aging: A Problem With Cause and Consequence.

Circ Res 2016 Feb;118(3):379-81

From the Department of Biomedical Engineering, Yale University, New Haven, CT (J.D.H.); Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN (D.G.H.); Departments of Surgery and Biomedical Engineering, University of Michigan, Ann Arbor, MI (C.A.F.); Institut National de la Santé et del la Recherche Médicale U961, Université Henri Poincaré, Nancy, France (P.L.); and Department of Pharmacology and INSERM U970, Université Paris-Descartes, Paris, France (S.L.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745997PMC
February 2016

A discrete mesoscopic particle model of the mechanics of a multi-constituent arterial wall.

J R Soc Interface 2016 Jan;13(114):20150964

Division of Applied Mathematics, Brown University, Providence, RI 02912, USA

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http://dx.doi.org/10.1098/rsif.2015.0964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759800PMC
January 2016

A Computational Model of Biochemomechanical Effects of Intraluminal Thrombus on the Enlargement of Abdominal Aortic Aneurysms.

Ann Biomed Eng 2015 Dec 13;43(12):2852-2867. Epub 2015 Jun 13.

Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, Zagreb, Croatia.

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http://dx.doi.org/10.1007/s10439-015-1354-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626374PMC
December 2015

Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm.

J Vasc Surg 2015 Sep 20;62(3):585-93. Epub 2015 Jul 20.

Department of Bioengineering, Department of Cardiothoracic Surgery, Department of Surgery, Center for Vascular Remodeling and Regeneration, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pa. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2014.11.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550501PMC
September 2015

Design and Use of a Novel Bioreactor for Regeneration of Biaxially Stretched Tissue-Engineered Vessels.

Tissue Eng Part C Methods 2015 Aug 20;21(8):841-51. Epub 2015 Mar 20.

1 Department of Biomedical Engineering, Yale University , New Haven, Connecticut.

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http://dx.doi.org/10.1089/ten.TEC.2014.0287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523101PMC
August 2015

An Experimental-Computational Study of Catheter Induced Alterations in Pulse Wave Velocity in Anesthetized Mice.

Ann Biomed Eng 2015 Jul 20;43(7):1555-70. Epub 2015 Feb 20.

Department of Biomedical Engineering, King's College London, London, UK.

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http://dx.doi.org/10.1007/s10439-015-1272-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497847PMC
July 2015

Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections.

Circ Res 2015 Apr;116(8):1448-61

From the Departments of Biomedical Engineering (J.D.H., M.A.S.), Medicine (Cardiology) (M.A.S.), Cell Biology (M.A.S.), and Surgery (G.T.), Yale University, New Haven, CT; and Department of Internal Medicine, University of Texas Health Science Center, Houston (D.M.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.304936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420625PMC
April 2015

Multimodal optical measurement in vitro of surface deformations and wall thickness of the pressurized aortic arch.

J Biomed Opt 2015 Apr;20(4):046005

Yale University, Department of Biomedical Engineering, New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1117/1.JBO.20.4.046005DOI Listing
April 2015

A microstructurally inspired damage model for early venous thrombus.

J Mech Behav Biomed Mater 2015 Mar 17;55:12-20. Epub 2015 Oct 17.

Department of Biomedical Engineering, Yale University, New Haven, CT, United States.

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http://www.manuelrausch.com/s/JMBBM15.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S175161611500379
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http://dx.doi.org/10.1016/j.jmbbm.2015.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695289PMC
March 2015

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point.

Elife 2015 Feb 2;4. Epub 2015 Feb 2.

Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, United States.

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http://dx.doi.org/10.7554/eLife.04645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337723PMC
February 2015

A hypothesis-driven parametric study of effects of polymeric scaffold properties on tissue engineered neovessel formation.

Acta Biomater 2015 Jan 5;11:283-94. Epub 2014 Oct 5.

Department of Biomedical Engineering, Yale University, New Haven, CT, USA; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2014.09.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256111PMC
January 2015

Mechanotransduction and extracellular matrix homeostasis.

Nat Rev Mol Cell Biol 2014 Dec 22;15(12):802-12. Epub 2014 Oct 22.

1] Department of Biomedical Engineering, Yale University. [2] Department of Cell Biology, Yale University. [3] Department of Medicine, Yale University, New Haven, Connecticut, 06520 USA.

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http://dx.doi.org/10.1038/nrm3896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513363PMC
December 2014

Sequential multimodal microscopic imaging and biaxial mechanical testing of living multicomponent tissue constructs.

Ann Biomed Eng 2014 Sep 10;42(9):1791-805. Epub 2014 May 10.

Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.

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http://dx.doi.org/10.1007/s10439-014-1019-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008701PMC
September 2014

Cell biology. Dysfunctional mechanosensing in aneurysms.

Science 2014 May;344(6183):477-9

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1126/science.1253026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360903PMC
May 2014

Biomechanical roles of medial pooling of glycosaminoglycans in thoracic aortic dissection.

Biomech Model Mechanobiol 2014 Jan 15;13(1):13-25. Epub 2013 Mar 15.

Department of Biomedical Engineering, Malone Engineering Center, Yale University, 55 Prospect Street, New Haven, CT, 06520, USA.

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http://link.springer.com/10.1007/s10237-013-0482-3
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http://dx.doi.org/10.1007/s10237-013-0482-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918738PMC
January 2014

Multi-Scale Computational Model of Three-Dimensional Hemodynamics within a Deformable Full-Body Arterial Network.

J Comput Phys 2013 Jul;244:22-40

Department of Bioengineering, Stanford University, Stanford, CA 94305 USA ; Department of Biomedical Engineering, King's College London, London SE1 7EH, UK.

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http://dx.doi.org/10.1016/j.jcp.2012.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667207PMC
July 2013

An efficient framework for optimization and parameter sensitivity analysis in arterial growth and remodeling computations.

Comput Methods Appl Mech Eng 2013 Apr;256:200-210

Department of Mechanical and Aerospace Engineering, UCSD, 9500 Gilman Drive, La Jolla, CA, United States.

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http://dx.doi.org/10.1016/j.cma.2012.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635687PMC
April 2013

Toward large-scale computational fluid-solid-growth models of intracranial aneurysms.

Yale J Biol Med 2012 Jun 25;85(2):217-28. Epub 2012 Jun 25.

Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375664PMC
June 2012

Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report.

Arterioscler Thromb Vasc Biol 2012 Mar 17;32(3):756-9. Epub 2011 Nov 17.

Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1161/ATVBAHA.111.238113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288647PMC
March 2012

A Multilayered Wall Model of Arterial Growth and Remodeling.

Mech Mater 2012 Jan;44:110-119

Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, I. Lučića 5, Croatia.

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http://dx.doi.org/10.1016/j.mechmat.2011.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237688PMC
January 2012

Carotid artery mechanical properties and stresses quantified using in vivo data from normotensive and hypertensive humans.

Biomech Model Mechanobiol 2011 Dec 5;10(6):867-82. Epub 2011 Jan 5.

CNRS EAC 4396, Centre de Recherches Chirurgicales, Faculté de Médecine, Université Paris-Est Créteil Val de Marne (UPEC), 8 rue du Général Sarrail, 94010 Créteil, France.

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http://link.springer.com/10.1007/s10237-010-0279-6
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http://dx.doi.org/10.1007/s10237-010-0279-6DOI Listing
December 2011

Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome.

Cardiovasc Res 2011 Nov 5;92(2):287-95. Epub 2011 Jul 5.

Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvr195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193833PMC
November 2011

Ensuring congruency in multiscale modeling: towards linking agent based and continuum biomechanical models of arterial adaptation.

Ann Biomed Eng 2011 Nov 2;39(11):2669-82. Epub 2011 Aug 2.

Department of Biomedical Engineering, Texas A&M University, College Station, USA.

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http://dx.doi.org/10.1007/s10439-011-0363-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207323PMC
November 2011

Differential remodeling responses of cerebral and skeletal muscle arterioles in a novel organ culture system.

Med Biol Eng Comput 2011 Sep 23;49(9):1015-23. Epub 2011 Jul 23.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, College Station, TX 77843-4458, USA.

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http://dx.doi.org/10.1007/s11517-011-0807-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516281PMC
September 2011

Automated measurement and statistical modelling of elastic laminae in arteries.

Comput Methods Biomech Biomed Engin 2010 Dec;13(6):749-63

Department of Computer Science, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.1080/10255840903580033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972381PMC
December 2010

Time course of carotid artery growth and remodeling in response to altered pulsatility.

Am J Physiol Heart Circ Physiol 2010 Dec 17;299(6):H1875-83. Epub 2010 Sep 17.

Department of Engineering Technology, University of Houston, Houston, USA.

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http://dx.doi.org/10.1152/ajpheart.00872.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006283PMC
December 2010

Perivascular tethering modulates the geometry and biomechanics of cerebral arterioles.

J Biomech 2010 Oct 22;43(14):2717-21. Epub 2010 Jul 22.

Department of Systems Biology and Translational Medicine, Texas A&M Health Science Center, College Station, TX, USA.

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http://dx.doi.org/10.1016/j.jbiomech.2010.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963660PMC
October 2010

Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling.

Proc Natl Acad Sci U S A 2010 Feb 1;107(8):3335-9. Epub 2009 Dec 1.

Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1073/pnas.0907813106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840446PMC
February 2010

Transforming growth factor-beta signaling in hypertensive remodeling of porcine aorta.

Am J Physiol Heart Circ Physiol 2009 Dec 28;297(6):H2044-53. Epub 2009 Aug 28.

Department of Systems Biology and Translational Medicine, TAMHSC, 336 Reynolds Medical Bldg., College Station, TX 77843-1114, USA.

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http://dx.doi.org/10.1152/ajpheart.01015.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793137PMC
December 2009

Modeling effects of axial extension on arterial growth and remodeling.

Med Biol Eng Comput 2009 Sep 1;47(9):979-87. Epub 2009 Aug 1.

Department of Biomedical Engineering, 337 Zachry Engineering Center, Texas A&M University, College Station, TX 77843-3120, USA.

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http://link.springer.com/10.1007/s11517-009-0513-5
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607502PMC
September 2009

Characterization of engineered tissue development under biaxial stretch using nonlinear optical microscopy.

Tissue Eng Part A 2009 Jul;15(7):1553-64

Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.

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http://dx.doi.org/10.1089/ten.tea.2008.0287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742218PMC
July 2009

A microstructurally motivated model of the mechanical behavior of tissue engineered blood vessels.

Ann Biomed Eng 2008 Nov 22;36(11):1782-92. Epub 2008 Aug 22.

Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1007/s10439-008-9554-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605792PMC
November 2008

Quantification of the mechanical behavior of carotid arteries from wild-type, dystrophin-deficient, and sarcoglycan-delta knockout mice.

J Biomech 2008 Nov 7;41(15):3213-8. Epub 2008 Oct 7.

George W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering, and The Petite Institute for Biomedical Engineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.

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http://dx.doi.org/10.1016/j.jbiomech.2008.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688405PMC
November 2008

Growth and remodeling in a thick-walled artery model: effects of spatial variations in wall constituents.

Biomech Model Mechanobiol 2008 Aug 2;7(4):245-62. Epub 2007 Sep 2.

Department of Biomedical Engineering, Washington University, Campus Box 1097, St Louis, MO 63130, USA.

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http://link.springer.com/10.1007/s10237-007-0101-2
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http://dx.doi.org/10.1007/s10237-007-0101-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2594015PMC
August 2008

Mechanisms of arterial remodeling in hypertension: coupled roles of wall shear and intramural stress.

Authors:
Jay D Humphrey

Hypertension 2008 Aug 9;52(2):195-200. Epub 2008 Jun 9.

Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, Texas A&M University, College Station, TX 77843-3120, USA.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.107.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.103440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753501PMC
August 2008

Characterization of arterial wall mechanical behavior and stresses from human clinical data.

J Biomech 2008 Aug 5;41(12):2618-27. Epub 2008 Aug 5.

CNRS UMR 7054, Faculté de Médecine, Université Paris 12, 8 Rue du Général Sarrail, Créteil F-94010, France.

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http://dx.doi.org/10.1016/j.jbiomech.2008.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761214PMC
August 2008

Time courses of growth and remodeling of porcine aortic media during hypertension: a quantitative immunohistochemical examination.

J Histochem Cytochem 2008 Apr 10;56(4):359-70. Epub 2007 Dec 10.

Department of Systems Biology and Translational Medicine, Texas A&M Health Science Center, Reynolds Medical Building, 1114 TAMU, College Station, TX 77843-1114, USA.

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http://dx.doi.org/10.1369/jhc.7A7324.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2326104PMC
April 2008

Effects of biaxial stretch on arteriolar function in vitro.

Am J Physiol Heart Circ Physiol 2007 May 5;292(5):H2378-86. Epub 2007 Jan 5.

Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, MO 65212, USA.

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http://www.physiology.org/doi/10.1152/ajpheart.00810.2006
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May 2007

Biaxial biomechanical adaptations of mouse carotid arteries cultured at altered axial extension.

J Biomech 2007 5;40(4):766-76. Epub 2006 Jun 5.

Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.1016/j.jbiomech.2006.03.018DOI Listing
April 2007

Influence of glycerol on the mechanical reversibility and thermal damage susceptibility of collagenous tissues.

IEEE Trans Biomed Eng 2006 Apr;53(4):747-53

Texas A&M University, College Station, TX 7784, USA.

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http://ieeexplore.ieee.org/document/1608525/
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http://dx.doi.org/10.1109/TBME.2006.870232DOI Listing
April 2006

A 2D constrained mixture model for arterial adaptations to large changes in flow, pressure and axial stretch.

Math Med Biol 2005 Dec;22(4):347-69

Department of Biomedical Engineering and M.E. DeBakey Institute, Texas A&M University, 337 Zachry Engineering Center, TAMU 3120, College Station, 77843, USA.

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http://dx.doi.org/10.1093/imammb/dqi014DOI Listing
December 2005

Stress distribution in a circular membrane with a central fixation.

J Biomech Eng 2005 Jun;127(3):549-53

Department of Biomedical Engineering, Texas A&M University 337 Zachry Engineering Center, 3120 TAMU College Station, TX 77843-3120, USA.

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http://dx.doi.org/10.1115/1.1894389DOI Listing
June 2005

Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles.

Hypertension 2004 Dec 18;44(6):935-43. Epub 2004 Oct 18.

Department of Medical Physiology, College of Medicine, Texas A&M University System Health Science Center, College Station, Tex, USA.

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http://dx.doi.org/10.1161/01.HYP.0000146907.82869.f2DOI Listing
December 2004

Building a functional artery: issues from the perspective of mechanics.

Front Biosci 2004 Sep 1;9:2045-55. Epub 2004 Sep 1.

Department of Biomedical Engineering and M.E. DeBakey Institute, Texas A and M University, College Station, TX 77843-3120, USA.

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http://dx.doi.org/10.2741/1387DOI Listing
September 2004

A novel aortic coarctation model for studying hypertension in the pig.

J Invest Surg 2003 Jan-Feb;16(1):35-44

Michael E. DeBakey Institute for Comparative Cardiovascular Sciences and Biomedical Devices, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4474, USA.

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April 2004

Kinetics of thermal damage to a collagenous membrane under biaxial isotonic loading.

IEEE Trans Biomed Eng 2004 Feb;51(2):371-9

Department of Biomedical Engineering and M.E. DeBakey Institute, Texas A&M University, College Station, TX 77843-3120, USA.

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http://ieeexplore.ieee.org/document/1262115/
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http://dx.doi.org/10.1109/TBME.2003.820375DOI Listing
February 2004

A potential role of smooth muscle tone in early hypertension: a theoretical study.

J Biomech 2003 Nov;36(11):1595-601

Department of Biomedical Engineering and M.E. DeBakey Institute, Texas A&M University, 233 Zachry Engineering Center, College Station, TX 77843-3120, USA.

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http://dx.doi.org/10.1016/s0021-9290(03)00178-7DOI Listing
November 2003

A sub-domain inverse finite element characterization of hyperelastic membranes including soft tissues.

J Biomech Eng 2003 Jun;125(3):363-71

Department of Mathematics and Statistics, Texas Tech University, Lubbock, TX 79409-1042, USA.

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http://dx.doi.org/10.1115/1.1574333DOI Listing
June 2003

Biomechanics.

Biomech Model Mechanobiol 2002 Jun;1(1):1-2

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http://dx.doi.org/10.1007/s10237-002-0010-3DOI Listing
June 2002