Jay D Horton

Jay D Horton

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Jay D Horton

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Intravascular triglyceride lipolysis becomes crystal clear.

Authors:
Jay D Horton

Proc Natl Acad Sci U S A 2019 01 4;116(5):1480-1482. Epub 2019 Jan 4.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.1820330116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358687PMC
January 2019

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.

Mol Metab 2018 08 23;14:121-129. Epub 2018 May 23.

Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034037PMC
August 2018

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity.

Mol Metab 2018 05 2;11:1-17. Epub 2018 Mar 2.

Touchstone Diabetes Center, Department of Internal Medicines, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001360PMC
May 2018

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice.

J Lipid Res 2018 03 15;59(3):475-487. Epub 2018 Jan 15.

Departments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390

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http://dx.doi.org/10.1194/jlr.M081836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832931PMC
March 2018

Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice.

J Lipid Res 2017 08 9;58(8):1661-1669. Epub 2017 Jun 9.

Departments of Internal Medicine and Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX

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http://dx.doi.org/10.1194/jlr.M076844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538287PMC
August 2017

An adipo-biliary-uridine axis that regulates energy homeostasis.

Science 2017 03 16;355(6330). Epub 2017 Mar 16.

Touchstone Diabetes Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1126/science.aaf5375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832364PMC
March 2017

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.

N Engl J Med 2017 01 13;376(1):41-51. Epub 2016 Nov 13.

From Alnylam Pharmaceuticals, Cambridge, MA (K.F., S.W., A. Borodovsky, B.R.B., A. Strahs, V.C., R.S.K., A.V., A. Simon); the Medicines Company, Parsippany, NJ (P.W., D.K.); University of Texas Southwestern Medical Center, Dallas (J.D.H.); Richmond Pharmacology, St. George's University of London, London (J.T.); and Covance Clinical Research Unit, Leeds, United Kingdom (A. Brooks, C.F.).

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http://dx.doi.org/10.1056/NEJMoa1609243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778873PMC
January 2017

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism.

Proc Natl Acad Sci U S A 2017 01 17;114(5):1189-1194. Epub 2017 Jan 17.

Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1620506114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293102PMC
January 2017

AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue.

Mol Metab 2016 Jul 13;5(7):491-505. Epub 2016 May 13.

Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921804PMC
July 2016

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.

J Lipid Res 2016 Apr 15;57(4):616-30. Epub 2016 Feb 15.

Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.

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http://www.jlr.org/content/early/2016/02/15/jlr.M065896.full
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http://www.jlr.org/lookup/doi/10.1194/jlr.M065896
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http://dx.doi.org/10.1194/jlr.M065896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808770PMC
April 2016

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice.

J Lipid Res 2014 Dec 30;55(12):2541-53. Epub 2014 Sep 30.

Advanced Imaging Research Center-Division of Metabolic Mechanisms of Disease, The University of Texas Southwestern Medical Center, Dallas, TX Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1194/jlr.M052308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242447PMC
December 2014

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance.

J Lipid Res 2014 Dec 3;55(12):2597-605. Epub 2014 Oct 3.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.

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http://dx.doi.org/10.1194/jlr.M054353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242452PMC
December 2014

Acetate dependence of tumors.

Cell 2014 Dec;159(7):1591-602

Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272450PMC
December 2014

An acetate switch regulates stress erythropoiesis.

Nat Med 2014 Sep 10;20(9):1018-26. Epub 2014 Aug 10.

1] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. [2] Department of Medicine, VA North Texas Health Care System, Dallas, Texas, USA. [3].

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http://dx.doi.org/10.1038/nm.3587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159437PMC
September 2014

Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.

J Lipid Res 2014 Feb 30;55(2):276-88. Epub 2013 Nov 30.

Department of Molecular Genetics, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1194/jlr.M045799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886666PMC
February 2014

Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice.

J Biol Chem 2014 Feb 14;289(8):4762-77. Epub 2014 Jan 14.

From the Division of Nutrition and Metabolic Diseases, Department of Internal Medicine and Center for Human Nutrition.

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http://dx.doi.org/10.1074/jbc.M113.530998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931038PMC
February 2014

Opening up new fronts in the fight against cholesterol.

Elife 2013 Apr 9;2:e00663. Epub 2013 Apr 9.

is at the Department of Molecular Genetics and the Howard Hughes Medical Institute , University of Texas Southwestern Medical Center , Dallas , United States

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http://dx.doi.org/10.7554/eLife.00663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622229PMC
April 2013

Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model.

Am J Physiol Endocrinol Metab 2013 Feb 26;304(4):E444-51. Epub 2012 Dec 26.

Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.physiology.org/doi/10.1152/ajpendo.00347.2012
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http://dx.doi.org/10.1152/ajpendo.00347.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566507PMC
February 2013

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism.

J Clin Invest 2013 Jan 21;123(1):455-68. Epub 2012 Dec 21.

Touchstone Diabetes Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1172/JCI62819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533268PMC
January 2013

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice.

J Clin Invest 2012 Apr 19;122(4):1262-70. Epub 2012 Mar 19.

Department of Medicine, Columbia University, New York, New York 10032, USA.

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http://www.jci.org/articles/view/61919
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http://dx.doi.org/10.1172/JCI61919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314476PMC
April 2012

Enhanced fatty acid flux triggered by adiponectin overexpression.

Endocrinology 2012 Jan 1;153(1):113-22. Epub 2011 Nov 1.

Touchstone Diabetes Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9052, USA.

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http://dx.doi.org/10.1210/en.2011-1339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249680PMC
January 2012

Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people.

Transl Res 2011 Nov 19;158(5):302-6. Epub 2011 Jul 19.

Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1016/j.trsl.2011.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200562PMC
November 2011

Human fatty liver disease: old questions and new insights.

Science 2011 Jun;332(6037):1519-23

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1126/science.1204265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229276PMC
June 2011

Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans.

J Lipid Res 2010 Nov 16;51(11):3359-63. Epub 2010 Aug 16.

Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

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http://dx.doi.org/10.1194/jlr.P009860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952577PMC
November 2010

Crystal structure of Spot 14, a modulator of fatty acid synthesis.

Proc Natl Acad Sci U S A 2010 Nov 15;107(44):18820-5. Epub 2010 Oct 15.

Department of Biochemistry and Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9050, USA.

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http://dx.doi.org/10.1073/pnas.1012736107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973905PMC
November 2010

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

Diabetes 2010 Aug 3;59(8):1899-905. Epub 2010 Jun 3.

Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.2337/db10-0308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911053PMC
August 2010

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.

Proc Natl Acad Sci U S A 2010 May 10;107(21):9626-31. Epub 2010 May 10.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1073/pnas.1001292107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906888PMC
May 2010

Genetic and metabolic determinants of plasma PCSK9 levels.

J Clin Endocrinol Metab 2009 Jul 7;94(7):2537-43. Epub 2009 Apr 7.

Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2009-0141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708952PMC
July 2009

PCSK9: a convertase that coordinates LDL catabolism.

J Lipid Res 2009 Apr 19;50 Suppl:S172-7. Epub 2008 Nov 19.

Department of Internal Medicine, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1194/jlr.R800091-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674748PMC
April 2009

Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells.

J Biol Chem 2009 Apr 17;284(16):10561-70. Epub 2009 Feb 17.

Departments of Molecular Genetics, Biochemistry, and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1074/jbc.M808802200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667743PMC
April 2009

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice.

J Lipid Res 2009 Mar 6;50(3):412-23. Epub 2008 Oct 6.

Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9046, USA.

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http://www.jlr.org/content/50/3/412.full.pdf
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http://www.jlr.org/cgi/doi/10.1194/jlr.M800383-JLR200
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http://dx.doi.org/10.1194/jlr.M800383-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638104PMC
March 2009

Plasma PCSK9 preferentially reduces liver LDL receptors in mice.

J Lipid Res 2008 Jun 19;49(6):1303-11. Epub 2008 Mar 19.

Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1194/jlr.M800027-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386900PMC
June 2008

Physiology. Unfolding lipid metabolism.

Authors:
Jay D Horton

Science 2008 Jun;320(5882):1433-4

Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1126/science.1159651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701207PMC
June 2008

Molecular basis for LDL receptor recognition by PCSK9.

Proc Natl Acad Sci U S A 2008 Feb 4;105(6):1820-5. Epub 2008 Feb 4.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9050, USA.

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http://dx.doi.org/10.1073/pnas.0712064105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538846PMC
February 2008

Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells.

J Biol Chem 2007 Jul 29;282(29):20799-803. Epub 2007 May 29.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C700095200
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http://dx.doi.org/10.1074/jbc.C700095200DOI Listing
July 2007

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.

J Biol Chem 2007 Jun 23;282(25):18602-12. Epub 2007 Apr 23.

Department of Molecular Genetics, the Donald W. Reynolds Cardiovascular Clinical Research Center, Howard Hughes Institute, University of Texas Southwestern Medical Center, Dallas 75390, USA.

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http://dx.doi.org/10.1074/jbc.M702027200DOI Listing
June 2007

Molecular biology of PCSK9: its role in LDL metabolism.

Trends Biochem Sci 2007 Feb 9;32(2):71-7. Epub 2007 Jan 9.

Departments of Internal Medicine and Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1016/j.tibs.2006.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711871PMC
February 2007

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote.

Am J Hum Genet 2006 Sep 18;79(3):514-23. Epub 2006 Jul 18.

Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA.

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http://dx.doi.org/10.1086/507488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559532PMC
September 2006

WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data.

BMC Bioinformatics 2006 Jan 19;7:30. Epub 2006 Jan 19.

Advanced Biomedical Computing Center, National Cancer Institute-Frederick/SAIC-Frederick Inc., Frederick, MD 21702, USA.

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http://dx.doi.org/10.1186/1471-2105-7-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1388242PMC
January 2006

Cholesterol accumulation and liver cell death in mice with Niemann-Pick type C disease.

Hepatology 2005 Oct;42(4):886-93

Department of Pediatrics, University of Texas Southwestern Medical School, Dallas, TX 75390-8887, USA.

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http://doi.wiley.com/10.1002/hep.20868
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October 2005

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

J Clin Invest 2005 Sep 11;115(9):2489-98. Epub 2005 Aug 11.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI25614
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http://dx.doi.org/10.1172/JCI25614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1184040PMC
September 2005

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9.

Proc Natl Acad Sci U S A 2005 Apr 1;102(15):5374-9. Epub 2005 Apr 1.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046, USA.

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http://www.jbc.org/content/early/2007/05/29/jbc.C700095200.f
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http://www.pnas.org/cgi/doi/10.1073/pnas.0501652102
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http://dx.doi.org/10.1073/pnas.0501652102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC556275PMC
April 2005

LXRs regulate the balance between fat storage and oxidation.

Cell Metab 2005 Apr;1(4):231-44

Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S155041310500060
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http://dx.doi.org/10.1016/j.cmet.2005.03.001DOI Listing
April 2005

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.

Cell Metab 2005 Jan;1(1):41-51

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1016/j.cmet.2004.11.004DOI Listing
January 2005

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity.

Hepatology 2004 Dec;40(6):1387-95

Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1002/hep.20466DOI Listing
December 2004

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

J Biol Chem 2004 Nov 22;279(48):50630-8. Epub 2004 Sep 22.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M410077200
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http://dx.doi.org/10.1074/jbc.M410077200DOI Listing
November 2004

Molecular mediators of hepatic steatosis and liver injury.

J Clin Invest 2004 Jul;114(2):147-52

Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390-9046, USA.

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http://dx.doi.org/10.1172/JCI22422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC449757PMC
July 2004

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.

Proc Natl Acad Sci U S A 2004 May 26;101(19):7281-6. Epub 2004 Apr 26.

Department of Biochemistry, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0401516101
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http://dx.doi.org/10.1073/pnas.0401516101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC409910PMC
May 2004

ATP-citrate lyase deficiency in the mouse.

J Biol Chem 2004 Mar 8;279(10):9557-64. Epub 2003 Dec 8.

Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141, USA.

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http://dx.doi.org/10.1074/jbc.M310512200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888281PMC
March 2004

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.

Proc Natl Acad Sci U S A 2003 Oct 25;100(21):12027-32. Epub 2003 Sep 25.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.

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http://dx.doi.org/10.1073/pnas.1534923100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC218707PMC
October 2003

Gallstone disease and its complications.

Semin Gastrointest Dis 2003 Oct;14(4):165-77

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.

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October 2003

Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

J Biol Chem 2003 Sep 10;278(38):36652-60. Epub 2003 Jul 10.

Departments of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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http://dx.doi.org/10.1074/jbc.M306540200DOI Listing
September 2003

Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.

J Biol Chem 2003 Feb 13;278(9):7335-43. Epub 2002 Dec 13.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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http://dx.doi.org/10.1074/jbc.M211684200DOI Listing
February 2003

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol.

J Clin Invest 2002 Sep;110(5):671-80

Department of Molecular Genetics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9046, USA.

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http://dx.doi.org/10.1172/JCI16001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151111PMC
September 2002

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.

J Lipid Res 2002 May;43(5):772-84

Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8887, USA.

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May 2002

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

J Clin Invest 2002 May;109(9):1125-31

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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http://dx.doi.org/10.1172/JCI15593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150968PMC
May 2002

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.

J Biol Chem 2002 Mar 8;277(11):9520-8. Epub 2002 Jan 8.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA.

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http://dx.doi.org/10.1074/jbc.M111421200DOI Listing
March 2002